Exosomes in Liquid Biopsy: The Nanometric World in the Pursuit of Precision Oncology

Among the different components that can be analyzed in liquid biopsy, the utility of exosomes is particularly promising because of their presence in all biological fluids and their potential for multicomponent analyses. Exosomes are extracellular vesicles with an average size of ~100 nm in diameter...
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Autor*in:	Karmele Valencia [verfasserIn] Luis M. Montuenga [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	exosomes cancer liquid biopsy biomarkers

Übergeordnetes Werk:	In: Cancers - MDPI AG, 2010, 13(2021), 9, p 2147
Übergeordnetes Werk:	volume:13 ; year:2021 ; number:9, p 2147

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/cancers13092147

Katalog-ID:	DOAJ016765532

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520			\|a Among the different components that can be analyzed in liquid biopsy, the utility of exosomes is particularly promising because of their presence in all biological fluids and their potential for multicomponent analyses. Exosomes are extracellular vesicles with an average size of ~100 nm in diameter with an endosomal origin. All eukaryotic cells release exosomes as part of their active physiology. In an oncologic patient, up to 10% of all the circulating exosomes are estimated to be tumor-derived exosomes. Exosome content mirrors the features of its cell of origin in terms of DNA, RNA, lipids, metabolites, and cytosolic/cell-surface proteins. Due to their multifactorial content, exosomes constitute a unique tool to capture the complexity and enormous heterogeneity of cancer in a longitudinal manner. Due to molecular features such as high nucleic acid concentrations and elevated coverage of genomic driver gene sequences, exosomes will probably become the “gold standard” liquid biopsy analyte in the near future.
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allfieldsSound	10.3390/cancers13092147 doi (DE-627)DOAJ016765532 (DE-599)DOAJ3fd8f5ac035d4b6aa271a670164d1254 DE-627 ger DE-627 rakwb eng RC254-282 Karmele Valencia verfasserin aut Exosomes in Liquid Biopsy: The Nanometric World in the Pursuit of Precision Oncology 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Among the different components that can be analyzed in liquid biopsy, the utility of exosomes is particularly promising because of their presence in all biological fluids and their potential for multicomponent analyses. Exosomes are extracellular vesicles with an average size of ~100 nm in diameter with an endosomal origin. All eukaryotic cells release exosomes as part of their active physiology. In an oncologic patient, up to 10% of all the circulating exosomes are estimated to be tumor-derived exosomes. Exosome content mirrors the features of its cell of origin in terms of DNA, RNA, lipids, metabolites, and cytosolic/cell-surface proteins. Due to their multifactorial content, exosomes constitute a unique tool to capture the complexity and enormous heterogeneity of cancer in a longitudinal manner. Due to molecular features such as high nucleic acid concentrations and elevated coverage of genomic driver gene sequences, exosomes will probably become the “gold standard” liquid biopsy analyte in the near future. exosomes cancer liquid biopsy biomarkers Neoplasms. Tumors. Oncology. Including cancer and carcinogens Luis M. Montuenga verfasserin aut In Cancers MDPI AG, 2010 13(2021), 9, p 2147 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:13 year:2021 number:9, p 2147 https://doi.org/10.3390/cancers13092147 kostenfrei https://doaj.org/article/3fd8f5ac035d4b6aa271a670164d1254 kostenfrei https://www.mdpi.com/2072-6694/13/9/2147 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2021 9, p 2147
language	English
source	In Cancers 13(2021), 9, p 2147 volume:13 year:2021 number:9, p 2147
sourceStr	In Cancers 13(2021), 9, p 2147 volume:13 year:2021 number:9, p 2147
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	exosomes cancer liquid biopsy biomarkers Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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container_title	Cancers
authorswithroles_txt_mv	Karmele Valencia @@aut@@ Luis M. Montuenga @@aut@@
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author	Karmele Valencia
spellingShingle	Karmele Valencia misc RC254-282 misc exosomes misc cancer misc liquid biopsy misc biomarkers misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Exosomes in Liquid Biopsy: The Nanometric World in the Pursuit of Precision Oncology
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topic_title	RC254-282 Exosomes in Liquid Biopsy: The Nanometric World in the Pursuit of Precision Oncology exosomes cancer liquid biopsy biomarkers
topic	misc RC254-282 misc exosomes misc cancer misc liquid biopsy misc biomarkers misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc exosomes misc cancer misc liquid biopsy misc biomarkers misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title_sort	exosomes in liquid biopsy: the nanometric world in the pursuit of precision oncology
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title_auth	Exosomes in Liquid Biopsy: The Nanometric World in the Pursuit of Precision Oncology
abstract	Among the different components that can be analyzed in liquid biopsy, the utility of exosomes is particularly promising because of their presence in all biological fluids and their potential for multicomponent analyses. Exosomes are extracellular vesicles with an average size of ~100 nm in diameter with an endosomal origin. All eukaryotic cells release exosomes as part of their active physiology. In an oncologic patient, up to 10% of all the circulating exosomes are estimated to be tumor-derived exosomes. Exosome content mirrors the features of its cell of origin in terms of DNA, RNA, lipids, metabolites, and cytosolic/cell-surface proteins. Due to their multifactorial content, exosomes constitute a unique tool to capture the complexity and enormous heterogeneity of cancer in a longitudinal manner. Due to molecular features such as high nucleic acid concentrations and elevated coverage of genomic driver gene sequences, exosomes will probably become the “gold standard” liquid biopsy analyte in the near future.
abstractGer	Among the different components that can be analyzed in liquid biopsy, the utility of exosomes is particularly promising because of their presence in all biological fluids and their potential for multicomponent analyses. Exosomes are extracellular vesicles with an average size of ~100 nm in diameter with an endosomal origin. All eukaryotic cells release exosomes as part of their active physiology. In an oncologic patient, up to 10% of all the circulating exosomes are estimated to be tumor-derived exosomes. Exosome content mirrors the features of its cell of origin in terms of DNA, RNA, lipids, metabolites, and cytosolic/cell-surface proteins. Due to their multifactorial content, exosomes constitute a unique tool to capture the complexity and enormous heterogeneity of cancer in a longitudinal manner. Due to molecular features such as high nucleic acid concentrations and elevated coverage of genomic driver gene sequences, exosomes will probably become the “gold standard” liquid biopsy analyte in the near future.
abstract_unstemmed	Among the different components that can be analyzed in liquid biopsy, the utility of exosomes is particularly promising because of their presence in all biological fluids and their potential for multicomponent analyses. Exosomes are extracellular vesicles with an average size of ~100 nm in diameter with an endosomal origin. All eukaryotic cells release exosomes as part of their active physiology. In an oncologic patient, up to 10% of all the circulating exosomes are estimated to be tumor-derived exosomes. Exosome content mirrors the features of its cell of origin in terms of DNA, RNA, lipids, metabolites, and cytosolic/cell-surface proteins. Due to their multifactorial content, exosomes constitute a unique tool to capture the complexity and enormous heterogeneity of cancer in a longitudinal manner. Due to molecular features such as high nucleic acid concentrations and elevated coverage of genomic driver gene sequences, exosomes will probably become the “gold standard” liquid biopsy analyte in the near future.
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title_short	Exosomes in Liquid Biopsy: The Nanometric World in the Pursuit of Precision Oncology
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score	7.3984203

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Exosomes in Liquid Biopsy: The Nanometric World in the Pursuit of Precision Oncology

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