Characterization of the L-Arginine/Nitric Oxide Pathway and Oxidative Stress in Pediatric Patients with Atopic Diseases

Introduction: L-Arginine (Arg) is a semi-essential amino acid. Constitutive and inducible nitric oxide synthase (NOS) isoforms convert Arg to nitric oxide (NO), a potent vaso- and bronchodilator with multiple biological functions. Atopic dermatitis (AD) and bronchial asthma (BA) are atopic diseases...
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Autor*in:	Beatrice Hanusch [verfasserIn] Kathrin Sinningen [verfasserIn] Folke Brinkmann [verfasserIn] Stefanie Dillenhöfer [verfasserIn] Mirjam Frank [verfasserIn] Karl-Heinz Jöckel [verfasserIn] Cordula Koerner-Rettberg [verfasserIn] Martin Holtmann [verfasserIn] Tanja Legenbauer [verfasserIn] Christian Langrock [verfasserIn] Thomas Reinehr [verfasserIn] Patricia Maasjosthusmann [verfasserIn] Bibiana Beckmann [verfasserIn] Eckard Hamelmann [verfasserIn] Dimitrios Tsikas [verfasserIn] Thomas Lücke [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	atopic diseases nitric oxide attention deficit/hyperactivity syndrome bronchial asthma atopic dermatitis common pediatric diseases

Übergeordnetes Werk:	In: International Journal of Molecular Sciences - MDPI AG, 2003, 23(2022), 4, p 2136
Übergeordnetes Werk:	volume:23 ; year:2022 ; number:4, p 2136

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.3390/ijms23042136

Katalog-ID:	DOAJ017574161

Internformat


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100	0		\|a Beatrice Hanusch \|e verfasserin \|4 aut
245	1	0	\|a Characterization of the L-Arginine/Nitric Oxide Pathway and Oxidative Stress in Pediatric Patients with Atopic Diseases
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520			\|a Introduction: L-Arginine (Arg) is a semi-essential amino acid. Constitutive and inducible nitric oxide synthase (NOS) isoforms convert Arg to nitric oxide (NO), a potent vaso- and bronchodilator with multiple biological functions. Atopic dermatitis (AD) and bronchial asthma (BA) are atopic diseases affecting many children globally. Several studies analyzed NO in airways, yet the systemic synthesis of NO in AD and BA in children with BA, AD or both is elusive. Methods: In a multicenter study, blood and urine were obtained from 130 of 302 participating children for the measurement of metabolites of the Arg/NO pathway (BA 31.5%; AD 5.4%; AD + BA 36.1%; attention deficit hyperactivity disorder (ADHD) 12.3%). In plasma and urine amino acids Arg and homoarginine (hArg), both substrates of NOS, asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA), both inhibitors of NOS, dimethylamine (DMA), and nitrite and nitrate, were measured by gas chromatography–mass spectrometry. Malondialdehyde (MDA) was measured in plasma and urine samples to evaluate possible effects of oxidative stress. Results: There were no differences in the Arg/NO pathway between the groups of children with different atopic diseases. In comparison to children with ADHD, children with AD, BA or AD and BA had higher plasma nitrite (<i<p</i< < 0.001) and nitrate (<i<p</i< < 0.001) concentrations, suggesting higher systemic NO synthesis in AD and BA. Urinary excretion of DMA was also higher (<i<p</i< = 0.028) in AD and BA compared to patients with ADHD, suggesting elevated ADMA metabolization. Discussion/Conclusion: The Arg/NO pathway is activated in atopic diseases independent of severity. Systemic NO synthesis is increased in children with an atopic disease. Plasma and urinary MDA levels did not differ between the groups, suggesting no effect of oxidative stress on the Arg/NO pathway in atopic diseases.
650		4	\|a atopic diseases
650		4	\|a nitric oxide
650		4	\|a attention deficit/hyperactivity syndrome
650		4	\|a bronchial asthma
650		4	\|a atopic dermatitis
650		4	\|a common pediatric diseases
653		0	\|a Biology (General)
653		0	\|a Chemistry
700	0		\|a Kathrin Sinningen \|e verfasserin \|4 aut
700	0		\|a Folke Brinkmann \|e verfasserin \|4 aut
700	0		\|a Stefanie Dillenhöfer \|e verfasserin \|4 aut
700	0		\|a Mirjam Frank \|e verfasserin \|4 aut
700	0		\|a Karl-Heinz Jöckel \|e verfasserin \|4 aut
700	0		\|a Cordula Koerner-Rettberg \|e verfasserin \|4 aut
700	0		\|a Martin Holtmann \|e verfasserin \|4 aut
700	0		\|a Tanja Legenbauer \|e verfasserin \|4 aut
700	0		\|a Christian Langrock \|e verfasserin \|4 aut
700	0		\|a Thomas Reinehr \|e verfasserin \|4 aut
700	0		\|a Patricia Maasjosthusmann \|e verfasserin \|4 aut
700	0		\|a Bibiana Beckmann \|e verfasserin \|4 aut
700	0		\|a Eckard Hamelmann \|e verfasserin \|4 aut
700	0		\|a Dimitrios Tsikas \|e verfasserin \|4 aut
700	0		\|a Thomas Lücke \|e verfasserin \|4 aut
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allfields	10.3390/ijms23042136 doi (DE-627)DOAJ017574161 (DE-599)DOAJaf816304098e4a7687fa560cdce71b11 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Beatrice Hanusch verfasserin aut Characterization of the L-Arginine/Nitric Oxide Pathway and Oxidative Stress in Pediatric Patients with Atopic Diseases 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: L-Arginine (Arg) is a semi-essential amino acid. Constitutive and inducible nitric oxide synthase (NOS) isoforms convert Arg to nitric oxide (NO), a potent vaso- and bronchodilator with multiple biological functions. Atopic dermatitis (AD) and bronchial asthma (BA) are atopic diseases affecting many children globally. Several studies analyzed NO in airways, yet the systemic synthesis of NO in AD and BA in children with BA, AD or both is elusive. Methods: In a multicenter study, blood and urine were obtained from 130 of 302 participating children for the measurement of metabolites of the Arg/NO pathway (BA 31.5%; AD 5.4%; AD + BA 36.1%; attention deficit hyperactivity disorder (ADHD) 12.3%). In plasma and urine amino acids Arg and homoarginine (hArg), both substrates of NOS, asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA), both inhibitors of NOS, dimethylamine (DMA), and nitrite and nitrate, were measured by gas chromatography–mass spectrometry. Malondialdehyde (MDA) was measured in plasma and urine samples to evaluate possible effects of oxidative stress. Results: There were no differences in the Arg/NO pathway between the groups of children with different atopic diseases. In comparison to children with ADHD, children with AD, BA or AD and BA had higher plasma nitrite (<i<p</i< < 0.001) and nitrate (<i<p</i< < 0.001) concentrations, suggesting higher systemic NO synthesis in AD and BA. Urinary excretion of DMA was also higher (<i<p</i< = 0.028) in AD and BA compared to patients with ADHD, suggesting elevated ADMA metabolization. Discussion/Conclusion: The Arg/NO pathway is activated in atopic diseases independent of severity. Systemic NO synthesis is increased in children with an atopic disease. Plasma and urinary MDA levels did not differ between the groups, suggesting no effect of oxidative stress on the Arg/NO pathway in atopic diseases. atopic diseases nitric oxide attention deficit/hyperactivity syndrome bronchial asthma atopic dermatitis common pediatric diseases Biology (General) Chemistry Kathrin Sinningen verfasserin aut Folke Brinkmann verfasserin aut Stefanie Dillenhöfer verfasserin aut Mirjam Frank verfasserin aut Karl-Heinz Jöckel verfasserin aut Cordula Koerner-Rettberg verfasserin aut Martin Holtmann verfasserin aut Tanja Legenbauer verfasserin aut Christian Langrock verfasserin aut Thomas Reinehr verfasserin aut Patricia Maasjosthusmann verfasserin aut Bibiana Beckmann verfasserin aut Eckard Hamelmann verfasserin aut Dimitrios Tsikas verfasserin aut Thomas Lücke verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 23(2022), 4, p 2136 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:23 year:2022 number:4, p 2136 https://doi.org/10.3390/ijms23042136 kostenfrei https://doaj.org/article/af816304098e4a7687fa560cdce71b11 kostenfrei https://www.mdpi.com/1422-0067/23/4/2136 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 4, p 2136
spelling	10.3390/ijms23042136 doi (DE-627)DOAJ017574161 (DE-599)DOAJaf816304098e4a7687fa560cdce71b11 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Beatrice Hanusch verfasserin aut Characterization of the L-Arginine/Nitric Oxide Pathway and Oxidative Stress in Pediatric Patients with Atopic Diseases 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: L-Arginine (Arg) is a semi-essential amino acid. Constitutive and inducible nitric oxide synthase (NOS) isoforms convert Arg to nitric oxide (NO), a potent vaso- and bronchodilator with multiple biological functions. Atopic dermatitis (AD) and bronchial asthma (BA) are atopic diseases affecting many children globally. Several studies analyzed NO in airways, yet the systemic synthesis of NO in AD and BA in children with BA, AD or both is elusive. Methods: In a multicenter study, blood and urine were obtained from 130 of 302 participating children for the measurement of metabolites of the Arg/NO pathway (BA 31.5%; AD 5.4%; AD + BA 36.1%; attention deficit hyperactivity disorder (ADHD) 12.3%). In plasma and urine amino acids Arg and homoarginine (hArg), both substrates of NOS, asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA), both inhibitors of NOS, dimethylamine (DMA), and nitrite and nitrate, were measured by gas chromatography–mass spectrometry. Malondialdehyde (MDA) was measured in plasma and urine samples to evaluate possible effects of oxidative stress. Results: There were no differences in the Arg/NO pathway between the groups of children with different atopic diseases. In comparison to children with ADHD, children with AD, BA or AD and BA had higher plasma nitrite (<i<p</i< < 0.001) and nitrate (<i<p</i< < 0.001) concentrations, suggesting higher systemic NO synthesis in AD and BA. Urinary excretion of DMA was also higher (<i<p</i< = 0.028) in AD and BA compared to patients with ADHD, suggesting elevated ADMA metabolization. Discussion/Conclusion: The Arg/NO pathway is activated in atopic diseases independent of severity. Systemic NO synthesis is increased in children with an atopic disease. Plasma and urinary MDA levels did not differ between the groups, suggesting no effect of oxidative stress on the Arg/NO pathway in atopic diseases. atopic diseases nitric oxide attention deficit/hyperactivity syndrome bronchial asthma atopic dermatitis common pediatric diseases Biology (General) Chemistry Kathrin Sinningen verfasserin aut Folke Brinkmann verfasserin aut Stefanie Dillenhöfer verfasserin aut Mirjam Frank verfasserin aut Karl-Heinz Jöckel verfasserin aut Cordula Koerner-Rettberg verfasserin aut Martin Holtmann verfasserin aut Tanja Legenbauer verfasserin aut Christian Langrock verfasserin aut Thomas Reinehr verfasserin aut Patricia Maasjosthusmann verfasserin aut Bibiana Beckmann verfasserin aut Eckard Hamelmann verfasserin aut Dimitrios Tsikas verfasserin aut Thomas Lücke verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 23(2022), 4, p 2136 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:23 year:2022 number:4, p 2136 https://doi.org/10.3390/ijms23042136 kostenfrei https://doaj.org/article/af816304098e4a7687fa560cdce71b11 kostenfrei https://www.mdpi.com/1422-0067/23/4/2136 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 4, p 2136
allfields_unstemmed	10.3390/ijms23042136 doi (DE-627)DOAJ017574161 (DE-599)DOAJaf816304098e4a7687fa560cdce71b11 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Beatrice Hanusch verfasserin aut Characterization of the L-Arginine/Nitric Oxide Pathway and Oxidative Stress in Pediatric Patients with Atopic Diseases 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: L-Arginine (Arg) is a semi-essential amino acid. Constitutive and inducible nitric oxide synthase (NOS) isoforms convert Arg to nitric oxide (NO), a potent vaso- and bronchodilator with multiple biological functions. Atopic dermatitis (AD) and bronchial asthma (BA) are atopic diseases affecting many children globally. Several studies analyzed NO in airways, yet the systemic synthesis of NO in AD and BA in children with BA, AD or both is elusive. Methods: In a multicenter study, blood and urine were obtained from 130 of 302 participating children for the measurement of metabolites of the Arg/NO pathway (BA 31.5%; AD 5.4%; AD + BA 36.1%; attention deficit hyperactivity disorder (ADHD) 12.3%). In plasma and urine amino acids Arg and homoarginine (hArg), both substrates of NOS, asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA), both inhibitors of NOS, dimethylamine (DMA), and nitrite and nitrate, were measured by gas chromatography–mass spectrometry. Malondialdehyde (MDA) was measured in plasma and urine samples to evaluate possible effects of oxidative stress. Results: There were no differences in the Arg/NO pathway between the groups of children with different atopic diseases. In comparison to children with ADHD, children with AD, BA or AD and BA had higher plasma nitrite (<i<p</i< < 0.001) and nitrate (<i<p</i< < 0.001) concentrations, suggesting higher systemic NO synthesis in AD and BA. Urinary excretion of DMA was also higher (<i<p</i< = 0.028) in AD and BA compared to patients with ADHD, suggesting elevated ADMA metabolization. Discussion/Conclusion: The Arg/NO pathway is activated in atopic diseases independent of severity. Systemic NO synthesis is increased in children with an atopic disease. Plasma and urinary MDA levels did not differ between the groups, suggesting no effect of oxidative stress on the Arg/NO pathway in atopic diseases. atopic diseases nitric oxide attention deficit/hyperactivity syndrome bronchial asthma atopic dermatitis common pediatric diseases Biology (General) Chemistry Kathrin Sinningen verfasserin aut Folke Brinkmann verfasserin aut Stefanie Dillenhöfer verfasserin aut Mirjam Frank verfasserin aut Karl-Heinz Jöckel verfasserin aut Cordula Koerner-Rettberg verfasserin aut Martin Holtmann verfasserin aut Tanja Legenbauer verfasserin aut Christian Langrock verfasserin aut Thomas Reinehr verfasserin aut Patricia Maasjosthusmann verfasserin aut Bibiana Beckmann verfasserin aut Eckard Hamelmann verfasserin aut Dimitrios Tsikas verfasserin aut Thomas Lücke verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 23(2022), 4, p 2136 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:23 year:2022 number:4, p 2136 https://doi.org/10.3390/ijms23042136 kostenfrei https://doaj.org/article/af816304098e4a7687fa560cdce71b11 kostenfrei https://www.mdpi.com/1422-0067/23/4/2136 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 4, p 2136
allfieldsGer	10.3390/ijms23042136 doi (DE-627)DOAJ017574161 (DE-599)DOAJaf816304098e4a7687fa560cdce71b11 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Beatrice Hanusch verfasserin aut Characterization of the L-Arginine/Nitric Oxide Pathway and Oxidative Stress in Pediatric Patients with Atopic Diseases 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: L-Arginine (Arg) is a semi-essential amino acid. Constitutive and inducible nitric oxide synthase (NOS) isoforms convert Arg to nitric oxide (NO), a potent vaso- and bronchodilator with multiple biological functions. Atopic dermatitis (AD) and bronchial asthma (BA) are atopic diseases affecting many children globally. Several studies analyzed NO in airways, yet the systemic synthesis of NO in AD and BA in children with BA, AD or both is elusive. Methods: In a multicenter study, blood and urine were obtained from 130 of 302 participating children for the measurement of metabolites of the Arg/NO pathway (BA 31.5%; AD 5.4%; AD + BA 36.1%; attention deficit hyperactivity disorder (ADHD) 12.3%). In plasma and urine amino acids Arg and homoarginine (hArg), both substrates of NOS, asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA), both inhibitors of NOS, dimethylamine (DMA), and nitrite and nitrate, were measured by gas chromatography–mass spectrometry. Malondialdehyde (MDA) was measured in plasma and urine samples to evaluate possible effects of oxidative stress. Results: There were no differences in the Arg/NO pathway between the groups of children with different atopic diseases. In comparison to children with ADHD, children with AD, BA or AD and BA had higher plasma nitrite (<i<p</i< < 0.001) and nitrate (<i<p</i< < 0.001) concentrations, suggesting higher systemic NO synthesis in AD and BA. Urinary excretion of DMA was also higher (<i<p</i< = 0.028) in AD and BA compared to patients with ADHD, suggesting elevated ADMA metabolization. Discussion/Conclusion: The Arg/NO pathway is activated in atopic diseases independent of severity. Systemic NO synthesis is increased in children with an atopic disease. Plasma and urinary MDA levels did not differ between the groups, suggesting no effect of oxidative stress on the Arg/NO pathway in atopic diseases. atopic diseases nitric oxide attention deficit/hyperactivity syndrome bronchial asthma atopic dermatitis common pediatric diseases Biology (General) Chemistry Kathrin Sinningen verfasserin aut Folke Brinkmann verfasserin aut Stefanie Dillenhöfer verfasserin aut Mirjam Frank verfasserin aut Karl-Heinz Jöckel verfasserin aut Cordula Koerner-Rettberg verfasserin aut Martin Holtmann verfasserin aut Tanja Legenbauer verfasserin aut Christian Langrock verfasserin aut Thomas Reinehr verfasserin aut Patricia Maasjosthusmann verfasserin aut Bibiana Beckmann verfasserin aut Eckard Hamelmann verfasserin aut Dimitrios Tsikas verfasserin aut Thomas Lücke verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 23(2022), 4, p 2136 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:23 year:2022 number:4, p 2136 https://doi.org/10.3390/ijms23042136 kostenfrei https://doaj.org/article/af816304098e4a7687fa560cdce71b11 kostenfrei https://www.mdpi.com/1422-0067/23/4/2136 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 4, p 2136
allfieldsSound	10.3390/ijms23042136 doi (DE-627)DOAJ017574161 (DE-599)DOAJaf816304098e4a7687fa560cdce71b11 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Beatrice Hanusch verfasserin aut Characterization of the L-Arginine/Nitric Oxide Pathway and Oxidative Stress in Pediatric Patients with Atopic Diseases 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: L-Arginine (Arg) is a semi-essential amino acid. Constitutive and inducible nitric oxide synthase (NOS) isoforms convert Arg to nitric oxide (NO), a potent vaso- and bronchodilator with multiple biological functions. Atopic dermatitis (AD) and bronchial asthma (BA) are atopic diseases affecting many children globally. Several studies analyzed NO in airways, yet the systemic synthesis of NO in AD and BA in children with BA, AD or both is elusive. Methods: In a multicenter study, blood and urine were obtained from 130 of 302 participating children for the measurement of metabolites of the Arg/NO pathway (BA 31.5%; AD 5.4%; AD + BA 36.1%; attention deficit hyperactivity disorder (ADHD) 12.3%). In plasma and urine amino acids Arg and homoarginine (hArg), both substrates of NOS, asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA), both inhibitors of NOS, dimethylamine (DMA), and nitrite and nitrate, were measured by gas chromatography–mass spectrometry. Malondialdehyde (MDA) was measured in plasma and urine samples to evaluate possible effects of oxidative stress. Results: There were no differences in the Arg/NO pathway between the groups of children with different atopic diseases. In comparison to children with ADHD, children with AD, BA or AD and BA had higher plasma nitrite (<i<p</i< < 0.001) and nitrate (<i<p</i< < 0.001) concentrations, suggesting higher systemic NO synthesis in AD and BA. Urinary excretion of DMA was also higher (<i<p</i< = 0.028) in AD and BA compared to patients with ADHD, suggesting elevated ADMA metabolization. Discussion/Conclusion: The Arg/NO pathway is activated in atopic diseases independent of severity. Systemic NO synthesis is increased in children with an atopic disease. Plasma and urinary MDA levels did not differ between the groups, suggesting no effect of oxidative stress on the Arg/NO pathway in atopic diseases. atopic diseases nitric oxide attention deficit/hyperactivity syndrome bronchial asthma atopic dermatitis common pediatric diseases Biology (General) Chemistry Kathrin Sinningen verfasserin aut Folke Brinkmann verfasserin aut Stefanie Dillenhöfer verfasserin aut Mirjam Frank verfasserin aut Karl-Heinz Jöckel verfasserin aut Cordula Koerner-Rettberg verfasserin aut Martin Holtmann verfasserin aut Tanja Legenbauer verfasserin aut Christian Langrock verfasserin aut Thomas Reinehr verfasserin aut Patricia Maasjosthusmann verfasserin aut Bibiana Beckmann verfasserin aut Eckard Hamelmann verfasserin aut Dimitrios Tsikas verfasserin aut Thomas Lücke verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 23(2022), 4, p 2136 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:23 year:2022 number:4, p 2136 https://doi.org/10.3390/ijms23042136 kostenfrei https://doaj.org/article/af816304098e4a7687fa560cdce71b11 kostenfrei https://www.mdpi.com/1422-0067/23/4/2136 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 4, p 2136
language	English
source	In International Journal of Molecular Sciences 23(2022), 4, p 2136 volume:23 year:2022 number:4, p 2136
sourceStr	In International Journal of Molecular Sciences 23(2022), 4, p 2136 volume:23 year:2022 number:4, p 2136
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	atopic diseases nitric oxide attention deficit/hyperactivity syndrome bronchial asthma atopic dermatitis common pediatric diseases Biology (General) Chemistry
isfreeaccess_bool	true
container_title	International Journal of Molecular Sciences
authorswithroles_txt_mv	Beatrice Hanusch @@aut@@ Kathrin Sinningen @@aut@@ Folke Brinkmann @@aut@@ Stefanie Dillenhöfer @@aut@@ Mirjam Frank @@aut@@ Karl-Heinz Jöckel @@aut@@ Cordula Koerner-Rettberg @@aut@@ Martin Holtmann @@aut@@ Tanja Legenbauer @@aut@@ Christian Langrock @@aut@@ Thomas Reinehr @@aut@@ Patricia Maasjosthusmann @@aut@@ Bibiana Beckmann @@aut@@ Eckard Hamelmann @@aut@@ Dimitrios Tsikas @@aut@@ Thomas Lücke @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	316340715
id	DOAJ017574161
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ017574161</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20240414185044.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230226s2022 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.3390/ijms23042136</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ017574161</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJaf816304098e4a7687fa560cdce71b11</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">QH301-705.5</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">QD1-999</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Beatrice Hanusch</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Characterization of the L-Arginine/Nitric Oxide Pathway and Oxidative Stress in Pediatric Patients with Atopic Diseases</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2022</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Introduction: L-Arginine (Arg) is a semi-essential amino acid. Constitutive and inducible nitric oxide synthase (NOS) isoforms convert Arg to nitric oxide (NO), a potent vaso- and bronchodilator with multiple biological functions. Atopic dermatitis (AD) and bronchial asthma (BA) are atopic diseases affecting many children globally. Several studies analyzed NO in airways, yet the systemic synthesis of NO in AD and BA in children with BA, AD or both is elusive. Methods: In a multicenter study, blood and urine were obtained from 130 of 302 participating children for the measurement of metabolites of the Arg/NO pathway (BA 31.5%; AD 5.4%; AD + BA 36.1%; attention deficit hyperactivity disorder (ADHD) 12.3%). In plasma and urine amino acids Arg and homoarginine (hArg), both substrates of NOS, asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA), both inhibitors of NOS, dimethylamine (DMA), and nitrite and nitrate, were measured by gas chromatography–mass spectrometry. Malondialdehyde (MDA) was measured in plasma and urine samples to evaluate possible effects of oxidative stress. Results: There were no differences in the Arg/NO pathway between the groups of children with different atopic diseases. In comparison to children with ADHD, children with AD, BA or AD and BA had higher plasma nitrite (<i<p</i< < 0.001) and nitrate (<i<p</i< < 0.001) concentrations, suggesting higher systemic NO synthesis in AD and BA. Urinary excretion of DMA was also higher (<i<p</i< = 0.028) in AD and BA compared to patients with ADHD, suggesting elevated ADMA metabolization. Discussion/Conclusion: The Arg/NO pathway is activated in atopic diseases independent of severity. Systemic NO synthesis is increased in children with an atopic disease. 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callnumber-first	Q - Science
author	Beatrice Hanusch
spellingShingle	Beatrice Hanusch misc QH301-705.5 misc QD1-999 misc atopic diseases misc nitric oxide misc attention deficit/hyperactivity syndrome misc bronchial asthma misc atopic dermatitis misc common pediatric diseases misc Biology (General) misc Chemistry Characterization of the L-Arginine/Nitric Oxide Pathway and Oxidative Stress in Pediatric Patients with Atopic Diseases
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topic_title	QH301-705.5 QD1-999 Characterization of the L-Arginine/Nitric Oxide Pathway and Oxidative Stress in Pediatric Patients with Atopic Diseases atopic diseases nitric oxide attention deficit/hyperactivity syndrome bronchial asthma atopic dermatitis common pediatric diseases
topic	misc QH301-705.5 misc QD1-999 misc atopic diseases misc nitric oxide misc attention deficit/hyperactivity syndrome misc bronchial asthma misc atopic dermatitis misc common pediatric diseases misc Biology (General) misc Chemistry
topic_unstemmed	misc QH301-705.5 misc QD1-999 misc atopic diseases misc nitric oxide misc attention deficit/hyperactivity syndrome misc bronchial asthma misc atopic dermatitis misc common pediatric diseases misc Biology (General) misc Chemistry
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title	Characterization of the L-Arginine/Nitric Oxide Pathway and Oxidative Stress in Pediatric Patients with Atopic Diseases
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title_full	Characterization of the L-Arginine/Nitric Oxide Pathway and Oxidative Stress in Pediatric Patients with Atopic Diseases
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author_browse	Beatrice Hanusch Kathrin Sinningen Folke Brinkmann Stefanie Dillenhöfer Mirjam Frank Karl-Heinz Jöckel Cordula Koerner-Rettberg Martin Holtmann Tanja Legenbauer Christian Langrock Thomas Reinehr Patricia Maasjosthusmann Bibiana Beckmann Eckard Hamelmann Dimitrios Tsikas Thomas Lücke
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doi_str_mv	10.3390/ijms23042136
author2-role	verfasserin
title_sort	characterization of the l-arginine/nitric oxide pathway and oxidative stress in pediatric patients with atopic diseases
callnumber	QH301-705.5
title_auth	Characterization of the L-Arginine/Nitric Oxide Pathway and Oxidative Stress in Pediatric Patients with Atopic Diseases
abstract	Introduction: L-Arginine (Arg) is a semi-essential amino acid. Constitutive and inducible nitric oxide synthase (NOS) isoforms convert Arg to nitric oxide (NO), a potent vaso- and bronchodilator with multiple biological functions. Atopic dermatitis (AD) and bronchial asthma (BA) are atopic diseases affecting many children globally. Several studies analyzed NO in airways, yet the systemic synthesis of NO in AD and BA in children with BA, AD or both is elusive. Methods: In a multicenter study, blood and urine were obtained from 130 of 302 participating children for the measurement of metabolites of the Arg/NO pathway (BA 31.5%; AD 5.4%; AD + BA 36.1%; attention deficit hyperactivity disorder (ADHD) 12.3%). In plasma and urine amino acids Arg and homoarginine (hArg), both substrates of NOS, asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA), both inhibitors of NOS, dimethylamine (DMA), and nitrite and nitrate, were measured by gas chromatography–mass spectrometry. Malondialdehyde (MDA) was measured in plasma and urine samples to evaluate possible effects of oxidative stress. Results: There were no differences in the Arg/NO pathway between the groups of children with different atopic diseases. In comparison to children with ADHD, children with AD, BA or AD and BA had higher plasma nitrite (<i<p</i< < 0.001) and nitrate (<i<p</i< < 0.001) concentrations, suggesting higher systemic NO synthesis in AD and BA. Urinary excretion of DMA was also higher (<i<p</i< = 0.028) in AD and BA compared to patients with ADHD, suggesting elevated ADMA metabolization. Discussion/Conclusion: The Arg/NO pathway is activated in atopic diseases independent of severity. Systemic NO synthesis is increased in children with an atopic disease. Plasma and urinary MDA levels did not differ between the groups, suggesting no effect of oxidative stress on the Arg/NO pathway in atopic diseases.
abstractGer	Introduction: L-Arginine (Arg) is a semi-essential amino acid. Constitutive and inducible nitric oxide synthase (NOS) isoforms convert Arg to nitric oxide (NO), a potent vaso- and bronchodilator with multiple biological functions. Atopic dermatitis (AD) and bronchial asthma (BA) are atopic diseases affecting many children globally. Several studies analyzed NO in airways, yet the systemic synthesis of NO in AD and BA in children with BA, AD or both is elusive. Methods: In a multicenter study, blood and urine were obtained from 130 of 302 participating children for the measurement of metabolites of the Arg/NO pathway (BA 31.5%; AD 5.4%; AD + BA 36.1%; attention deficit hyperactivity disorder (ADHD) 12.3%). In plasma and urine amino acids Arg and homoarginine (hArg), both substrates of NOS, asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA), both inhibitors of NOS, dimethylamine (DMA), and nitrite and nitrate, were measured by gas chromatography–mass spectrometry. Malondialdehyde (MDA) was measured in plasma and urine samples to evaluate possible effects of oxidative stress. Results: There were no differences in the Arg/NO pathway between the groups of children with different atopic diseases. In comparison to children with ADHD, children with AD, BA or AD and BA had higher plasma nitrite (<i<p</i< < 0.001) and nitrate (<i<p</i< < 0.001) concentrations, suggesting higher systemic NO synthesis in AD and BA. Urinary excretion of DMA was also higher (<i<p</i< = 0.028) in AD and BA compared to patients with ADHD, suggesting elevated ADMA metabolization. Discussion/Conclusion: The Arg/NO pathway is activated in atopic diseases independent of severity. Systemic NO synthesis is increased in children with an atopic disease. Plasma and urinary MDA levels did not differ between the groups, suggesting no effect of oxidative stress on the Arg/NO pathway in atopic diseases.
abstract_unstemmed	Introduction: L-Arginine (Arg) is a semi-essential amino acid. Constitutive and inducible nitric oxide synthase (NOS) isoforms convert Arg to nitric oxide (NO), a potent vaso- and bronchodilator with multiple biological functions. Atopic dermatitis (AD) and bronchial asthma (BA) are atopic diseases affecting many children globally. Several studies analyzed NO in airways, yet the systemic synthesis of NO in AD and BA in children with BA, AD or both is elusive. Methods: In a multicenter study, blood and urine were obtained from 130 of 302 participating children for the measurement of metabolites of the Arg/NO pathway (BA 31.5%; AD 5.4%; AD + BA 36.1%; attention deficit hyperactivity disorder (ADHD) 12.3%). In plasma and urine amino acids Arg and homoarginine (hArg), both substrates of NOS, asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA), both inhibitors of NOS, dimethylamine (DMA), and nitrite and nitrate, were measured by gas chromatography–mass spectrometry. Malondialdehyde (MDA) was measured in plasma and urine samples to evaluate possible effects of oxidative stress. Results: There were no differences in the Arg/NO pathway between the groups of children with different atopic diseases. In comparison to children with ADHD, children with AD, BA or AD and BA had higher plasma nitrite (<i<p</i< < 0.001) and nitrate (<i<p</i< < 0.001) concentrations, suggesting higher systemic NO synthesis in AD and BA. Urinary excretion of DMA was also higher (<i<p</i< = 0.028) in AD and BA compared to patients with ADHD, suggesting elevated ADMA metabolization. Discussion/Conclusion: The Arg/NO pathway is activated in atopic diseases independent of severity. Systemic NO synthesis is increased in children with an atopic disease. Plasma and urinary MDA levels did not differ between the groups, suggesting no effect of oxidative stress on the Arg/NO pathway in atopic diseases.
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title_short	Characterization of the L-Arginine/Nitric Oxide Pathway and Oxidative Stress in Pediatric Patients with Atopic Diseases
url	https://doi.org/10.3390/ijms23042136 https://doaj.org/article/af816304098e4a7687fa560cdce71b11 https://www.mdpi.com/1422-0067/23/4/2136 https://doaj.org/toc/1661-6596 https://doaj.org/toc/1422-0067
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author2	Kathrin Sinningen Folke Brinkmann Stefanie Dillenhöfer Mirjam Frank Karl-Heinz Jöckel Cordula Koerner-Rettberg Martin Holtmann Tanja Legenbauer Christian Langrock Thomas Reinehr Patricia Maasjosthusmann Bibiana Beckmann Eckard Hamelmann Dimitrios Tsikas Thomas Lücke
author2Str	Kathrin Sinningen Folke Brinkmann Stefanie Dillenhöfer Mirjam Frank Karl-Heinz Jöckel Cordula Koerner-Rettberg Martin Holtmann Tanja Legenbauer Christian Langrock Thomas Reinehr Patricia Maasjosthusmann Bibiana Beckmann Eckard Hamelmann Dimitrios Tsikas Thomas Lücke
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Characterization of the L-Arginine/Nitric Oxide Pathway and Oxidative Stress in Pediatric Patients with Atopic Diseases

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