ARNI in HFrEF—One-Centre Experience in the Era before the 2021 ESC HF Recommendations

Background: Sacubitril/valsartan, an angiotensin receptor–neprilysin inhibitor (ARNI), has demonstrated a survival benefit and reduces heart failure hospitalization in patients with heart failure with reduced left ventricular ejection fraction (HFrEF); however, our experience in this field is limited. This study aimed to summarize a real clinical practice of the use of ARNI in HFrEF patients hospitalized due to HFrEF in the era before the 2021 ESC HF recommendations, as well as assess their clinical outcome with regard to ARNI administration. Methods and Materials: Overall, 613 patients with HFrEF hospitalized in 2018–2020 were enrolled into a retrospective one-centre cross-sectional analysis. The study population was categorized into patients receiving (82/13.4%) and not-receiving (531/82.6%) ARNI. Clinical outcomes defined as rehospitalization, number of rehospitalizations, time to the first rehospitalization and death from any cause were analysed in the 1–2 year follow-up in the ARNI and non-ARNI groups, matched as to age and LVEF. Results: Clinical characteristics revealed the following differences between ARNI and non-ARNI groups: A higher percentage of cardiovascular implantable electronic devices (CIED) (<i<p</i< = 0.014) and defibrillators with cardiac resynchronization therapy (CRT-D) (<i<p</i< = 0.038), higher frequency of atrial fibrillation (<i<p</i< = 0.002) and history of stroke (<i<p</i< = 0.024) were in the ARNI group. The percentage of patients with HFrEF NYHA III/IV presented an increasing trend to be higher in the ARNI (64.1%) as compared to the non-ARNI group (51.5%, <i<p</i< = 0.154). Incidence of rehospitalization, number of rehospitalizations and time to the first rehospitalization were comparable between the groups. There were no differences between the numbers of deaths of any cause in the ARNI (28%) and non-ARNI (28%) groups. The independent negative predictor of death in the whole population of ARNI and non-ARNI groups was the coexistence of coronary artery disease (CAD) (beta= −0.924, HR 0.806, <i<p</i< = 0.011). Conclusions: Our current positive experience in ARNI therapy is limited to extremely severe patients with HFrEF. Regardless of the more advanced HF and HF comorbidities, the patients treated with ARNI presented similar mortality and rehospitalizations as the patients treated by standard therapy. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Rafał Niemiec [verfasserIn] Irmina Morawska [verfasserIn] Maria Stec [verfasserIn] Wiktoria Kuczmik [verfasserIn] Andrzej S. Swinarew [verfasserIn] Arkadiusz Stanula [verfasserIn] Katarzyna Mizia-Stec [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	heart failure heart failure with reduced left ventricular ejection fraction sacubitril/valsartan HF HFrEF ARNI

Übergeordnetes Werk:	In: International Journal of Environmental Research and Public Health - MDPI AG, 2005, 19(2022), 2089, p 2089
Übergeordnetes Werk:	volume:19 ; year:2022 ; number:2089, p 2089

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.3390/ijerph19042089

Katalog-ID:	DOAJ017575249

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520			\|a Background: Sacubitril/valsartan, an angiotensin receptor–neprilysin inhibitor (ARNI), has demonstrated a survival benefit and reduces heart failure hospitalization in patients with heart failure with reduced left ventricular ejection fraction (HFrEF); however, our experience in this field is limited. This study aimed to summarize a real clinical practice of the use of ARNI in HFrEF patients hospitalized due to HFrEF in the era before the 2021 ESC HF recommendations, as well as assess their clinical outcome with regard to ARNI administration. Methods and Materials: Overall, 613 patients with HFrEF hospitalized in 2018–2020 were enrolled into a retrospective one-centre cross-sectional analysis. The study population was categorized into patients receiving (82/13.4%) and not-receiving (531/82.6%) ARNI. Clinical outcomes defined as rehospitalization, number of rehospitalizations, time to the first rehospitalization and death from any cause were analysed in the 1–2 year follow-up in the ARNI and non-ARNI groups, matched as to age and LVEF. Results: Clinical characteristics revealed the following differences between ARNI and non-ARNI groups: A higher percentage of cardiovascular implantable electronic devices (CIED) (<i<p</i< = 0.014) and defibrillators with cardiac resynchronization therapy (CRT-D) (<i<p</i< = 0.038), higher frequency of atrial fibrillation (<i<p</i< = 0.002) and history of stroke (<i<p</i< = 0.024) were in the ARNI group. The percentage of patients with HFrEF NYHA III/IV presented an increasing trend to be higher in the ARNI (64.1%) as compared to the non-ARNI group (51.5%, <i<p</i< = 0.154). Incidence of rehospitalization, number of rehospitalizations and time to the first rehospitalization were comparable between the groups. There were no differences between the numbers of deaths of any cause in the ARNI (28%) and non-ARNI (28%) groups. The independent negative predictor of death in the whole population of ARNI and non-ARNI groups was the coexistence of coronary artery disease (CAD) (beta= −0.924, HR 0.806, <i<p</i< = 0.011). Conclusions: Our current positive experience in ARNI therapy is limited to extremely severe patients with HFrEF. Regardless of the more advanced HF and HF comorbidities, the patients treated with ARNI presented similar mortality and rehospitalizations as the patients treated by standard therapy.
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allfields	10.3390/ijerph19042089 doi (DE-627)DOAJ017575249 (DE-599)DOAJ39850b443f074e4cb604fad8d7e40b3e DE-627 ger DE-627 rakwb eng Rafał Niemiec verfasserin aut ARNI in HFrEF—One-Centre Experience in the Era before the 2021 ESC HF Recommendations 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Sacubitril/valsartan, an angiotensin receptor–neprilysin inhibitor (ARNI), has demonstrated a survival benefit and reduces heart failure hospitalization in patients with heart failure with reduced left ventricular ejection fraction (HFrEF); however, our experience in this field is limited. This study aimed to summarize a real clinical practice of the use of ARNI in HFrEF patients hospitalized due to HFrEF in the era before the 2021 ESC HF recommendations, as well as assess their clinical outcome with regard to ARNI administration. Methods and Materials: Overall, 613 patients with HFrEF hospitalized in 2018–2020 were enrolled into a retrospective one-centre cross-sectional analysis. The study population was categorized into patients receiving (82/13.4%) and not-receiving (531/82.6%) ARNI. Clinical outcomes defined as rehospitalization, number of rehospitalizations, time to the first rehospitalization and death from any cause were analysed in the 1–2 year follow-up in the ARNI and non-ARNI groups, matched as to age and LVEF. Results: Clinical characteristics revealed the following differences between ARNI and non-ARNI groups: A higher percentage of cardiovascular implantable electronic devices (CIED) (<i<p</i< = 0.014) and defibrillators with cardiac resynchronization therapy (CRT-D) (<i<p</i< = 0.038), higher frequency of atrial fibrillation (<i<p</i< = 0.002) and history of stroke (<i<p</i< = 0.024) were in the ARNI group. The percentage of patients with HFrEF NYHA III/IV presented an increasing trend to be higher in the ARNI (64.1%) as compared to the non-ARNI group (51.5%, <i<p</i< = 0.154). Incidence of rehospitalization, number of rehospitalizations and time to the first rehospitalization were comparable between the groups. There were no differences between the numbers of deaths of any cause in the ARNI (28%) and non-ARNI (28%) groups. The independent negative predictor of death in the whole population of ARNI and non-ARNI groups was the coexistence of coronary artery disease (CAD) (beta= −0.924, HR 0.806, <i<p</i< = 0.011). Conclusions: Our current positive experience in ARNI therapy is limited to extremely severe patients with HFrEF. Regardless of the more advanced HF and HF comorbidities, the patients treated with ARNI presented similar mortality and rehospitalizations as the patients treated by standard therapy. heart failure heart failure with reduced left ventricular ejection fraction sacubitril/valsartan HF HFrEF ARNI Medicine R Irmina Morawska verfasserin aut Maria Stec verfasserin aut Wiktoria Kuczmik verfasserin aut Andrzej S. Swinarew verfasserin aut Arkadiusz Stanula verfasserin aut Katarzyna Mizia-Stec verfasserin aut In International Journal of Environmental Research and Public Health MDPI AG, 2005 19(2022), 2089, p 2089 (DE-627)477992463 (DE-600)2175195-X 16604601 nnns volume:19 year:2022 number:2089, p 2089 https://doi.org/10.3390/ijerph19042089 kostenfrei https://doaj.org/article/39850b443f074e4cb604fad8d7e40b3e kostenfrei https://www.mdpi.com/1660-4601/19/4/2089 kostenfrei https://doaj.org/toc/1661-7827 Journal toc kostenfrei https://doaj.org/toc/1660-4601 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2153 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2022 2089, p 2089
spelling	10.3390/ijerph19042089 doi (DE-627)DOAJ017575249 (DE-599)DOAJ39850b443f074e4cb604fad8d7e40b3e DE-627 ger DE-627 rakwb eng Rafał Niemiec verfasserin aut ARNI in HFrEF—One-Centre Experience in the Era before the 2021 ESC HF Recommendations 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Sacubitril/valsartan, an angiotensin receptor–neprilysin inhibitor (ARNI), has demonstrated a survival benefit and reduces heart failure hospitalization in patients with heart failure with reduced left ventricular ejection fraction (HFrEF); however, our experience in this field is limited. This study aimed to summarize a real clinical practice of the use of ARNI in HFrEF patients hospitalized due to HFrEF in the era before the 2021 ESC HF recommendations, as well as assess their clinical outcome with regard to ARNI administration. Methods and Materials: Overall, 613 patients with HFrEF hospitalized in 2018–2020 were enrolled into a retrospective one-centre cross-sectional analysis. The study population was categorized into patients receiving (82/13.4%) and not-receiving (531/82.6%) ARNI. Clinical outcomes defined as rehospitalization, number of rehospitalizations, time to the first rehospitalization and death from any cause were analysed in the 1–2 year follow-up in the ARNI and non-ARNI groups, matched as to age and LVEF. Results: Clinical characteristics revealed the following differences between ARNI and non-ARNI groups: A higher percentage of cardiovascular implantable electronic devices (CIED) (<i<p</i< = 0.014) and defibrillators with cardiac resynchronization therapy (CRT-D) (<i<p</i< = 0.038), higher frequency of atrial fibrillation (<i<p</i< = 0.002) and history of stroke (<i<p</i< = 0.024) were in the ARNI group. The percentage of patients with HFrEF NYHA III/IV presented an increasing trend to be higher in the ARNI (64.1%) as compared to the non-ARNI group (51.5%, <i<p</i< = 0.154). Incidence of rehospitalization, number of rehospitalizations and time to the first rehospitalization were comparable between the groups. There were no differences between the numbers of deaths of any cause in the ARNI (28%) and non-ARNI (28%) groups. The independent negative predictor of death in the whole population of ARNI and non-ARNI groups was the coexistence of coronary artery disease (CAD) (beta= −0.924, HR 0.806, <i<p</i< = 0.011). Conclusions: Our current positive experience in ARNI therapy is limited to extremely severe patients with HFrEF. Regardless of the more advanced HF and HF comorbidities, the patients treated with ARNI presented similar mortality and rehospitalizations as the patients treated by standard therapy. heart failure heart failure with reduced left ventricular ejection fraction sacubitril/valsartan HF HFrEF ARNI Medicine R Irmina Morawska verfasserin aut Maria Stec verfasserin aut Wiktoria Kuczmik verfasserin aut Andrzej S. Swinarew verfasserin aut Arkadiusz Stanula verfasserin aut Katarzyna Mizia-Stec verfasserin aut In International Journal of Environmental Research and Public Health MDPI AG, 2005 19(2022), 2089, p 2089 (DE-627)477992463 (DE-600)2175195-X 16604601 nnns volume:19 year:2022 number:2089, p 2089 https://doi.org/10.3390/ijerph19042089 kostenfrei https://doaj.org/article/39850b443f074e4cb604fad8d7e40b3e kostenfrei https://www.mdpi.com/1660-4601/19/4/2089 kostenfrei https://doaj.org/toc/1661-7827 Journal toc kostenfrei https://doaj.org/toc/1660-4601 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2153 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2022 2089, p 2089
allfields_unstemmed	10.3390/ijerph19042089 doi (DE-627)DOAJ017575249 (DE-599)DOAJ39850b443f074e4cb604fad8d7e40b3e DE-627 ger DE-627 rakwb eng Rafał Niemiec verfasserin aut ARNI in HFrEF—One-Centre Experience in the Era before the 2021 ESC HF Recommendations 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Sacubitril/valsartan, an angiotensin receptor–neprilysin inhibitor (ARNI), has demonstrated a survival benefit and reduces heart failure hospitalization in patients with heart failure with reduced left ventricular ejection fraction (HFrEF); however, our experience in this field is limited. This study aimed to summarize a real clinical practice of the use of ARNI in HFrEF patients hospitalized due to HFrEF in the era before the 2021 ESC HF recommendations, as well as assess their clinical outcome with regard to ARNI administration. Methods and Materials: Overall, 613 patients with HFrEF hospitalized in 2018–2020 were enrolled into a retrospective one-centre cross-sectional analysis. The study population was categorized into patients receiving (82/13.4%) and not-receiving (531/82.6%) ARNI. Clinical outcomes defined as rehospitalization, number of rehospitalizations, time to the first rehospitalization and death from any cause were analysed in the 1–2 year follow-up in the ARNI and non-ARNI groups, matched as to age and LVEF. Results: Clinical characteristics revealed the following differences between ARNI and non-ARNI groups: A higher percentage of cardiovascular implantable electronic devices (CIED) (<i<p</i< = 0.014) and defibrillators with cardiac resynchronization therapy (CRT-D) (<i<p</i< = 0.038), higher frequency of atrial fibrillation (<i<p</i< = 0.002) and history of stroke (<i<p</i< = 0.024) were in the ARNI group. The percentage of patients with HFrEF NYHA III/IV presented an increasing trend to be higher in the ARNI (64.1%) as compared to the non-ARNI group (51.5%, <i<p</i< = 0.154). Incidence of rehospitalization, number of rehospitalizations and time to the first rehospitalization were comparable between the groups. There were no differences between the numbers of deaths of any cause in the ARNI (28%) and non-ARNI (28%) groups. The independent negative predictor of death in the whole population of ARNI and non-ARNI groups was the coexistence of coronary artery disease (CAD) (beta= −0.924, HR 0.806, <i<p</i< = 0.011). Conclusions: Our current positive experience in ARNI therapy is limited to extremely severe patients with HFrEF. Regardless of the more advanced HF and HF comorbidities, the patients treated with ARNI presented similar mortality and rehospitalizations as the patients treated by standard therapy. heart failure heart failure with reduced left ventricular ejection fraction sacubitril/valsartan HF HFrEF ARNI Medicine R Irmina Morawska verfasserin aut Maria Stec verfasserin aut Wiktoria Kuczmik verfasserin aut Andrzej S. Swinarew verfasserin aut Arkadiusz Stanula verfasserin aut Katarzyna Mizia-Stec verfasserin aut In International Journal of Environmental Research and Public Health MDPI AG, 2005 19(2022), 2089, p 2089 (DE-627)477992463 (DE-600)2175195-X 16604601 nnns volume:19 year:2022 number:2089, p 2089 https://doi.org/10.3390/ijerph19042089 kostenfrei https://doaj.org/article/39850b443f074e4cb604fad8d7e40b3e kostenfrei https://www.mdpi.com/1660-4601/19/4/2089 kostenfrei https://doaj.org/toc/1661-7827 Journal toc kostenfrei https://doaj.org/toc/1660-4601 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2153 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2022 2089, p 2089
allfieldsGer	10.3390/ijerph19042089 doi (DE-627)DOAJ017575249 (DE-599)DOAJ39850b443f074e4cb604fad8d7e40b3e DE-627 ger DE-627 rakwb eng Rafał Niemiec verfasserin aut ARNI in HFrEF—One-Centre Experience in the Era before the 2021 ESC HF Recommendations 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Sacubitril/valsartan, an angiotensin receptor–neprilysin inhibitor (ARNI), has demonstrated a survival benefit and reduces heart failure hospitalization in patients with heart failure with reduced left ventricular ejection fraction (HFrEF); however, our experience in this field is limited. This study aimed to summarize a real clinical practice of the use of ARNI in HFrEF patients hospitalized due to HFrEF in the era before the 2021 ESC HF recommendations, as well as assess their clinical outcome with regard to ARNI administration. Methods and Materials: Overall, 613 patients with HFrEF hospitalized in 2018–2020 were enrolled into a retrospective one-centre cross-sectional analysis. The study population was categorized into patients receiving (82/13.4%) and not-receiving (531/82.6%) ARNI. Clinical outcomes defined as rehospitalization, number of rehospitalizations, time to the first rehospitalization and death from any cause were analysed in the 1–2 year follow-up in the ARNI and non-ARNI groups, matched as to age and LVEF. Results: Clinical characteristics revealed the following differences between ARNI and non-ARNI groups: A higher percentage of cardiovascular implantable electronic devices (CIED) (<i<p</i< = 0.014) and defibrillators with cardiac resynchronization therapy (CRT-D) (<i<p</i< = 0.038), higher frequency of atrial fibrillation (<i<p</i< = 0.002) and history of stroke (<i<p</i< = 0.024) were in the ARNI group. The percentage of patients with HFrEF NYHA III/IV presented an increasing trend to be higher in the ARNI (64.1%) as compared to the non-ARNI group (51.5%, <i<p</i< = 0.154). Incidence of rehospitalization, number of rehospitalizations and time to the first rehospitalization were comparable between the groups. There were no differences between the numbers of deaths of any cause in the ARNI (28%) and non-ARNI (28%) groups. The independent negative predictor of death in the whole population of ARNI and non-ARNI groups was the coexistence of coronary artery disease (CAD) (beta= −0.924, HR 0.806, <i<p</i< = 0.011). Conclusions: Our current positive experience in ARNI therapy is limited to extremely severe patients with HFrEF. Regardless of the more advanced HF and HF comorbidities, the patients treated with ARNI presented similar mortality and rehospitalizations as the patients treated by standard therapy. heart failure heart failure with reduced left ventricular ejection fraction sacubitril/valsartan HF HFrEF ARNI Medicine R Irmina Morawska verfasserin aut Maria Stec verfasserin aut Wiktoria Kuczmik verfasserin aut Andrzej S. Swinarew verfasserin aut Arkadiusz Stanula verfasserin aut Katarzyna Mizia-Stec verfasserin aut In International Journal of Environmental Research and Public Health MDPI AG, 2005 19(2022), 2089, p 2089 (DE-627)477992463 (DE-600)2175195-X 16604601 nnns volume:19 year:2022 number:2089, p 2089 https://doi.org/10.3390/ijerph19042089 kostenfrei https://doaj.org/article/39850b443f074e4cb604fad8d7e40b3e kostenfrei https://www.mdpi.com/1660-4601/19/4/2089 kostenfrei https://doaj.org/toc/1661-7827 Journal toc kostenfrei https://doaj.org/toc/1660-4601 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2153 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2022 2089, p 2089
allfieldsSound	10.3390/ijerph19042089 doi (DE-627)DOAJ017575249 (DE-599)DOAJ39850b443f074e4cb604fad8d7e40b3e DE-627 ger DE-627 rakwb eng Rafał Niemiec verfasserin aut ARNI in HFrEF—One-Centre Experience in the Era before the 2021 ESC HF Recommendations 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Sacubitril/valsartan, an angiotensin receptor–neprilysin inhibitor (ARNI), has demonstrated a survival benefit and reduces heart failure hospitalization in patients with heart failure with reduced left ventricular ejection fraction (HFrEF); however, our experience in this field is limited. This study aimed to summarize a real clinical practice of the use of ARNI in HFrEF patients hospitalized due to HFrEF in the era before the 2021 ESC HF recommendations, as well as assess their clinical outcome with regard to ARNI administration. Methods and Materials: Overall, 613 patients with HFrEF hospitalized in 2018–2020 were enrolled into a retrospective one-centre cross-sectional analysis. The study population was categorized into patients receiving (82/13.4%) and not-receiving (531/82.6%) ARNI. Clinical outcomes defined as rehospitalization, number of rehospitalizations, time to the first rehospitalization and death from any cause were analysed in the 1–2 year follow-up in the ARNI and non-ARNI groups, matched as to age and LVEF. Results: Clinical characteristics revealed the following differences between ARNI and non-ARNI groups: A higher percentage of cardiovascular implantable electronic devices (CIED) (<i<p</i< = 0.014) and defibrillators with cardiac resynchronization therapy (CRT-D) (<i<p</i< = 0.038), higher frequency of atrial fibrillation (<i<p</i< = 0.002) and history of stroke (<i<p</i< = 0.024) were in the ARNI group. The percentage of patients with HFrEF NYHA III/IV presented an increasing trend to be higher in the ARNI (64.1%) as compared to the non-ARNI group (51.5%, <i<p</i< = 0.154). Incidence of rehospitalization, number of rehospitalizations and time to the first rehospitalization were comparable between the groups. There were no differences between the numbers of deaths of any cause in the ARNI (28%) and non-ARNI (28%) groups. The independent negative predictor of death in the whole population of ARNI and non-ARNI groups was the coexistence of coronary artery disease (CAD) (beta= −0.924, HR 0.806, <i<p</i< = 0.011). Conclusions: Our current positive experience in ARNI therapy is limited to extremely severe patients with HFrEF. Regardless of the more advanced HF and HF comorbidities, the patients treated with ARNI presented similar mortality and rehospitalizations as the patients treated by standard therapy. heart failure heart failure with reduced left ventricular ejection fraction sacubitril/valsartan HF HFrEF ARNI Medicine R Irmina Morawska verfasserin aut Maria Stec verfasserin aut Wiktoria Kuczmik verfasserin aut Andrzej S. Swinarew verfasserin aut Arkadiusz Stanula verfasserin aut Katarzyna Mizia-Stec verfasserin aut In International Journal of Environmental Research and Public Health MDPI AG, 2005 19(2022), 2089, p 2089 (DE-627)477992463 (DE-600)2175195-X 16604601 nnns volume:19 year:2022 number:2089, p 2089 https://doi.org/10.3390/ijerph19042089 kostenfrei https://doaj.org/article/39850b443f074e4cb604fad8d7e40b3e kostenfrei https://www.mdpi.com/1660-4601/19/4/2089 kostenfrei https://doaj.org/toc/1661-7827 Journal toc kostenfrei https://doaj.org/toc/1660-4601 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2153 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2022 2089, p 2089
language	English
source	In International Journal of Environmental Research and Public Health 19(2022), 2089, p 2089 volume:19 year:2022 number:2089, p 2089
sourceStr	In International Journal of Environmental Research and Public Health 19(2022), 2089, p 2089 volume:19 year:2022 number:2089, p 2089
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	heart failure heart failure with reduced left ventricular ejection fraction sacubitril/valsartan HF HFrEF ARNI Medicine R
isfreeaccess_bool	true
container_title	International Journal of Environmental Research and Public Health
authorswithroles_txt_mv	Rafał Niemiec @@aut@@ Irmina Morawska @@aut@@ Maria Stec @@aut@@ Wiktoria Kuczmik @@aut@@ Andrzej S. Swinarew @@aut@@ Arkadiusz Stanula @@aut@@ Katarzyna Mizia-Stec @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	477992463
id	DOAJ017575249
language_de	englisch
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This study aimed to summarize a real clinical practice of the use of ARNI in HFrEF patients hospitalized due to HFrEF in the era before the 2021 ESC HF recommendations, as well as assess their clinical outcome with regard to ARNI administration. Methods and Materials: Overall, 613 patients with HFrEF hospitalized in 2018–2020 were enrolled into a retrospective one-centre cross-sectional analysis. The study population was categorized into patients receiving (82/13.4%) and not-receiving (531/82.6%) ARNI. Clinical outcomes defined as rehospitalization, number of rehospitalizations, time to the first rehospitalization and death from any cause were analysed in the 1–2 year follow-up in the ARNI and non-ARNI groups, matched as to age and LVEF. Results: Clinical characteristics revealed the following differences between ARNI and non-ARNI groups: A higher percentage of cardiovascular implantable electronic devices (CIED) (<i<p</i< = 0.014) and defibrillators with cardiac resynchronization therapy (CRT-D) (<i<p</i< = 0.038), higher frequency of atrial fibrillation (<i<p</i< = 0.002) and history of stroke (<i<p</i< = 0.024) were in the ARNI group. The percentage of patients with HFrEF NYHA III/IV presented an increasing trend to be higher in the ARNI (64.1%) as compared to the non-ARNI group (51.5%, <i<p</i< = 0.154). Incidence of rehospitalization, number of rehospitalizations and time to the first rehospitalization were comparable between the groups. There were no differences between the numbers of deaths of any cause in the ARNI (28%) and non-ARNI (28%) groups. The independent negative predictor of death in the whole population of ARNI and non-ARNI groups was the coexistence of coronary artery disease (CAD) (beta= −0.924, HR 0.806, <i<p</i< = 0.011). Conclusions: Our current positive experience in ARNI therapy is limited to extremely severe patients with HFrEF. 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author	Rafał Niemiec
spellingShingle	Rafał Niemiec misc heart failure misc heart failure with reduced left ventricular ejection fraction misc sacubitril/valsartan misc HF misc HFrEF misc ARNI misc Medicine misc R ARNI in HFrEF—One-Centre Experience in the Era before the 2021 ESC HF Recommendations
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topic_title	ARNI in HFrEF—One-Centre Experience in the Era before the 2021 ESC HF Recommendations heart failure heart failure with reduced left ventricular ejection fraction sacubitril/valsartan HF HFrEF ARNI
topic	misc heart failure misc heart failure with reduced left ventricular ejection fraction misc sacubitril/valsartan misc HF misc HFrEF misc ARNI misc Medicine misc R
topic_unstemmed	misc heart failure misc heart failure with reduced left ventricular ejection fraction misc sacubitril/valsartan misc HF misc HFrEF misc ARNI misc Medicine misc R
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title	ARNI in HFrEF—One-Centre Experience in the Era before the 2021 ESC HF Recommendations
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title_full	ARNI in HFrEF—One-Centre Experience in the Era before the 2021 ESC HF Recommendations
author_sort	Rafał Niemiec
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author_browse	Rafał Niemiec Irmina Morawska Maria Stec Wiktoria Kuczmik Andrzej S. Swinarew Arkadiusz Stanula Katarzyna Mizia-Stec
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author-letter	Rafał Niemiec
doi_str_mv	10.3390/ijerph19042089
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title_sort	arni in hfref—one-centre experience in the era before the 2021 esc hf recommendations
title_auth	ARNI in HFrEF—One-Centre Experience in the Era before the 2021 ESC HF Recommendations
abstract	Background: Sacubitril/valsartan, an angiotensin receptor–neprilysin inhibitor (ARNI), has demonstrated a survival benefit and reduces heart failure hospitalization in patients with heart failure with reduced left ventricular ejection fraction (HFrEF); however, our experience in this field is limited. This study aimed to summarize a real clinical practice of the use of ARNI in HFrEF patients hospitalized due to HFrEF in the era before the 2021 ESC HF recommendations, as well as assess their clinical outcome with regard to ARNI administration. Methods and Materials: Overall, 613 patients with HFrEF hospitalized in 2018–2020 were enrolled into a retrospective one-centre cross-sectional analysis. The study population was categorized into patients receiving (82/13.4%) and not-receiving (531/82.6%) ARNI. Clinical outcomes defined as rehospitalization, number of rehospitalizations, time to the first rehospitalization and death from any cause were analysed in the 1–2 year follow-up in the ARNI and non-ARNI groups, matched as to age and LVEF. Results: Clinical characteristics revealed the following differences between ARNI and non-ARNI groups: A higher percentage of cardiovascular implantable electronic devices (CIED) (<i<p</i< = 0.014) and defibrillators with cardiac resynchronization therapy (CRT-D) (<i<p</i< = 0.038), higher frequency of atrial fibrillation (<i<p</i< = 0.002) and history of stroke (<i<p</i< = 0.024) were in the ARNI group. The percentage of patients with HFrEF NYHA III/IV presented an increasing trend to be higher in the ARNI (64.1%) as compared to the non-ARNI group (51.5%, <i<p</i< = 0.154). Incidence of rehospitalization, number of rehospitalizations and time to the first rehospitalization were comparable between the groups. There were no differences between the numbers of deaths of any cause in the ARNI (28%) and non-ARNI (28%) groups. The independent negative predictor of death in the whole population of ARNI and non-ARNI groups was the coexistence of coronary artery disease (CAD) (beta= −0.924, HR 0.806, <i<p</i< = 0.011). Conclusions: Our current positive experience in ARNI therapy is limited to extremely severe patients with HFrEF. Regardless of the more advanced HF and HF comorbidities, the patients treated with ARNI presented similar mortality and rehospitalizations as the patients treated by standard therapy.
abstractGer	Background: Sacubitril/valsartan, an angiotensin receptor–neprilysin inhibitor (ARNI), has demonstrated a survival benefit and reduces heart failure hospitalization in patients with heart failure with reduced left ventricular ejection fraction (HFrEF); however, our experience in this field is limited. This study aimed to summarize a real clinical practice of the use of ARNI in HFrEF patients hospitalized due to HFrEF in the era before the 2021 ESC HF recommendations, as well as assess their clinical outcome with regard to ARNI administration. Methods and Materials: Overall, 613 patients with HFrEF hospitalized in 2018–2020 were enrolled into a retrospective one-centre cross-sectional analysis. The study population was categorized into patients receiving (82/13.4%) and not-receiving (531/82.6%) ARNI. Clinical outcomes defined as rehospitalization, number of rehospitalizations, time to the first rehospitalization and death from any cause were analysed in the 1–2 year follow-up in the ARNI and non-ARNI groups, matched as to age and LVEF. Results: Clinical characteristics revealed the following differences between ARNI and non-ARNI groups: A higher percentage of cardiovascular implantable electronic devices (CIED) (<i<p</i< = 0.014) and defibrillators with cardiac resynchronization therapy (CRT-D) (<i<p</i< = 0.038), higher frequency of atrial fibrillation (<i<p</i< = 0.002) and history of stroke (<i<p</i< = 0.024) were in the ARNI group. The percentage of patients with HFrEF NYHA III/IV presented an increasing trend to be higher in the ARNI (64.1%) as compared to the non-ARNI group (51.5%, <i<p</i< = 0.154). Incidence of rehospitalization, number of rehospitalizations and time to the first rehospitalization were comparable between the groups. There were no differences between the numbers of deaths of any cause in the ARNI (28%) and non-ARNI (28%) groups. The independent negative predictor of death in the whole population of ARNI and non-ARNI groups was the coexistence of coronary artery disease (CAD) (beta= −0.924, HR 0.806, <i<p</i< = 0.011). Conclusions: Our current positive experience in ARNI therapy is limited to extremely severe patients with HFrEF. Regardless of the more advanced HF and HF comorbidities, the patients treated with ARNI presented similar mortality and rehospitalizations as the patients treated by standard therapy.
abstract_unstemmed	Background: Sacubitril/valsartan, an angiotensin receptor–neprilysin inhibitor (ARNI), has demonstrated a survival benefit and reduces heart failure hospitalization in patients with heart failure with reduced left ventricular ejection fraction (HFrEF); however, our experience in this field is limited. This study aimed to summarize a real clinical practice of the use of ARNI in HFrEF patients hospitalized due to HFrEF in the era before the 2021 ESC HF recommendations, as well as assess their clinical outcome with regard to ARNI administration. Methods and Materials: Overall, 613 patients with HFrEF hospitalized in 2018–2020 were enrolled into a retrospective one-centre cross-sectional analysis. The study population was categorized into patients receiving (82/13.4%) and not-receiving (531/82.6%) ARNI. Clinical outcomes defined as rehospitalization, number of rehospitalizations, time to the first rehospitalization and death from any cause were analysed in the 1–2 year follow-up in the ARNI and non-ARNI groups, matched as to age and LVEF. Results: Clinical characteristics revealed the following differences between ARNI and non-ARNI groups: A higher percentage of cardiovascular implantable electronic devices (CIED) (<i<p</i< = 0.014) and defibrillators with cardiac resynchronization therapy (CRT-D) (<i<p</i< = 0.038), higher frequency of atrial fibrillation (<i<p</i< = 0.002) and history of stroke (<i<p</i< = 0.024) were in the ARNI group. The percentage of patients with HFrEF NYHA III/IV presented an increasing trend to be higher in the ARNI (64.1%) as compared to the non-ARNI group (51.5%, <i<p</i< = 0.154). Incidence of rehospitalization, number of rehospitalizations and time to the first rehospitalization were comparable between the groups. There were no differences between the numbers of deaths of any cause in the ARNI (28%) and non-ARNI (28%) groups. The independent negative predictor of death in the whole population of ARNI and non-ARNI groups was the coexistence of coronary artery disease (CAD) (beta= −0.924, HR 0.806, <i<p</i< = 0.011). Conclusions: Our current positive experience in ARNI therapy is limited to extremely severe patients with HFrEF. Regardless of the more advanced HF and HF comorbidities, the patients treated with ARNI presented similar mortality and rehospitalizations as the patients treated by standard therapy.
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title_short	ARNI in HFrEF—One-Centre Experience in the Era before the 2021 ESC HF Recommendations
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author2	Irmina Morawska Maria Stec Wiktoria Kuczmik Andrzej S. Swinarew Arkadiusz Stanula Katarzyna Mizia-Stec
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