Characterization of the L-Arginine/Nitric Oxide Pathway and Oxidative Stress in Pediatric Patients with Atopic Diseases
Introduction: L-Arginine (Arg) is a semi-essential amino acid. Constitutive and inducible nitric oxide synthase (NOS) isoforms convert Arg to nitric oxide (NO), a potent vaso- and bronchodilator with multiple biological functions. Atopic dermatitis (AD) and bronchial asthma (BA) are atopic diseases...
Ausführliche Beschreibung
Autor*in: |
Beatrice Hanusch [verfasserIn] Kathrin Sinningen [verfasserIn] Folke Brinkmann [verfasserIn] Stefanie Dillenhöfer [verfasserIn] Mirjam Frank [verfasserIn] Karl-Heinz Jöckel [verfasserIn] Cordula Koerner-Rettberg [verfasserIn] Martin Holtmann [verfasserIn] Tanja Legenbauer [verfasserIn] Christian Langrock [verfasserIn] Thomas Reinehr [verfasserIn] Patricia Maasjosthusmann [verfasserIn] Bibiana Beckmann [verfasserIn] Eckard Hamelmann [verfasserIn] Dimitrios Tsikas [verfasserIn] Thomas Lücke [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
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2022 |
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Übergeordnetes Werk: |
In: International Journal of Molecular Sciences - MDPI AG, 2003, 23(2022), 4, p 2136 |
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Übergeordnetes Werk: |
volume:23 ; year:2022 ; number:4, p 2136 |
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Link aufrufen |
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DOI / URN: |
10.3390/ijms23042136 |
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DOAJ017574161 |
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245 | 1 | 0 | |a Characterization of the L-Arginine/Nitric Oxide Pathway and Oxidative Stress in Pediatric Patients with Atopic Diseases |
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520 | |a Introduction: L-Arginine (Arg) is a semi-essential amino acid. Constitutive and inducible nitric oxide synthase (NOS) isoforms convert Arg to nitric oxide (NO), a potent vaso- and bronchodilator with multiple biological functions. Atopic dermatitis (AD) and bronchial asthma (BA) are atopic diseases affecting many children globally. Several studies analyzed NO in airways, yet the systemic synthesis of NO in AD and BA in children with BA, AD or both is elusive. Methods: In a multicenter study, blood and urine were obtained from 130 of 302 participating children for the measurement of metabolites of the Arg/NO pathway (BA 31.5%; AD 5.4%; AD + BA 36.1%; attention deficit hyperactivity disorder (ADHD) 12.3%). In plasma and urine amino acids Arg and homoarginine (hArg), both substrates of NOS, asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA), both inhibitors of NOS, dimethylamine (DMA), and nitrite and nitrate, were measured by gas chromatography–mass spectrometry. Malondialdehyde (MDA) was measured in plasma and urine samples to evaluate possible effects of oxidative stress. Results: There were no differences in the Arg/NO pathway between the groups of children with different atopic diseases. In comparison to children with ADHD, children with AD, BA or AD and BA had higher plasma nitrite (<i<p</i< < 0.001) and nitrate (<i<p</i< < 0.001) concentrations, suggesting higher systemic NO synthesis in AD and BA. Urinary excretion of DMA was also higher (<i<p</i< = 0.028) in AD and BA compared to patients with ADHD, suggesting elevated ADMA metabolization. Discussion/Conclusion: The Arg/NO pathway is activated in atopic diseases independent of severity. Systemic NO synthesis is increased in children with an atopic disease. Plasma and urinary MDA levels did not differ between the groups, suggesting no effect of oxidative stress on the Arg/NO pathway in atopic diseases. | ||
650 | 4 | |a atopic diseases | |
650 | 4 | |a nitric oxide | |
650 | 4 | |a attention deficit/hyperactivity syndrome | |
650 | 4 | |a bronchial asthma | |
650 | 4 | |a atopic dermatitis | |
650 | 4 | |a common pediatric diseases | |
653 | 0 | |a Biology (General) | |
653 | 0 | |a Chemistry | |
700 | 0 | |a Kathrin Sinningen |e verfasserin |4 aut | |
700 | 0 | |a Folke Brinkmann |e verfasserin |4 aut | |
700 | 0 | |a Stefanie Dillenhöfer |e verfasserin |4 aut | |
700 | 0 | |a Mirjam Frank |e verfasserin |4 aut | |
700 | 0 | |a Karl-Heinz Jöckel |e verfasserin |4 aut | |
700 | 0 | |a Cordula Koerner-Rettberg |e verfasserin |4 aut | |
700 | 0 | |a Martin Holtmann |e verfasserin |4 aut | |
700 | 0 | |a Tanja Legenbauer |e verfasserin |4 aut | |
700 | 0 | |a Christian Langrock |e verfasserin |4 aut | |
700 | 0 | |a Thomas Reinehr |e verfasserin |4 aut | |
700 | 0 | |a Patricia Maasjosthusmann |e verfasserin |4 aut | |
700 | 0 | |a Bibiana Beckmann |e verfasserin |4 aut | |
700 | 0 | |a Eckard Hamelmann |e verfasserin |4 aut | |
700 | 0 | |a Dimitrios Tsikas |e verfasserin |4 aut | |
700 | 0 | |a Thomas Lücke |e verfasserin |4 aut | |
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10.3390/ijms23042136 doi (DE-627)DOAJ017574161 (DE-599)DOAJaf816304098e4a7687fa560cdce71b11 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Beatrice Hanusch verfasserin aut Characterization of the L-Arginine/Nitric Oxide Pathway and Oxidative Stress in Pediatric Patients with Atopic Diseases 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: L-Arginine (Arg) is a semi-essential amino acid. Constitutive and inducible nitric oxide synthase (NOS) isoforms convert Arg to nitric oxide (NO), a potent vaso- and bronchodilator with multiple biological functions. Atopic dermatitis (AD) and bronchial asthma (BA) are atopic diseases affecting many children globally. Several studies analyzed NO in airways, yet the systemic synthesis of NO in AD and BA in children with BA, AD or both is elusive. Methods: In a multicenter study, blood and urine were obtained from 130 of 302 participating children for the measurement of metabolites of the Arg/NO pathway (BA 31.5%; AD 5.4%; AD + BA 36.1%; attention deficit hyperactivity disorder (ADHD) 12.3%). In plasma and urine amino acids Arg and homoarginine (hArg), both substrates of NOS, asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA), both inhibitors of NOS, dimethylamine (DMA), and nitrite and nitrate, were measured by gas chromatography–mass spectrometry. Malondialdehyde (MDA) was measured in plasma and urine samples to evaluate possible effects of oxidative stress. Results: There were no differences in the Arg/NO pathway between the groups of children with different atopic diseases. In comparison to children with ADHD, children with AD, BA or AD and BA had higher plasma nitrite (<i<p</i< < 0.001) and nitrate (<i<p</i< < 0.001) concentrations, suggesting higher systemic NO synthesis in AD and BA. Urinary excretion of DMA was also higher (<i<p</i< = 0.028) in AD and BA compared to patients with ADHD, suggesting elevated ADMA metabolization. Discussion/Conclusion: The Arg/NO pathway is activated in atopic diseases independent of severity. Systemic NO synthesis is increased in children with an atopic disease. Plasma and urinary MDA levels did not differ between the groups, suggesting no effect of oxidative stress on the Arg/NO pathway in atopic diseases. atopic diseases nitric oxide attention deficit/hyperactivity syndrome bronchial asthma atopic dermatitis common pediatric diseases Biology (General) Chemistry Kathrin Sinningen verfasserin aut Folke Brinkmann verfasserin aut Stefanie Dillenhöfer verfasserin aut Mirjam Frank verfasserin aut Karl-Heinz Jöckel verfasserin aut Cordula Koerner-Rettberg verfasserin aut Martin Holtmann verfasserin aut Tanja Legenbauer verfasserin aut Christian Langrock verfasserin aut Thomas Reinehr verfasserin aut Patricia Maasjosthusmann verfasserin aut Bibiana Beckmann verfasserin aut Eckard Hamelmann verfasserin aut Dimitrios Tsikas verfasserin aut Thomas Lücke verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 23(2022), 4, p 2136 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:23 year:2022 number:4, p 2136 https://doi.org/10.3390/ijms23042136 kostenfrei https://doaj.org/article/af816304098e4a7687fa560cdce71b11 kostenfrei https://www.mdpi.com/1422-0067/23/4/2136 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 4, p 2136 |
spelling |
10.3390/ijms23042136 doi (DE-627)DOAJ017574161 (DE-599)DOAJaf816304098e4a7687fa560cdce71b11 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Beatrice Hanusch verfasserin aut Characterization of the L-Arginine/Nitric Oxide Pathway and Oxidative Stress in Pediatric Patients with Atopic Diseases 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: L-Arginine (Arg) is a semi-essential amino acid. Constitutive and inducible nitric oxide synthase (NOS) isoforms convert Arg to nitric oxide (NO), a potent vaso- and bronchodilator with multiple biological functions. Atopic dermatitis (AD) and bronchial asthma (BA) are atopic diseases affecting many children globally. Several studies analyzed NO in airways, yet the systemic synthesis of NO in AD and BA in children with BA, AD or both is elusive. Methods: In a multicenter study, blood and urine were obtained from 130 of 302 participating children for the measurement of metabolites of the Arg/NO pathway (BA 31.5%; AD 5.4%; AD + BA 36.1%; attention deficit hyperactivity disorder (ADHD) 12.3%). In plasma and urine amino acids Arg and homoarginine (hArg), both substrates of NOS, asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA), both inhibitors of NOS, dimethylamine (DMA), and nitrite and nitrate, were measured by gas chromatography–mass spectrometry. Malondialdehyde (MDA) was measured in plasma and urine samples to evaluate possible effects of oxidative stress. Results: There were no differences in the Arg/NO pathway between the groups of children with different atopic diseases. In comparison to children with ADHD, children with AD, BA or AD and BA had higher plasma nitrite (<i<p</i< < 0.001) and nitrate (<i<p</i< < 0.001) concentrations, suggesting higher systemic NO synthesis in AD and BA. Urinary excretion of DMA was also higher (<i<p</i< = 0.028) in AD and BA compared to patients with ADHD, suggesting elevated ADMA metabolization. Discussion/Conclusion: The Arg/NO pathway is activated in atopic diseases independent of severity. Systemic NO synthesis is increased in children with an atopic disease. Plasma and urinary MDA levels did not differ between the groups, suggesting no effect of oxidative stress on the Arg/NO pathway in atopic diseases. atopic diseases nitric oxide attention deficit/hyperactivity syndrome bronchial asthma atopic dermatitis common pediatric diseases Biology (General) Chemistry Kathrin Sinningen verfasserin aut Folke Brinkmann verfasserin aut Stefanie Dillenhöfer verfasserin aut Mirjam Frank verfasserin aut Karl-Heinz Jöckel verfasserin aut Cordula Koerner-Rettberg verfasserin aut Martin Holtmann verfasserin aut Tanja Legenbauer verfasserin aut Christian Langrock verfasserin aut Thomas Reinehr verfasserin aut Patricia Maasjosthusmann verfasserin aut Bibiana Beckmann verfasserin aut Eckard Hamelmann verfasserin aut Dimitrios Tsikas verfasserin aut Thomas Lücke verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 23(2022), 4, p 2136 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:23 year:2022 number:4, p 2136 https://doi.org/10.3390/ijms23042136 kostenfrei https://doaj.org/article/af816304098e4a7687fa560cdce71b11 kostenfrei https://www.mdpi.com/1422-0067/23/4/2136 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 4, p 2136 |
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10.3390/ijms23042136 doi (DE-627)DOAJ017574161 (DE-599)DOAJaf816304098e4a7687fa560cdce71b11 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Beatrice Hanusch verfasserin aut Characterization of the L-Arginine/Nitric Oxide Pathway and Oxidative Stress in Pediatric Patients with Atopic Diseases 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: L-Arginine (Arg) is a semi-essential amino acid. Constitutive and inducible nitric oxide synthase (NOS) isoforms convert Arg to nitric oxide (NO), a potent vaso- and bronchodilator with multiple biological functions. Atopic dermatitis (AD) and bronchial asthma (BA) are atopic diseases affecting many children globally. Several studies analyzed NO in airways, yet the systemic synthesis of NO in AD and BA in children with BA, AD or both is elusive. Methods: In a multicenter study, blood and urine were obtained from 130 of 302 participating children for the measurement of metabolites of the Arg/NO pathway (BA 31.5%; AD 5.4%; AD + BA 36.1%; attention deficit hyperactivity disorder (ADHD) 12.3%). In plasma and urine amino acids Arg and homoarginine (hArg), both substrates of NOS, asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA), both inhibitors of NOS, dimethylamine (DMA), and nitrite and nitrate, were measured by gas chromatography–mass spectrometry. Malondialdehyde (MDA) was measured in plasma and urine samples to evaluate possible effects of oxidative stress. Results: There were no differences in the Arg/NO pathway between the groups of children with different atopic diseases. In comparison to children with ADHD, children with AD, BA or AD and BA had higher plasma nitrite (<i<p</i< < 0.001) and nitrate (<i<p</i< < 0.001) concentrations, suggesting higher systemic NO synthesis in AD and BA. Urinary excretion of DMA was also higher (<i<p</i< = 0.028) in AD and BA compared to patients with ADHD, suggesting elevated ADMA metabolization. Discussion/Conclusion: The Arg/NO pathway is activated in atopic diseases independent of severity. Systemic NO synthesis is increased in children with an atopic disease. Plasma and urinary MDA levels did not differ between the groups, suggesting no effect of oxidative stress on the Arg/NO pathway in atopic diseases. atopic diseases nitric oxide attention deficit/hyperactivity syndrome bronchial asthma atopic dermatitis common pediatric diseases Biology (General) Chemistry Kathrin Sinningen verfasserin aut Folke Brinkmann verfasserin aut Stefanie Dillenhöfer verfasserin aut Mirjam Frank verfasserin aut Karl-Heinz Jöckel verfasserin aut Cordula Koerner-Rettberg verfasserin aut Martin Holtmann verfasserin aut Tanja Legenbauer verfasserin aut Christian Langrock verfasserin aut Thomas Reinehr verfasserin aut Patricia Maasjosthusmann verfasserin aut Bibiana Beckmann verfasserin aut Eckard Hamelmann verfasserin aut Dimitrios Tsikas verfasserin aut Thomas Lücke verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 23(2022), 4, p 2136 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:23 year:2022 number:4, p 2136 https://doi.org/10.3390/ijms23042136 kostenfrei https://doaj.org/article/af816304098e4a7687fa560cdce71b11 kostenfrei https://www.mdpi.com/1422-0067/23/4/2136 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 4, p 2136 |
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10.3390/ijms23042136 doi (DE-627)DOAJ017574161 (DE-599)DOAJaf816304098e4a7687fa560cdce71b11 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Beatrice Hanusch verfasserin aut Characterization of the L-Arginine/Nitric Oxide Pathway and Oxidative Stress in Pediatric Patients with Atopic Diseases 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: L-Arginine (Arg) is a semi-essential amino acid. Constitutive and inducible nitric oxide synthase (NOS) isoforms convert Arg to nitric oxide (NO), a potent vaso- and bronchodilator with multiple biological functions. Atopic dermatitis (AD) and bronchial asthma (BA) are atopic diseases affecting many children globally. Several studies analyzed NO in airways, yet the systemic synthesis of NO in AD and BA in children with BA, AD or both is elusive. Methods: In a multicenter study, blood and urine were obtained from 130 of 302 participating children for the measurement of metabolites of the Arg/NO pathway (BA 31.5%; AD 5.4%; AD + BA 36.1%; attention deficit hyperactivity disorder (ADHD) 12.3%). In plasma and urine amino acids Arg and homoarginine (hArg), both substrates of NOS, asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA), both inhibitors of NOS, dimethylamine (DMA), and nitrite and nitrate, were measured by gas chromatography–mass spectrometry. Malondialdehyde (MDA) was measured in plasma and urine samples to evaluate possible effects of oxidative stress. Results: There were no differences in the Arg/NO pathway between the groups of children with different atopic diseases. In comparison to children with ADHD, children with AD, BA or AD and BA had higher plasma nitrite (<i<p</i< < 0.001) and nitrate (<i<p</i< < 0.001) concentrations, suggesting higher systemic NO synthesis in AD and BA. Urinary excretion of DMA was also higher (<i<p</i< = 0.028) in AD and BA compared to patients with ADHD, suggesting elevated ADMA metabolization. Discussion/Conclusion: The Arg/NO pathway is activated in atopic diseases independent of severity. Systemic NO synthesis is increased in children with an atopic disease. Plasma and urinary MDA levels did not differ between the groups, suggesting no effect of oxidative stress on the Arg/NO pathway in atopic diseases. atopic diseases nitric oxide attention deficit/hyperactivity syndrome bronchial asthma atopic dermatitis common pediatric diseases Biology (General) Chemistry Kathrin Sinningen verfasserin aut Folke Brinkmann verfasserin aut Stefanie Dillenhöfer verfasserin aut Mirjam Frank verfasserin aut Karl-Heinz Jöckel verfasserin aut Cordula Koerner-Rettberg verfasserin aut Martin Holtmann verfasserin aut Tanja Legenbauer verfasserin aut Christian Langrock verfasserin aut Thomas Reinehr verfasserin aut Patricia Maasjosthusmann verfasserin aut Bibiana Beckmann verfasserin aut Eckard Hamelmann verfasserin aut Dimitrios Tsikas verfasserin aut Thomas Lücke verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 23(2022), 4, p 2136 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:23 year:2022 number:4, p 2136 https://doi.org/10.3390/ijms23042136 kostenfrei https://doaj.org/article/af816304098e4a7687fa560cdce71b11 kostenfrei https://www.mdpi.com/1422-0067/23/4/2136 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 4, p 2136 |
allfieldsSound |
10.3390/ijms23042136 doi (DE-627)DOAJ017574161 (DE-599)DOAJaf816304098e4a7687fa560cdce71b11 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Beatrice Hanusch verfasserin aut Characterization of the L-Arginine/Nitric Oxide Pathway and Oxidative Stress in Pediatric Patients with Atopic Diseases 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: L-Arginine (Arg) is a semi-essential amino acid. Constitutive and inducible nitric oxide synthase (NOS) isoforms convert Arg to nitric oxide (NO), a potent vaso- and bronchodilator with multiple biological functions. Atopic dermatitis (AD) and bronchial asthma (BA) are atopic diseases affecting many children globally. Several studies analyzed NO in airways, yet the systemic synthesis of NO in AD and BA in children with BA, AD or both is elusive. Methods: In a multicenter study, blood and urine were obtained from 130 of 302 participating children for the measurement of metabolites of the Arg/NO pathway (BA 31.5%; AD 5.4%; AD + BA 36.1%; attention deficit hyperactivity disorder (ADHD) 12.3%). In plasma and urine amino acids Arg and homoarginine (hArg), both substrates of NOS, asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA), both inhibitors of NOS, dimethylamine (DMA), and nitrite and nitrate, were measured by gas chromatography–mass spectrometry. Malondialdehyde (MDA) was measured in plasma and urine samples to evaluate possible effects of oxidative stress. Results: There were no differences in the Arg/NO pathway between the groups of children with different atopic diseases. In comparison to children with ADHD, children with AD, BA or AD and BA had higher plasma nitrite (<i<p</i< < 0.001) and nitrate (<i<p</i< < 0.001) concentrations, suggesting higher systemic NO synthesis in AD and BA. Urinary excretion of DMA was also higher (<i<p</i< = 0.028) in AD and BA compared to patients with ADHD, suggesting elevated ADMA metabolization. Discussion/Conclusion: The Arg/NO pathway is activated in atopic diseases independent of severity. Systemic NO synthesis is increased in children with an atopic disease. Plasma and urinary MDA levels did not differ between the groups, suggesting no effect of oxidative stress on the Arg/NO pathway in atopic diseases. atopic diseases nitric oxide attention deficit/hyperactivity syndrome bronchial asthma atopic dermatitis common pediatric diseases Biology (General) Chemistry Kathrin Sinningen verfasserin aut Folke Brinkmann verfasserin aut Stefanie Dillenhöfer verfasserin aut Mirjam Frank verfasserin aut Karl-Heinz Jöckel verfasserin aut Cordula Koerner-Rettberg verfasserin aut Martin Holtmann verfasserin aut Tanja Legenbauer verfasserin aut Christian Langrock verfasserin aut Thomas Reinehr verfasserin aut Patricia Maasjosthusmann verfasserin aut Bibiana Beckmann verfasserin aut Eckard Hamelmann verfasserin aut Dimitrios Tsikas verfasserin aut Thomas Lücke verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 23(2022), 4, p 2136 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:23 year:2022 number:4, p 2136 https://doi.org/10.3390/ijms23042136 kostenfrei https://doaj.org/article/af816304098e4a7687fa560cdce71b11 kostenfrei https://www.mdpi.com/1422-0067/23/4/2136 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 4, p 2136 |
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Beatrice Hanusch @@aut@@ Kathrin Sinningen @@aut@@ Folke Brinkmann @@aut@@ Stefanie Dillenhöfer @@aut@@ Mirjam Frank @@aut@@ Karl-Heinz Jöckel @@aut@@ Cordula Koerner-Rettberg @@aut@@ Martin Holtmann @@aut@@ Tanja Legenbauer @@aut@@ Christian Langrock @@aut@@ Thomas Reinehr @@aut@@ Patricia Maasjosthusmann @@aut@@ Bibiana Beckmann @@aut@@ Eckard Hamelmann @@aut@@ Dimitrios Tsikas @@aut@@ Thomas Lücke @@aut@@ |
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Constitutive and inducible nitric oxide synthase (NOS) isoforms convert Arg to nitric oxide (NO), a potent vaso- and bronchodilator with multiple biological functions. Atopic dermatitis (AD) and bronchial asthma (BA) are atopic diseases affecting many children globally. Several studies analyzed NO in airways, yet the systemic synthesis of NO in AD and BA in children with BA, AD or both is elusive. Methods: In a multicenter study, blood and urine were obtained from 130 of 302 participating children for the measurement of metabolites of the Arg/NO pathway (BA 31.5%; AD 5.4%; AD + BA 36.1%; attention deficit hyperactivity disorder (ADHD) 12.3%). In plasma and urine amino acids Arg and homoarginine (hArg), both substrates of NOS, asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA), both inhibitors of NOS, dimethylamine (DMA), and nitrite and nitrate, were measured by gas chromatography–mass spectrometry. Malondialdehyde (MDA) was measured in plasma and urine samples to evaluate possible effects of oxidative stress. Results: There were no differences in the Arg/NO pathway between the groups of children with different atopic diseases. In comparison to children with ADHD, children with AD, BA or AD and BA had higher plasma nitrite (<i<p</i< < 0.001) and nitrate (<i<p</i< < 0.001) concentrations, suggesting higher systemic NO synthesis in AD and BA. Urinary excretion of DMA was also higher (<i<p</i< = 0.028) in AD and BA compared to patients with ADHD, suggesting elevated ADMA metabolization. Discussion/Conclusion: The Arg/NO pathway is activated in atopic diseases independent of severity. Systemic NO synthesis is increased in children with an atopic disease. 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Beatrice Hanusch misc QH301-705.5 misc QD1-999 misc atopic diseases misc nitric oxide misc attention deficit/hyperactivity syndrome misc bronchial asthma misc atopic dermatitis misc common pediatric diseases misc Biology (General) misc Chemistry Characterization of the L-Arginine/Nitric Oxide Pathway and Oxidative Stress in Pediatric Patients with Atopic Diseases |
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QH301-705.5 QD1-999 Characterization of the L-Arginine/Nitric Oxide Pathway and Oxidative Stress in Pediatric Patients with Atopic Diseases atopic diseases nitric oxide attention deficit/hyperactivity syndrome bronchial asthma atopic dermatitis common pediatric diseases |
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Characterization of the L-Arginine/Nitric Oxide Pathway and Oxidative Stress in Pediatric Patients with Atopic Diseases |
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characterization of the l-arginine/nitric oxide pathway and oxidative stress in pediatric patients with atopic diseases |
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Characterization of the L-Arginine/Nitric Oxide Pathway and Oxidative Stress in Pediatric Patients with Atopic Diseases |
abstract |
Introduction: L-Arginine (Arg) is a semi-essential amino acid. Constitutive and inducible nitric oxide synthase (NOS) isoforms convert Arg to nitric oxide (NO), a potent vaso- and bronchodilator with multiple biological functions. Atopic dermatitis (AD) and bronchial asthma (BA) are atopic diseases affecting many children globally. Several studies analyzed NO in airways, yet the systemic synthesis of NO in AD and BA in children with BA, AD or both is elusive. Methods: In a multicenter study, blood and urine were obtained from 130 of 302 participating children for the measurement of metabolites of the Arg/NO pathway (BA 31.5%; AD 5.4%; AD + BA 36.1%; attention deficit hyperactivity disorder (ADHD) 12.3%). In plasma and urine amino acids Arg and homoarginine (hArg), both substrates of NOS, asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA), both inhibitors of NOS, dimethylamine (DMA), and nitrite and nitrate, were measured by gas chromatography–mass spectrometry. Malondialdehyde (MDA) was measured in plasma and urine samples to evaluate possible effects of oxidative stress. Results: There were no differences in the Arg/NO pathway between the groups of children with different atopic diseases. In comparison to children with ADHD, children with AD, BA or AD and BA had higher plasma nitrite (<i<p</i< < 0.001) and nitrate (<i<p</i< < 0.001) concentrations, suggesting higher systemic NO synthesis in AD and BA. Urinary excretion of DMA was also higher (<i<p</i< = 0.028) in AD and BA compared to patients with ADHD, suggesting elevated ADMA metabolization. Discussion/Conclusion: The Arg/NO pathway is activated in atopic diseases independent of severity. Systemic NO synthesis is increased in children with an atopic disease. Plasma and urinary MDA levels did not differ between the groups, suggesting no effect of oxidative stress on the Arg/NO pathway in atopic diseases. |
abstractGer |
Introduction: L-Arginine (Arg) is a semi-essential amino acid. Constitutive and inducible nitric oxide synthase (NOS) isoforms convert Arg to nitric oxide (NO), a potent vaso- and bronchodilator with multiple biological functions. Atopic dermatitis (AD) and bronchial asthma (BA) are atopic diseases affecting many children globally. Several studies analyzed NO in airways, yet the systemic synthesis of NO in AD and BA in children with BA, AD or both is elusive. Methods: In a multicenter study, blood and urine were obtained from 130 of 302 participating children for the measurement of metabolites of the Arg/NO pathway (BA 31.5%; AD 5.4%; AD + BA 36.1%; attention deficit hyperactivity disorder (ADHD) 12.3%). In plasma and urine amino acids Arg and homoarginine (hArg), both substrates of NOS, asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA), both inhibitors of NOS, dimethylamine (DMA), and nitrite and nitrate, were measured by gas chromatography–mass spectrometry. Malondialdehyde (MDA) was measured in plasma and urine samples to evaluate possible effects of oxidative stress. Results: There were no differences in the Arg/NO pathway between the groups of children with different atopic diseases. In comparison to children with ADHD, children with AD, BA or AD and BA had higher plasma nitrite (<i<p</i< < 0.001) and nitrate (<i<p</i< < 0.001) concentrations, suggesting higher systemic NO synthesis in AD and BA. Urinary excretion of DMA was also higher (<i<p</i< = 0.028) in AD and BA compared to patients with ADHD, suggesting elevated ADMA metabolization. Discussion/Conclusion: The Arg/NO pathway is activated in atopic diseases independent of severity. Systemic NO synthesis is increased in children with an atopic disease. Plasma and urinary MDA levels did not differ between the groups, suggesting no effect of oxidative stress on the Arg/NO pathway in atopic diseases. |
abstract_unstemmed |
Introduction: L-Arginine (Arg) is a semi-essential amino acid. Constitutive and inducible nitric oxide synthase (NOS) isoforms convert Arg to nitric oxide (NO), a potent vaso- and bronchodilator with multiple biological functions. Atopic dermatitis (AD) and bronchial asthma (BA) are atopic diseases affecting many children globally. Several studies analyzed NO in airways, yet the systemic synthesis of NO in AD and BA in children with BA, AD or both is elusive. Methods: In a multicenter study, blood and urine were obtained from 130 of 302 participating children for the measurement of metabolites of the Arg/NO pathway (BA 31.5%; AD 5.4%; AD + BA 36.1%; attention deficit hyperactivity disorder (ADHD) 12.3%). In plasma and urine amino acids Arg and homoarginine (hArg), both substrates of NOS, asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA), both inhibitors of NOS, dimethylamine (DMA), and nitrite and nitrate, were measured by gas chromatography–mass spectrometry. Malondialdehyde (MDA) was measured in plasma and urine samples to evaluate possible effects of oxidative stress. Results: There were no differences in the Arg/NO pathway between the groups of children with different atopic diseases. In comparison to children with ADHD, children with AD, BA or AD and BA had higher plasma nitrite (<i<p</i< < 0.001) and nitrate (<i<p</i< < 0.001) concentrations, suggesting higher systemic NO synthesis in AD and BA. Urinary excretion of DMA was also higher (<i<p</i< = 0.028) in AD and BA compared to patients with ADHD, suggesting elevated ADMA metabolization. Discussion/Conclusion: The Arg/NO pathway is activated in atopic diseases independent of severity. Systemic NO synthesis is increased in children with an atopic disease. Plasma and urinary MDA levels did not differ between the groups, suggesting no effect of oxidative stress on the Arg/NO pathway in atopic diseases. |
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Characterization of the L-Arginine/Nitric Oxide Pathway and Oxidative Stress in Pediatric Patients with Atopic Diseases |
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