Identification of Mycoses in Developing Countries

Extensive advances in technology offer a vast variety of diagnostic methods that save time and costs, but identification of fungal species causing human infections remains challenging in developing countries. Since the echinocandins, antifungals widely used to treat invasive mycoses, are still unava...
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Gespeichert in:

Autor*in:	Amir Arastehfar [verfasserIn] Brian L. Wickes [verfasserIn] Macit Ilkit [verfasserIn] David H. Pincus [verfasserIn] Farnaz Daneshnia [verfasserIn] Weihua Pan [verfasserIn] Wenjie Fang [verfasserIn] Teun Boekhout [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	phenotypic assays molecular tools serology nanopore sequencing

Übergeordnetes Werk:	In: Journal of Fungi - MDPI AG, 2015, 5(2019), 4, p 90
Übergeordnetes Werk:	volume:5 ; year:2019 ; number:4, p 90

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/jof5040090

Katalog-ID:	DOAJ017340403

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allfieldsSound	10.3390/jof5040090 doi (DE-627)DOAJ017340403 (DE-599)DOAJ1db654b5735949d3b65261e43c8a0568 DE-627 ger DE-627 rakwb eng QH301-705.5 Amir Arastehfar verfasserin aut Identification of Mycoses in Developing Countries 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Extensive advances in technology offer a vast variety of diagnostic methods that save time and costs, but identification of fungal species causing human infections remains challenging in developing countries. Since the echinocandins, antifungals widely used to treat invasive mycoses, are still unavailable in developing countries where a considerable number of problematic fungal species are present, rapid and reliable identification is of paramount importance. Unaffordability, large footprints, lack of skilled personnel, and high costs associated with maintenance and infrastructure are the main factors precluding the establishment of high-precision technologies that can replace inexpensive yet time-consuming and inaccurate phenotypic methods. In addition, point-of-care lateral flow assay tests are available for the diagnosis of <i<Aspergillus</i< and <i<Cryptococcus</i< and are highly relevant for developing countries. An <i<Aspergillus</i< galactomannan lateral flow assay is also now available. Real-time PCR remains difficult to standardize and is not widespread in countries with limited resources. Isothermal and conventional PCR-based amplification assays may be alternative solutions. The combination of real-time PCR and serological assays can significantly increase diagnostic efficiency. However, this approach is too expensive for medical institutions in developing countries. Further advances in next-generation sequencing and other innovative technologies such as clustered regularly interspaced short palindromic repeats (CRISPR)-based diagnostic tools may lead to efficient, alternate methods that can be used in point-of-care assays, which may supplement or replace some of the current technologies and improve the diagnostics of fungal infections in developing countries. phenotypic assays molecular tools serology nanopore sequencing Biology (General) Brian L. Wickes verfasserin aut Macit Ilkit verfasserin aut David H. Pincus verfasserin aut Farnaz Daneshnia verfasserin aut Weihua Pan verfasserin aut Wenjie Fang verfasserin aut Teun Boekhout verfasserin aut In Journal of Fungi MDPI AG, 2015 5(2019), 4, p 90 (DE-627)796588538 (DE-600)2784229-0 2309608X nnns volume:5 year:2019 number:4, p 90 https://doi.org/10.3390/jof5040090 kostenfrei https://doaj.org/article/1db654b5735949d3b65261e43c8a0568 kostenfrei https://www.mdpi.com/2309-608X/5/4/90 kostenfrei https://doaj.org/toc/2309-608X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2019 4, p 90
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author	Amir Arastehfar
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topic_title	QH301-705.5 Identification of Mycoses in Developing Countries phenotypic assays molecular tools serology nanopore sequencing
topic	misc QH301-705.5 misc phenotypic assays misc molecular tools misc serology misc nanopore sequencing misc Biology (General)
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title	Identification of Mycoses in Developing Countries
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title_full	Identification of Mycoses in Developing Countries
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title_sort	identification of mycoses in developing countries
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title_auth	Identification of Mycoses in Developing Countries
abstract	Extensive advances in technology offer a vast variety of diagnostic methods that save time and costs, but identification of fungal species causing human infections remains challenging in developing countries. Since the echinocandins, antifungals widely used to treat invasive mycoses, are still unavailable in developing countries where a considerable number of problematic fungal species are present, rapid and reliable identification is of paramount importance. Unaffordability, large footprints, lack of skilled personnel, and high costs associated with maintenance and infrastructure are the main factors precluding the establishment of high-precision technologies that can replace inexpensive yet time-consuming and inaccurate phenotypic methods. In addition, point-of-care lateral flow assay tests are available for the diagnosis of <i<Aspergillus</i< and <i<Cryptococcus</i< and are highly relevant for developing countries. An <i<Aspergillus</i< galactomannan lateral flow assay is also now available. Real-time PCR remains difficult to standardize and is not widespread in countries with limited resources. Isothermal and conventional PCR-based amplification assays may be alternative solutions. The combination of real-time PCR and serological assays can significantly increase diagnostic efficiency. However, this approach is too expensive for medical institutions in developing countries. Further advances in next-generation sequencing and other innovative technologies such as clustered regularly interspaced short palindromic repeats (CRISPR)-based diagnostic tools may lead to efficient, alternate methods that can be used in point-of-care assays, which may supplement or replace some of the current technologies and improve the diagnostics of fungal infections in developing countries.
abstractGer	Extensive advances in technology offer a vast variety of diagnostic methods that save time and costs, but identification of fungal species causing human infections remains challenging in developing countries. Since the echinocandins, antifungals widely used to treat invasive mycoses, are still unavailable in developing countries where a considerable number of problematic fungal species are present, rapid and reliable identification is of paramount importance. Unaffordability, large footprints, lack of skilled personnel, and high costs associated with maintenance and infrastructure are the main factors precluding the establishment of high-precision technologies that can replace inexpensive yet time-consuming and inaccurate phenotypic methods. In addition, point-of-care lateral flow assay tests are available for the diagnosis of <i<Aspergillus</i< and <i<Cryptococcus</i< and are highly relevant for developing countries. An <i<Aspergillus</i< galactomannan lateral flow assay is also now available. Real-time PCR remains difficult to standardize and is not widespread in countries with limited resources. Isothermal and conventional PCR-based amplification assays may be alternative solutions. The combination of real-time PCR and serological assays can significantly increase diagnostic efficiency. However, this approach is too expensive for medical institutions in developing countries. Further advances in next-generation sequencing and other innovative technologies such as clustered regularly interspaced short palindromic repeats (CRISPR)-based diagnostic tools may lead to efficient, alternate methods that can be used in point-of-care assays, which may supplement or replace some of the current technologies and improve the diagnostics of fungal infections in developing countries.
abstract_unstemmed	Extensive advances in technology offer a vast variety of diagnostic methods that save time and costs, but identification of fungal species causing human infections remains challenging in developing countries. Since the echinocandins, antifungals widely used to treat invasive mycoses, are still unavailable in developing countries where a considerable number of problematic fungal species are present, rapid and reliable identification is of paramount importance. Unaffordability, large footprints, lack of skilled personnel, and high costs associated with maintenance and infrastructure are the main factors precluding the establishment of high-precision technologies that can replace inexpensive yet time-consuming and inaccurate phenotypic methods. In addition, point-of-care lateral flow assay tests are available for the diagnosis of <i<Aspergillus</i< and <i<Cryptococcus</i< and are highly relevant for developing countries. An <i<Aspergillus</i< galactomannan lateral flow assay is also now available. Real-time PCR remains difficult to standardize and is not widespread in countries with limited resources. Isothermal and conventional PCR-based amplification assays may be alternative solutions. The combination of real-time PCR and serological assays can significantly increase diagnostic efficiency. However, this approach is too expensive for medical institutions in developing countries. Further advances in next-generation sequencing and other innovative technologies such as clustered regularly interspaced short palindromic repeats (CRISPR)-based diagnostic tools may lead to efficient, alternate methods that can be used in point-of-care assays, which may supplement or replace some of the current technologies and improve the diagnostics of fungal infections in developing countries.
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title_short	Identification of Mycoses in Developing Countries
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Identification of Mycoses in Developing Countries

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