Stereotactic Ablative Radiosurgery for Locally-Advanced or Recurrent Skull Base Malignancies with Prior External Beam Radiation Therapy

Purpose: Stereotactic ablative radiotherapy (SABR) is an attractive modality to treat malignancies invading the skull base as it can deliver a highly conformal dose with minimal toxicity. However, variation exists in the prescribed dose and fractionation. The purpose of our study is to examine the...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Karen Mann Xu [verfasserIn] Kimmen eQuan [verfasserIn] David Anthony Clump [verfasserIn] Robert L Ferris [verfasserIn] Dwight E Heron [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2015

Schlagwörter:	SAbR Re-irradiation High-dose low toxicities skull base malignancies

Übergeordnetes Werk:	In: Frontiers in Oncology - Frontiers Media S.A., 2012, 5(2015)
Übergeordnetes Werk:	volume:5 ; year:2015

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fonc.2015.00065

Katalog-ID:	DOAJ016930762

Internformat


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520			\|a Purpose: Stereotactic ablative radiotherapy (SABR) is an attractive modality to treat malignancies invading the skull base as it can deliver a highly conformal dose with minimal toxicity. However, variation exists in the prescribed dose and fractionation. The purpose of our study is to examine the local control, survival and toxicities in SABR for the treatment of malignant skull base tumors. Methods and Materials: A total of 31 patients and 40 locally-advanced or recurrent head and neck malignancies involving the skull base treated with a common SABR regimen which delivers a radiation dose of 44 Gy in 5 fractions from January 1st, 2004 to December 31st, 2013 were retrospectively reviewed. The local control rate (LC), progression-free survival rate (PFS), overall survival rate (OS) and toxicities were reported.Results: The median follow-up time of all patients was 11.4 months (range: 0.6-67.2 months). The median tumor volume was 27 cm3 (range: 2.4-205 cm3). All patients received prior EBRT with a median radiation dose of 64 Gy (range: 24-75.6 Gy) delivered in 12 to 42 fractions. 20 patients had surgeries prior to SABR. 19 patients received chemotherapy. Specifically, 8 patients received concurrent cetuximab (ErbituxTM) with SABR. The median time-to-progression (TTP) was 3.3 months (range: 0-16.9 months). For the 29 patients (93.5%) who died, the median time from the end of first SABR to death was 10.3 months (range: 0.5-41.4 months). The estimated 1-year overall survival (OS) rate was 35%. The estimated 2-year OS rate was 12%. Treatment was well-tolerated without grade 4 or 5 treatment-related toxicities.Conclusions: SABR has been shown to achieve low toxicities in locally-advanced or recurrent, previously irradiated head and neck malignancies invading the skull base.
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allfields	10.3389/fonc.2015.00065 doi (DE-627)DOAJ016930762 (DE-599)DOAJ16ea240a857e480b8082a27b52c91a5a DE-627 ger DE-627 rakwb eng RC254-282 Karen Mann Xu verfasserin aut Stereotactic Ablative Radiosurgery for Locally-Advanced or Recurrent Skull Base Malignancies with Prior External Beam Radiation Therapy 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose: Stereotactic ablative radiotherapy (SABR) is an attractive modality to treat malignancies invading the skull base as it can deliver a highly conformal dose with minimal toxicity. However, variation exists in the prescribed dose and fractionation. The purpose of our study is to examine the local control, survival and toxicities in SABR for the treatment of malignant skull base tumors. Methods and Materials: A total of 31 patients and 40 locally-advanced or recurrent head and neck malignancies involving the skull base treated with a common SABR regimen which delivers a radiation dose of 44 Gy in 5 fractions from January 1st, 2004 to December 31st, 2013 were retrospectively reviewed. The local control rate (LC), progression-free survival rate (PFS), overall survival rate (OS) and toxicities were reported.Results: The median follow-up time of all patients was 11.4 months (range: 0.6-67.2 months). The median tumor volume was 27 cm3 (range: 2.4-205 cm3). All patients received prior EBRT with a median radiation dose of 64 Gy (range: 24-75.6 Gy) delivered in 12 to 42 fractions. 20 patients had surgeries prior to SABR. 19 patients received chemotherapy. Specifically, 8 patients received concurrent cetuximab (ErbituxTM) with SABR. The median time-to-progression (TTP) was 3.3 months (range: 0-16.9 months). For the 29 patients (93.5%) who died, the median time from the end of first SABR to death was 10.3 months (range: 0.5-41.4 months). The estimated 1-year overall survival (OS) rate was 35%. The estimated 2-year OS rate was 12%. Treatment was well-tolerated without grade 4 or 5 treatment-related toxicities.Conclusions: SABR has been shown to achieve low toxicities in locally-advanced or recurrent, previously irradiated head and neck malignancies invading the skull base. SAbR Re-irradiation High-dose low toxicities skull base malignancies Neoplasms. Tumors. Oncology. Including cancer and carcinogens Kimmen eQuan verfasserin aut David Anthony Clump verfasserin aut Robert L Ferris verfasserin aut Robert L Ferris verfasserin aut Dwight E Heron verfasserin aut Dwight E Heron verfasserin aut In Frontiers in Oncology Frontiers Media S.A., 2012 5(2015) (DE-627)684965518 (DE-600)2649216-7 2234943X nnns volume:5 year:2015 https://doi.org/10.3389/fonc.2015.00065 kostenfrei https://doaj.org/article/16ea240a857e480b8082a27b52c91a5a kostenfrei http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00065/full kostenfrei https://doaj.org/toc/2234-943X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2015
spelling	10.3389/fonc.2015.00065 doi (DE-627)DOAJ016930762 (DE-599)DOAJ16ea240a857e480b8082a27b52c91a5a DE-627 ger DE-627 rakwb eng RC254-282 Karen Mann Xu verfasserin aut Stereotactic Ablative Radiosurgery for Locally-Advanced or Recurrent Skull Base Malignancies with Prior External Beam Radiation Therapy 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose: Stereotactic ablative radiotherapy (SABR) is an attractive modality to treat malignancies invading the skull base as it can deliver a highly conformal dose with minimal toxicity. However, variation exists in the prescribed dose and fractionation. The purpose of our study is to examine the local control, survival and toxicities in SABR for the treatment of malignant skull base tumors. Methods and Materials: A total of 31 patients and 40 locally-advanced or recurrent head and neck malignancies involving the skull base treated with a common SABR regimen which delivers a radiation dose of 44 Gy in 5 fractions from January 1st, 2004 to December 31st, 2013 were retrospectively reviewed. The local control rate (LC), progression-free survival rate (PFS), overall survival rate (OS) and toxicities were reported.Results: The median follow-up time of all patients was 11.4 months (range: 0.6-67.2 months). The median tumor volume was 27 cm3 (range: 2.4-205 cm3). All patients received prior EBRT with a median radiation dose of 64 Gy (range: 24-75.6 Gy) delivered in 12 to 42 fractions. 20 patients had surgeries prior to SABR. 19 patients received chemotherapy. Specifically, 8 patients received concurrent cetuximab (ErbituxTM) with SABR. The median time-to-progression (TTP) was 3.3 months (range: 0-16.9 months). For the 29 patients (93.5%) who died, the median time from the end of first SABR to death was 10.3 months (range: 0.5-41.4 months). The estimated 1-year overall survival (OS) rate was 35%. The estimated 2-year OS rate was 12%. Treatment was well-tolerated without grade 4 or 5 treatment-related toxicities.Conclusions: SABR has been shown to achieve low toxicities in locally-advanced or recurrent, previously irradiated head and neck malignancies invading the skull base. SAbR Re-irradiation High-dose low toxicities skull base malignancies Neoplasms. Tumors. Oncology. Including cancer and carcinogens Kimmen eQuan verfasserin aut David Anthony Clump verfasserin aut Robert L Ferris verfasserin aut Robert L Ferris verfasserin aut Dwight E Heron verfasserin aut Dwight E Heron verfasserin aut In Frontiers in Oncology Frontiers Media S.A., 2012 5(2015) (DE-627)684965518 (DE-600)2649216-7 2234943X nnns volume:5 year:2015 https://doi.org/10.3389/fonc.2015.00065 kostenfrei https://doaj.org/article/16ea240a857e480b8082a27b52c91a5a kostenfrei http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00065/full kostenfrei https://doaj.org/toc/2234-943X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2015
allfields_unstemmed	10.3389/fonc.2015.00065 doi (DE-627)DOAJ016930762 (DE-599)DOAJ16ea240a857e480b8082a27b52c91a5a DE-627 ger DE-627 rakwb eng RC254-282 Karen Mann Xu verfasserin aut Stereotactic Ablative Radiosurgery for Locally-Advanced or Recurrent Skull Base Malignancies with Prior External Beam Radiation Therapy 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose: Stereotactic ablative radiotherapy (SABR) is an attractive modality to treat malignancies invading the skull base as it can deliver a highly conformal dose with minimal toxicity. However, variation exists in the prescribed dose and fractionation. The purpose of our study is to examine the local control, survival and toxicities in SABR for the treatment of malignant skull base tumors. Methods and Materials: A total of 31 patients and 40 locally-advanced or recurrent head and neck malignancies involving the skull base treated with a common SABR regimen which delivers a radiation dose of 44 Gy in 5 fractions from January 1st, 2004 to December 31st, 2013 were retrospectively reviewed. The local control rate (LC), progression-free survival rate (PFS), overall survival rate (OS) and toxicities were reported.Results: The median follow-up time of all patients was 11.4 months (range: 0.6-67.2 months). The median tumor volume was 27 cm3 (range: 2.4-205 cm3). All patients received prior EBRT with a median radiation dose of 64 Gy (range: 24-75.6 Gy) delivered in 12 to 42 fractions. 20 patients had surgeries prior to SABR. 19 patients received chemotherapy. Specifically, 8 patients received concurrent cetuximab (ErbituxTM) with SABR. The median time-to-progression (TTP) was 3.3 months (range: 0-16.9 months). For the 29 patients (93.5%) who died, the median time from the end of first SABR to death was 10.3 months (range: 0.5-41.4 months). The estimated 1-year overall survival (OS) rate was 35%. The estimated 2-year OS rate was 12%. Treatment was well-tolerated without grade 4 or 5 treatment-related toxicities.Conclusions: SABR has been shown to achieve low toxicities in locally-advanced or recurrent, previously irradiated head and neck malignancies invading the skull base. SAbR Re-irradiation High-dose low toxicities skull base malignancies Neoplasms. Tumors. Oncology. Including cancer and carcinogens Kimmen eQuan verfasserin aut David Anthony Clump verfasserin aut Robert L Ferris verfasserin aut Robert L Ferris verfasserin aut Dwight E Heron verfasserin aut Dwight E Heron verfasserin aut In Frontiers in Oncology Frontiers Media S.A., 2012 5(2015) (DE-627)684965518 (DE-600)2649216-7 2234943X nnns volume:5 year:2015 https://doi.org/10.3389/fonc.2015.00065 kostenfrei https://doaj.org/article/16ea240a857e480b8082a27b52c91a5a kostenfrei http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00065/full kostenfrei https://doaj.org/toc/2234-943X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2015
allfieldsGer	10.3389/fonc.2015.00065 doi (DE-627)DOAJ016930762 (DE-599)DOAJ16ea240a857e480b8082a27b52c91a5a DE-627 ger DE-627 rakwb eng RC254-282 Karen Mann Xu verfasserin aut Stereotactic Ablative Radiosurgery for Locally-Advanced or Recurrent Skull Base Malignancies with Prior External Beam Radiation Therapy 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose: Stereotactic ablative radiotherapy (SABR) is an attractive modality to treat malignancies invading the skull base as it can deliver a highly conformal dose with minimal toxicity. However, variation exists in the prescribed dose and fractionation. The purpose of our study is to examine the local control, survival and toxicities in SABR for the treatment of malignant skull base tumors. Methods and Materials: A total of 31 patients and 40 locally-advanced or recurrent head and neck malignancies involving the skull base treated with a common SABR regimen which delivers a radiation dose of 44 Gy in 5 fractions from January 1st, 2004 to December 31st, 2013 were retrospectively reviewed. The local control rate (LC), progression-free survival rate (PFS), overall survival rate (OS) and toxicities were reported.Results: The median follow-up time of all patients was 11.4 months (range: 0.6-67.2 months). The median tumor volume was 27 cm3 (range: 2.4-205 cm3). All patients received prior EBRT with a median radiation dose of 64 Gy (range: 24-75.6 Gy) delivered in 12 to 42 fractions. 20 patients had surgeries prior to SABR. 19 patients received chemotherapy. Specifically, 8 patients received concurrent cetuximab (ErbituxTM) with SABR. The median time-to-progression (TTP) was 3.3 months (range: 0-16.9 months). For the 29 patients (93.5%) who died, the median time from the end of first SABR to death was 10.3 months (range: 0.5-41.4 months). The estimated 1-year overall survival (OS) rate was 35%. The estimated 2-year OS rate was 12%. Treatment was well-tolerated without grade 4 or 5 treatment-related toxicities.Conclusions: SABR has been shown to achieve low toxicities in locally-advanced or recurrent, previously irradiated head and neck malignancies invading the skull base. SAbR Re-irradiation High-dose low toxicities skull base malignancies Neoplasms. Tumors. Oncology. Including cancer and carcinogens Kimmen eQuan verfasserin aut David Anthony Clump verfasserin aut Robert L Ferris verfasserin aut Robert L Ferris verfasserin aut Dwight E Heron verfasserin aut Dwight E Heron verfasserin aut In Frontiers in Oncology Frontiers Media S.A., 2012 5(2015) (DE-627)684965518 (DE-600)2649216-7 2234943X nnns volume:5 year:2015 https://doi.org/10.3389/fonc.2015.00065 kostenfrei https://doaj.org/article/16ea240a857e480b8082a27b52c91a5a kostenfrei http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00065/full kostenfrei https://doaj.org/toc/2234-943X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2015
allfieldsSound	10.3389/fonc.2015.00065 doi (DE-627)DOAJ016930762 (DE-599)DOAJ16ea240a857e480b8082a27b52c91a5a DE-627 ger DE-627 rakwb eng RC254-282 Karen Mann Xu verfasserin aut Stereotactic Ablative Radiosurgery for Locally-Advanced or Recurrent Skull Base Malignancies with Prior External Beam Radiation Therapy 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose: Stereotactic ablative radiotherapy (SABR) is an attractive modality to treat malignancies invading the skull base as it can deliver a highly conformal dose with minimal toxicity. However, variation exists in the prescribed dose and fractionation. The purpose of our study is to examine the local control, survival and toxicities in SABR for the treatment of malignant skull base tumors. Methods and Materials: A total of 31 patients and 40 locally-advanced or recurrent head and neck malignancies involving the skull base treated with a common SABR regimen which delivers a radiation dose of 44 Gy in 5 fractions from January 1st, 2004 to December 31st, 2013 were retrospectively reviewed. The local control rate (LC), progression-free survival rate (PFS), overall survival rate (OS) and toxicities were reported.Results: The median follow-up time of all patients was 11.4 months (range: 0.6-67.2 months). The median tumor volume was 27 cm3 (range: 2.4-205 cm3). All patients received prior EBRT with a median radiation dose of 64 Gy (range: 24-75.6 Gy) delivered in 12 to 42 fractions. 20 patients had surgeries prior to SABR. 19 patients received chemotherapy. Specifically, 8 patients received concurrent cetuximab (ErbituxTM) with SABR. The median time-to-progression (TTP) was 3.3 months (range: 0-16.9 months). For the 29 patients (93.5%) who died, the median time from the end of first SABR to death was 10.3 months (range: 0.5-41.4 months). The estimated 1-year overall survival (OS) rate was 35%. The estimated 2-year OS rate was 12%. Treatment was well-tolerated without grade 4 or 5 treatment-related toxicities.Conclusions: SABR has been shown to achieve low toxicities in locally-advanced or recurrent, previously irradiated head and neck malignancies invading the skull base. SAbR Re-irradiation High-dose low toxicities skull base malignancies Neoplasms. Tumors. Oncology. Including cancer and carcinogens Kimmen eQuan verfasserin aut David Anthony Clump verfasserin aut Robert L Ferris verfasserin aut Robert L Ferris verfasserin aut Dwight E Heron verfasserin aut Dwight E Heron verfasserin aut In Frontiers in Oncology Frontiers Media S.A., 2012 5(2015) (DE-627)684965518 (DE-600)2649216-7 2234943X nnns volume:5 year:2015 https://doi.org/10.3389/fonc.2015.00065 kostenfrei https://doaj.org/article/16ea240a857e480b8082a27b52c91a5a kostenfrei http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00065/full kostenfrei https://doaj.org/toc/2234-943X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2015
language	English
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callnumber-first	R - Medicine
author	Karen Mann Xu
spellingShingle	Karen Mann Xu misc RC254-282 misc SAbR misc Re-irradiation misc High-dose misc low toxicities misc skull base malignancies misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Stereotactic Ablative Radiosurgery for Locally-Advanced or Recurrent Skull Base Malignancies with Prior External Beam Radiation Therapy
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topic_title	RC254-282 Stereotactic Ablative Radiosurgery for Locally-Advanced or Recurrent Skull Base Malignancies with Prior External Beam Radiation Therapy SAbR Re-irradiation High-dose low toxicities skull base malignancies
topic	misc RC254-282 misc SAbR misc Re-irradiation misc High-dose misc low toxicities misc skull base malignancies misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc SAbR misc Re-irradiation misc High-dose misc low toxicities misc skull base malignancies misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Stereotactic Ablative Radiosurgery for Locally-Advanced or Recurrent Skull Base Malignancies with Prior External Beam Radiation Therapy
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title_full	Stereotactic Ablative Radiosurgery for Locally-Advanced or Recurrent Skull Base Malignancies with Prior External Beam Radiation Therapy
author_sort	Karen Mann Xu
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title_sort	stereotactic ablative radiosurgery for locally-advanced or recurrent skull base malignancies with prior external beam radiation therapy
callnumber	RC254-282
title_auth	Stereotactic Ablative Radiosurgery for Locally-Advanced or Recurrent Skull Base Malignancies with Prior External Beam Radiation Therapy
abstract	Purpose: Stereotactic ablative radiotherapy (SABR) is an attractive modality to treat malignancies invading the skull base as it can deliver a highly conformal dose with minimal toxicity. However, variation exists in the prescribed dose and fractionation. The purpose of our study is to examine the local control, survival and toxicities in SABR for the treatment of malignant skull base tumors. Methods and Materials: A total of 31 patients and 40 locally-advanced or recurrent head and neck malignancies involving the skull base treated with a common SABR regimen which delivers a radiation dose of 44 Gy in 5 fractions from January 1st, 2004 to December 31st, 2013 were retrospectively reviewed. The local control rate (LC), progression-free survival rate (PFS), overall survival rate (OS) and toxicities were reported.Results: The median follow-up time of all patients was 11.4 months (range: 0.6-67.2 months). The median tumor volume was 27 cm3 (range: 2.4-205 cm3). All patients received prior EBRT with a median radiation dose of 64 Gy (range: 24-75.6 Gy) delivered in 12 to 42 fractions. 20 patients had surgeries prior to SABR. 19 patients received chemotherapy. Specifically, 8 patients received concurrent cetuximab (ErbituxTM) with SABR. The median time-to-progression (TTP) was 3.3 months (range: 0-16.9 months). For the 29 patients (93.5%) who died, the median time from the end of first SABR to death was 10.3 months (range: 0.5-41.4 months). The estimated 1-year overall survival (OS) rate was 35%. The estimated 2-year OS rate was 12%. Treatment was well-tolerated without grade 4 or 5 treatment-related toxicities.Conclusions: SABR has been shown to achieve low toxicities in locally-advanced or recurrent, previously irradiated head and neck malignancies invading the skull base.
abstractGer	Purpose: Stereotactic ablative radiotherapy (SABR) is an attractive modality to treat malignancies invading the skull base as it can deliver a highly conformal dose with minimal toxicity. However, variation exists in the prescribed dose and fractionation. The purpose of our study is to examine the local control, survival and toxicities in SABR for the treatment of malignant skull base tumors. Methods and Materials: A total of 31 patients and 40 locally-advanced or recurrent head and neck malignancies involving the skull base treated with a common SABR regimen which delivers a radiation dose of 44 Gy in 5 fractions from January 1st, 2004 to December 31st, 2013 were retrospectively reviewed. The local control rate (LC), progression-free survival rate (PFS), overall survival rate (OS) and toxicities were reported.Results: The median follow-up time of all patients was 11.4 months (range: 0.6-67.2 months). The median tumor volume was 27 cm3 (range: 2.4-205 cm3). All patients received prior EBRT with a median radiation dose of 64 Gy (range: 24-75.6 Gy) delivered in 12 to 42 fractions. 20 patients had surgeries prior to SABR. 19 patients received chemotherapy. Specifically, 8 patients received concurrent cetuximab (ErbituxTM) with SABR. The median time-to-progression (TTP) was 3.3 months (range: 0-16.9 months). For the 29 patients (93.5%) who died, the median time from the end of first SABR to death was 10.3 months (range: 0.5-41.4 months). The estimated 1-year overall survival (OS) rate was 35%. The estimated 2-year OS rate was 12%. Treatment was well-tolerated without grade 4 or 5 treatment-related toxicities.Conclusions: SABR has been shown to achieve low toxicities in locally-advanced or recurrent, previously irradiated head and neck malignancies invading the skull base.
abstract_unstemmed	Purpose: Stereotactic ablative radiotherapy (SABR) is an attractive modality to treat malignancies invading the skull base as it can deliver a highly conformal dose with minimal toxicity. However, variation exists in the prescribed dose and fractionation. The purpose of our study is to examine the local control, survival and toxicities in SABR for the treatment of malignant skull base tumors. Methods and Materials: A total of 31 patients and 40 locally-advanced or recurrent head and neck malignancies involving the skull base treated with a common SABR regimen which delivers a radiation dose of 44 Gy in 5 fractions from January 1st, 2004 to December 31st, 2013 were retrospectively reviewed. The local control rate (LC), progression-free survival rate (PFS), overall survival rate (OS) and toxicities were reported.Results: The median follow-up time of all patients was 11.4 months (range: 0.6-67.2 months). The median tumor volume was 27 cm3 (range: 2.4-205 cm3). All patients received prior EBRT with a median radiation dose of 64 Gy (range: 24-75.6 Gy) delivered in 12 to 42 fractions. 20 patients had surgeries prior to SABR. 19 patients received chemotherapy. Specifically, 8 patients received concurrent cetuximab (ErbituxTM) with SABR. The median time-to-progression (TTP) was 3.3 months (range: 0-16.9 months). For the 29 patients (93.5%) who died, the median time from the end of first SABR to death was 10.3 months (range: 0.5-41.4 months). The estimated 1-year overall survival (OS) rate was 35%. The estimated 2-year OS rate was 12%. Treatment was well-tolerated without grade 4 or 5 treatment-related toxicities.Conclusions: SABR has been shown to achieve low toxicities in locally-advanced or recurrent, previously irradiated head and neck malignancies invading the skull base.
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title_short	Stereotactic Ablative Radiosurgery for Locally-Advanced or Recurrent Skull Base Malignancies with Prior External Beam Radiation Therapy
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doi_str	10.3389/fonc.2015.00065
callnumber-a	RC254-282
up_date	2024-07-03T23:37:32.574Z
_version_	1803602994231508995
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However, variation exists in the prescribed dose and fractionation. The purpose of our study is to examine the local control, survival and toxicities in SABR for the treatment of malignant skull base tumors. Methods and Materials: A total of 31 patients and 40 locally-advanced or recurrent head and neck malignancies involving the skull base treated with a common SABR regimen which delivers a radiation dose of 44 Gy in 5 fractions from January 1st, 2004 to December 31st, 2013 were retrospectively reviewed. The local control rate (LC), progression-free survival rate (PFS), overall survival rate (OS) and toxicities were reported.Results: The median follow-up time of all patients was 11.4 months (range: 0.6-67.2 months). The median tumor volume was 27 cm3 (range: 2.4-205 cm3). All patients received prior EBRT with a median radiation dose of 64 Gy (range: 24-75.6 Gy) delivered in 12 to 42 fractions. 20 patients had surgeries prior to SABR. 19 patients received chemotherapy. Specifically, 8 patients received concurrent cetuximab (ErbituxTM) with SABR. The median time-to-progression (TTP) was 3.3 months (range: 0-16.9 months). For the 29 patients (93.5%) who died, the median time from the end of first SABR to death was 10.3 months (range: 0.5-41.4 months). The estimated 1-year overall survival (OS) rate was 35%. The estimated 2-year OS rate was 12%. Treatment was well-tolerated without grade 4 or 5 treatment-related toxicities.Conclusions: SABR has been shown to achieve low toxicities in locally-advanced or recurrent, previously irradiated head and neck malignancies invading the skull base.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">SAbR</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Re-irradiation</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">High-dose</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">low toxicities</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">skull base malignancies</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Neoplasms. Tumors. Oncology. 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