Perlecan-targeted nanoparticles for drug delivery to triple-negative breast cancer

Aim: We previously developed two antibodies that bind to a cell surface protein, perlecan, overexpressed in triple-negative breast cancer (TNBC). The goal of this study was to investigate these antibodies as targeting ligands for nanoparticle-mediated drug delivery. Methods: Paclitaxel-loaded poly(D...
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Gespeichert in:

Autor*in:	Vidhi Khanna [verfasserIn] Stephen Kalscheuer [verfasserIn] Ameya Kirtane [verfasserIn] Wenqiu Zhang [verfasserIn] Jayanth Panyam [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	antibody perlecan polymeric nanoparticles targeted drug delivery triple-negative breast cancer

Übergeordnetes Werk:	In: Future Drug Discovery - Future Science Ltd, 2021, 1(2019), 1
Übergeordnetes Werk:	volume:1 ; year:2019 ; number:1

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.4155/fdd-2019-0005

Katalog-ID:	DOAJ018156940

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520			\|a Aim: We previously developed two antibodies that bind to a cell surface protein, perlecan, overexpressed in triple-negative breast cancer (TNBC). The goal of this study was to investigate these antibodies as targeting ligands for nanoparticle-mediated drug delivery. Methods: Paclitaxel-loaded poly(D,L-lactide-co-glycolide) nanoparticles were functionalized with antibodies using thiol–maleimide chemistry. Effect of antibody functionalization on therapeutic efficacy of drug-loaded nanoparticles was investigated using in vitro and in vivo models of TNBC. Results: The antibodies were covalently conjugated to nanoparticles without affecting antibody binding affinity or nanoparticle properties. Perlecan-targeted nanoparticles showed improved cell uptake, retention, cytotoxicity in vitro and enhanced tumor growth inhibition in vivo. Conclusion: The data presented here indicates that perlecan-targeted nanoparticles can improve tumor drug delivery to TNBC.
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spelling	10.4155/fdd-2019-0005 doi (DE-627)DOAJ018156940 (DE-599)DOAJfed46dc7e368456fb067112c542cf48b DE-627 ger DE-627 rakwb eng RS1-441 Vidhi Khanna verfasserin aut Perlecan-targeted nanoparticles for drug delivery to triple-negative breast cancer 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aim: We previously developed two antibodies that bind to a cell surface protein, perlecan, overexpressed in triple-negative breast cancer (TNBC). The goal of this study was to investigate these antibodies as targeting ligands for nanoparticle-mediated drug delivery. Methods: Paclitaxel-loaded poly(D,L-lactide-co-glycolide) nanoparticles were functionalized with antibodies using thiol–maleimide chemistry. Effect of antibody functionalization on therapeutic efficacy of drug-loaded nanoparticles was investigated using in vitro and in vivo models of TNBC. Results: The antibodies were covalently conjugated to nanoparticles without affecting antibody binding affinity or nanoparticle properties. Perlecan-targeted nanoparticles showed improved cell uptake, retention, cytotoxicity in vitro and enhanced tumor growth inhibition in vivo. Conclusion: The data presented here indicates that perlecan-targeted nanoparticles can improve tumor drug delivery to TNBC. antibody perlecan polymeric nanoparticles targeted drug delivery triple-negative breast cancer Pharmacy and materia medica Stephen Kalscheuer verfasserin aut Ameya Kirtane verfasserin aut Wenqiu Zhang verfasserin aut Jayanth Panyam verfasserin aut In Future Drug Discovery Future Science Ltd, 2021 1(2019), 1 (DE-627)1760793973 26313316 nnns volume:1 year:2019 number:1 https://doi.org/10.4155/fdd-2019-0005 kostenfrei https://doaj.org/article/fed46dc7e368456fb067112c542cf48b kostenfrei https://www.future-science.com/doi/10.4155/fdd-2019-0005 kostenfrei https://doaj.org/toc/2631-3316 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2019 1
allfields_unstemmed	10.4155/fdd-2019-0005 doi (DE-627)DOAJ018156940 (DE-599)DOAJfed46dc7e368456fb067112c542cf48b DE-627 ger DE-627 rakwb eng RS1-441 Vidhi Khanna verfasserin aut Perlecan-targeted nanoparticles for drug delivery to triple-negative breast cancer 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aim: We previously developed two antibodies that bind to a cell surface protein, perlecan, overexpressed in triple-negative breast cancer (TNBC). The goal of this study was to investigate these antibodies as targeting ligands for nanoparticle-mediated drug delivery. Methods: Paclitaxel-loaded poly(D,L-lactide-co-glycolide) nanoparticles were functionalized with antibodies using thiol–maleimide chemistry. Effect of antibody functionalization on therapeutic efficacy of drug-loaded nanoparticles was investigated using in vitro and in vivo models of TNBC. Results: The antibodies were covalently conjugated to nanoparticles without affecting antibody binding affinity or nanoparticle properties. Perlecan-targeted nanoparticles showed improved cell uptake, retention, cytotoxicity in vitro and enhanced tumor growth inhibition in vivo. Conclusion: The data presented here indicates that perlecan-targeted nanoparticles can improve tumor drug delivery to TNBC. antibody perlecan polymeric nanoparticles targeted drug delivery triple-negative breast cancer Pharmacy and materia medica Stephen Kalscheuer verfasserin aut Ameya Kirtane verfasserin aut Wenqiu Zhang verfasserin aut Jayanth Panyam verfasserin aut In Future Drug Discovery Future Science Ltd, 2021 1(2019), 1 (DE-627)1760793973 26313316 nnns volume:1 year:2019 number:1 https://doi.org/10.4155/fdd-2019-0005 kostenfrei https://doaj.org/article/fed46dc7e368456fb067112c542cf48b kostenfrei https://www.future-science.com/doi/10.4155/fdd-2019-0005 kostenfrei https://doaj.org/toc/2631-3316 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2019 1
allfieldsGer	10.4155/fdd-2019-0005 doi (DE-627)DOAJ018156940 (DE-599)DOAJfed46dc7e368456fb067112c542cf48b DE-627 ger DE-627 rakwb eng RS1-441 Vidhi Khanna verfasserin aut Perlecan-targeted nanoparticles for drug delivery to triple-negative breast cancer 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aim: We previously developed two antibodies that bind to a cell surface protein, perlecan, overexpressed in triple-negative breast cancer (TNBC). The goal of this study was to investigate these antibodies as targeting ligands for nanoparticle-mediated drug delivery. Methods: Paclitaxel-loaded poly(D,L-lactide-co-glycolide) nanoparticles were functionalized with antibodies using thiol–maleimide chemistry. Effect of antibody functionalization on therapeutic efficacy of drug-loaded nanoparticles was investigated using in vitro and in vivo models of TNBC. Results: The antibodies were covalently conjugated to nanoparticles without affecting antibody binding affinity or nanoparticle properties. Perlecan-targeted nanoparticles showed improved cell uptake, retention, cytotoxicity in vitro and enhanced tumor growth inhibition in vivo. Conclusion: The data presented here indicates that perlecan-targeted nanoparticles can improve tumor drug delivery to TNBC. antibody perlecan polymeric nanoparticles targeted drug delivery triple-negative breast cancer Pharmacy and materia medica Stephen Kalscheuer verfasserin aut Ameya Kirtane verfasserin aut Wenqiu Zhang verfasserin aut Jayanth Panyam verfasserin aut In Future Drug Discovery Future Science Ltd, 2021 1(2019), 1 (DE-627)1760793973 26313316 nnns volume:1 year:2019 number:1 https://doi.org/10.4155/fdd-2019-0005 kostenfrei https://doaj.org/article/fed46dc7e368456fb067112c542cf48b kostenfrei https://www.future-science.com/doi/10.4155/fdd-2019-0005 kostenfrei https://doaj.org/toc/2631-3316 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2019 1
allfieldsSound	10.4155/fdd-2019-0005 doi (DE-627)DOAJ018156940 (DE-599)DOAJfed46dc7e368456fb067112c542cf48b DE-627 ger DE-627 rakwb eng RS1-441 Vidhi Khanna verfasserin aut Perlecan-targeted nanoparticles for drug delivery to triple-negative breast cancer 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aim: We previously developed two antibodies that bind to a cell surface protein, perlecan, overexpressed in triple-negative breast cancer (TNBC). The goal of this study was to investigate these antibodies as targeting ligands for nanoparticle-mediated drug delivery. Methods: Paclitaxel-loaded poly(D,L-lactide-co-glycolide) nanoparticles were functionalized with antibodies using thiol–maleimide chemistry. Effect of antibody functionalization on therapeutic efficacy of drug-loaded nanoparticles was investigated using in vitro and in vivo models of TNBC. Results: The antibodies were covalently conjugated to nanoparticles without affecting antibody binding affinity or nanoparticle properties. Perlecan-targeted nanoparticles showed improved cell uptake, retention, cytotoxicity in vitro and enhanced tumor growth inhibition in vivo. Conclusion: The data presented here indicates that perlecan-targeted nanoparticles can improve tumor drug delivery to TNBC. antibody perlecan polymeric nanoparticles targeted drug delivery triple-negative breast cancer Pharmacy and materia medica Stephen Kalscheuer verfasserin aut Ameya Kirtane verfasserin aut Wenqiu Zhang verfasserin aut Jayanth Panyam verfasserin aut In Future Drug Discovery Future Science Ltd, 2021 1(2019), 1 (DE-627)1760793973 26313316 nnns volume:1 year:2019 number:1 https://doi.org/10.4155/fdd-2019-0005 kostenfrei https://doaj.org/article/fed46dc7e368456fb067112c542cf48b kostenfrei https://www.future-science.com/doi/10.4155/fdd-2019-0005 kostenfrei https://doaj.org/toc/2631-3316 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2019 1
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topic_facet	antibody perlecan polymeric nanoparticles targeted drug delivery triple-negative breast cancer Pharmacy and materia medica
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authorswithroles_txt_mv	Vidhi Khanna @@aut@@ Stephen Kalscheuer @@aut@@ Ameya Kirtane @@aut@@ Wenqiu Zhang @@aut@@ Jayanth Panyam @@aut@@
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callnumber-first	R - Medicine
author	Vidhi Khanna
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topic_title	RS1-441 Perlecan-targeted nanoparticles for drug delivery to triple-negative breast cancer antibody perlecan polymeric nanoparticles targeted drug delivery triple-negative breast cancer
topic	misc RS1-441 misc antibody misc perlecan misc polymeric nanoparticles misc targeted drug delivery misc triple-negative breast cancer misc Pharmacy and materia medica
topic_unstemmed	misc RS1-441 misc antibody misc perlecan misc polymeric nanoparticles misc targeted drug delivery misc triple-negative breast cancer misc Pharmacy and materia medica
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title	Perlecan-targeted nanoparticles for drug delivery to triple-negative breast cancer
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title_full	Perlecan-targeted nanoparticles for drug delivery to triple-negative breast cancer
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title_sort	perlecan-targeted nanoparticles for drug delivery to triple-negative breast cancer
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title_auth	Perlecan-targeted nanoparticles for drug delivery to triple-negative breast cancer
abstract	Aim: We previously developed two antibodies that bind to a cell surface protein, perlecan, overexpressed in triple-negative breast cancer (TNBC). The goal of this study was to investigate these antibodies as targeting ligands for nanoparticle-mediated drug delivery. Methods: Paclitaxel-loaded poly(D,L-lactide-co-glycolide) nanoparticles were functionalized with antibodies using thiol–maleimide chemistry. Effect of antibody functionalization on therapeutic efficacy of drug-loaded nanoparticles was investigated using in vitro and in vivo models of TNBC. Results: The antibodies were covalently conjugated to nanoparticles without affecting antibody binding affinity or nanoparticle properties. Perlecan-targeted nanoparticles showed improved cell uptake, retention, cytotoxicity in vitro and enhanced tumor growth inhibition in vivo. Conclusion: The data presented here indicates that perlecan-targeted nanoparticles can improve tumor drug delivery to TNBC.
abstractGer	Aim: We previously developed two antibodies that bind to a cell surface protein, perlecan, overexpressed in triple-negative breast cancer (TNBC). The goal of this study was to investigate these antibodies as targeting ligands for nanoparticle-mediated drug delivery. Methods: Paclitaxel-loaded poly(D,L-lactide-co-glycolide) nanoparticles were functionalized with antibodies using thiol–maleimide chemistry. Effect of antibody functionalization on therapeutic efficacy of drug-loaded nanoparticles was investigated using in vitro and in vivo models of TNBC. Results: The antibodies were covalently conjugated to nanoparticles without affecting antibody binding affinity or nanoparticle properties. Perlecan-targeted nanoparticles showed improved cell uptake, retention, cytotoxicity in vitro and enhanced tumor growth inhibition in vivo. Conclusion: The data presented here indicates that perlecan-targeted nanoparticles can improve tumor drug delivery to TNBC.
abstract_unstemmed	Aim: We previously developed two antibodies that bind to a cell surface protein, perlecan, overexpressed in triple-negative breast cancer (TNBC). The goal of this study was to investigate these antibodies as targeting ligands for nanoparticle-mediated drug delivery. Methods: Paclitaxel-loaded poly(D,L-lactide-co-glycolide) nanoparticles were functionalized with antibodies using thiol–maleimide chemistry. Effect of antibody functionalization on therapeutic efficacy of drug-loaded nanoparticles was investigated using in vitro and in vivo models of TNBC. Results: The antibodies were covalently conjugated to nanoparticles without affecting antibody binding affinity or nanoparticle properties. Perlecan-targeted nanoparticles showed improved cell uptake, retention, cytotoxicity in vitro and enhanced tumor growth inhibition in vivo. Conclusion: The data presented here indicates that perlecan-targeted nanoparticles can improve tumor drug delivery to TNBC.
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title_short	Perlecan-targeted nanoparticles for drug delivery to triple-negative breast cancer
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