Ring finger protein 11 inhibits melanocortin 3 and 4 receptor signaling
Intact melanocortin signaling via the G protein-coupled receptors (GPCRs) melanocortin receptor 4 (MC4R) and melanocortin receptor 3 (MC3R) is crucial for body weight maintenance. So far, no connection between melanocortin signaling and hypothalamic inflammation has been reported. Using a bimolecula...
Ausführliche Beschreibung
Autor*in: |
Anne Müller [verfasserIn] Lars Niederstadt [verfasserIn] Wenke Jonas [verfasserIn] Chun-Xia Yi [verfasserIn] Franziska Meyer [verfasserIn] Petra Wiedmer [verfasserIn] Jana Fischer [verfasserIn] Carsten Grötzinger [verfasserIn] Annette Schürmann [verfasserIn] Matthias Tschöp [verfasserIn] Gunnar Kleinau [verfasserIn] Annette Grüters [verfasserIn] Heiko Krude [verfasserIn] Heike Biebermann [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2016 |
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Übergeordnetes Werk: |
In: Frontiers in Endocrinology - Frontiers Media S.A., 2011, 7(2016) |
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Übergeordnetes Werk: |
volume:7 ; year:2016 |
Links: |
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DOI / URN: |
10.3389/fendo.2016.00109 |
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Katalog-ID: |
DOAJ01698062X |
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10.3389/fendo.2016.00109 doi (DE-627)DOAJ01698062X (DE-599)DOAJ96d82d05fe2d4aada5986c9637c38bf6 DE-627 ger DE-627 rakwb eng RC648-665 Anne Müller verfasserin aut Ring finger protein 11 inhibits melanocortin 3 and 4 receptor signaling 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Intact melanocortin signaling via the G protein-coupled receptors (GPCRs) melanocortin receptor 4 (MC4R) and melanocortin receptor 3 (MC3R) is crucial for body weight maintenance. So far, no connection between melanocortin signaling and hypothalamic inflammation has been reported. Using a bimolecular fluorescence complementation library screen, we identified a new interaction partner for these receptors, ring finger protein 11 (RNF11). RNF11 participates in the constitution of the A20 complex that is involved in reduction of tumor necrosis factor F-induced NFB signaling, an important pathway in hypothalamic inflammation. Mice treated with high-fat diet (HFD) for 3 days demonstrated a trend toward an increase in hypothalamic Rnf11 expression, as shown for other inflammatory markers under HFD. Furthermore, Gs-mediated signaling of MC3/4R was demonstrated to be strongly reduced to 20 - 40% by co-expression of RNF11 despite unchanged total receptor expression. Cell surface expression was not affected for MC3R but resulted in a significant reduction of MC4R to 61% by co-expression with RNF11.Mechanisms linking HFD, inflammation, and metabolism remain partially understood. In this study, a new axis between signaling of specific body weight regulating GPCRs and factors involved in hypothalamic inflammation is suggested. Inflammation G protein coupled receptor protein network weight regulation Protein complementation assay Diseases of the endocrine glands. Clinical endocrinology Lars Niederstadt verfasserin aut Wenke Jonas verfasserin aut Wenke Jonas verfasserin aut Chun-Xia Yi verfasserin aut Franziska Meyer verfasserin aut Petra Wiedmer verfasserin aut Jana Fischer verfasserin aut Carsten Grötzinger verfasserin aut Annette Schürmann verfasserin aut Annette Schürmann verfasserin aut Matthias Tschöp verfasserin aut Matthias Tschöp verfasserin aut Gunnar Kleinau verfasserin aut Annette Grüters verfasserin aut Heiko Krude verfasserin aut Heike Biebermann verfasserin aut In Frontiers in Endocrinology Frontiers Media S.A., 2011 7(2016) (DE-627)645090948 (DE-600)2592084-4 16642392 nnns volume:7 year:2016 https://doi.org/10.3389/fendo.2016.00109 kostenfrei https://doaj.org/article/96d82d05fe2d4aada5986c9637c38bf6 kostenfrei http://journal.frontiersin.org/Journal/10.3389/fendo.2016.00109/full kostenfrei https://doaj.org/toc/1664-2392 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2016 |
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10.3389/fendo.2016.00109 doi (DE-627)DOAJ01698062X (DE-599)DOAJ96d82d05fe2d4aada5986c9637c38bf6 DE-627 ger DE-627 rakwb eng RC648-665 Anne Müller verfasserin aut Ring finger protein 11 inhibits melanocortin 3 and 4 receptor signaling 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Intact melanocortin signaling via the G protein-coupled receptors (GPCRs) melanocortin receptor 4 (MC4R) and melanocortin receptor 3 (MC3R) is crucial for body weight maintenance. So far, no connection between melanocortin signaling and hypothalamic inflammation has been reported. Using a bimolecular fluorescence complementation library screen, we identified a new interaction partner for these receptors, ring finger protein 11 (RNF11). RNF11 participates in the constitution of the A20 complex that is involved in reduction of tumor necrosis factor F-induced NFB signaling, an important pathway in hypothalamic inflammation. Mice treated with high-fat diet (HFD) for 3 days demonstrated a trend toward an increase in hypothalamic Rnf11 expression, as shown for other inflammatory markers under HFD. Furthermore, Gs-mediated signaling of MC3/4R was demonstrated to be strongly reduced to 20 - 40% by co-expression of RNF11 despite unchanged total receptor expression. Cell surface expression was not affected for MC3R but resulted in a significant reduction of MC4R to 61% by co-expression with RNF11.Mechanisms linking HFD, inflammation, and metabolism remain partially understood. In this study, a new axis between signaling of specific body weight regulating GPCRs and factors involved in hypothalamic inflammation is suggested. Inflammation G protein coupled receptor protein network weight regulation Protein complementation assay Diseases of the endocrine glands. Clinical endocrinology Lars Niederstadt verfasserin aut Wenke Jonas verfasserin aut Wenke Jonas verfasserin aut Chun-Xia Yi verfasserin aut Franziska Meyer verfasserin aut Petra Wiedmer verfasserin aut Jana Fischer verfasserin aut Carsten Grötzinger verfasserin aut Annette Schürmann verfasserin aut Annette Schürmann verfasserin aut Matthias Tschöp verfasserin aut Matthias Tschöp verfasserin aut Gunnar Kleinau verfasserin aut Annette Grüters verfasserin aut Heiko Krude verfasserin aut Heike Biebermann verfasserin aut In Frontiers in Endocrinology Frontiers Media S.A., 2011 7(2016) (DE-627)645090948 (DE-600)2592084-4 16642392 nnns volume:7 year:2016 https://doi.org/10.3389/fendo.2016.00109 kostenfrei https://doaj.org/article/96d82d05fe2d4aada5986c9637c38bf6 kostenfrei http://journal.frontiersin.org/Journal/10.3389/fendo.2016.00109/full kostenfrei https://doaj.org/toc/1664-2392 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2016 |
allfieldsGer |
10.3389/fendo.2016.00109 doi (DE-627)DOAJ01698062X (DE-599)DOAJ96d82d05fe2d4aada5986c9637c38bf6 DE-627 ger DE-627 rakwb eng RC648-665 Anne Müller verfasserin aut Ring finger protein 11 inhibits melanocortin 3 and 4 receptor signaling 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Intact melanocortin signaling via the G protein-coupled receptors (GPCRs) melanocortin receptor 4 (MC4R) and melanocortin receptor 3 (MC3R) is crucial for body weight maintenance. So far, no connection between melanocortin signaling and hypothalamic inflammation has been reported. Using a bimolecular fluorescence complementation library screen, we identified a new interaction partner for these receptors, ring finger protein 11 (RNF11). RNF11 participates in the constitution of the A20 complex that is involved in reduction of tumor necrosis factor F-induced NFB signaling, an important pathway in hypothalamic inflammation. Mice treated with high-fat diet (HFD) for 3 days demonstrated a trend toward an increase in hypothalamic Rnf11 expression, as shown for other inflammatory markers under HFD. Furthermore, Gs-mediated signaling of MC3/4R was demonstrated to be strongly reduced to 20 - 40% by co-expression of RNF11 despite unchanged total receptor expression. Cell surface expression was not affected for MC3R but resulted in a significant reduction of MC4R to 61% by co-expression with RNF11.Mechanisms linking HFD, inflammation, and metabolism remain partially understood. In this study, a new axis between signaling of specific body weight regulating GPCRs and factors involved in hypothalamic inflammation is suggested. Inflammation G protein coupled receptor protein network weight regulation Protein complementation assay Diseases of the endocrine glands. Clinical endocrinology Lars Niederstadt verfasserin aut Wenke Jonas verfasserin aut Wenke Jonas verfasserin aut Chun-Xia Yi verfasserin aut Franziska Meyer verfasserin aut Petra Wiedmer verfasserin aut Jana Fischer verfasserin aut Carsten Grötzinger verfasserin aut Annette Schürmann verfasserin aut Annette Schürmann verfasserin aut Matthias Tschöp verfasserin aut Matthias Tschöp verfasserin aut Gunnar Kleinau verfasserin aut Annette Grüters verfasserin aut Heiko Krude verfasserin aut Heike Biebermann verfasserin aut In Frontiers in Endocrinology Frontiers Media S.A., 2011 7(2016) (DE-627)645090948 (DE-600)2592084-4 16642392 nnns volume:7 year:2016 https://doi.org/10.3389/fendo.2016.00109 kostenfrei https://doaj.org/article/96d82d05fe2d4aada5986c9637c38bf6 kostenfrei http://journal.frontiersin.org/Journal/10.3389/fendo.2016.00109/full kostenfrei https://doaj.org/toc/1664-2392 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2016 |
allfieldsSound |
10.3389/fendo.2016.00109 doi (DE-627)DOAJ01698062X (DE-599)DOAJ96d82d05fe2d4aada5986c9637c38bf6 DE-627 ger DE-627 rakwb eng RC648-665 Anne Müller verfasserin aut Ring finger protein 11 inhibits melanocortin 3 and 4 receptor signaling 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Intact melanocortin signaling via the G protein-coupled receptors (GPCRs) melanocortin receptor 4 (MC4R) and melanocortin receptor 3 (MC3R) is crucial for body weight maintenance. So far, no connection between melanocortin signaling and hypothalamic inflammation has been reported. Using a bimolecular fluorescence complementation library screen, we identified a new interaction partner for these receptors, ring finger protein 11 (RNF11). RNF11 participates in the constitution of the A20 complex that is involved in reduction of tumor necrosis factor F-induced NFB signaling, an important pathway in hypothalamic inflammation. Mice treated with high-fat diet (HFD) for 3 days demonstrated a trend toward an increase in hypothalamic Rnf11 expression, as shown for other inflammatory markers under HFD. Furthermore, Gs-mediated signaling of MC3/4R was demonstrated to be strongly reduced to 20 - 40% by co-expression of RNF11 despite unchanged total receptor expression. Cell surface expression was not affected for MC3R but resulted in a significant reduction of MC4R to 61% by co-expression with RNF11.Mechanisms linking HFD, inflammation, and metabolism remain partially understood. In this study, a new axis between signaling of specific body weight regulating GPCRs and factors involved in hypothalamic inflammation is suggested. Inflammation G protein coupled receptor protein network weight regulation Protein complementation assay Diseases of the endocrine glands. Clinical endocrinology Lars Niederstadt verfasserin aut Wenke Jonas verfasserin aut Wenke Jonas verfasserin aut Chun-Xia Yi verfasserin aut Franziska Meyer verfasserin aut Petra Wiedmer verfasserin aut Jana Fischer verfasserin aut Carsten Grötzinger verfasserin aut Annette Schürmann verfasserin aut Annette Schürmann verfasserin aut Matthias Tschöp verfasserin aut Matthias Tschöp verfasserin aut Gunnar Kleinau verfasserin aut Annette Grüters verfasserin aut Heiko Krude verfasserin aut Heike Biebermann verfasserin aut In Frontiers in Endocrinology Frontiers Media S.A., 2011 7(2016) (DE-627)645090948 (DE-600)2592084-4 16642392 nnns volume:7 year:2016 https://doi.org/10.3389/fendo.2016.00109 kostenfrei https://doaj.org/article/96d82d05fe2d4aada5986c9637c38bf6 kostenfrei http://journal.frontiersin.org/Journal/10.3389/fendo.2016.00109/full kostenfrei https://doaj.org/toc/1664-2392 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2016 |
language |
English |
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In Frontiers in Endocrinology 7(2016) volume:7 year:2016 |
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Intact melanocortin signaling via the G protein-coupled receptors (GPCRs) melanocortin receptor 4 (MC4R) and melanocortin receptor 3 (MC3R) is crucial for body weight maintenance. So far, no connection between melanocortin signaling and hypothalamic inflammation has been reported. Using a bimolecular fluorescence complementation library screen, we identified a new interaction partner for these receptors, ring finger protein 11 (RNF11). RNF11 participates in the constitution of the A20 complex that is involved in reduction of tumor necrosis factor F-induced NFB signaling, an important pathway in hypothalamic inflammation. Mice treated with high-fat diet (HFD) for 3 days demonstrated a trend toward an increase in hypothalamic Rnf11 expression, as shown for other inflammatory markers under HFD. Furthermore, Gs-mediated signaling of MC3/4R was demonstrated to be strongly reduced to 20 - 40% by co-expression of RNF11 despite unchanged total receptor expression. Cell surface expression was not affected for MC3R but resulted in a significant reduction of MC4R to 61% by co-expression with RNF11.Mechanisms linking HFD, inflammation, and metabolism remain partially understood. In this study, a new axis between signaling of specific body weight regulating GPCRs and factors involved in hypothalamic inflammation is suggested. |
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Intact melanocortin signaling via the G protein-coupled receptors (GPCRs) melanocortin receptor 4 (MC4R) and melanocortin receptor 3 (MC3R) is crucial for body weight maintenance. So far, no connection between melanocortin signaling and hypothalamic inflammation has been reported. Using a bimolecular fluorescence complementation library screen, we identified a new interaction partner for these receptors, ring finger protein 11 (RNF11). RNF11 participates in the constitution of the A20 complex that is involved in reduction of tumor necrosis factor F-induced NFB signaling, an important pathway in hypothalamic inflammation. Mice treated with high-fat diet (HFD) for 3 days demonstrated a trend toward an increase in hypothalamic Rnf11 expression, as shown for other inflammatory markers under HFD. Furthermore, Gs-mediated signaling of MC3/4R was demonstrated to be strongly reduced to 20 - 40% by co-expression of RNF11 despite unchanged total receptor expression. Cell surface expression was not affected for MC3R but resulted in a significant reduction of MC4R to 61% by co-expression with RNF11.Mechanisms linking HFD, inflammation, and metabolism remain partially understood. In this study, a new axis between signaling of specific body weight regulating GPCRs and factors involved in hypothalamic inflammation is suggested. |
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Intact melanocortin signaling via the G protein-coupled receptors (GPCRs) melanocortin receptor 4 (MC4R) and melanocortin receptor 3 (MC3R) is crucial for body weight maintenance. So far, no connection between melanocortin signaling and hypothalamic inflammation has been reported. Using a bimolecular fluorescence complementation library screen, we identified a new interaction partner for these receptors, ring finger protein 11 (RNF11). RNF11 participates in the constitution of the A20 complex that is involved in reduction of tumor necrosis factor F-induced NFB signaling, an important pathway in hypothalamic inflammation. Mice treated with high-fat diet (HFD) for 3 days demonstrated a trend toward an increase in hypothalamic Rnf11 expression, as shown for other inflammatory markers under HFD. Furthermore, Gs-mediated signaling of MC3/4R was demonstrated to be strongly reduced to 20 - 40% by co-expression of RNF11 despite unchanged total receptor expression. Cell surface expression was not affected for MC3R but resulted in a significant reduction of MC4R to 61% by co-expression with RNF11.Mechanisms linking HFD, inflammation, and metabolism remain partially understood. In this study, a new axis between signaling of specific body weight regulating GPCRs and factors involved in hypothalamic inflammation is suggested. |
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So far, no connection between melanocortin signaling and hypothalamic inflammation has been reported. Using a bimolecular fluorescence complementation library screen, we identified a new interaction partner for these receptors, ring finger protein 11 (RNF11). RNF11 participates in the constitution of the A20 complex that is involved in reduction of tumor necrosis factor F-induced NFB signaling, an important pathway in hypothalamic inflammation. Mice treated with high-fat diet (HFD) for 3 days demonstrated a trend toward an increase in hypothalamic Rnf11 expression, as shown for other inflammatory markers under HFD. Furthermore, Gs-mediated signaling of MC3/4R was demonstrated to be strongly reduced to 20 - 40% by co-expression of RNF11 despite unchanged total receptor expression. Cell surface expression was not affected for MC3R but resulted in a significant reduction of MC4R to 61% by co-expression with RNF11.Mechanisms linking HFD, inflammation, and metabolism remain partially understood. In this study, a new axis between signaling of specific body weight regulating GPCRs and factors involved in hypothalamic inflammation is suggested.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Inflammation</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">G protein coupled receptor</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">protein network</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">weight regulation</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Protein complementation assay</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Diseases of the endocrine glands. 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