Vascular endothelial growth factor and KIT expression in relation with microvascular density and tumor grade in supratentorial astrocytic tumors
PURPOSE: To evaluate the relationship between microvascular density and the expression of vascular endothelial growth factor (VEGF) and KIT as possible markers of angiogenic stimulus in astrocytic tumors and correlate it with histopathological grading. METHODS: We enrolled 99 surgical specimens of s...
Ausführliche Beschreibung
Autor*in: |
Thaís Heinke [verfasserIn] Kleber Simões do Espiríto Santo [verfasserIn] Adhemar Longatto Filho [verfasserIn] João Norberto Stavale [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2013 |
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In: Acta Cirúrgica Brasileira - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, 2004, 28(2013), 1, Seite 48-54 |
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Übergeordnetes Werk: |
volume:28 ; year:2013 ; number:1 ; pages:48-54 |
Links: |
Link aufrufen |
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DOI / URN: |
10.1590/S0102-86502013000100008 |
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Katalog-ID: |
DOAJ01802694X |
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10.1590/S0102-86502013000100008 doi (DE-627)DOAJ01802694X (DE-599)DOAJ53df521b01b944acb00a61c7c6de6ba4 DE-627 ger DE-627 rakwb eng RD1-811 Thaís Heinke verfasserin aut Vascular endothelial growth factor and KIT expression in relation with microvascular density and tumor grade in supratentorial astrocytic tumors 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier PURPOSE: To evaluate the relationship between microvascular density and the expression of vascular endothelial growth factor (VEGF) and KIT as possible markers of angiogenic stimulus in astrocytic tumors and correlate it with histopathological grading. METHODS: We enrolled 99 surgical specimens of supratentorial astrocytic tumors for analysis of VEGF and KIT and subsequent correlation with MVD and grading. RESULTS: KIT and VEGF expression correlated with microvascular density (p<0.005) and both VEGF and microvascular density correlated with grading (p<0.005). KIT had no significant relationship with grading (p=0.657). CONCLUSION: KIT and VEGF constitute important pathways in the angiogenesis of astrocytomas and therefore are promising prognostic tools and options for therapeutic intervention. Glioma Neovascularization, Pathologic Immunohistochemistry Surgery Kleber Simões do Espiríto Santo verfasserin aut Adhemar Longatto Filho verfasserin aut João Norberto Stavale verfasserin aut In Acta Cirúrgica Brasileira Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, 2004 28(2013), 1, Seite 48-54 (DE-627)320500519 (DE-600)2012156-8 16782674 nnns volume:28 year:2013 number:1 pages:48-54 https://doi.org/10.1590/S0102-86502013000100008 kostenfrei https://doaj.org/article/53df521b01b944acb00a61c7c6de6ba4 kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502013000100008&tlng=en kostenfrei http://www.scielo.br/pdf/acb/v28n1/v28n1a08.pdf kostenfrei https://doaj.org/toc/0102-8650 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 28 2013 1 48-54 |
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10.1590/S0102-86502013000100008 doi (DE-627)DOAJ01802694X (DE-599)DOAJ53df521b01b944acb00a61c7c6de6ba4 DE-627 ger DE-627 rakwb eng RD1-811 Thaís Heinke verfasserin aut Vascular endothelial growth factor and KIT expression in relation with microvascular density and tumor grade in supratentorial astrocytic tumors 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier PURPOSE: To evaluate the relationship between microvascular density and the expression of vascular endothelial growth factor (VEGF) and KIT as possible markers of angiogenic stimulus in astrocytic tumors and correlate it with histopathological grading. METHODS: We enrolled 99 surgical specimens of supratentorial astrocytic tumors for analysis of VEGF and KIT and subsequent correlation with MVD and grading. RESULTS: KIT and VEGF expression correlated with microvascular density (p<0.005) and both VEGF and microvascular density correlated with grading (p<0.005). KIT had no significant relationship with grading (p=0.657). CONCLUSION: KIT and VEGF constitute important pathways in the angiogenesis of astrocytomas and therefore are promising prognostic tools and options for therapeutic intervention. Glioma Neovascularization, Pathologic Immunohistochemistry Surgery Kleber Simões do Espiríto Santo verfasserin aut Adhemar Longatto Filho verfasserin aut João Norberto Stavale verfasserin aut In Acta Cirúrgica Brasileira Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, 2004 28(2013), 1, Seite 48-54 (DE-627)320500519 (DE-600)2012156-8 16782674 nnns volume:28 year:2013 number:1 pages:48-54 https://doi.org/10.1590/S0102-86502013000100008 kostenfrei https://doaj.org/article/53df521b01b944acb00a61c7c6de6ba4 kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502013000100008&tlng=en kostenfrei http://www.scielo.br/pdf/acb/v28n1/v28n1a08.pdf kostenfrei https://doaj.org/toc/0102-8650 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 28 2013 1 48-54 |
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10.1590/S0102-86502013000100008 doi (DE-627)DOAJ01802694X (DE-599)DOAJ53df521b01b944acb00a61c7c6de6ba4 DE-627 ger DE-627 rakwb eng RD1-811 Thaís Heinke verfasserin aut Vascular endothelial growth factor and KIT expression in relation with microvascular density and tumor grade in supratentorial astrocytic tumors 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier PURPOSE: To evaluate the relationship between microvascular density and the expression of vascular endothelial growth factor (VEGF) and KIT as possible markers of angiogenic stimulus in astrocytic tumors and correlate it with histopathological grading. METHODS: We enrolled 99 surgical specimens of supratentorial astrocytic tumors for analysis of VEGF and KIT and subsequent correlation with MVD and grading. RESULTS: KIT and VEGF expression correlated with microvascular density (p<0.005) and both VEGF and microvascular density correlated with grading (p<0.005). KIT had no significant relationship with grading (p=0.657). CONCLUSION: KIT and VEGF constitute important pathways in the angiogenesis of astrocytomas and therefore are promising prognostic tools and options for therapeutic intervention. Glioma Neovascularization, Pathologic Immunohistochemistry Surgery Kleber Simões do Espiríto Santo verfasserin aut Adhemar Longatto Filho verfasserin aut João Norberto Stavale verfasserin aut In Acta Cirúrgica Brasileira Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, 2004 28(2013), 1, Seite 48-54 (DE-627)320500519 (DE-600)2012156-8 16782674 nnns volume:28 year:2013 number:1 pages:48-54 https://doi.org/10.1590/S0102-86502013000100008 kostenfrei https://doaj.org/article/53df521b01b944acb00a61c7c6de6ba4 kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502013000100008&tlng=en kostenfrei http://www.scielo.br/pdf/acb/v28n1/v28n1a08.pdf kostenfrei https://doaj.org/toc/0102-8650 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 28 2013 1 48-54 |
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10.1590/S0102-86502013000100008 doi (DE-627)DOAJ01802694X (DE-599)DOAJ53df521b01b944acb00a61c7c6de6ba4 DE-627 ger DE-627 rakwb eng RD1-811 Thaís Heinke verfasserin aut Vascular endothelial growth factor and KIT expression in relation with microvascular density and tumor grade in supratentorial astrocytic tumors 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier PURPOSE: To evaluate the relationship between microvascular density and the expression of vascular endothelial growth factor (VEGF) and KIT as possible markers of angiogenic stimulus in astrocytic tumors and correlate it with histopathological grading. METHODS: We enrolled 99 surgical specimens of supratentorial astrocytic tumors for analysis of VEGF and KIT and subsequent correlation with MVD and grading. RESULTS: KIT and VEGF expression correlated with microvascular density (p<0.005) and both VEGF and microvascular density correlated with grading (p<0.005). KIT had no significant relationship with grading (p=0.657). CONCLUSION: KIT and VEGF constitute important pathways in the angiogenesis of astrocytomas and therefore are promising prognostic tools and options for therapeutic intervention. Glioma Neovascularization, Pathologic Immunohistochemistry Surgery Kleber Simões do Espiríto Santo verfasserin aut Adhemar Longatto Filho verfasserin aut João Norberto Stavale verfasserin aut In Acta Cirúrgica Brasileira Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, 2004 28(2013), 1, Seite 48-54 (DE-627)320500519 (DE-600)2012156-8 16782674 nnns volume:28 year:2013 number:1 pages:48-54 https://doi.org/10.1590/S0102-86502013000100008 kostenfrei https://doaj.org/article/53df521b01b944acb00a61c7c6de6ba4 kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502013000100008&tlng=en kostenfrei http://www.scielo.br/pdf/acb/v28n1/v28n1a08.pdf kostenfrei https://doaj.org/toc/0102-8650 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 28 2013 1 48-54 |
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10.1590/S0102-86502013000100008 doi (DE-627)DOAJ01802694X (DE-599)DOAJ53df521b01b944acb00a61c7c6de6ba4 DE-627 ger DE-627 rakwb eng RD1-811 Thaís Heinke verfasserin aut Vascular endothelial growth factor and KIT expression in relation with microvascular density and tumor grade in supratentorial astrocytic tumors 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier PURPOSE: To evaluate the relationship between microvascular density and the expression of vascular endothelial growth factor (VEGF) and KIT as possible markers of angiogenic stimulus in astrocytic tumors and correlate it with histopathological grading. METHODS: We enrolled 99 surgical specimens of supratentorial astrocytic tumors for analysis of VEGF and KIT and subsequent correlation with MVD and grading. RESULTS: KIT and VEGF expression correlated with microvascular density (p<0.005) and both VEGF and microvascular density correlated with grading (p<0.005). KIT had no significant relationship with grading (p=0.657). CONCLUSION: KIT and VEGF constitute important pathways in the angiogenesis of astrocytomas and therefore are promising prognostic tools and options for therapeutic intervention. Glioma Neovascularization, Pathologic Immunohistochemistry Surgery Kleber Simões do Espiríto Santo verfasserin aut Adhemar Longatto Filho verfasserin aut João Norberto Stavale verfasserin aut In Acta Cirúrgica Brasileira Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, 2004 28(2013), 1, Seite 48-54 (DE-627)320500519 (DE-600)2012156-8 16782674 nnns volume:28 year:2013 number:1 pages:48-54 https://doi.org/10.1590/S0102-86502013000100008 kostenfrei https://doaj.org/article/53df521b01b944acb00a61c7c6de6ba4 kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502013000100008&tlng=en kostenfrei http://www.scielo.br/pdf/acb/v28n1/v28n1a08.pdf kostenfrei https://doaj.org/toc/0102-8650 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 28 2013 1 48-54 |
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Vascular endothelial growth factor and KIT expression in relation with microvascular density and tumor grade in supratentorial astrocytic tumors |
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PURPOSE: To evaluate the relationship between microvascular density and the expression of vascular endothelial growth factor (VEGF) and KIT as possible markers of angiogenic stimulus in astrocytic tumors and correlate it with histopathological grading. METHODS: We enrolled 99 surgical specimens of supratentorial astrocytic tumors for analysis of VEGF and KIT and subsequent correlation with MVD and grading. RESULTS: KIT and VEGF expression correlated with microvascular density (p<0.005) and both VEGF and microvascular density correlated with grading (p<0.005). KIT had no significant relationship with grading (p=0.657). CONCLUSION: KIT and VEGF constitute important pathways in the angiogenesis of astrocytomas and therefore are promising prognostic tools and options for therapeutic intervention. |
abstractGer |
PURPOSE: To evaluate the relationship between microvascular density and the expression of vascular endothelial growth factor (VEGF) and KIT as possible markers of angiogenic stimulus in astrocytic tumors and correlate it with histopathological grading. METHODS: We enrolled 99 surgical specimens of supratentorial astrocytic tumors for analysis of VEGF and KIT and subsequent correlation with MVD and grading. RESULTS: KIT and VEGF expression correlated with microvascular density (p<0.005) and both VEGF and microvascular density correlated with grading (p<0.005). KIT had no significant relationship with grading (p=0.657). CONCLUSION: KIT and VEGF constitute important pathways in the angiogenesis of astrocytomas and therefore are promising prognostic tools and options for therapeutic intervention. |
abstract_unstemmed |
PURPOSE: To evaluate the relationship between microvascular density and the expression of vascular endothelial growth factor (VEGF) and KIT as possible markers of angiogenic stimulus in astrocytic tumors and correlate it with histopathological grading. METHODS: We enrolled 99 surgical specimens of supratentorial astrocytic tumors for analysis of VEGF and KIT and subsequent correlation with MVD and grading. RESULTS: KIT and VEGF expression correlated with microvascular density (p<0.005) and both VEGF and microvascular density correlated with grading (p<0.005). KIT had no significant relationship with grading (p=0.657). CONCLUSION: KIT and VEGF constitute important pathways in the angiogenesis of astrocytomas and therefore are promising prognostic tools and options for therapeutic intervention. |
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