Early Relief of Pruritus in Atopic Dermatitis with Crisaborole Ointment, A Non-steroidal, Phosphodiesterase 4 Inhibitor

Pruritus occurs in all patients with atopic dermatitis and requires quick relief to reduce disease exacerbation and improve quality of life. Crisaborole ointment is a non-steroidal phosphodiesterase 4 inhibitor for the treatment of mild-to-moderate atopic dermatitis. This post hoc analysis explores...
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Autor*in:	Gil Yosipovitch [verfasserIn] Linda F. Gold [verfasserIn] Mark G. Lebwohl [verfasserIn] Jonathan I. Silverberg [verfasserIn] Anna M. Tallman [verfasserIn] Lee T. Zane [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	atopicdermatitis pruritus crisaborole phosphodiesterase4inhibitor

Übergeordnetes Werk:	In: Acta Dermato-Venereologica - Medical Journals Sweden, 2011, 98(2018), 5, Seite 484-489
Übergeordnetes Werk:	volume:98 ; year:2018 ; number:5 ; pages:484-489

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.2340/00015555-2893

Katalog-ID:	DOAJ018114709

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allfields	10.2340/00015555-2893 doi (DE-627)DOAJ018114709 (DE-599)DOAJef1a41c9d0db41ec90ed6c2c7d0cc965 DE-627 ger DE-627 rakwb eng RL1-803 Gil Yosipovitch verfasserin aut Early Relief of Pruritus in Atopic Dermatitis with Crisaborole Ointment, A Non-steroidal, Phosphodiesterase 4 Inhibitor 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Pruritus occurs in all patients with atopic dermatitis and requires quick relief to reduce disease exacerbation and improve quality of life. Crisaborole ointment is a non-steroidal phosphodiesterase 4 inhibitor for the treatment of mild-to-moderate atopic dermatitis. This post hoc analysis explores crisaborole ointment for early relief of pruritus in patients with mild to moderate atopic dermatitis from 2 phase III studies. Patients received crisaborole or vehicle twice daily for 28 days. Pruritus was graded on a 4-point scale of none (0) to severe (3). Early improvement in pruritus required a score of none (0) or mild (1), with a ≥ 1-grade improvement from baseline on day 6. Significantly more patients experienced early improvement in pruritus with crisaborole than with vehicle (56.6% vs 39.5%; p <0.001), including at earliest assessment (day 2, 34.3% vs 27.3%; p = 0.013). Crisaborole is a topical treatment option that can rapidly relieve atopic dermatitis-associated pruritus. atopicdermatitis pruritus crisaborole phosphodiesterase4inhibitor Dermatology Linda F. Gold verfasserin aut Mark G. Lebwohl verfasserin aut Jonathan I. Silverberg verfasserin aut Anna M. Tallman verfasserin aut Lee T. Zane verfasserin aut In Acta Dermato-Venereologica Medical Journals Sweden, 2011 98(2018), 5, Seite 484-489 (DE-627)302725431 (DE-600)1492617-9 16512057 nnns volume:98 year:2018 number:5 pages:484-489 https://doi.org/10.2340/00015555-2893 kostenfrei https://doaj.org/article/ef1a41c9d0db41ec90ed6c2c7d0cc965 kostenfrei https://www.medicaljournals.se/acta/content/html/10.2340/00015555-2893 kostenfrei https://doaj.org/toc/0001-5555 Journal toc kostenfrei https://doaj.org/toc/1651-2057 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 98 2018 5 484-489
spelling	10.2340/00015555-2893 doi (DE-627)DOAJ018114709 (DE-599)DOAJef1a41c9d0db41ec90ed6c2c7d0cc965 DE-627 ger DE-627 rakwb eng RL1-803 Gil Yosipovitch verfasserin aut Early Relief of Pruritus in Atopic Dermatitis with Crisaborole Ointment, A Non-steroidal, Phosphodiesterase 4 Inhibitor 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Pruritus occurs in all patients with atopic dermatitis and requires quick relief to reduce disease exacerbation and improve quality of life. Crisaborole ointment is a non-steroidal phosphodiesterase 4 inhibitor for the treatment of mild-to-moderate atopic dermatitis. This post hoc analysis explores crisaborole ointment for early relief of pruritus in patients with mild to moderate atopic dermatitis from 2 phase III studies. Patients received crisaborole or vehicle twice daily for 28 days. Pruritus was graded on a 4-point scale of none (0) to severe (3). Early improvement in pruritus required a score of none (0) or mild (1), with a ≥ 1-grade improvement from baseline on day 6. Significantly more patients experienced early improvement in pruritus with crisaborole than with vehicle (56.6% vs 39.5%; p <0.001), including at earliest assessment (day 2, 34.3% vs 27.3%; p = 0.013). Crisaborole is a topical treatment option that can rapidly relieve atopic dermatitis-associated pruritus. atopicdermatitis pruritus crisaborole phosphodiesterase4inhibitor Dermatology Linda F. Gold verfasserin aut Mark G. Lebwohl verfasserin aut Jonathan I. Silverberg verfasserin aut Anna M. Tallman verfasserin aut Lee T. Zane verfasserin aut In Acta Dermato-Venereologica Medical Journals Sweden, 2011 98(2018), 5, Seite 484-489 (DE-627)302725431 (DE-600)1492617-9 16512057 nnns volume:98 year:2018 number:5 pages:484-489 https://doi.org/10.2340/00015555-2893 kostenfrei https://doaj.org/article/ef1a41c9d0db41ec90ed6c2c7d0cc965 kostenfrei https://www.medicaljournals.se/acta/content/html/10.2340/00015555-2893 kostenfrei https://doaj.org/toc/0001-5555 Journal toc kostenfrei https://doaj.org/toc/1651-2057 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 98 2018 5 484-489
allfields_unstemmed	10.2340/00015555-2893 doi (DE-627)DOAJ018114709 (DE-599)DOAJef1a41c9d0db41ec90ed6c2c7d0cc965 DE-627 ger DE-627 rakwb eng RL1-803 Gil Yosipovitch verfasserin aut Early Relief of Pruritus in Atopic Dermatitis with Crisaborole Ointment, A Non-steroidal, Phosphodiesterase 4 Inhibitor 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Pruritus occurs in all patients with atopic dermatitis and requires quick relief to reduce disease exacerbation and improve quality of life. Crisaborole ointment is a non-steroidal phosphodiesterase 4 inhibitor for the treatment of mild-to-moderate atopic dermatitis. This post hoc analysis explores crisaborole ointment for early relief of pruritus in patients with mild to moderate atopic dermatitis from 2 phase III studies. Patients received crisaborole or vehicle twice daily for 28 days. Pruritus was graded on a 4-point scale of none (0) to severe (3). Early improvement in pruritus required a score of none (0) or mild (1), with a ≥ 1-grade improvement from baseline on day 6. Significantly more patients experienced early improvement in pruritus with crisaborole than with vehicle (56.6% vs 39.5%; p <0.001), including at earliest assessment (day 2, 34.3% vs 27.3%; p = 0.013). Crisaborole is a topical treatment option that can rapidly relieve atopic dermatitis-associated pruritus. atopicdermatitis pruritus crisaborole phosphodiesterase4inhibitor Dermatology Linda F. Gold verfasserin aut Mark G. Lebwohl verfasserin aut Jonathan I. Silverberg verfasserin aut Anna M. Tallman verfasserin aut Lee T. Zane verfasserin aut In Acta Dermato-Venereologica Medical Journals Sweden, 2011 98(2018), 5, Seite 484-489 (DE-627)302725431 (DE-600)1492617-9 16512057 nnns volume:98 year:2018 number:5 pages:484-489 https://doi.org/10.2340/00015555-2893 kostenfrei https://doaj.org/article/ef1a41c9d0db41ec90ed6c2c7d0cc965 kostenfrei https://www.medicaljournals.se/acta/content/html/10.2340/00015555-2893 kostenfrei https://doaj.org/toc/0001-5555 Journal toc kostenfrei https://doaj.org/toc/1651-2057 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 98 2018 5 484-489
allfieldsGer	10.2340/00015555-2893 doi (DE-627)DOAJ018114709 (DE-599)DOAJef1a41c9d0db41ec90ed6c2c7d0cc965 DE-627 ger DE-627 rakwb eng RL1-803 Gil Yosipovitch verfasserin aut Early Relief of Pruritus in Atopic Dermatitis with Crisaborole Ointment, A Non-steroidal, Phosphodiesterase 4 Inhibitor 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Pruritus occurs in all patients with atopic dermatitis and requires quick relief to reduce disease exacerbation and improve quality of life. Crisaborole ointment is a non-steroidal phosphodiesterase 4 inhibitor for the treatment of mild-to-moderate atopic dermatitis. This post hoc analysis explores crisaborole ointment for early relief of pruritus in patients with mild to moderate atopic dermatitis from 2 phase III studies. Patients received crisaborole or vehicle twice daily for 28 days. Pruritus was graded on a 4-point scale of none (0) to severe (3). Early improvement in pruritus required a score of none (0) or mild (1), with a ≥ 1-grade improvement from baseline on day 6. Significantly more patients experienced early improvement in pruritus with crisaborole than with vehicle (56.6% vs 39.5%; p <0.001), including at earliest assessment (day 2, 34.3% vs 27.3%; p = 0.013). Crisaborole is a topical treatment option that can rapidly relieve atopic dermatitis-associated pruritus. atopicdermatitis pruritus crisaborole phosphodiesterase4inhibitor Dermatology Linda F. Gold verfasserin aut Mark G. Lebwohl verfasserin aut Jonathan I. Silverberg verfasserin aut Anna M. Tallman verfasserin aut Lee T. Zane verfasserin aut In Acta Dermato-Venereologica Medical Journals Sweden, 2011 98(2018), 5, Seite 484-489 (DE-627)302725431 (DE-600)1492617-9 16512057 nnns volume:98 year:2018 number:5 pages:484-489 https://doi.org/10.2340/00015555-2893 kostenfrei https://doaj.org/article/ef1a41c9d0db41ec90ed6c2c7d0cc965 kostenfrei https://www.medicaljournals.se/acta/content/html/10.2340/00015555-2893 kostenfrei https://doaj.org/toc/0001-5555 Journal toc kostenfrei https://doaj.org/toc/1651-2057 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 98 2018 5 484-489
allfieldsSound	10.2340/00015555-2893 doi (DE-627)DOAJ018114709 (DE-599)DOAJef1a41c9d0db41ec90ed6c2c7d0cc965 DE-627 ger DE-627 rakwb eng RL1-803 Gil Yosipovitch verfasserin aut Early Relief of Pruritus in Atopic Dermatitis with Crisaborole Ointment, A Non-steroidal, Phosphodiesterase 4 Inhibitor 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Pruritus occurs in all patients with atopic dermatitis and requires quick relief to reduce disease exacerbation and improve quality of life. Crisaborole ointment is a non-steroidal phosphodiesterase 4 inhibitor for the treatment of mild-to-moderate atopic dermatitis. This post hoc analysis explores crisaborole ointment for early relief of pruritus in patients with mild to moderate atopic dermatitis from 2 phase III studies. Patients received crisaborole or vehicle twice daily for 28 days. Pruritus was graded on a 4-point scale of none (0) to severe (3). Early improvement in pruritus required a score of none (0) or mild (1), with a ≥ 1-grade improvement from baseline on day 6. Significantly more patients experienced early improvement in pruritus with crisaborole than with vehicle (56.6% vs 39.5%; p <0.001), including at earliest assessment (day 2, 34.3% vs 27.3%; p = 0.013). Crisaborole is a topical treatment option that can rapidly relieve atopic dermatitis-associated pruritus. atopicdermatitis pruritus crisaborole phosphodiesterase4inhibitor Dermatology Linda F. Gold verfasserin aut Mark G. Lebwohl verfasserin aut Jonathan I. Silverberg verfasserin aut Anna M. Tallman verfasserin aut Lee T. Zane verfasserin aut In Acta Dermato-Venereologica Medical Journals Sweden, 2011 98(2018), 5, Seite 484-489 (DE-627)302725431 (DE-600)1492617-9 16512057 nnns volume:98 year:2018 number:5 pages:484-489 https://doi.org/10.2340/00015555-2893 kostenfrei https://doaj.org/article/ef1a41c9d0db41ec90ed6c2c7d0cc965 kostenfrei https://www.medicaljournals.se/acta/content/html/10.2340/00015555-2893 kostenfrei https://doaj.org/toc/0001-5555 Journal toc kostenfrei https://doaj.org/toc/1651-2057 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 98 2018 5 484-489
language	English
source	In Acta Dermato-Venereologica 98(2018), 5, Seite 484-489 volume:98 year:2018 number:5 pages:484-489
sourceStr	In Acta Dermato-Venereologica 98(2018), 5, Seite 484-489 volume:98 year:2018 number:5 pages:484-489
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	atopicdermatitis pruritus crisaborole phosphodiesterase4inhibitor Dermatology
isfreeaccess_bool	true
container_title	Acta Dermato-Venereologica
authorswithroles_txt_mv	Gil Yosipovitch @@aut@@ Linda F. Gold @@aut@@ Mark G. Lebwohl @@aut@@ Jonathan I. Silverberg @@aut@@ Anna M. Tallman @@aut@@ Lee T. Zane @@aut@@
publishDateDaySort_date	2018-01-01T00:00:00Z
hierarchy_top_id	302725431
id	DOAJ018114709
language_de	englisch
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callnumber-first	R - Medicine
author	Gil Yosipovitch
spellingShingle	Gil Yosipovitch misc RL1-803 misc atopicdermatitis misc pruritus misc crisaborole misc phosphodiesterase4inhibitor misc Dermatology Early Relief of Pruritus in Atopic Dermatitis with Crisaborole Ointment, A Non-steroidal, Phosphodiesterase 4 Inhibitor
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topic_title	RL1-803 Early Relief of Pruritus in Atopic Dermatitis with Crisaborole Ointment, A Non-steroidal, Phosphodiesterase 4 Inhibitor atopicdermatitis pruritus crisaborole phosphodiesterase4inhibitor
topic	misc RL1-803 misc atopicdermatitis misc pruritus misc crisaborole misc phosphodiesterase4inhibitor misc Dermatology
topic_unstemmed	misc RL1-803 misc atopicdermatitis misc pruritus misc crisaborole misc phosphodiesterase4inhibitor misc Dermatology
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title	Early Relief of Pruritus in Atopic Dermatitis with Crisaborole Ointment, A Non-steroidal, Phosphodiesterase 4 Inhibitor
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title_full	Early Relief of Pruritus in Atopic Dermatitis with Crisaborole Ointment, A Non-steroidal, Phosphodiesterase 4 Inhibitor
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author_browse	Gil Yosipovitch Linda F. Gold Mark G. Lebwohl Jonathan I. Silverberg Anna M. Tallman Lee T. Zane
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title_sort	early relief of pruritus in atopic dermatitis with crisaborole ointment, a non-steroidal, phosphodiesterase 4 inhibitor
callnumber	RL1-803
title_auth	Early Relief of Pruritus in Atopic Dermatitis with Crisaborole Ointment, A Non-steroidal, Phosphodiesterase 4 Inhibitor
abstract	Pruritus occurs in all patients with atopic dermatitis and requires quick relief to reduce disease exacerbation and improve quality of life. Crisaborole ointment is a non-steroidal phosphodiesterase 4 inhibitor for the treatment of mild-to-moderate atopic dermatitis. This post hoc analysis explores crisaborole ointment for early relief of pruritus in patients with mild to moderate atopic dermatitis from 2 phase III studies. Patients received crisaborole or vehicle twice daily for 28 days. Pruritus was graded on a 4-point scale of none (0) to severe (3). Early improvement in pruritus required a score of none (0) or mild (1), with a ≥ 1-grade improvement from baseline on day 6. Significantly more patients experienced early improvement in pruritus with crisaborole than with vehicle (56.6% vs 39.5%; p <0.001), including at earliest assessment (day 2, 34.3% vs 27.3%; p = 0.013). Crisaborole is a topical treatment option that can rapidly relieve atopic dermatitis-associated pruritus.
abstractGer	Pruritus occurs in all patients with atopic dermatitis and requires quick relief to reduce disease exacerbation and improve quality of life. Crisaborole ointment is a non-steroidal phosphodiesterase 4 inhibitor for the treatment of mild-to-moderate atopic dermatitis. This post hoc analysis explores crisaborole ointment for early relief of pruritus in patients with mild to moderate atopic dermatitis from 2 phase III studies. Patients received crisaborole or vehicle twice daily for 28 days. Pruritus was graded on a 4-point scale of none (0) to severe (3). Early improvement in pruritus required a score of none (0) or mild (1), with a ≥ 1-grade improvement from baseline on day 6. Significantly more patients experienced early improvement in pruritus with crisaborole than with vehicle (56.6% vs 39.5%; p <0.001), including at earliest assessment (day 2, 34.3% vs 27.3%; p = 0.013). Crisaborole is a topical treatment option that can rapidly relieve atopic dermatitis-associated pruritus.
abstract_unstemmed	Pruritus occurs in all patients with atopic dermatitis and requires quick relief to reduce disease exacerbation and improve quality of life. Crisaborole ointment is a non-steroidal phosphodiesterase 4 inhibitor for the treatment of mild-to-moderate atopic dermatitis. This post hoc analysis explores crisaborole ointment for early relief of pruritus in patients with mild to moderate atopic dermatitis from 2 phase III studies. Patients received crisaborole or vehicle twice daily for 28 days. Pruritus was graded on a 4-point scale of none (0) to severe (3). Early improvement in pruritus required a score of none (0) or mild (1), with a ≥ 1-grade improvement from baseline on day 6. Significantly more patients experienced early improvement in pruritus with crisaborole than with vehicle (56.6% vs 39.5%; p <0.001), including at earliest assessment (day 2, 34.3% vs 27.3%; p = 0.013). Crisaborole is a topical treatment option that can rapidly relieve atopic dermatitis-associated pruritus.
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title_short	Early Relief of Pruritus in Atopic Dermatitis with Crisaborole Ointment, A Non-steroidal, Phosphodiesterase 4 Inhibitor
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