A Higher Angiogenin Expression is Associated With a Nonnuclear Maspin Location in Laryngeal Carcinoma

ObjectivesIn numerous malignancies, angiogenin (ANG) and Maspin are important proangiogenic and antiangiogenic regulators, respectively. The aim of this study was to identify potential relationships between the biological roles of these two proteins in laryngeal squamous cell carcinoma (LSCC).Method...
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Autor*in:	Andrea Lovato [verfasserIn] Marco Lionello [verfasserIn] Alberto Staffieri [verfasserIn] Stella Blandamura [verfasserIn] Giulia Tealdo [verfasserIn] Luciano Giacomelli [verfasserIn] Claudia Staffieri [verfasserIn] Gino Marioni [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2015

Schlagwörter:	Laryngeal Neoplasms Angiogenin SERPIN-B5 Intracellular Space Prognosis

Übergeordnetes Werk:	In: Clinical and Experimental Otorhinolaryngology - Korean Society of Otorhinolaryngology-Head and Neck Surgery, 2018, 8(2015), 3, Seite 268-274
Übergeordnetes Werk:	volume:8 ; year:2015 ; number:3 ; pages:268-274

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.3342/ceo.2015.8.3.268

Katalog-ID:	DOAJ016960440

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520			\|a ObjectivesIn numerous malignancies, angiogenin (ANG) and Maspin are important proangiogenic and antiangiogenic regulators, respectively. The aim of this study was to identify potential relationships between the biological roles of these two proteins in laryngeal squamous cell carcinoma (LSCC).MethodsImmunohistochemical staining for ANG and Maspin was performed on specimens from 76 consecutive LSCC patients treated with surgery alone, considering the subcellular pattern of Maspin expression. Univariate and multivariate statistical models were used for prognostic purposes.ResultsOn univariate analysis, a different level of ANG expression was seen for patients stratified by subcellular Maspin expression pattern: the mean ANG expression was higher in cases with a nonnuclear MASPIN expression than in those with a nuclear pattern (P=0.002). Disease-free survival (DFS; in months) differed significantly when patients were stratified by N stage (P=0.01). Patients whose Maspin expression was nonnuclear (i.e., it was cytoplasmic or there was none) had a significantly higher recurrence rate (P<0.001), and shorter DFS (P=0.01) than those with a nuclear Maspin pattern. The mean ANG expression was significantly higher in cases with loco-regional recurrent disease (P=0.007); and patients with an ANG expression ≥5.0% had a significantly shorter DFS than those with an ANG expression <5.0% (P=0.007). On multivariate analysis, ANG expression ≥5.0% was a significant, independent, negative prognostic factor in terms of DFS (P=0.041).ConclusionOur results support the hypothesis that a higher ANG expression is associated with a nonnuclear Maspin expression pattern in patients with LSCC. Further studies are needed to clarify the relationship between the ANG and Maspin pathways, and their potential diagnostic and therapeutic role in LSCC.
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allfields	10.3342/ceo.2015.8.3.268 doi (DE-627)DOAJ016960440 (DE-599)DOAJ89e2dd50df524192a560d0231966fc70 DE-627 ger DE-627 rakwb eng RF1-547 Andrea Lovato verfasserin aut A Higher Angiogenin Expression is Associated With a Nonnuclear Maspin Location in Laryngeal Carcinoma 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ObjectivesIn numerous malignancies, angiogenin (ANG) and Maspin are important proangiogenic and antiangiogenic regulators, respectively. The aim of this study was to identify potential relationships between the biological roles of these two proteins in laryngeal squamous cell carcinoma (LSCC).MethodsImmunohistochemical staining for ANG and Maspin was performed on specimens from 76 consecutive LSCC patients treated with surgery alone, considering the subcellular pattern of Maspin expression. Univariate and multivariate statistical models were used for prognostic purposes.ResultsOn univariate analysis, a different level of ANG expression was seen for patients stratified by subcellular Maspin expression pattern: the mean ANG expression was higher in cases with a nonnuclear MASPIN expression than in those with a nuclear pattern (P=0.002). Disease-free survival (DFS; in months) differed significantly when patients were stratified by N stage (P=0.01). Patients whose Maspin expression was nonnuclear (i.e., it was cytoplasmic or there was none) had a significantly higher recurrence rate (P<0.001), and shorter DFS (P=0.01) than those with a nuclear Maspin pattern. The mean ANG expression was significantly higher in cases with loco-regional recurrent disease (P=0.007); and patients with an ANG expression ≥5.0% had a significantly shorter DFS than those with an ANG expression <5.0% (P=0.007). On multivariate analysis, ANG expression ≥5.0% was a significant, independent, negative prognostic factor in terms of DFS (P=0.041).ConclusionOur results support the hypothesis that a higher ANG expression is associated with a nonnuclear Maspin expression pattern in patients with LSCC. Further studies are needed to clarify the relationship between the ANG and Maspin pathways, and their potential diagnostic and therapeutic role in LSCC. Laryngeal Neoplasms Angiogenin SERPIN-B5 Intracellular Space Prognosis Medicine R Otorhinolaryngology Marco Lionello verfasserin aut Alberto Staffieri verfasserin aut Stella Blandamura verfasserin aut Giulia Tealdo verfasserin aut Luciano Giacomelli verfasserin aut Claudia Staffieri verfasserin aut Gino Marioni verfasserin aut In Clinical and Experimental Otorhinolaryngology Korean Society of Otorhinolaryngology-Head and Neck Surgery, 2018 8(2015), 3, Seite 268-274 (DE-627)598790594 (DE-600)2491719-9 20050720 nnns volume:8 year:2015 number:3 pages:268-274 https://doi.org/10.3342/ceo.2015.8.3.268 kostenfrei https://doaj.org/article/89e2dd50df524192a560d0231966fc70 kostenfrei http://www.e-ceo.org/upload/pdf/ceo-8-268.pdf kostenfrei https://doaj.org/toc/1976-8710 Journal toc kostenfrei https://doaj.org/toc/2005-0720 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2015 3 268-274
spelling	10.3342/ceo.2015.8.3.268 doi (DE-627)DOAJ016960440 (DE-599)DOAJ89e2dd50df524192a560d0231966fc70 DE-627 ger DE-627 rakwb eng RF1-547 Andrea Lovato verfasserin aut A Higher Angiogenin Expression is Associated With a Nonnuclear Maspin Location in Laryngeal Carcinoma 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ObjectivesIn numerous malignancies, angiogenin (ANG) and Maspin are important proangiogenic and antiangiogenic regulators, respectively. The aim of this study was to identify potential relationships between the biological roles of these two proteins in laryngeal squamous cell carcinoma (LSCC).MethodsImmunohistochemical staining for ANG and Maspin was performed on specimens from 76 consecutive LSCC patients treated with surgery alone, considering the subcellular pattern of Maspin expression. Univariate and multivariate statistical models were used for prognostic purposes.ResultsOn univariate analysis, a different level of ANG expression was seen for patients stratified by subcellular Maspin expression pattern: the mean ANG expression was higher in cases with a nonnuclear MASPIN expression than in those with a nuclear pattern (P=0.002). Disease-free survival (DFS; in months) differed significantly when patients were stratified by N stage (P=0.01). Patients whose Maspin expression was nonnuclear (i.e., it was cytoplasmic or there was none) had a significantly higher recurrence rate (P<0.001), and shorter DFS (P=0.01) than those with a nuclear Maspin pattern. The mean ANG expression was significantly higher in cases with loco-regional recurrent disease (P=0.007); and patients with an ANG expression ≥5.0% had a significantly shorter DFS than those with an ANG expression <5.0% (P=0.007). On multivariate analysis, ANG expression ≥5.0% was a significant, independent, negative prognostic factor in terms of DFS (P=0.041).ConclusionOur results support the hypothesis that a higher ANG expression is associated with a nonnuclear Maspin expression pattern in patients with LSCC. Further studies are needed to clarify the relationship between the ANG and Maspin pathways, and their potential diagnostic and therapeutic role in LSCC. Laryngeal Neoplasms Angiogenin SERPIN-B5 Intracellular Space Prognosis Medicine R Otorhinolaryngology Marco Lionello verfasserin aut Alberto Staffieri verfasserin aut Stella Blandamura verfasserin aut Giulia Tealdo verfasserin aut Luciano Giacomelli verfasserin aut Claudia Staffieri verfasserin aut Gino Marioni verfasserin aut In Clinical and Experimental Otorhinolaryngology Korean Society of Otorhinolaryngology-Head and Neck Surgery, 2018 8(2015), 3, Seite 268-274 (DE-627)598790594 (DE-600)2491719-9 20050720 nnns volume:8 year:2015 number:3 pages:268-274 https://doi.org/10.3342/ceo.2015.8.3.268 kostenfrei https://doaj.org/article/89e2dd50df524192a560d0231966fc70 kostenfrei http://www.e-ceo.org/upload/pdf/ceo-8-268.pdf kostenfrei https://doaj.org/toc/1976-8710 Journal toc kostenfrei https://doaj.org/toc/2005-0720 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2015 3 268-274
allfields_unstemmed	10.3342/ceo.2015.8.3.268 doi (DE-627)DOAJ016960440 (DE-599)DOAJ89e2dd50df524192a560d0231966fc70 DE-627 ger DE-627 rakwb eng RF1-547 Andrea Lovato verfasserin aut A Higher Angiogenin Expression is Associated With a Nonnuclear Maspin Location in Laryngeal Carcinoma 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ObjectivesIn numerous malignancies, angiogenin (ANG) and Maspin are important proangiogenic and antiangiogenic regulators, respectively. The aim of this study was to identify potential relationships between the biological roles of these two proteins in laryngeal squamous cell carcinoma (LSCC).MethodsImmunohistochemical staining for ANG and Maspin was performed on specimens from 76 consecutive LSCC patients treated with surgery alone, considering the subcellular pattern of Maspin expression. Univariate and multivariate statistical models were used for prognostic purposes.ResultsOn univariate analysis, a different level of ANG expression was seen for patients stratified by subcellular Maspin expression pattern: the mean ANG expression was higher in cases with a nonnuclear MASPIN expression than in those with a nuclear pattern (P=0.002). Disease-free survival (DFS; in months) differed significantly when patients were stratified by N stage (P=0.01). Patients whose Maspin expression was nonnuclear (i.e., it was cytoplasmic or there was none) had a significantly higher recurrence rate (P<0.001), and shorter DFS (P=0.01) than those with a nuclear Maspin pattern. The mean ANG expression was significantly higher in cases with loco-regional recurrent disease (P=0.007); and patients with an ANG expression ≥5.0% had a significantly shorter DFS than those with an ANG expression <5.0% (P=0.007). On multivariate analysis, ANG expression ≥5.0% was a significant, independent, negative prognostic factor in terms of DFS (P=0.041).ConclusionOur results support the hypothesis that a higher ANG expression is associated with a nonnuclear Maspin expression pattern in patients with LSCC. Further studies are needed to clarify the relationship between the ANG and Maspin pathways, and their potential diagnostic and therapeutic role in LSCC. Laryngeal Neoplasms Angiogenin SERPIN-B5 Intracellular Space Prognosis Medicine R Otorhinolaryngology Marco Lionello verfasserin aut Alberto Staffieri verfasserin aut Stella Blandamura verfasserin aut Giulia Tealdo verfasserin aut Luciano Giacomelli verfasserin aut Claudia Staffieri verfasserin aut Gino Marioni verfasserin aut In Clinical and Experimental Otorhinolaryngology Korean Society of Otorhinolaryngology-Head and Neck Surgery, 2018 8(2015), 3, Seite 268-274 (DE-627)598790594 (DE-600)2491719-9 20050720 nnns volume:8 year:2015 number:3 pages:268-274 https://doi.org/10.3342/ceo.2015.8.3.268 kostenfrei https://doaj.org/article/89e2dd50df524192a560d0231966fc70 kostenfrei http://www.e-ceo.org/upload/pdf/ceo-8-268.pdf kostenfrei https://doaj.org/toc/1976-8710 Journal toc kostenfrei https://doaj.org/toc/2005-0720 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2015 3 268-274
allfieldsGer	10.3342/ceo.2015.8.3.268 doi (DE-627)DOAJ016960440 (DE-599)DOAJ89e2dd50df524192a560d0231966fc70 DE-627 ger DE-627 rakwb eng RF1-547 Andrea Lovato verfasserin aut A Higher Angiogenin Expression is Associated With a Nonnuclear Maspin Location in Laryngeal Carcinoma 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ObjectivesIn numerous malignancies, angiogenin (ANG) and Maspin are important proangiogenic and antiangiogenic regulators, respectively. The aim of this study was to identify potential relationships between the biological roles of these two proteins in laryngeal squamous cell carcinoma (LSCC).MethodsImmunohistochemical staining for ANG and Maspin was performed on specimens from 76 consecutive LSCC patients treated with surgery alone, considering the subcellular pattern of Maspin expression. Univariate and multivariate statistical models were used for prognostic purposes.ResultsOn univariate analysis, a different level of ANG expression was seen for patients stratified by subcellular Maspin expression pattern: the mean ANG expression was higher in cases with a nonnuclear MASPIN expression than in those with a nuclear pattern (P=0.002). Disease-free survival (DFS; in months) differed significantly when patients were stratified by N stage (P=0.01). Patients whose Maspin expression was nonnuclear (i.e., it was cytoplasmic or there was none) had a significantly higher recurrence rate (P<0.001), and shorter DFS (P=0.01) than those with a nuclear Maspin pattern. The mean ANG expression was significantly higher in cases with loco-regional recurrent disease (P=0.007); and patients with an ANG expression ≥5.0% had a significantly shorter DFS than those with an ANG expression <5.0% (P=0.007). On multivariate analysis, ANG expression ≥5.0% was a significant, independent, negative prognostic factor in terms of DFS (P=0.041).ConclusionOur results support the hypothesis that a higher ANG expression is associated with a nonnuclear Maspin expression pattern in patients with LSCC. Further studies are needed to clarify the relationship between the ANG and Maspin pathways, and their potential diagnostic and therapeutic role in LSCC. Laryngeal Neoplasms Angiogenin SERPIN-B5 Intracellular Space Prognosis Medicine R Otorhinolaryngology Marco Lionello verfasserin aut Alberto Staffieri verfasserin aut Stella Blandamura verfasserin aut Giulia Tealdo verfasserin aut Luciano Giacomelli verfasserin aut Claudia Staffieri verfasserin aut Gino Marioni verfasserin aut In Clinical and Experimental Otorhinolaryngology Korean Society of Otorhinolaryngology-Head and Neck Surgery, 2018 8(2015), 3, Seite 268-274 (DE-627)598790594 (DE-600)2491719-9 20050720 nnns volume:8 year:2015 number:3 pages:268-274 https://doi.org/10.3342/ceo.2015.8.3.268 kostenfrei https://doaj.org/article/89e2dd50df524192a560d0231966fc70 kostenfrei http://www.e-ceo.org/upload/pdf/ceo-8-268.pdf kostenfrei https://doaj.org/toc/1976-8710 Journal toc kostenfrei https://doaj.org/toc/2005-0720 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2015 3 268-274
allfieldsSound	10.3342/ceo.2015.8.3.268 doi (DE-627)DOAJ016960440 (DE-599)DOAJ89e2dd50df524192a560d0231966fc70 DE-627 ger DE-627 rakwb eng RF1-547 Andrea Lovato verfasserin aut A Higher Angiogenin Expression is Associated With a Nonnuclear Maspin Location in Laryngeal Carcinoma 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ObjectivesIn numerous malignancies, angiogenin (ANG) and Maspin are important proangiogenic and antiangiogenic regulators, respectively. The aim of this study was to identify potential relationships between the biological roles of these two proteins in laryngeal squamous cell carcinoma (LSCC).MethodsImmunohistochemical staining for ANG and Maspin was performed on specimens from 76 consecutive LSCC patients treated with surgery alone, considering the subcellular pattern of Maspin expression. Univariate and multivariate statistical models were used for prognostic purposes.ResultsOn univariate analysis, a different level of ANG expression was seen for patients stratified by subcellular Maspin expression pattern: the mean ANG expression was higher in cases with a nonnuclear MASPIN expression than in those with a nuclear pattern (P=0.002). Disease-free survival (DFS; in months) differed significantly when patients were stratified by N stage (P=0.01). Patients whose Maspin expression was nonnuclear (i.e., it was cytoplasmic or there was none) had a significantly higher recurrence rate (P<0.001), and shorter DFS (P=0.01) than those with a nuclear Maspin pattern. The mean ANG expression was significantly higher in cases with loco-regional recurrent disease (P=0.007); and patients with an ANG expression ≥5.0% had a significantly shorter DFS than those with an ANG expression <5.0% (P=0.007). On multivariate analysis, ANG expression ≥5.0% was a significant, independent, negative prognostic factor in terms of DFS (P=0.041).ConclusionOur results support the hypothesis that a higher ANG expression is associated with a nonnuclear Maspin expression pattern in patients with LSCC. Further studies are needed to clarify the relationship between the ANG and Maspin pathways, and their potential diagnostic and therapeutic role in LSCC. Laryngeal Neoplasms Angiogenin SERPIN-B5 Intracellular Space Prognosis Medicine R Otorhinolaryngology Marco Lionello verfasserin aut Alberto Staffieri verfasserin aut Stella Blandamura verfasserin aut Giulia Tealdo verfasserin aut Luciano Giacomelli verfasserin aut Claudia Staffieri verfasserin aut Gino Marioni verfasserin aut In Clinical and Experimental Otorhinolaryngology Korean Society of Otorhinolaryngology-Head and Neck Surgery, 2018 8(2015), 3, Seite 268-274 (DE-627)598790594 (DE-600)2491719-9 20050720 nnns volume:8 year:2015 number:3 pages:268-274 https://doi.org/10.3342/ceo.2015.8.3.268 kostenfrei https://doaj.org/article/89e2dd50df524192a560d0231966fc70 kostenfrei http://www.e-ceo.org/upload/pdf/ceo-8-268.pdf kostenfrei https://doaj.org/toc/1976-8710 Journal toc kostenfrei https://doaj.org/toc/2005-0720 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2015 3 268-274
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source	In Clinical and Experimental Otorhinolaryngology 8(2015), 3, Seite 268-274 volume:8 year:2015 number:3 pages:268-274
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authorswithroles_txt_mv	Andrea Lovato @@aut@@ Marco Lionello @@aut@@ Alberto Staffieri @@aut@@ Stella Blandamura @@aut@@ Giulia Tealdo @@aut@@ Luciano Giacomelli @@aut@@ Claudia Staffieri @@aut@@ Gino Marioni @@aut@@
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Patients whose Maspin expression was nonnuclear (i.e., it was cytoplasmic or there was none) had a significantly higher recurrence rate (P<0.001), and shorter DFS (P=0.01) than those with a nuclear Maspin pattern. The mean ANG expression was significantly higher in cases with loco-regional recurrent disease (P=0.007); and patients with an ANG expression ≥5.0% had a significantly shorter DFS than those with an ANG expression <5.0% (P=0.007). On multivariate analysis, ANG expression ≥5.0% was a significant, independent, negative prognostic factor in terms of DFS (P=0.041).ConclusionOur results support the hypothesis that a higher ANG expression is associated with a nonnuclear Maspin expression pattern in patients with LSCC. 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topic_title	RF1-547 A Higher Angiogenin Expression is Associated With a Nonnuclear Maspin Location in Laryngeal Carcinoma Laryngeal Neoplasms Angiogenin SERPIN-B5 Intracellular Space Prognosis
topic	misc RF1-547 misc Laryngeal Neoplasms misc Angiogenin misc SERPIN-B5 misc Intracellular Space misc Prognosis misc Medicine misc R misc Otorhinolaryngology
topic_unstemmed	misc RF1-547 misc Laryngeal Neoplasms misc Angiogenin misc SERPIN-B5 misc Intracellular Space misc Prognosis misc Medicine misc R misc Otorhinolaryngology
topic_browse	misc RF1-547 misc Laryngeal Neoplasms misc Angiogenin misc SERPIN-B5 misc Intracellular Space misc Prognosis misc Medicine misc R misc Otorhinolaryngology
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title	A Higher Angiogenin Expression is Associated With a Nonnuclear Maspin Location in Laryngeal Carcinoma
ctrlnum	(DE-627)DOAJ016960440 (DE-599)DOAJ89e2dd50df524192a560d0231966fc70
title_full	A Higher Angiogenin Expression is Associated With a Nonnuclear Maspin Location in Laryngeal Carcinoma
author_sort	Andrea Lovato
journal	Clinical and Experimental Otorhinolaryngology
journalStr	Clinical and Experimental Otorhinolaryngology
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author_browse	Andrea Lovato Marco Lionello Alberto Staffieri Stella Blandamura Giulia Tealdo Luciano Giacomelli Claudia Staffieri Gino Marioni
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class	RF1-547
format_se	Elektronische Aufsätze
author-letter	Andrea Lovato
doi_str_mv	10.3342/ceo.2015.8.3.268
author2-role	verfasserin
title_sort	higher angiogenin expression is associated with a nonnuclear maspin location in laryngeal carcinoma
callnumber	RF1-547
title_auth	A Higher Angiogenin Expression is Associated With a Nonnuclear Maspin Location in Laryngeal Carcinoma
abstract	ObjectivesIn numerous malignancies, angiogenin (ANG) and Maspin are important proangiogenic and antiangiogenic regulators, respectively. The aim of this study was to identify potential relationships between the biological roles of these two proteins in laryngeal squamous cell carcinoma (LSCC).MethodsImmunohistochemical staining for ANG and Maspin was performed on specimens from 76 consecutive LSCC patients treated with surgery alone, considering the subcellular pattern of Maspin expression. Univariate and multivariate statistical models were used for prognostic purposes.ResultsOn univariate analysis, a different level of ANG expression was seen for patients stratified by subcellular Maspin expression pattern: the mean ANG expression was higher in cases with a nonnuclear MASPIN expression than in those with a nuclear pattern (P=0.002). Disease-free survival (DFS; in months) differed significantly when patients were stratified by N stage (P=0.01). Patients whose Maspin expression was nonnuclear (i.e., it was cytoplasmic or there was none) had a significantly higher recurrence rate (P<0.001), and shorter DFS (P=0.01) than those with a nuclear Maspin pattern. The mean ANG expression was significantly higher in cases with loco-regional recurrent disease (P=0.007); and patients with an ANG expression ≥5.0% had a significantly shorter DFS than those with an ANG expression <5.0% (P=0.007). On multivariate analysis, ANG expression ≥5.0% was a significant, independent, negative prognostic factor in terms of DFS (P=0.041).ConclusionOur results support the hypothesis that a higher ANG expression is associated with a nonnuclear Maspin expression pattern in patients with LSCC. Further studies are needed to clarify the relationship between the ANG and Maspin pathways, and their potential diagnostic and therapeutic role in LSCC.
abstractGer	ObjectivesIn numerous malignancies, angiogenin (ANG) and Maspin are important proangiogenic and antiangiogenic regulators, respectively. The aim of this study was to identify potential relationships between the biological roles of these two proteins in laryngeal squamous cell carcinoma (LSCC).MethodsImmunohistochemical staining for ANG and Maspin was performed on specimens from 76 consecutive LSCC patients treated with surgery alone, considering the subcellular pattern of Maspin expression. Univariate and multivariate statistical models were used for prognostic purposes.ResultsOn univariate analysis, a different level of ANG expression was seen for patients stratified by subcellular Maspin expression pattern: the mean ANG expression was higher in cases with a nonnuclear MASPIN expression than in those with a nuclear pattern (P=0.002). Disease-free survival (DFS; in months) differed significantly when patients were stratified by N stage (P=0.01). Patients whose Maspin expression was nonnuclear (i.e., it was cytoplasmic or there was none) had a significantly higher recurrence rate (P<0.001), and shorter DFS (P=0.01) than those with a nuclear Maspin pattern. The mean ANG expression was significantly higher in cases with loco-regional recurrent disease (P=0.007); and patients with an ANG expression ≥5.0% had a significantly shorter DFS than those with an ANG expression <5.0% (P=0.007). On multivariate analysis, ANG expression ≥5.0% was a significant, independent, negative prognostic factor in terms of DFS (P=0.041).ConclusionOur results support the hypothesis that a higher ANG expression is associated with a nonnuclear Maspin expression pattern in patients with LSCC. Further studies are needed to clarify the relationship between the ANG and Maspin pathways, and their potential diagnostic and therapeutic role in LSCC.
abstract_unstemmed	ObjectivesIn numerous malignancies, angiogenin (ANG) and Maspin are important proangiogenic and antiangiogenic regulators, respectively. The aim of this study was to identify potential relationships between the biological roles of these two proteins in laryngeal squamous cell carcinoma (LSCC).MethodsImmunohistochemical staining for ANG and Maspin was performed on specimens from 76 consecutive LSCC patients treated with surgery alone, considering the subcellular pattern of Maspin expression. Univariate and multivariate statistical models were used for prognostic purposes.ResultsOn univariate analysis, a different level of ANG expression was seen for patients stratified by subcellular Maspin expression pattern: the mean ANG expression was higher in cases with a nonnuclear MASPIN expression than in those with a nuclear pattern (P=0.002). Disease-free survival (DFS; in months) differed significantly when patients were stratified by N stage (P=0.01). Patients whose Maspin expression was nonnuclear (i.e., it was cytoplasmic or there was none) had a significantly higher recurrence rate (P<0.001), and shorter DFS (P=0.01) than those with a nuclear Maspin pattern. The mean ANG expression was significantly higher in cases with loco-regional recurrent disease (P=0.007); and patients with an ANG expression ≥5.0% had a significantly shorter DFS than those with an ANG expression <5.0% (P=0.007). On multivariate analysis, ANG expression ≥5.0% was a significant, independent, negative prognostic factor in terms of DFS (P=0.041).ConclusionOur results support the hypothesis that a higher ANG expression is associated with a nonnuclear Maspin expression pattern in patients with LSCC. Further studies are needed to clarify the relationship between the ANG and Maspin pathways, and their potential diagnostic and therapeutic role in LSCC.
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title_short	A Higher Angiogenin Expression is Associated With a Nonnuclear Maspin Location in Laryngeal Carcinoma
url	https://doi.org/10.3342/ceo.2015.8.3.268 https://doaj.org/article/89e2dd50df524192a560d0231966fc70 http://www.e-ceo.org/upload/pdf/ceo-8-268.pdf https://doaj.org/toc/1976-8710 https://doaj.org/toc/2005-0720
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