Re-Emergence of Circulation of Seasonal Influenza during COVID-19 Pandemic in Russia and Receptor Specificity of New and Dominant Clade 3C.2a1b.2a.2 A(H3N2) Viruses in 2021–2022
The circulation of seasonal influenza in 2020–2021 around the world was drastically reduced after the start of the COVID-19 pandemic and the implementation of mitigation strategies. The influenza virus circulation reemerged in 2021–2022 with the global spread of the new genetic clade 3C.2a1b.2a.2 of...
Ausführliche Beschreibung
Autor*in: |
Natalia P. Kolosova [verfasserIn] Tatiana N. Ilyicheva [verfasserIn] Vasily V. Unguryan [verfasserIn] Alexey V. Danilenko [verfasserIn] Svetlana V. Svyatchenko [verfasserIn] Galina S. Onhonova [verfasserIn] Natalia I. Goncharova [verfasserIn] Maksim N. Kosenko [verfasserIn] Andrey S. Gudymo [verfasserIn] Vasiliy Y. Marchenko [verfasserIn] Alexander N. Shvalov [verfasserIn] Ivan M. Susloparov [verfasserIn] Tatiana V. Tregubchak [verfasserIn] Elena V. Gavrilova [verfasserIn] Rinat A. Maksyutov [verfasserIn] Alexander B. Ryzhikov [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
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2022 |
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In: Pathogens - MDPI AG, 2012, 11(2022), 11, p 1388 |
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Übergeordnetes Werk: |
volume:11 ; year:2022 ; number:11, p 1388 |
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DOI / URN: |
10.3390/pathogens11111388 |
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Katalog-ID: |
DOAJ01778672X |
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520 | |a The circulation of seasonal influenza in 2020–2021 around the world was drastically reduced after the start of the COVID-19 pandemic and the implementation of mitigation strategies. The influenza virus circulation reemerged in 2021–2022 with the global spread of the new genetic clade 3C.2a1b.2a.2 of A(H3N2) viruses. The purpose of this study was to characterize influenza viruses in the 2021–2022 season in Russia and to analyze the receptor specificity properties of the 3C.2a1b.2a.2 A(H3N2) viruses. Clinical influenza samples were collected at the local Sanitary-and-Epidemiological Centers of Rospotrebnadzor. Whole genome sequencing was performed using NGS. The receptor specificity of hemagglutinin was evaluated using molecular modeling and bio-layer interferometry. Clinical samples from 854 cases of influenza A and B were studied; A(H3N2) viruses were in the majority of the samples. All genetically studied A(H3N2) viruses belonged to the new genetic clade 3C.2a1b.2a.2. Molecular modeling analysis suggested a higher affinity of hemagglutinin of 3C.2a1b.2a.2. A(H3N2) viruses to the α2,6 human receptor. In vitro analysis using a trisaccharide 6’-Sialyl-N-acetyllactosamine receptor analog did not resolve the differences in the receptor specificity of 3C.2a1b.2a.2 clade viruses from viruses belonging to the 3C.2a1b.2a.1 clade. Further investigation of the A(H3N2) viruses is required for the evaluation of their possible adaptive advantages. Constant monitoring and characterization of influenza are critical for epidemiological analysis. | ||
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10.3390/pathogens11111388 doi (DE-627)DOAJ01778672X (DE-599)DOAJa24767aa96564eb195c34d782e22d60b DE-627 ger DE-627 rakwb eng Natalia P. Kolosova verfasserin aut Re-Emergence of Circulation of Seasonal Influenza during COVID-19 Pandemic in Russia and Receptor Specificity of New and Dominant Clade 3C.2a1b.2a.2 A(H3N2) Viruses in 2021–2022 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The circulation of seasonal influenza in 2020–2021 around the world was drastically reduced after the start of the COVID-19 pandemic and the implementation of mitigation strategies. The influenza virus circulation reemerged in 2021–2022 with the global spread of the new genetic clade 3C.2a1b.2a.2 of A(H3N2) viruses. The purpose of this study was to characterize influenza viruses in the 2021–2022 season in Russia and to analyze the receptor specificity properties of the 3C.2a1b.2a.2 A(H3N2) viruses. Clinical influenza samples were collected at the local Sanitary-and-Epidemiological Centers of Rospotrebnadzor. Whole genome sequencing was performed using NGS. The receptor specificity of hemagglutinin was evaluated using molecular modeling and bio-layer interferometry. Clinical samples from 854 cases of influenza A and B were studied; A(H3N2) viruses were in the majority of the samples. All genetically studied A(H3N2) viruses belonged to the new genetic clade 3C.2a1b.2a.2. Molecular modeling analysis suggested a higher affinity of hemagglutinin of 3C.2a1b.2a.2. A(H3N2) viruses to the α2,6 human receptor. In vitro analysis using a trisaccharide 6’-Sialyl-N-acetyllactosamine receptor analog did not resolve the differences in the receptor specificity of 3C.2a1b.2a.2 clade viruses from viruses belonging to the 3C.2a1b.2a.1 clade. Further investigation of the A(H3N2) viruses is required for the evaluation of their possible adaptive advantages. Constant monitoring and characterization of influenza are critical for epidemiological analysis. seasonal influenza virus COVID-19 pandemic influence monitoring molecular modeling A(H3N2) clade 3C.2a1b.2a.2 receptor specificity Medicine R Tatiana N. Ilyicheva verfasserin aut Vasily V. Unguryan verfasserin aut Alexey V. Danilenko verfasserin aut Svetlana V. Svyatchenko verfasserin aut Galina S. Onhonova verfasserin aut Natalia I. Goncharova verfasserin aut Maksim N. Kosenko verfasserin aut Andrey S. Gudymo verfasserin aut Vasiliy Y. Marchenko verfasserin aut Alexander N. Shvalov verfasserin aut Ivan M. Susloparov verfasserin aut Tatiana V. Tregubchak verfasserin aut Elena V. Gavrilova verfasserin aut Rinat A. Maksyutov verfasserin aut Alexander B. Ryzhikov verfasserin aut In Pathogens MDPI AG, 2012 11(2022), 11, p 1388 (DE-627)732627885 (DE-600)2695572-6 20760817 nnns volume:11 year:2022 number:11, p 1388 https://doi.org/10.3390/pathogens11111388 kostenfrei https://doaj.org/article/a24767aa96564eb195c34d782e22d60b kostenfrei https://www.mdpi.com/2076-0817/11/11/1388 kostenfrei https://doaj.org/toc/2076-0817 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 11, p 1388 |
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10.3390/pathogens11111388 doi (DE-627)DOAJ01778672X (DE-599)DOAJa24767aa96564eb195c34d782e22d60b DE-627 ger DE-627 rakwb eng Natalia P. Kolosova verfasserin aut Re-Emergence of Circulation of Seasonal Influenza during COVID-19 Pandemic in Russia and Receptor Specificity of New and Dominant Clade 3C.2a1b.2a.2 A(H3N2) Viruses in 2021–2022 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The circulation of seasonal influenza in 2020–2021 around the world was drastically reduced after the start of the COVID-19 pandemic and the implementation of mitigation strategies. The influenza virus circulation reemerged in 2021–2022 with the global spread of the new genetic clade 3C.2a1b.2a.2 of A(H3N2) viruses. The purpose of this study was to characterize influenza viruses in the 2021–2022 season in Russia and to analyze the receptor specificity properties of the 3C.2a1b.2a.2 A(H3N2) viruses. Clinical influenza samples were collected at the local Sanitary-and-Epidemiological Centers of Rospotrebnadzor. Whole genome sequencing was performed using NGS. The receptor specificity of hemagglutinin was evaluated using molecular modeling and bio-layer interferometry. Clinical samples from 854 cases of influenza A and B were studied; A(H3N2) viruses were in the majority of the samples. All genetically studied A(H3N2) viruses belonged to the new genetic clade 3C.2a1b.2a.2. Molecular modeling analysis suggested a higher affinity of hemagglutinin of 3C.2a1b.2a.2. A(H3N2) viruses to the α2,6 human receptor. In vitro analysis using a trisaccharide 6’-Sialyl-N-acetyllactosamine receptor analog did not resolve the differences in the receptor specificity of 3C.2a1b.2a.2 clade viruses from viruses belonging to the 3C.2a1b.2a.1 clade. Further investigation of the A(H3N2) viruses is required for the evaluation of their possible adaptive advantages. Constant monitoring and characterization of influenza are critical for epidemiological analysis. seasonal influenza virus COVID-19 pandemic influence monitoring molecular modeling A(H3N2) clade 3C.2a1b.2a.2 receptor specificity Medicine R Tatiana N. Ilyicheva verfasserin aut Vasily V. Unguryan verfasserin aut Alexey V. Danilenko verfasserin aut Svetlana V. Svyatchenko verfasserin aut Galina S. Onhonova verfasserin aut Natalia I. Goncharova verfasserin aut Maksim N. Kosenko verfasserin aut Andrey S. Gudymo verfasserin aut Vasiliy Y. Marchenko verfasserin aut Alexander N. Shvalov verfasserin aut Ivan M. Susloparov verfasserin aut Tatiana V. Tregubchak verfasserin aut Elena V. Gavrilova verfasserin aut Rinat A. Maksyutov verfasserin aut Alexander B. Ryzhikov verfasserin aut In Pathogens MDPI AG, 2012 11(2022), 11, p 1388 (DE-627)732627885 (DE-600)2695572-6 20760817 nnns volume:11 year:2022 number:11, p 1388 https://doi.org/10.3390/pathogens11111388 kostenfrei https://doaj.org/article/a24767aa96564eb195c34d782e22d60b kostenfrei https://www.mdpi.com/2076-0817/11/11/1388 kostenfrei https://doaj.org/toc/2076-0817 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 11, p 1388 |
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10.3390/pathogens11111388 doi (DE-627)DOAJ01778672X (DE-599)DOAJa24767aa96564eb195c34d782e22d60b DE-627 ger DE-627 rakwb eng Natalia P. Kolosova verfasserin aut Re-Emergence of Circulation of Seasonal Influenza during COVID-19 Pandemic in Russia and Receptor Specificity of New and Dominant Clade 3C.2a1b.2a.2 A(H3N2) Viruses in 2021–2022 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The circulation of seasonal influenza in 2020–2021 around the world was drastically reduced after the start of the COVID-19 pandemic and the implementation of mitigation strategies. The influenza virus circulation reemerged in 2021–2022 with the global spread of the new genetic clade 3C.2a1b.2a.2 of A(H3N2) viruses. The purpose of this study was to characterize influenza viruses in the 2021–2022 season in Russia and to analyze the receptor specificity properties of the 3C.2a1b.2a.2 A(H3N2) viruses. Clinical influenza samples were collected at the local Sanitary-and-Epidemiological Centers of Rospotrebnadzor. Whole genome sequencing was performed using NGS. The receptor specificity of hemagglutinin was evaluated using molecular modeling and bio-layer interferometry. Clinical samples from 854 cases of influenza A and B were studied; A(H3N2) viruses were in the majority of the samples. All genetically studied A(H3N2) viruses belonged to the new genetic clade 3C.2a1b.2a.2. Molecular modeling analysis suggested a higher affinity of hemagglutinin of 3C.2a1b.2a.2. A(H3N2) viruses to the α2,6 human receptor. In vitro analysis using a trisaccharide 6’-Sialyl-N-acetyllactosamine receptor analog did not resolve the differences in the receptor specificity of 3C.2a1b.2a.2 clade viruses from viruses belonging to the 3C.2a1b.2a.1 clade. Further investigation of the A(H3N2) viruses is required for the evaluation of their possible adaptive advantages. Constant monitoring and characterization of influenza are critical for epidemiological analysis. seasonal influenza virus COVID-19 pandemic influence monitoring molecular modeling A(H3N2) clade 3C.2a1b.2a.2 receptor specificity Medicine R Tatiana N. Ilyicheva verfasserin aut Vasily V. Unguryan verfasserin aut Alexey V. Danilenko verfasserin aut Svetlana V. Svyatchenko verfasserin aut Galina S. Onhonova verfasserin aut Natalia I. Goncharova verfasserin aut Maksim N. Kosenko verfasserin aut Andrey S. Gudymo verfasserin aut Vasiliy Y. Marchenko verfasserin aut Alexander N. Shvalov verfasserin aut Ivan M. Susloparov verfasserin aut Tatiana V. Tregubchak verfasserin aut Elena V. Gavrilova verfasserin aut Rinat A. Maksyutov verfasserin aut Alexander B. Ryzhikov verfasserin aut In Pathogens MDPI AG, 2012 11(2022), 11, p 1388 (DE-627)732627885 (DE-600)2695572-6 20760817 nnns volume:11 year:2022 number:11, p 1388 https://doi.org/10.3390/pathogens11111388 kostenfrei https://doaj.org/article/a24767aa96564eb195c34d782e22d60b kostenfrei https://www.mdpi.com/2076-0817/11/11/1388 kostenfrei https://doaj.org/toc/2076-0817 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 11, p 1388 |
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10.3390/pathogens11111388 doi (DE-627)DOAJ01778672X (DE-599)DOAJa24767aa96564eb195c34d782e22d60b DE-627 ger DE-627 rakwb eng Natalia P. Kolosova verfasserin aut Re-Emergence of Circulation of Seasonal Influenza during COVID-19 Pandemic in Russia and Receptor Specificity of New and Dominant Clade 3C.2a1b.2a.2 A(H3N2) Viruses in 2021–2022 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The circulation of seasonal influenza in 2020–2021 around the world was drastically reduced after the start of the COVID-19 pandemic and the implementation of mitigation strategies. The influenza virus circulation reemerged in 2021–2022 with the global spread of the new genetic clade 3C.2a1b.2a.2 of A(H3N2) viruses. The purpose of this study was to characterize influenza viruses in the 2021–2022 season in Russia and to analyze the receptor specificity properties of the 3C.2a1b.2a.2 A(H3N2) viruses. Clinical influenza samples were collected at the local Sanitary-and-Epidemiological Centers of Rospotrebnadzor. Whole genome sequencing was performed using NGS. The receptor specificity of hemagglutinin was evaluated using molecular modeling and bio-layer interferometry. Clinical samples from 854 cases of influenza A and B were studied; A(H3N2) viruses were in the majority of the samples. All genetically studied A(H3N2) viruses belonged to the new genetic clade 3C.2a1b.2a.2. Molecular modeling analysis suggested a higher affinity of hemagglutinin of 3C.2a1b.2a.2. A(H3N2) viruses to the α2,6 human receptor. In vitro analysis using a trisaccharide 6’-Sialyl-N-acetyllactosamine receptor analog did not resolve the differences in the receptor specificity of 3C.2a1b.2a.2 clade viruses from viruses belonging to the 3C.2a1b.2a.1 clade. Further investigation of the A(H3N2) viruses is required for the evaluation of their possible adaptive advantages. Constant monitoring and characterization of influenza are critical for epidemiological analysis. seasonal influenza virus COVID-19 pandemic influence monitoring molecular modeling A(H3N2) clade 3C.2a1b.2a.2 receptor specificity Medicine R Tatiana N. Ilyicheva verfasserin aut Vasily V. Unguryan verfasserin aut Alexey V. Danilenko verfasserin aut Svetlana V. Svyatchenko verfasserin aut Galina S. Onhonova verfasserin aut Natalia I. Goncharova verfasserin aut Maksim N. Kosenko verfasserin aut Andrey S. Gudymo verfasserin aut Vasiliy Y. Marchenko verfasserin aut Alexander N. Shvalov verfasserin aut Ivan M. Susloparov verfasserin aut Tatiana V. Tregubchak verfasserin aut Elena V. Gavrilova verfasserin aut Rinat A. Maksyutov verfasserin aut Alexander B. Ryzhikov verfasserin aut In Pathogens MDPI AG, 2012 11(2022), 11, p 1388 (DE-627)732627885 (DE-600)2695572-6 20760817 nnns volume:11 year:2022 number:11, p 1388 https://doi.org/10.3390/pathogens11111388 kostenfrei https://doaj.org/article/a24767aa96564eb195c34d782e22d60b kostenfrei https://www.mdpi.com/2076-0817/11/11/1388 kostenfrei https://doaj.org/toc/2076-0817 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 11, p 1388 |
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10.3390/pathogens11111388 doi (DE-627)DOAJ01778672X (DE-599)DOAJa24767aa96564eb195c34d782e22d60b DE-627 ger DE-627 rakwb eng Natalia P. Kolosova verfasserin aut Re-Emergence of Circulation of Seasonal Influenza during COVID-19 Pandemic in Russia and Receptor Specificity of New and Dominant Clade 3C.2a1b.2a.2 A(H3N2) Viruses in 2021–2022 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The circulation of seasonal influenza in 2020–2021 around the world was drastically reduced after the start of the COVID-19 pandemic and the implementation of mitigation strategies. The influenza virus circulation reemerged in 2021–2022 with the global spread of the new genetic clade 3C.2a1b.2a.2 of A(H3N2) viruses. The purpose of this study was to characterize influenza viruses in the 2021–2022 season in Russia and to analyze the receptor specificity properties of the 3C.2a1b.2a.2 A(H3N2) viruses. Clinical influenza samples were collected at the local Sanitary-and-Epidemiological Centers of Rospotrebnadzor. Whole genome sequencing was performed using NGS. The receptor specificity of hemagglutinin was evaluated using molecular modeling and bio-layer interferometry. Clinical samples from 854 cases of influenza A and B were studied; A(H3N2) viruses were in the majority of the samples. All genetically studied A(H3N2) viruses belonged to the new genetic clade 3C.2a1b.2a.2. Molecular modeling analysis suggested a higher affinity of hemagglutinin of 3C.2a1b.2a.2. A(H3N2) viruses to the α2,6 human receptor. In vitro analysis using a trisaccharide 6’-Sialyl-N-acetyllactosamine receptor analog did not resolve the differences in the receptor specificity of 3C.2a1b.2a.2 clade viruses from viruses belonging to the 3C.2a1b.2a.1 clade. Further investigation of the A(H3N2) viruses is required for the evaluation of their possible adaptive advantages. Constant monitoring and characterization of influenza are critical for epidemiological analysis. seasonal influenza virus COVID-19 pandemic influence monitoring molecular modeling A(H3N2) clade 3C.2a1b.2a.2 receptor specificity Medicine R Tatiana N. Ilyicheva verfasserin aut Vasily V. Unguryan verfasserin aut Alexey V. Danilenko verfasserin aut Svetlana V. Svyatchenko verfasserin aut Galina S. Onhonova verfasserin aut Natalia I. Goncharova verfasserin aut Maksim N. Kosenko verfasserin aut Andrey S. Gudymo verfasserin aut Vasiliy Y. Marchenko verfasserin aut Alexander N. Shvalov verfasserin aut Ivan M. Susloparov verfasserin aut Tatiana V. Tregubchak verfasserin aut Elena V. Gavrilova verfasserin aut Rinat A. Maksyutov verfasserin aut Alexander B. Ryzhikov verfasserin aut In Pathogens MDPI AG, 2012 11(2022), 11, p 1388 (DE-627)732627885 (DE-600)2695572-6 20760817 nnns volume:11 year:2022 number:11, p 1388 https://doi.org/10.3390/pathogens11111388 kostenfrei https://doaj.org/article/a24767aa96564eb195c34d782e22d60b kostenfrei https://www.mdpi.com/2076-0817/11/11/1388 kostenfrei https://doaj.org/toc/2076-0817 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 11, p 1388 |
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Re-Emergence of Circulation of Seasonal Influenza during COVID-19 Pandemic in Russia and Receptor Specificity of New and Dominant Clade 3C.2a1b.2a.2 A(H3N2) Viruses in 2021–2022 |
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Re-Emergence of Circulation of Seasonal Influenza during COVID-19 Pandemic in Russia and Receptor Specificity of New and Dominant Clade 3C.2a1b.2a.2 A(H3N2) Viruses in 2021–2022 |
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Natalia P. Kolosova |
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Natalia P. Kolosova Tatiana N. Ilyicheva Vasily V. Unguryan Alexey V. Danilenko Svetlana V. Svyatchenko Galina S. Onhonova Natalia I. Goncharova Maksim N. Kosenko Andrey S. Gudymo Vasiliy Y. Marchenko Alexander N. Shvalov Ivan M. Susloparov Tatiana V. Tregubchak Elena V. Gavrilova Rinat A. Maksyutov Alexander B. Ryzhikov |
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10.3390/pathogens11111388 |
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re-emergence of circulation of seasonal influenza during covid-19 pandemic in russia and receptor specificity of new and dominant clade 3c.2a1b.2a.2 a(h3n2) viruses in 2021–2022 |
title_auth |
Re-Emergence of Circulation of Seasonal Influenza during COVID-19 Pandemic in Russia and Receptor Specificity of New and Dominant Clade 3C.2a1b.2a.2 A(H3N2) Viruses in 2021–2022 |
abstract |
The circulation of seasonal influenza in 2020–2021 around the world was drastically reduced after the start of the COVID-19 pandemic and the implementation of mitigation strategies. The influenza virus circulation reemerged in 2021–2022 with the global spread of the new genetic clade 3C.2a1b.2a.2 of A(H3N2) viruses. The purpose of this study was to characterize influenza viruses in the 2021–2022 season in Russia and to analyze the receptor specificity properties of the 3C.2a1b.2a.2 A(H3N2) viruses. Clinical influenza samples were collected at the local Sanitary-and-Epidemiological Centers of Rospotrebnadzor. Whole genome sequencing was performed using NGS. The receptor specificity of hemagglutinin was evaluated using molecular modeling and bio-layer interferometry. Clinical samples from 854 cases of influenza A and B were studied; A(H3N2) viruses were in the majority of the samples. All genetically studied A(H3N2) viruses belonged to the new genetic clade 3C.2a1b.2a.2. Molecular modeling analysis suggested a higher affinity of hemagglutinin of 3C.2a1b.2a.2. A(H3N2) viruses to the α2,6 human receptor. In vitro analysis using a trisaccharide 6’-Sialyl-N-acetyllactosamine receptor analog did not resolve the differences in the receptor specificity of 3C.2a1b.2a.2 clade viruses from viruses belonging to the 3C.2a1b.2a.1 clade. Further investigation of the A(H3N2) viruses is required for the evaluation of their possible adaptive advantages. Constant monitoring and characterization of influenza are critical for epidemiological analysis. |
abstractGer |
The circulation of seasonal influenza in 2020–2021 around the world was drastically reduced after the start of the COVID-19 pandemic and the implementation of mitigation strategies. The influenza virus circulation reemerged in 2021–2022 with the global spread of the new genetic clade 3C.2a1b.2a.2 of A(H3N2) viruses. The purpose of this study was to characterize influenza viruses in the 2021–2022 season in Russia and to analyze the receptor specificity properties of the 3C.2a1b.2a.2 A(H3N2) viruses. Clinical influenza samples were collected at the local Sanitary-and-Epidemiological Centers of Rospotrebnadzor. Whole genome sequencing was performed using NGS. The receptor specificity of hemagglutinin was evaluated using molecular modeling and bio-layer interferometry. Clinical samples from 854 cases of influenza A and B were studied; A(H3N2) viruses were in the majority of the samples. All genetically studied A(H3N2) viruses belonged to the new genetic clade 3C.2a1b.2a.2. Molecular modeling analysis suggested a higher affinity of hemagglutinin of 3C.2a1b.2a.2. A(H3N2) viruses to the α2,6 human receptor. In vitro analysis using a trisaccharide 6’-Sialyl-N-acetyllactosamine receptor analog did not resolve the differences in the receptor specificity of 3C.2a1b.2a.2 clade viruses from viruses belonging to the 3C.2a1b.2a.1 clade. Further investigation of the A(H3N2) viruses is required for the evaluation of their possible adaptive advantages. Constant monitoring and characterization of influenza are critical for epidemiological analysis. |
abstract_unstemmed |
The circulation of seasonal influenza in 2020–2021 around the world was drastically reduced after the start of the COVID-19 pandemic and the implementation of mitigation strategies. The influenza virus circulation reemerged in 2021–2022 with the global spread of the new genetic clade 3C.2a1b.2a.2 of A(H3N2) viruses. The purpose of this study was to characterize influenza viruses in the 2021–2022 season in Russia and to analyze the receptor specificity properties of the 3C.2a1b.2a.2 A(H3N2) viruses. Clinical influenza samples were collected at the local Sanitary-and-Epidemiological Centers of Rospotrebnadzor. Whole genome sequencing was performed using NGS. The receptor specificity of hemagglutinin was evaluated using molecular modeling and bio-layer interferometry. Clinical samples from 854 cases of influenza A and B were studied; A(H3N2) viruses were in the majority of the samples. All genetically studied A(H3N2) viruses belonged to the new genetic clade 3C.2a1b.2a.2. Molecular modeling analysis suggested a higher affinity of hemagglutinin of 3C.2a1b.2a.2. A(H3N2) viruses to the α2,6 human receptor. In vitro analysis using a trisaccharide 6’-Sialyl-N-acetyllactosamine receptor analog did not resolve the differences in the receptor specificity of 3C.2a1b.2a.2 clade viruses from viruses belonging to the 3C.2a1b.2a.1 clade. Further investigation of the A(H3N2) viruses is required for the evaluation of their possible adaptive advantages. Constant monitoring and characterization of influenza are critical for epidemiological analysis. |
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Re-Emergence of Circulation of Seasonal Influenza during COVID-19 Pandemic in Russia and Receptor Specificity of New and Dominant Clade 3C.2a1b.2a.2 A(H3N2) Viruses in 2021–2022 |
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