Arterial Blood, Rather Than Venous Blood, is a Better Source for Circulating Melanoma Cells

Background: CTCs provide prognostic information and their application is under investigation in multiple tumor types. Of the multiple variables inherent in any such process, none is more important to outcome than the appropriateness of the sample source. To address this question, we investigated CTC...
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Autor*in:	Mizue Terai [verfasserIn] Zhaomei Mu [verfasserIn] David J. Eschelman [verfasserIn] Carin F. Gonsalves [verfasserIn] Ken Kageyama [verfasserIn] Inna Chervoneva [verfasserIn] Marlana Orloff [verfasserIn] Ryan Weight [verfasserIn] Michael J. Mastrangelo [verfasserIn] Massimo Cristofanilli [verfasserIn] Takami Sato [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2015

Schlagwörter:	Uveal melanoma Circulating tumor cells Hepatic metastasis Arterial venous Peripheral venous CTC count***

Übergeordnetes Werk:	In: EBioMedicine - Elsevier, 2015, 2(2015), 11, Seite 1821-1826
Übergeordnetes Werk:	volume:2 ; year:2015 ; number:11 ; pages:1821-1826

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.ebiom.2015.09.019

Katalog-ID:	DOAJ017435439

Internformat


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520			\|a Background: CTCs provide prognostic information and their application is under investigation in multiple tumor types. Of the multiple variables inherent in any such process, none is more important to outcome than the appropriateness of the sample source. To address this question, we investigated CTCs in paired peripheral venous and arterial blood specimens obtained from stage IV uveal melanoma patients. Methods: Blood specimens were obtained from both common femoral arteries and antecubital veins in 17 uveal melanoma patients with multiple hepatic metastases for CTC measurements. Finding: CTCs were detectable with greater frequency (100%) and in larger numbers (median 5, range 1 to 168) in all arterial blood specimens than in venous samples (52.9%; median 1, range 0 to 8). Patients with hepatic as well as extra-hepatic metastasis showed higher number of arterial CTCs, compared to patients with liver-only metastasis (p = 0.003). There was no significant association between the number of arterial CTCs and the tumor burden within the liver in patients who had liver-only metastases. Interpretation: Our data indicate that arterial blood specimens might be a better source of circulating uveal melanoma cells. Although less conveniently processed, perhaps arterial blood should be evaluated as sample source for measurement of CTCs.
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650		4	\|a Circulating tumor cells
650		4	\|a Hepatic metastasis
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650		4	\|a Peripheral venous
650		4	\|a CTC count***
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700	0		\|a Zhaomei Mu \|e verfasserin \|4 aut
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700	0		\|a Carin F. Gonsalves \|e verfasserin \|4 aut
700	0		\|a Ken Kageyama \|e verfasserin \|4 aut
700	0		\|a Inna Chervoneva \|e verfasserin \|4 aut
700	0		\|a Marlana Orloff \|e verfasserin \|4 aut
700	0		\|a Ryan Weight \|e verfasserin \|4 aut
700	0		\|a Michael J. Mastrangelo \|e verfasserin \|4 aut
700	0		\|a Massimo Cristofanilli \|e verfasserin \|4 aut
700	0		\|a Takami Sato \|e verfasserin \|4 aut
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publishDate	2015
allfields	10.1016/j.ebiom.2015.09.019 doi (DE-627)DOAJ017435439 (DE-599)DOAJ24d8188ad8b847579f79c7832bf982d1 DE-627 ger DE-627 rakwb eng R5-920 Mizue Terai verfasserin aut Arterial Blood, Rather Than Venous Blood, is a Better Source for Circulating Melanoma Cells 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: CTCs provide prognostic information and their application is under investigation in multiple tumor types. Of the multiple variables inherent in any such process, none is more important to outcome than the appropriateness of the sample source. To address this question, we investigated CTCs in paired peripheral venous and arterial blood specimens obtained from stage IV uveal melanoma patients. Methods: Blood specimens were obtained from both common femoral arteries and antecubital veins in 17 uveal melanoma patients with multiple hepatic metastases for CTC measurements. Finding: CTCs were detectable with greater frequency (100%) and in larger numbers (median 5, range 1 to 168) in all arterial blood specimens than in venous samples (52.9%; median 1, range 0 to 8). Patients with hepatic as well as extra-hepatic metastasis showed higher number of arterial CTCs, compared to patients with liver-only metastasis (p = 0.003). There was no significant association between the number of arterial CTCs and the tumor burden within the liver in patients who had liver-only metastases. Interpretation: Our data indicate that arterial blood specimens might be a better source of circulating uveal melanoma cells. Although less conveniently processed, perhaps arterial blood should be evaluated as sample source for measurement of CTCs. Uveal melanoma Circulating tumor cells Hepatic metastasis Arterial venous Peripheral venous CTC count*** Medicine R Medicine (General) Zhaomei Mu verfasserin aut David J. Eschelman verfasserin aut Carin F. Gonsalves verfasserin aut Ken Kageyama verfasserin aut Inna Chervoneva verfasserin aut Marlana Orloff verfasserin aut Ryan Weight verfasserin aut Michael J. Mastrangelo verfasserin aut Massimo Cristofanilli verfasserin aut Takami Sato verfasserin aut In EBioMedicine Elsevier, 2015 2(2015), 11, Seite 1821-1826 (DE-627)802540074 (DE-600)2799017-5 23523964 nnns volume:2 year:2015 number:11 pages:1821-1826 https://doi.org/10.1016/j.ebiom.2015.09.019 kostenfrei https://doaj.org/article/24d8188ad8b847579f79c7832bf982d1 kostenfrei http://www.sciencedirect.com/science/article/pii/S2352396415301389 kostenfrei https://doaj.org/toc/2352-3964 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 2 2015 11 1821-1826
spelling	10.1016/j.ebiom.2015.09.019 doi (DE-627)DOAJ017435439 (DE-599)DOAJ24d8188ad8b847579f79c7832bf982d1 DE-627 ger DE-627 rakwb eng R5-920 Mizue Terai verfasserin aut Arterial Blood, Rather Than Venous Blood, is a Better Source for Circulating Melanoma Cells 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: CTCs provide prognostic information and their application is under investigation in multiple tumor types. Of the multiple variables inherent in any such process, none is more important to outcome than the appropriateness of the sample source. To address this question, we investigated CTCs in paired peripheral venous and arterial blood specimens obtained from stage IV uveal melanoma patients. Methods: Blood specimens were obtained from both common femoral arteries and antecubital veins in 17 uveal melanoma patients with multiple hepatic metastases for CTC measurements. Finding: CTCs were detectable with greater frequency (100%) and in larger numbers (median 5, range 1 to 168) in all arterial blood specimens than in venous samples (52.9%; median 1, range 0 to 8). Patients with hepatic as well as extra-hepatic metastasis showed higher number of arterial CTCs, compared to patients with liver-only metastasis (p = 0.003). There was no significant association between the number of arterial CTCs and the tumor burden within the liver in patients who had liver-only metastases. Interpretation: Our data indicate that arterial blood specimens might be a better source of circulating uveal melanoma cells. Although less conveniently processed, perhaps arterial blood should be evaluated as sample source for measurement of CTCs. Uveal melanoma Circulating tumor cells Hepatic metastasis Arterial venous Peripheral venous CTC count*** Medicine R Medicine (General) Zhaomei Mu verfasserin aut David J. Eschelman verfasserin aut Carin F. Gonsalves verfasserin aut Ken Kageyama verfasserin aut Inna Chervoneva verfasserin aut Marlana Orloff verfasserin aut Ryan Weight verfasserin aut Michael J. Mastrangelo verfasserin aut Massimo Cristofanilli verfasserin aut Takami Sato verfasserin aut In EBioMedicine Elsevier, 2015 2(2015), 11, Seite 1821-1826 (DE-627)802540074 (DE-600)2799017-5 23523964 nnns volume:2 year:2015 number:11 pages:1821-1826 https://doi.org/10.1016/j.ebiom.2015.09.019 kostenfrei https://doaj.org/article/24d8188ad8b847579f79c7832bf982d1 kostenfrei http://www.sciencedirect.com/science/article/pii/S2352396415301389 kostenfrei https://doaj.org/toc/2352-3964 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 2 2015 11 1821-1826
allfields_unstemmed	10.1016/j.ebiom.2015.09.019 doi (DE-627)DOAJ017435439 (DE-599)DOAJ24d8188ad8b847579f79c7832bf982d1 DE-627 ger DE-627 rakwb eng R5-920 Mizue Terai verfasserin aut Arterial Blood, Rather Than Venous Blood, is a Better Source for Circulating Melanoma Cells 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: CTCs provide prognostic information and their application is under investigation in multiple tumor types. Of the multiple variables inherent in any such process, none is more important to outcome than the appropriateness of the sample source. To address this question, we investigated CTCs in paired peripheral venous and arterial blood specimens obtained from stage IV uveal melanoma patients. Methods: Blood specimens were obtained from both common femoral arteries and antecubital veins in 17 uveal melanoma patients with multiple hepatic metastases for CTC measurements. Finding: CTCs were detectable with greater frequency (100%) and in larger numbers (median 5, range 1 to 168) in all arterial blood specimens than in venous samples (52.9%; median 1, range 0 to 8). Patients with hepatic as well as extra-hepatic metastasis showed higher number of arterial CTCs, compared to patients with liver-only metastasis (p = 0.003). There was no significant association between the number of arterial CTCs and the tumor burden within the liver in patients who had liver-only metastases. Interpretation: Our data indicate that arterial blood specimens might be a better source of circulating uveal melanoma cells. Although less conveniently processed, perhaps arterial blood should be evaluated as sample source for measurement of CTCs. Uveal melanoma Circulating tumor cells Hepatic metastasis Arterial venous Peripheral venous CTC count*** Medicine R Medicine (General) Zhaomei Mu verfasserin aut David J. Eschelman verfasserin aut Carin F. Gonsalves verfasserin aut Ken Kageyama verfasserin aut Inna Chervoneva verfasserin aut Marlana Orloff verfasserin aut Ryan Weight verfasserin aut Michael J. Mastrangelo verfasserin aut Massimo Cristofanilli verfasserin aut Takami Sato verfasserin aut In EBioMedicine Elsevier, 2015 2(2015), 11, Seite 1821-1826 (DE-627)802540074 (DE-600)2799017-5 23523964 nnns volume:2 year:2015 number:11 pages:1821-1826 https://doi.org/10.1016/j.ebiom.2015.09.019 kostenfrei https://doaj.org/article/24d8188ad8b847579f79c7832bf982d1 kostenfrei http://www.sciencedirect.com/science/article/pii/S2352396415301389 kostenfrei https://doaj.org/toc/2352-3964 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 2 2015 11 1821-1826
allfieldsGer	10.1016/j.ebiom.2015.09.019 doi (DE-627)DOAJ017435439 (DE-599)DOAJ24d8188ad8b847579f79c7832bf982d1 DE-627 ger DE-627 rakwb eng R5-920 Mizue Terai verfasserin aut Arterial Blood, Rather Than Venous Blood, is a Better Source for Circulating Melanoma Cells 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: CTCs provide prognostic information and their application is under investigation in multiple tumor types. Of the multiple variables inherent in any such process, none is more important to outcome than the appropriateness of the sample source. To address this question, we investigated CTCs in paired peripheral venous and arterial blood specimens obtained from stage IV uveal melanoma patients. Methods: Blood specimens were obtained from both common femoral arteries and antecubital veins in 17 uveal melanoma patients with multiple hepatic metastases for CTC measurements. Finding: CTCs were detectable with greater frequency (100%) and in larger numbers (median 5, range 1 to 168) in all arterial blood specimens than in venous samples (52.9%; median 1, range 0 to 8). Patients with hepatic as well as extra-hepatic metastasis showed higher number of arterial CTCs, compared to patients with liver-only metastasis (p = 0.003). There was no significant association between the number of arterial CTCs and the tumor burden within the liver in patients who had liver-only metastases. Interpretation: Our data indicate that arterial blood specimens might be a better source of circulating uveal melanoma cells. Although less conveniently processed, perhaps arterial blood should be evaluated as sample source for measurement of CTCs. Uveal melanoma Circulating tumor cells Hepatic metastasis Arterial venous Peripheral venous CTC count*** Medicine R Medicine (General) Zhaomei Mu verfasserin aut David J. Eschelman verfasserin aut Carin F. Gonsalves verfasserin aut Ken Kageyama verfasserin aut Inna Chervoneva verfasserin aut Marlana Orloff verfasserin aut Ryan Weight verfasserin aut Michael J. Mastrangelo verfasserin aut Massimo Cristofanilli verfasserin aut Takami Sato verfasserin aut In EBioMedicine Elsevier, 2015 2(2015), 11, Seite 1821-1826 (DE-627)802540074 (DE-600)2799017-5 23523964 nnns volume:2 year:2015 number:11 pages:1821-1826 https://doi.org/10.1016/j.ebiom.2015.09.019 kostenfrei https://doaj.org/article/24d8188ad8b847579f79c7832bf982d1 kostenfrei http://www.sciencedirect.com/science/article/pii/S2352396415301389 kostenfrei https://doaj.org/toc/2352-3964 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 2 2015 11 1821-1826
allfieldsSound	10.1016/j.ebiom.2015.09.019 doi (DE-627)DOAJ017435439 (DE-599)DOAJ24d8188ad8b847579f79c7832bf982d1 DE-627 ger DE-627 rakwb eng R5-920 Mizue Terai verfasserin aut Arterial Blood, Rather Than Venous Blood, is a Better Source for Circulating Melanoma Cells 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: CTCs provide prognostic information and their application is under investigation in multiple tumor types. Of the multiple variables inherent in any such process, none is more important to outcome than the appropriateness of the sample source. To address this question, we investigated CTCs in paired peripheral venous and arterial blood specimens obtained from stage IV uveal melanoma patients. Methods: Blood specimens were obtained from both common femoral arteries and antecubital veins in 17 uveal melanoma patients with multiple hepatic metastases for CTC measurements. Finding: CTCs were detectable with greater frequency (100%) and in larger numbers (median 5, range 1 to 168) in all arterial blood specimens than in venous samples (52.9%; median 1, range 0 to 8). Patients with hepatic as well as extra-hepatic metastasis showed higher number of arterial CTCs, compared to patients with liver-only metastasis (p = 0.003). There was no significant association between the number of arterial CTCs and the tumor burden within the liver in patients who had liver-only metastases. Interpretation: Our data indicate that arterial blood specimens might be a better source of circulating uveal melanoma cells. Although less conveniently processed, perhaps arterial blood should be evaluated as sample source for measurement of CTCs. Uveal melanoma Circulating tumor cells Hepatic metastasis Arterial venous Peripheral venous CTC count*** Medicine R Medicine (General) Zhaomei Mu verfasserin aut David J. Eschelman verfasserin aut Carin F. Gonsalves verfasserin aut Ken Kageyama verfasserin aut Inna Chervoneva verfasserin aut Marlana Orloff verfasserin aut Ryan Weight verfasserin aut Michael J. Mastrangelo verfasserin aut Massimo Cristofanilli verfasserin aut Takami Sato verfasserin aut In EBioMedicine Elsevier, 2015 2(2015), 11, Seite 1821-1826 (DE-627)802540074 (DE-600)2799017-5 23523964 nnns volume:2 year:2015 number:11 pages:1821-1826 https://doi.org/10.1016/j.ebiom.2015.09.019 kostenfrei https://doaj.org/article/24d8188ad8b847579f79c7832bf982d1 kostenfrei http://www.sciencedirect.com/science/article/pii/S2352396415301389 kostenfrei https://doaj.org/toc/2352-3964 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 2 2015 11 1821-1826
language	English
source	In EBioMedicine 2(2015), 11, Seite 1821-1826 volume:2 year:2015 number:11 pages:1821-1826
sourceStr	In EBioMedicine 2(2015), 11, Seite 1821-1826 volume:2 year:2015 number:11 pages:1821-1826
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Uveal melanoma Circulating tumor cells Hepatic metastasis Arterial venous Peripheral venous CTC count*** Medicine R Medicine (General)
isfreeaccess_bool	true
container_title	EBioMedicine
authorswithroles_txt_mv	Mizue Terai @@aut@@ Zhaomei Mu @@aut@@ David J. Eschelman @@aut@@ Carin F. Gonsalves @@aut@@ Ken Kageyama @@aut@@ Inna Chervoneva @@aut@@ Marlana Orloff @@aut@@ Ryan Weight @@aut@@ Michael J. Mastrangelo @@aut@@ Massimo Cristofanilli @@aut@@ Takami Sato @@aut@@
publishDateDaySort_date	2015-01-01T00:00:00Z
hierarchy_top_id	802540074
id	DOAJ017435439
language_de	englisch
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callnumber-first	R - Medicine
author	Mizue Terai
spellingShingle	Mizue Terai misc R5-920 misc Uveal melanoma misc Circulating tumor cells misc Hepatic metastasis misc Arterial venous misc Peripheral venous misc CTC count*** misc Medicine misc R misc Medicine (General) Arterial Blood, Rather Than Venous Blood, is a Better Source for Circulating Melanoma Cells
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topic_title	R5-920 Arterial Blood, Rather Than Venous Blood, is a Better Source for Circulating Melanoma Cells Uveal melanoma Circulating tumor cells Hepatic metastasis Arterial venous Peripheral venous CTC count***
topic	misc R5-920 misc Uveal melanoma misc Circulating tumor cells misc Hepatic metastasis misc Arterial venous misc Peripheral venous misc CTC count*** misc Medicine misc R misc Medicine (General)
topic_unstemmed	misc R5-920 misc Uveal melanoma misc Circulating tumor cells misc Hepatic metastasis misc Arterial venous misc Peripheral venous misc CTC count*** misc Medicine misc R misc Medicine (General)
topic_browse	misc R5-920 misc Uveal melanoma misc Circulating tumor cells misc Hepatic metastasis misc Arterial venous misc Peripheral venous misc CTC count*** misc Medicine misc R misc Medicine (General)
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title	Arterial Blood, Rather Than Venous Blood, is a Better Source for Circulating Melanoma Cells
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title_full	Arterial Blood, Rather Than Venous Blood, is a Better Source for Circulating Melanoma Cells
author_sort	Mizue Terai
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author_browse	Mizue Terai Zhaomei Mu David J. Eschelman Carin F. Gonsalves Ken Kageyama Inna Chervoneva Marlana Orloff Ryan Weight Michael J. Mastrangelo Massimo Cristofanilli Takami Sato
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title_sort	arterial blood, rather than venous blood, is a better source for circulating melanoma cells
callnumber	R5-920
title_auth	Arterial Blood, Rather Than Venous Blood, is a Better Source for Circulating Melanoma Cells
abstract	Background: CTCs provide prognostic information and their application is under investigation in multiple tumor types. Of the multiple variables inherent in any such process, none is more important to outcome than the appropriateness of the sample source. To address this question, we investigated CTCs in paired peripheral venous and arterial blood specimens obtained from stage IV uveal melanoma patients. Methods: Blood specimens were obtained from both common femoral arteries and antecubital veins in 17 uveal melanoma patients with multiple hepatic metastases for CTC measurements. Finding: CTCs were detectable with greater frequency (100%) and in larger numbers (median 5, range 1 to 168) in all arterial blood specimens than in venous samples (52.9%; median 1, range 0 to 8). Patients with hepatic as well as extra-hepatic metastasis showed higher number of arterial CTCs, compared to patients with liver-only metastasis (p = 0.003). There was no significant association between the number of arterial CTCs and the tumor burden within the liver in patients who had liver-only metastases. Interpretation: Our data indicate that arterial blood specimens might be a better source of circulating uveal melanoma cells. Although less conveniently processed, perhaps arterial blood should be evaluated as sample source for measurement of CTCs.
abstractGer	Background: CTCs provide prognostic information and their application is under investigation in multiple tumor types. Of the multiple variables inherent in any such process, none is more important to outcome than the appropriateness of the sample source. To address this question, we investigated CTCs in paired peripheral venous and arterial blood specimens obtained from stage IV uveal melanoma patients. Methods: Blood specimens were obtained from both common femoral arteries and antecubital veins in 17 uveal melanoma patients with multiple hepatic metastases for CTC measurements. Finding: CTCs were detectable with greater frequency (100%) and in larger numbers (median 5, range 1 to 168) in all arterial blood specimens than in venous samples (52.9%; median 1, range 0 to 8). Patients with hepatic as well as extra-hepatic metastasis showed higher number of arterial CTCs, compared to patients with liver-only metastasis (p = 0.003). There was no significant association between the number of arterial CTCs and the tumor burden within the liver in patients who had liver-only metastases. Interpretation: Our data indicate that arterial blood specimens might be a better source of circulating uveal melanoma cells. Although less conveniently processed, perhaps arterial blood should be evaluated as sample source for measurement of CTCs.
abstract_unstemmed	Background: CTCs provide prognostic information and their application is under investigation in multiple tumor types. Of the multiple variables inherent in any such process, none is more important to outcome than the appropriateness of the sample source. To address this question, we investigated CTCs in paired peripheral venous and arterial blood specimens obtained from stage IV uveal melanoma patients. Methods: Blood specimens were obtained from both common femoral arteries and antecubital veins in 17 uveal melanoma patients with multiple hepatic metastases for CTC measurements. Finding: CTCs were detectable with greater frequency (100%) and in larger numbers (median 5, range 1 to 168) in all arterial blood specimens than in venous samples (52.9%; median 1, range 0 to 8). Patients with hepatic as well as extra-hepatic metastasis showed higher number of arterial CTCs, compared to patients with liver-only metastasis (p = 0.003). There was no significant association between the number of arterial CTCs and the tumor burden within the liver in patients who had liver-only metastases. Interpretation: Our data indicate that arterial blood specimens might be a better source of circulating uveal melanoma cells. Although less conveniently processed, perhaps arterial blood should be evaluated as sample source for measurement of CTCs.
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title_short	Arterial Blood, Rather Than Venous Blood, is a Better Source for Circulating Melanoma Cells
url	https://doi.org/10.1016/j.ebiom.2015.09.019 https://doaj.org/article/24d8188ad8b847579f79c7832bf982d1 http://www.sciencedirect.com/science/article/pii/S2352396415301389 https://doaj.org/toc/2352-3964
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author2	Zhaomei Mu David J. Eschelman Carin F. Gonsalves Ken Kageyama Inna Chervoneva Marlana Orloff Ryan Weight Michael J. Mastrangelo Massimo Cristofanilli Takami Sato
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Arterial Blood, Rather Than Venous Blood, is a Better Source for Circulating Melanoma Cells

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