The search for new biomarkers for cognition in schizophrenia

The search for biomarkers in cognition has been the focus of a large part of the research on patients suffering from schizophrenia. The scientific literature is heterogeneous, and few studies establishing an integrative model of pathogenesis and therapeutic response are available in this field. In t...
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Autor*in:	Rafael Penadés [verfasserIn] Clemente García-Rizo [verfasserIn] Miquel Bioque [verfasserIn] Alexandre González-Rodríguez [verfasserIn] Bibiana Cabrera [verfasserIn] Gisela Mezquida [verfasserIn] Miquel Bernardo [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2015

Schlagwörter:	Schizophrenia Cognition Biomarkers Inflammation Prolactin BDNF

Übergeordnetes Werk:	In: Schizophrenia Research: Cognition - Elsevier, 2016, 2(2015), 4, Seite 172-178
Übergeordnetes Werk:	volume:2 ; year:2015 ; number:4 ; pages:172-178

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.scog.2015.10.004

Katalog-ID:	DOAJ016900049

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allfields	10.1016/j.scog.2015.10.004 doi (DE-627)DOAJ016900049 (DE-599)DOAJcd4dfc8cd1d740198d1491f75db5da4c DE-627 ger DE-627 rakwb eng RC346-429 Rafael Penadés verfasserin aut The search for new biomarkers for cognition in schizophrenia 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The search for biomarkers in cognition has been the focus of a large part of the research on patients suffering from schizophrenia. The scientific literature is heterogeneous, and few studies establishing an integrative model of pathogenesis and therapeutic response are available in this field. In this review, we aimed to summarize three essential aspects correlated with cognitive performance: 1) the relationship between inflammation and cognition in schizophrenia, 2) the role of prolactin in cognition, and 3) the association between cognition and neurotrophic factors, particularly brain-derived neurotrophic factor (BDNF). Several studies support the association of inflammatory markers with cognitive status in schizophrenia. In recent decades, the development of effective therapies for cognitive impairment in schizophrenia has focused on the search for anti-inflammatory and immunomodulatory medications. Conversely, the implications of prolactin and its functions in cognition, the transition to psychosis and the diagnosis and prognosis of schizophrenia have been established independent of antipsychotic treatment. With regard to neurotrophic factors, a recent study has correlated BDNF levels with cognitive recovery in schizophrenic patients treated with cognitive remediation. We conclude that although there is a diversity of biomarkers focused on cognitive function in schizophrenia, BDNF is the biomarker that has accumulated the vast majority of evidence in the current literature. Schizophrenia Cognition Biomarkers Inflammation Prolactin BDNF Neurology. Diseases of the nervous system Clemente García-Rizo verfasserin aut Miquel Bioque verfasserin aut Alexandre González-Rodríguez verfasserin aut Bibiana Cabrera verfasserin aut Gisela Mezquida verfasserin aut Miquel Bernardo verfasserin aut In Schizophrenia Research: Cognition Elsevier, 2016 2(2015), 4, Seite 172-178 (DE-627)805638512 (DE-600)2800609-4 22150013 nnns volume:2 year:2015 number:4 pages:172-178 https://doi.org/10.1016/j.scog.2015.10.004 kostenfrei https://doaj.org/article/cd4dfc8cd1d740198d1491f75db5da4c kostenfrei http://www.sciencedirect.com/science/article/pii/S2215001315000335 kostenfrei https://doaj.org/toc/2215-0013 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 2 2015 4 172-178
spelling	10.1016/j.scog.2015.10.004 doi (DE-627)DOAJ016900049 (DE-599)DOAJcd4dfc8cd1d740198d1491f75db5da4c DE-627 ger DE-627 rakwb eng RC346-429 Rafael Penadés verfasserin aut The search for new biomarkers for cognition in schizophrenia 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The search for biomarkers in cognition has been the focus of a large part of the research on patients suffering from schizophrenia. The scientific literature is heterogeneous, and few studies establishing an integrative model of pathogenesis and therapeutic response are available in this field. In this review, we aimed to summarize three essential aspects correlated with cognitive performance: 1) the relationship between inflammation and cognition in schizophrenia, 2) the role of prolactin in cognition, and 3) the association between cognition and neurotrophic factors, particularly brain-derived neurotrophic factor (BDNF). Several studies support the association of inflammatory markers with cognitive status in schizophrenia. In recent decades, the development of effective therapies for cognitive impairment in schizophrenia has focused on the search for anti-inflammatory and immunomodulatory medications. Conversely, the implications of prolactin and its functions in cognition, the transition to psychosis and the diagnosis and prognosis of schizophrenia have been established independent of antipsychotic treatment. With regard to neurotrophic factors, a recent study has correlated BDNF levels with cognitive recovery in schizophrenic patients treated with cognitive remediation. We conclude that although there is a diversity of biomarkers focused on cognitive function in schizophrenia, BDNF is the biomarker that has accumulated the vast majority of evidence in the current literature. Schizophrenia Cognition Biomarkers Inflammation Prolactin BDNF Neurology. Diseases of the nervous system Clemente García-Rizo verfasserin aut Miquel Bioque verfasserin aut Alexandre González-Rodríguez verfasserin aut Bibiana Cabrera verfasserin aut Gisela Mezquida verfasserin aut Miquel Bernardo verfasserin aut In Schizophrenia Research: Cognition Elsevier, 2016 2(2015), 4, Seite 172-178 (DE-627)805638512 (DE-600)2800609-4 22150013 nnns volume:2 year:2015 number:4 pages:172-178 https://doi.org/10.1016/j.scog.2015.10.004 kostenfrei https://doaj.org/article/cd4dfc8cd1d740198d1491f75db5da4c kostenfrei http://www.sciencedirect.com/science/article/pii/S2215001315000335 kostenfrei https://doaj.org/toc/2215-0013 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 2 2015 4 172-178
allfields_unstemmed	10.1016/j.scog.2015.10.004 doi (DE-627)DOAJ016900049 (DE-599)DOAJcd4dfc8cd1d740198d1491f75db5da4c DE-627 ger DE-627 rakwb eng RC346-429 Rafael Penadés verfasserin aut The search for new biomarkers for cognition in schizophrenia 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The search for biomarkers in cognition has been the focus of a large part of the research on patients suffering from schizophrenia. The scientific literature is heterogeneous, and few studies establishing an integrative model of pathogenesis and therapeutic response are available in this field. In this review, we aimed to summarize three essential aspects correlated with cognitive performance: 1) the relationship between inflammation and cognition in schizophrenia, 2) the role of prolactin in cognition, and 3) the association between cognition and neurotrophic factors, particularly brain-derived neurotrophic factor (BDNF). Several studies support the association of inflammatory markers with cognitive status in schizophrenia. In recent decades, the development of effective therapies for cognitive impairment in schizophrenia has focused on the search for anti-inflammatory and immunomodulatory medications. Conversely, the implications of prolactin and its functions in cognition, the transition to psychosis and the diagnosis and prognosis of schizophrenia have been established independent of antipsychotic treatment. With regard to neurotrophic factors, a recent study has correlated BDNF levels with cognitive recovery in schizophrenic patients treated with cognitive remediation. We conclude that although there is a diversity of biomarkers focused on cognitive function in schizophrenia, BDNF is the biomarker that has accumulated the vast majority of evidence in the current literature. Schizophrenia Cognition Biomarkers Inflammation Prolactin BDNF Neurology. Diseases of the nervous system Clemente García-Rizo verfasserin aut Miquel Bioque verfasserin aut Alexandre González-Rodríguez verfasserin aut Bibiana Cabrera verfasserin aut Gisela Mezquida verfasserin aut Miquel Bernardo verfasserin aut In Schizophrenia Research: Cognition Elsevier, 2016 2(2015), 4, Seite 172-178 (DE-627)805638512 (DE-600)2800609-4 22150013 nnns volume:2 year:2015 number:4 pages:172-178 https://doi.org/10.1016/j.scog.2015.10.004 kostenfrei https://doaj.org/article/cd4dfc8cd1d740198d1491f75db5da4c kostenfrei http://www.sciencedirect.com/science/article/pii/S2215001315000335 kostenfrei https://doaj.org/toc/2215-0013 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 2 2015 4 172-178
allfieldsGer	10.1016/j.scog.2015.10.004 doi (DE-627)DOAJ016900049 (DE-599)DOAJcd4dfc8cd1d740198d1491f75db5da4c DE-627 ger DE-627 rakwb eng RC346-429 Rafael Penadés verfasserin aut The search for new biomarkers for cognition in schizophrenia 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The search for biomarkers in cognition has been the focus of a large part of the research on patients suffering from schizophrenia. The scientific literature is heterogeneous, and few studies establishing an integrative model of pathogenesis and therapeutic response are available in this field. In this review, we aimed to summarize three essential aspects correlated with cognitive performance: 1) the relationship between inflammation and cognition in schizophrenia, 2) the role of prolactin in cognition, and 3) the association between cognition and neurotrophic factors, particularly brain-derived neurotrophic factor (BDNF). Several studies support the association of inflammatory markers with cognitive status in schizophrenia. In recent decades, the development of effective therapies for cognitive impairment in schizophrenia has focused on the search for anti-inflammatory and immunomodulatory medications. Conversely, the implications of prolactin and its functions in cognition, the transition to psychosis and the diagnosis and prognosis of schizophrenia have been established independent of antipsychotic treatment. With regard to neurotrophic factors, a recent study has correlated BDNF levels with cognitive recovery in schizophrenic patients treated with cognitive remediation. We conclude that although there is a diversity of biomarkers focused on cognitive function in schizophrenia, BDNF is the biomarker that has accumulated the vast majority of evidence in the current literature. Schizophrenia Cognition Biomarkers Inflammation Prolactin BDNF Neurology. Diseases of the nervous system Clemente García-Rizo verfasserin aut Miquel Bioque verfasserin aut Alexandre González-Rodríguez verfasserin aut Bibiana Cabrera verfasserin aut Gisela Mezquida verfasserin aut Miquel Bernardo verfasserin aut In Schizophrenia Research: Cognition Elsevier, 2016 2(2015), 4, Seite 172-178 (DE-627)805638512 (DE-600)2800609-4 22150013 nnns volume:2 year:2015 number:4 pages:172-178 https://doi.org/10.1016/j.scog.2015.10.004 kostenfrei https://doaj.org/article/cd4dfc8cd1d740198d1491f75db5da4c kostenfrei http://www.sciencedirect.com/science/article/pii/S2215001315000335 kostenfrei https://doaj.org/toc/2215-0013 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 2 2015 4 172-178
allfieldsSound	10.1016/j.scog.2015.10.004 doi (DE-627)DOAJ016900049 (DE-599)DOAJcd4dfc8cd1d740198d1491f75db5da4c DE-627 ger DE-627 rakwb eng RC346-429 Rafael Penadés verfasserin aut The search for new biomarkers for cognition in schizophrenia 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The search for biomarkers in cognition has been the focus of a large part of the research on patients suffering from schizophrenia. The scientific literature is heterogeneous, and few studies establishing an integrative model of pathogenesis and therapeutic response are available in this field. In this review, we aimed to summarize three essential aspects correlated with cognitive performance: 1) the relationship between inflammation and cognition in schizophrenia, 2) the role of prolactin in cognition, and 3) the association between cognition and neurotrophic factors, particularly brain-derived neurotrophic factor (BDNF). Several studies support the association of inflammatory markers with cognitive status in schizophrenia. In recent decades, the development of effective therapies for cognitive impairment in schizophrenia has focused on the search for anti-inflammatory and immunomodulatory medications. Conversely, the implications of prolactin and its functions in cognition, the transition to psychosis and the diagnosis and prognosis of schizophrenia have been established independent of antipsychotic treatment. With regard to neurotrophic factors, a recent study has correlated BDNF levels with cognitive recovery in schizophrenic patients treated with cognitive remediation. We conclude that although there is a diversity of biomarkers focused on cognitive function in schizophrenia, BDNF is the biomarker that has accumulated the vast majority of evidence in the current literature. Schizophrenia Cognition Biomarkers Inflammation Prolactin BDNF Neurology. Diseases of the nervous system Clemente García-Rizo verfasserin aut Miquel Bioque verfasserin aut Alexandre González-Rodríguez verfasserin aut Bibiana Cabrera verfasserin aut Gisela Mezquida verfasserin aut Miquel Bernardo verfasserin aut In Schizophrenia Research: Cognition Elsevier, 2016 2(2015), 4, Seite 172-178 (DE-627)805638512 (DE-600)2800609-4 22150013 nnns volume:2 year:2015 number:4 pages:172-178 https://doi.org/10.1016/j.scog.2015.10.004 kostenfrei https://doaj.org/article/cd4dfc8cd1d740198d1491f75db5da4c kostenfrei http://www.sciencedirect.com/science/article/pii/S2215001315000335 kostenfrei https://doaj.org/toc/2215-0013 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 2 2015 4 172-178
language	English
source	In Schizophrenia Research: Cognition 2(2015), 4, Seite 172-178 volume:2 year:2015 number:4 pages:172-178
sourceStr	In Schizophrenia Research: Cognition 2(2015), 4, Seite 172-178 volume:2 year:2015 number:4 pages:172-178
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Schizophrenia Cognition Biomarkers Inflammation Prolactin BDNF Neurology. Diseases of the nervous system
isfreeaccess_bool	true
container_title	Schizophrenia Research: Cognition
authorswithroles_txt_mv	Rafael Penadés @@aut@@ Clemente García-Rizo @@aut@@ Miquel Bioque @@aut@@ Alexandre González-Rodríguez @@aut@@ Bibiana Cabrera @@aut@@ Gisela Mezquida @@aut@@ Miquel Bernardo @@aut@@
publishDateDaySort_date	2015-01-01T00:00:00Z
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language_de	englisch
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callnumber-first	R - Medicine
author	Rafael Penadés
spellingShingle	Rafael Penadés misc RC346-429 misc Schizophrenia misc Cognition misc Biomarkers misc Inflammation misc Prolactin misc BDNF misc Neurology. Diseases of the nervous system The search for new biomarkers for cognition in schizophrenia
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topic_title	RC346-429 The search for new biomarkers for cognition in schizophrenia Schizophrenia Cognition Biomarkers Inflammation Prolactin BDNF
topic	misc RC346-429 misc Schizophrenia misc Cognition misc Biomarkers misc Inflammation misc Prolactin misc BDNF misc Neurology. Diseases of the nervous system
topic_unstemmed	misc RC346-429 misc Schizophrenia misc Cognition misc Biomarkers misc Inflammation misc Prolactin misc BDNF misc Neurology. Diseases of the nervous system
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title	The search for new biomarkers for cognition in schizophrenia
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title_full	The search for new biomarkers for cognition in schizophrenia
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title_sort	search for new biomarkers for cognition in schizophrenia
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title_auth	The search for new biomarkers for cognition in schizophrenia
abstract	The search for biomarkers in cognition has been the focus of a large part of the research on patients suffering from schizophrenia. The scientific literature is heterogeneous, and few studies establishing an integrative model of pathogenesis and therapeutic response are available in this field. In this review, we aimed to summarize three essential aspects correlated with cognitive performance: 1) the relationship between inflammation and cognition in schizophrenia, 2) the role of prolactin in cognition, and 3) the association between cognition and neurotrophic factors, particularly brain-derived neurotrophic factor (BDNF). Several studies support the association of inflammatory markers with cognitive status in schizophrenia. In recent decades, the development of effective therapies for cognitive impairment in schizophrenia has focused on the search for anti-inflammatory and immunomodulatory medications. Conversely, the implications of prolactin and its functions in cognition, the transition to psychosis and the diagnosis and prognosis of schizophrenia have been established independent of antipsychotic treatment. With regard to neurotrophic factors, a recent study has correlated BDNF levels with cognitive recovery in schizophrenic patients treated with cognitive remediation. We conclude that although there is a diversity of biomarkers focused on cognitive function in schizophrenia, BDNF is the biomarker that has accumulated the vast majority of evidence in the current literature.
abstractGer	The search for biomarkers in cognition has been the focus of a large part of the research on patients suffering from schizophrenia. The scientific literature is heterogeneous, and few studies establishing an integrative model of pathogenesis and therapeutic response are available in this field. In this review, we aimed to summarize three essential aspects correlated with cognitive performance: 1) the relationship between inflammation and cognition in schizophrenia, 2) the role of prolactin in cognition, and 3) the association between cognition and neurotrophic factors, particularly brain-derived neurotrophic factor (BDNF). Several studies support the association of inflammatory markers with cognitive status in schizophrenia. In recent decades, the development of effective therapies for cognitive impairment in schizophrenia has focused on the search for anti-inflammatory and immunomodulatory medications. Conversely, the implications of prolactin and its functions in cognition, the transition to psychosis and the diagnosis and prognosis of schizophrenia have been established independent of antipsychotic treatment. With regard to neurotrophic factors, a recent study has correlated BDNF levels with cognitive recovery in schizophrenic patients treated with cognitive remediation. We conclude that although there is a diversity of biomarkers focused on cognitive function in schizophrenia, BDNF is the biomarker that has accumulated the vast majority of evidence in the current literature.
abstract_unstemmed	The search for biomarkers in cognition has been the focus of a large part of the research on patients suffering from schizophrenia. The scientific literature is heterogeneous, and few studies establishing an integrative model of pathogenesis and therapeutic response are available in this field. In this review, we aimed to summarize three essential aspects correlated with cognitive performance: 1) the relationship between inflammation and cognition in schizophrenia, 2) the role of prolactin in cognition, and 3) the association between cognition and neurotrophic factors, particularly brain-derived neurotrophic factor (BDNF). Several studies support the association of inflammatory markers with cognitive status in schizophrenia. In recent decades, the development of effective therapies for cognitive impairment in schizophrenia has focused on the search for anti-inflammatory and immunomodulatory medications. Conversely, the implications of prolactin and its functions in cognition, the transition to psychosis and the diagnosis and prognosis of schizophrenia have been established independent of antipsychotic treatment. With regard to neurotrophic factors, a recent study has correlated BDNF levels with cognitive recovery in schizophrenic patients treated with cognitive remediation. We conclude that although there is a diversity of biomarkers focused on cognitive function in schizophrenia, BDNF is the biomarker that has accumulated the vast majority of evidence in the current literature.
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title_short	The search for new biomarkers for cognition in schizophrenia
url	https://doi.org/10.1016/j.scog.2015.10.004 https://doaj.org/article/cd4dfc8cd1d740198d1491f75db5da4c http://www.sciencedirect.com/science/article/pii/S2215001315000335 https://doaj.org/toc/2215-0013
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The search for new biomarkers for cognition in schizophrenia

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