Antimicrobial Activity of <i<Eucalyptus globulus</i<, <i<Azadirachta indica</i<, <i<Glycyrrhiza glabra</i<, <i<Rheum palmatum</i< Extracts and Rhein against <i<Porphyromonas gingivalis</i<

Novel plant-derived antimicrobials are of interest in dentistry, especially in the treatment of periodontitis, since the use of established substances is associated with side effects and concerns of antimicrobial resistance have been raised. Thus, the present study was performed to quantify the anti...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Lena Katharina Müller-Heupt [verfasserIn] Nina Vierengel [verfasserIn] Jonathan Groß [verfasserIn] Till Opatz [verfasserIn] James Deschner [verfasserIn] Friederike D. von Loewenich [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	broth microdilution plant extracts rhein

Übergeordnetes Werk:	In: Antibiotics - MDPI AG, 2013, 11(2022), 2, p 186
Übergeordnetes Werk:	volume:11 ; year:2022 ; number:2, p 186

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/antibiotics11020186

Katalog-ID:	DOAJ017516536

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allfields	10.3390/antibiotics11020186 doi (DE-627)DOAJ017516536 (DE-599)DOAJ0e7fa415f7b54383adba0475c9b0a5b8 DE-627 ger DE-627 rakwb eng RM1-950 Lena Katharina Müller-Heupt verfasserin aut Antimicrobial Activity of <i<Eucalyptus globulus</i<, <i<Azadirachta indica</i<, <i<Glycyrrhiza glabra</i<, <i<Rheum palmatum</i< Extracts and Rhein against <i<Porphyromonas gingivalis</i< 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Novel plant-derived antimicrobials are of interest in dentistry, especially in the treatment of periodontitis, since the use of established substances is associated with side effects and concerns of antimicrobial resistance have been raised. Thus, the present study was performed to quantify the antimicrobial efficacy of crude plant extracts against <i<Porphyromonas gingivalis</i<, a pathogen associated with periodontitis. The minimal inhibitory concentrations (MICs) of <i<Eucalyptus globulus</i< leaf, <i<Azadirachta indica</i< leaf, <i<Glycyrrhiza glabra</i< root and <i<Rheum palmatum</i< root extracts were determined by broth microdilution for <i<P. gingivalis</i< ATCC 33277 according to CLSI (Clinical and Laboratory Standards Institute). The MICs for the <i<E. globulus</i<, <i<A. indica</i< and <i<G. glabra</i< extracts ranged from 64 mg/L to 1024 mg/L. The lowest MIC was determined for an ethanolic <i<R. palmatum</i< extract with 4 mg/L. The MIC for the anthraquinone rhein was also measured, as the antimicrobial activity of <i<P. palmatum</i< root extracts can be partially traced back to rhein. Rhein showed a remarkably low MIC of 0.125 mg/L. However, the major compounds of the <i<R. palmatum</i< root extract were not further separated and purified. In conclusion, <i<R. palmatum</i< root extracts should be further studied for the treatment of periodontitis. <i<Azadirachta indica</i< broth microdilution <i<Glycyrrhiza glabra</i< plant extracts <i<Porphyromonas gingivalis</i< rhein Therapeutics. Pharmacology Nina Vierengel verfasserin aut Jonathan Groß verfasserin aut Till Opatz verfasserin aut James Deschner verfasserin aut Friederike D. von Loewenich verfasserin aut In Antibiotics MDPI AG, 2013 11(2022), 2, p 186 (DE-627)726120596 (DE-600)2681345-2 20796382 nnns volume:11 year:2022 number:2, p 186 https://doi.org/10.3390/antibiotics11020186 kostenfrei https://doaj.org/article/0e7fa415f7b54383adba0475c9b0a5b8 kostenfrei https://www.mdpi.com/2079-6382/11/2/186 kostenfrei https://doaj.org/toc/2079-6382 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 2, p 186
spelling	10.3390/antibiotics11020186 doi (DE-627)DOAJ017516536 (DE-599)DOAJ0e7fa415f7b54383adba0475c9b0a5b8 DE-627 ger DE-627 rakwb eng RM1-950 Lena Katharina Müller-Heupt verfasserin aut Antimicrobial Activity of <i<Eucalyptus globulus</i<, <i<Azadirachta indica</i<, <i<Glycyrrhiza glabra</i<, <i<Rheum palmatum</i< Extracts and Rhein against <i<Porphyromonas gingivalis</i< 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Novel plant-derived antimicrobials are of interest in dentistry, especially in the treatment of periodontitis, since the use of established substances is associated with side effects and concerns of antimicrobial resistance have been raised. Thus, the present study was performed to quantify the antimicrobial efficacy of crude plant extracts against <i<Porphyromonas gingivalis</i<, a pathogen associated with periodontitis. The minimal inhibitory concentrations (MICs) of <i<Eucalyptus globulus</i< leaf, <i<Azadirachta indica</i< leaf, <i<Glycyrrhiza glabra</i< root and <i<Rheum palmatum</i< root extracts were determined by broth microdilution for <i<P. gingivalis</i< ATCC 33277 according to CLSI (Clinical and Laboratory Standards Institute). The MICs for the <i<E. globulus</i<, <i<A. indica</i< and <i<G. glabra</i< extracts ranged from 64 mg/L to 1024 mg/L. The lowest MIC was determined for an ethanolic <i<R. palmatum</i< extract with 4 mg/L. The MIC for the anthraquinone rhein was also measured, as the antimicrobial activity of <i<P. palmatum</i< root extracts can be partially traced back to rhein. Rhein showed a remarkably low MIC of 0.125 mg/L. However, the major compounds of the <i<R. palmatum</i< root extract were not further separated and purified. In conclusion, <i<R. palmatum</i< root extracts should be further studied for the treatment of periodontitis. <i<Azadirachta indica</i< broth microdilution <i<Glycyrrhiza glabra</i< plant extracts <i<Porphyromonas gingivalis</i< rhein Therapeutics. Pharmacology Nina Vierengel verfasserin aut Jonathan Groß verfasserin aut Till Opatz verfasserin aut James Deschner verfasserin aut Friederike D. von Loewenich verfasserin aut In Antibiotics MDPI AG, 2013 11(2022), 2, p 186 (DE-627)726120596 (DE-600)2681345-2 20796382 nnns volume:11 year:2022 number:2, p 186 https://doi.org/10.3390/antibiotics11020186 kostenfrei https://doaj.org/article/0e7fa415f7b54383adba0475c9b0a5b8 kostenfrei https://www.mdpi.com/2079-6382/11/2/186 kostenfrei https://doaj.org/toc/2079-6382 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 2, p 186
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topic_title	RM1-950 Antimicrobial Activity of <i<Eucalyptus globulus</i<, <i<Azadirachta indica</i<, <i<Glycyrrhiza glabra</i<, <i<Rheum palmatum</i< Extracts and Rhein against <i<Porphyromonas gingivalis</i< <i<Azadirachta indica</i< broth microdilution <i<Glycyrrhiza glabra</i< plant extracts <i<Porphyromonas gingivalis</i< rhein
topic	misc RM1-950 misc <i<Azadirachta indica</i< misc broth microdilution misc <i<Glycyrrhiza glabra</i< misc plant extracts misc <i<Porphyromonas gingivalis</i< misc rhein misc Therapeutics. Pharmacology
topic_unstemmed	misc RM1-950 misc <i<Azadirachta indica</i< misc broth microdilution misc <i<Glycyrrhiza glabra</i< misc plant extracts misc <i<Porphyromonas gingivalis</i< misc rhein misc Therapeutics. Pharmacology
topic_browse	misc RM1-950 misc <i<Azadirachta indica</i< misc broth microdilution misc <i<Glycyrrhiza glabra</i< misc plant extracts misc <i<Porphyromonas gingivalis</i< misc rhein misc Therapeutics. Pharmacology
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title	Antimicrobial Activity of <i<Eucalyptus globulus</i<, <i<Azadirachta indica</i<, <i<Glycyrrhiza glabra</i<, <i<Rheum palmatum</i< Extracts and Rhein against <i<Porphyromonas gingivalis</i<
ctrlnum	(DE-627)DOAJ017516536 (DE-599)DOAJ0e7fa415f7b54383adba0475c9b0a5b8
title_full	Antimicrobial Activity of <i<Eucalyptus globulus</i<, <i<Azadirachta indica</i<, <i<Glycyrrhiza glabra</i<, <i<Rheum palmatum</i< Extracts and Rhein against <i<Porphyromonas gingivalis</i<
author_sort	Lena Katharina Müller-Heupt
journal	Antibiotics
journalStr	Antibiotics
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lang_code	eng
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publishDateSort	2022
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author_browse	Lena Katharina Müller-Heupt Nina Vierengel Jonathan Groß Till Opatz James Deschner Friederike D. von Loewenich
container_volume	11
class	RM1-950
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author-letter	Lena Katharina Müller-Heupt
doi_str_mv	10.3390/antibiotics11020186
author2-role	verfasserin
title_sort	antimicrobial activity of <i<eucalyptus globulus</i<, <i<azadirachta indica</i<, <i<glycyrrhiza glabra</i<, <i<rheum palmatum</i< extracts and rhein against <i<porphyromonas gingivalis</i<
callnumber	RM1-950
title_auth	Antimicrobial Activity of <i<Eucalyptus globulus</i<, <i<Azadirachta indica</i<, <i<Glycyrrhiza glabra</i<, <i<Rheum palmatum</i< Extracts and Rhein against <i<Porphyromonas gingivalis</i<
abstract	Novel plant-derived antimicrobials are of interest in dentistry, especially in the treatment of periodontitis, since the use of established substances is associated with side effects and concerns of antimicrobial resistance have been raised. Thus, the present study was performed to quantify the antimicrobial efficacy of crude plant extracts against <i<Porphyromonas gingivalis</i<, a pathogen associated with periodontitis. The minimal inhibitory concentrations (MICs) of <i<Eucalyptus globulus</i< leaf, <i<Azadirachta indica</i< leaf, <i<Glycyrrhiza glabra</i< root and <i<Rheum palmatum</i< root extracts were determined by broth microdilution for <i<P. gingivalis</i< ATCC 33277 according to CLSI (Clinical and Laboratory Standards Institute). The MICs for the <i<E. globulus</i<, <i<A. indica</i< and <i<G. glabra</i< extracts ranged from 64 mg/L to 1024 mg/L. The lowest MIC was determined for an ethanolic <i<R. palmatum</i< extract with 4 mg/L. The MIC for the anthraquinone rhein was also measured, as the antimicrobial activity of <i<P. palmatum</i< root extracts can be partially traced back to rhein. Rhein showed a remarkably low MIC of 0.125 mg/L. However, the major compounds of the <i<R. palmatum</i< root extract were not further separated and purified. In conclusion, <i<R. palmatum</i< root extracts should be further studied for the treatment of periodontitis.
abstractGer	Novel plant-derived antimicrobials are of interest in dentistry, especially in the treatment of periodontitis, since the use of established substances is associated with side effects and concerns of antimicrobial resistance have been raised. Thus, the present study was performed to quantify the antimicrobial efficacy of crude plant extracts against <i<Porphyromonas gingivalis</i<, a pathogen associated with periodontitis. The minimal inhibitory concentrations (MICs) of <i<Eucalyptus globulus</i< leaf, <i<Azadirachta indica</i< leaf, <i<Glycyrrhiza glabra</i< root and <i<Rheum palmatum</i< root extracts were determined by broth microdilution for <i<P. gingivalis</i< ATCC 33277 according to CLSI (Clinical and Laboratory Standards Institute). The MICs for the <i<E. globulus</i<, <i<A. indica</i< and <i<G. glabra</i< extracts ranged from 64 mg/L to 1024 mg/L. The lowest MIC was determined for an ethanolic <i<R. palmatum</i< extract with 4 mg/L. The MIC for the anthraquinone rhein was also measured, as the antimicrobial activity of <i<P. palmatum</i< root extracts can be partially traced back to rhein. Rhein showed a remarkably low MIC of 0.125 mg/L. However, the major compounds of the <i<R. palmatum</i< root extract were not further separated and purified. In conclusion, <i<R. palmatum</i< root extracts should be further studied for the treatment of periodontitis.
abstract_unstemmed	Novel plant-derived antimicrobials are of interest in dentistry, especially in the treatment of periodontitis, since the use of established substances is associated with side effects and concerns of antimicrobial resistance have been raised. Thus, the present study was performed to quantify the antimicrobial efficacy of crude plant extracts against <i<Porphyromonas gingivalis</i<, a pathogen associated with periodontitis. The minimal inhibitory concentrations (MICs) of <i<Eucalyptus globulus</i< leaf, <i<Azadirachta indica</i< leaf, <i<Glycyrrhiza glabra</i< root and <i<Rheum palmatum</i< root extracts were determined by broth microdilution for <i<P. gingivalis</i< ATCC 33277 according to CLSI (Clinical and Laboratory Standards Institute). The MICs for the <i<E. globulus</i<, <i<A. indica</i< and <i<G. glabra</i< extracts ranged from 64 mg/L to 1024 mg/L. The lowest MIC was determined for an ethanolic <i<R. palmatum</i< extract with 4 mg/L. The MIC for the anthraquinone rhein was also measured, as the antimicrobial activity of <i<P. palmatum</i< root extracts can be partially traced back to rhein. Rhein showed a remarkably low MIC of 0.125 mg/L. However, the major compounds of the <i<R. palmatum</i< root extract were not further separated and purified. In conclusion, <i<R. palmatum</i< root extracts should be further studied for the treatment of periodontitis.
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container_issue	2, p 186
title_short	Antimicrobial Activity of <i<Eucalyptus globulus</i<, <i<Azadirachta indica</i<, <i<Glycyrrhiza glabra</i<, <i<Rheum palmatum</i< Extracts and Rhein against <i<Porphyromonas gingivalis</i<
url	https://doi.org/10.3390/antibiotics11020186 https://doaj.org/article/0e7fa415f7b54383adba0475c9b0a5b8 https://www.mdpi.com/2079-6382/11/2/186 https://doaj.org/toc/2079-6382
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author2	Nina Vierengel Jonathan Groß Till Opatz James Deschner Friederike D. von Loewenich
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up_date	2024-07-04T01:55:00.811Z
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