High grade gliomas: The role of dynamic contrast-enhanced susceptibility-weighted perfusion MRI and proton MR spectroscopic imaging in differentiating grade III from grade IV

Background: Advanced MR imaging techniques provide physiologic information which complements the conventional MRI findings. Purpose: To evaluate the role of dynamic contrast-enhanced perfusion MRI and proton MR spectroscopy (MRS) in differentiating grade-III from grade-IV glioma. Results: 40 patient...
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Autor*in:	Sayed Zidan [verfasserIn] Hazim I. Tantawy [verfasserIn] Mansour Abdelmagid Makia [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2016

Schlagwörter:	MRS Dynamic contrast-enhanced perfusion MRI Glioma grade III Glioma grade IV

Übergeordnetes Werk:	In: The Egyptian Journal of Radiology and Nuclear Medicine - SpringerOpen, 2016, 47(2016), 4, Seite 1565-1573
Übergeordnetes Werk:	volume:47 ; year:2016 ; number:4 ; pages:1565-1573

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.ejrnm.2016.10.002

Katalog-ID:	DOAJ017469791

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authorswithroles_txt_mv	Sayed Zidan @@aut@@ Hazim I. Tantawy @@aut@@ Mansour Abdelmagid Makia @@aut@@
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callnumber-first	R - Medicine
author	Sayed Zidan
spellingShingle	Sayed Zidan misc R895-920 misc MRS misc Dynamic contrast-enhanced perfusion MRI misc Glioma grade III misc Glioma grade IV misc Medical physics. Medical radiology. Nuclear medicine High grade gliomas: The role of dynamic contrast-enhanced susceptibility-weighted perfusion MRI and proton MR spectroscopic imaging in differentiating grade III from grade IV
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topic_title	R895-920 High grade gliomas: The role of dynamic contrast-enhanced susceptibility-weighted perfusion MRI and proton MR spectroscopic imaging in differentiating grade III from grade IV MRS Dynamic contrast-enhanced perfusion MRI Glioma grade III Glioma grade IV
topic	misc R895-920 misc MRS misc Dynamic contrast-enhanced perfusion MRI misc Glioma grade III misc Glioma grade IV misc Medical physics. Medical radiology. Nuclear medicine
topic_unstemmed	misc R895-920 misc MRS misc Dynamic contrast-enhanced perfusion MRI misc Glioma grade III misc Glioma grade IV misc Medical physics. Medical radiology. Nuclear medicine
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title	High grade gliomas: The role of dynamic contrast-enhanced susceptibility-weighted perfusion MRI and proton MR spectroscopic imaging in differentiating grade III from grade IV
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title_full	High grade gliomas: The role of dynamic contrast-enhanced susceptibility-weighted perfusion MRI and proton MR spectroscopic imaging in differentiating grade III from grade IV
author_sort	Sayed Zidan
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title_sort	high grade gliomas: the role of dynamic contrast-enhanced susceptibility-weighted perfusion mri and proton mr spectroscopic imaging in differentiating grade iii from grade iv
callnumber	R895-920
title_auth	High grade gliomas: The role of dynamic contrast-enhanced susceptibility-weighted perfusion MRI and proton MR spectroscopic imaging in differentiating grade III from grade IV
abstract	Background: Advanced MR imaging techniques provide physiologic information which complements the conventional MRI findings. Purpose: To evaluate the role of dynamic contrast-enhanced perfusion MRI and proton MR spectroscopy (MRS) in differentiating grade-III from grade-IV glioma. Results: 40 patients with preliminary diagnosis of glioma according to the conventional MRI study and the WHO classification and grading of glioma underwent dynamic MRI study which revealed, 19 patients (47.5%) are diagnosed as grade-III, and 21 cases (52.5%) are diagnosed as grade-IV. The tumor core relative cerebral blood volume (rCBV) was highly significant (P = 0.000) in differentiating grade III from grade IV with cutoff value of 6,sensitivity of 90.5%, specificity of 68.4%, PVP of 76% and NPV of 86.7%. In proton MR spectroscopy, (CHo/Cr) ratio was significant in differentiating grade III from grade IV glioma (P = 0.02), while CHo/NAA, NAA/Cr and MI/Cr ratios were not significant. Conclusion: The rCBV estimation and the metabolite ratios separately or in combination increase the sensitivity of grading of glioma rather than the conventional MRI.
abstractGer	Background: Advanced MR imaging techniques provide physiologic information which complements the conventional MRI findings. Purpose: To evaluate the role of dynamic contrast-enhanced perfusion MRI and proton MR spectroscopy (MRS) in differentiating grade-III from grade-IV glioma. Results: 40 patients with preliminary diagnosis of glioma according to the conventional MRI study and the WHO classification and grading of glioma underwent dynamic MRI study which revealed, 19 patients (47.5%) are diagnosed as grade-III, and 21 cases (52.5%) are diagnosed as grade-IV. The tumor core relative cerebral blood volume (rCBV) was highly significant (P = 0.000) in differentiating grade III from grade IV with cutoff value of 6,sensitivity of 90.5%, specificity of 68.4%, PVP of 76% and NPV of 86.7%. In proton MR spectroscopy, (CHo/Cr) ratio was significant in differentiating grade III from grade IV glioma (P = 0.02), while CHo/NAA, NAA/Cr and MI/Cr ratios were not significant. Conclusion: The rCBV estimation and the metabolite ratios separately or in combination increase the sensitivity of grading of glioma rather than the conventional MRI.
abstract_unstemmed	Background: Advanced MR imaging techniques provide physiologic information which complements the conventional MRI findings. Purpose: To evaluate the role of dynamic contrast-enhanced perfusion MRI and proton MR spectroscopy (MRS) in differentiating grade-III from grade-IV glioma. Results: 40 patients with preliminary diagnosis of glioma according to the conventional MRI study and the WHO classification and grading of glioma underwent dynamic MRI study which revealed, 19 patients (47.5%) are diagnosed as grade-III, and 21 cases (52.5%) are diagnosed as grade-IV. The tumor core relative cerebral blood volume (rCBV) was highly significant (P = 0.000) in differentiating grade III from grade IV with cutoff value of 6,sensitivity of 90.5%, specificity of 68.4%, PVP of 76% and NPV of 86.7%. In proton MR spectroscopy, (CHo/Cr) ratio was significant in differentiating grade III from grade IV glioma (P = 0.02), while CHo/NAA, NAA/Cr and MI/Cr ratios were not significant. Conclusion: The rCBV estimation and the metabolite ratios separately or in combination increase the sensitivity of grading of glioma rather than the conventional MRI.
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title_short	High grade gliomas: The role of dynamic contrast-enhanced susceptibility-weighted perfusion MRI and proton MR spectroscopic imaging in differentiating grade III from grade IV
url	https://doi.org/10.1016/j.ejrnm.2016.10.002 https://doaj.org/article/daca2123b7284325814d6d828d1dead5 http://www.sciencedirect.com/science/article/pii/S0378603X16301905 https://doaj.org/toc/0378-603X
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author2	Hazim I. Tantawy Mansour Abdelmagid Makia
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up_date	2024-07-04T01:43:55.013Z
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High grade gliomas: The role of dynamic contrast-enhanced susceptibility-weighted perfusion MRI and proton MR spectroscopic imaging in differentiating grade III from grade IV

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