YTHDF1 promotes breast cancer cell growth, DNA damage repair and chemoresistance

Abstract Chemoresistance represents a major obstacle to the treatment of human cancers. Increased DNA repair capacity is one of the important mechanisms underlying chemoresistance. In silico analysis indicated that YTHDF1, an m6A binding protein, is a putative tumor promoter in breast cancer. Loss o...
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Autor*in:	Yu Sun [verfasserIn] Dan Dong [verfasserIn] Yuhong Xia [verfasserIn] Liying Hao [verfasserIn] Wei Wang [verfasserIn] Chenghai Zhao [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Übergeordnetes Werk:	In: Cell Death and Disease - Nature Publishing Group, 2010, 13(2022), 3, Seite 11
Übergeordnetes Werk:	volume:13 ; year:2022 ; number:3 ; pages:11

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1038/s41419-022-04672-5

Katalog-ID:	DOAJ018163963

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allfields	10.1038/s41419-022-04672-5 doi (DE-627)DOAJ018163963 (DE-599)DOAJc70f9966a99040c29796d841b6286abb DE-627 ger DE-627 rakwb eng QH573-671 Yu Sun verfasserin aut YTHDF1 promotes breast cancer cell growth, DNA damage repair and chemoresistance 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Chemoresistance represents a major obstacle to the treatment of human cancers. Increased DNA repair capacity is one of the important mechanisms underlying chemoresistance. In silico analysis indicated that YTHDF1, an m6A binding protein, is a putative tumor promoter in breast cancer. Loss of function studies further showed that YTHDF1 promotes breast cancer cell growth in vitro and in vivo. YTHDF1 facilitates S-phase entry, DNA replication and DNA damage repair, and accordingly YTHDF1 knockdown sensitizes breast cancer cells to Adriamycin and Cisplatin as well as Olaparib, a PARP inhibitor. E2F8 is a target molecule by YTHDF1 which modulates E2F8 mRNA stability and DNA damage repair in a METTL14-dependent manner. These data demonstrate that YTHDF1 has a tumor-promoting role in breast cancer, and is a novel target to overcome chemoresistance. Cytology Dan Dong verfasserin aut Yuhong Xia verfasserin aut Liying Hao verfasserin aut Wei Wang verfasserin aut Chenghai Zhao verfasserin aut In Cell Death and Disease Nature Publishing Group, 2010 13(2022), 3, Seite 11 (DE-627)620145250 (DE-600)2541626-1 20414889 nnns volume:13 year:2022 number:3 pages:11 https://doi.org/10.1038/s41419-022-04672-5 kostenfrei https://doaj.org/article/c70f9966a99040c29796d841b6286abb kostenfrei https://doi.org/10.1038/s41419-022-04672-5 kostenfrei https://doaj.org/toc/2041-4889 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022 3 11
spelling	10.1038/s41419-022-04672-5 doi (DE-627)DOAJ018163963 (DE-599)DOAJc70f9966a99040c29796d841b6286abb DE-627 ger DE-627 rakwb eng QH573-671 Yu Sun verfasserin aut YTHDF1 promotes breast cancer cell growth, DNA damage repair and chemoresistance 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Chemoresistance represents a major obstacle to the treatment of human cancers. Increased DNA repair capacity is one of the important mechanisms underlying chemoresistance. In silico analysis indicated that YTHDF1, an m6A binding protein, is a putative tumor promoter in breast cancer. Loss of function studies further showed that YTHDF1 promotes breast cancer cell growth in vitro and in vivo. YTHDF1 facilitates S-phase entry, DNA replication and DNA damage repair, and accordingly YTHDF1 knockdown sensitizes breast cancer cells to Adriamycin and Cisplatin as well as Olaparib, a PARP inhibitor. E2F8 is a target molecule by YTHDF1 which modulates E2F8 mRNA stability and DNA damage repair in a METTL14-dependent manner. These data demonstrate that YTHDF1 has a tumor-promoting role in breast cancer, and is a novel target to overcome chemoresistance. Cytology Dan Dong verfasserin aut Yuhong Xia verfasserin aut Liying Hao verfasserin aut Wei Wang verfasserin aut Chenghai Zhao verfasserin aut In Cell Death and Disease Nature Publishing Group, 2010 13(2022), 3, Seite 11 (DE-627)620145250 (DE-600)2541626-1 20414889 nnns volume:13 year:2022 number:3 pages:11 https://doi.org/10.1038/s41419-022-04672-5 kostenfrei https://doaj.org/article/c70f9966a99040c29796d841b6286abb kostenfrei https://doi.org/10.1038/s41419-022-04672-5 kostenfrei https://doaj.org/toc/2041-4889 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022 3 11
allfields_unstemmed	10.1038/s41419-022-04672-5 doi (DE-627)DOAJ018163963 (DE-599)DOAJc70f9966a99040c29796d841b6286abb DE-627 ger DE-627 rakwb eng QH573-671 Yu Sun verfasserin aut YTHDF1 promotes breast cancer cell growth, DNA damage repair and chemoresistance 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Chemoresistance represents a major obstacle to the treatment of human cancers. Increased DNA repair capacity is one of the important mechanisms underlying chemoresistance. In silico analysis indicated that YTHDF1, an m6A binding protein, is a putative tumor promoter in breast cancer. Loss of function studies further showed that YTHDF1 promotes breast cancer cell growth in vitro and in vivo. YTHDF1 facilitates S-phase entry, DNA replication and DNA damage repair, and accordingly YTHDF1 knockdown sensitizes breast cancer cells to Adriamycin and Cisplatin as well as Olaparib, a PARP inhibitor. E2F8 is a target molecule by YTHDF1 which modulates E2F8 mRNA stability and DNA damage repair in a METTL14-dependent manner. These data demonstrate that YTHDF1 has a tumor-promoting role in breast cancer, and is a novel target to overcome chemoresistance. Cytology Dan Dong verfasserin aut Yuhong Xia verfasserin aut Liying Hao verfasserin aut Wei Wang verfasserin aut Chenghai Zhao verfasserin aut In Cell Death and Disease Nature Publishing Group, 2010 13(2022), 3, Seite 11 (DE-627)620145250 (DE-600)2541626-1 20414889 nnns volume:13 year:2022 number:3 pages:11 https://doi.org/10.1038/s41419-022-04672-5 kostenfrei https://doaj.org/article/c70f9966a99040c29796d841b6286abb kostenfrei https://doi.org/10.1038/s41419-022-04672-5 kostenfrei https://doaj.org/toc/2041-4889 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022 3 11
allfieldsGer	10.1038/s41419-022-04672-5 doi (DE-627)DOAJ018163963 (DE-599)DOAJc70f9966a99040c29796d841b6286abb DE-627 ger DE-627 rakwb eng QH573-671 Yu Sun verfasserin aut YTHDF1 promotes breast cancer cell growth, DNA damage repair and chemoresistance 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Chemoresistance represents a major obstacle to the treatment of human cancers. Increased DNA repair capacity is one of the important mechanisms underlying chemoresistance. In silico analysis indicated that YTHDF1, an m6A binding protein, is a putative tumor promoter in breast cancer. Loss of function studies further showed that YTHDF1 promotes breast cancer cell growth in vitro and in vivo. YTHDF1 facilitates S-phase entry, DNA replication and DNA damage repair, and accordingly YTHDF1 knockdown sensitizes breast cancer cells to Adriamycin and Cisplatin as well as Olaparib, a PARP inhibitor. E2F8 is a target molecule by YTHDF1 which modulates E2F8 mRNA stability and DNA damage repair in a METTL14-dependent manner. These data demonstrate that YTHDF1 has a tumor-promoting role in breast cancer, and is a novel target to overcome chemoresistance. Cytology Dan Dong verfasserin aut Yuhong Xia verfasserin aut Liying Hao verfasserin aut Wei Wang verfasserin aut Chenghai Zhao verfasserin aut In Cell Death and Disease Nature Publishing Group, 2010 13(2022), 3, Seite 11 (DE-627)620145250 (DE-600)2541626-1 20414889 nnns volume:13 year:2022 number:3 pages:11 https://doi.org/10.1038/s41419-022-04672-5 kostenfrei https://doaj.org/article/c70f9966a99040c29796d841b6286abb kostenfrei https://doi.org/10.1038/s41419-022-04672-5 kostenfrei https://doaj.org/toc/2041-4889 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022 3 11
allfieldsSound	10.1038/s41419-022-04672-5 doi (DE-627)DOAJ018163963 (DE-599)DOAJc70f9966a99040c29796d841b6286abb DE-627 ger DE-627 rakwb eng QH573-671 Yu Sun verfasserin aut YTHDF1 promotes breast cancer cell growth, DNA damage repair and chemoresistance 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Chemoresistance represents a major obstacle to the treatment of human cancers. Increased DNA repair capacity is one of the important mechanisms underlying chemoresistance. In silico analysis indicated that YTHDF1, an m6A binding protein, is a putative tumor promoter in breast cancer. Loss of function studies further showed that YTHDF1 promotes breast cancer cell growth in vitro and in vivo. YTHDF1 facilitates S-phase entry, DNA replication and DNA damage repair, and accordingly YTHDF1 knockdown sensitizes breast cancer cells to Adriamycin and Cisplatin as well as Olaparib, a PARP inhibitor. E2F8 is a target molecule by YTHDF1 which modulates E2F8 mRNA stability and DNA damage repair in a METTL14-dependent manner. These data demonstrate that YTHDF1 has a tumor-promoting role in breast cancer, and is a novel target to overcome chemoresistance. Cytology Dan Dong verfasserin aut Yuhong Xia verfasserin aut Liying Hao verfasserin aut Wei Wang verfasserin aut Chenghai Zhao verfasserin aut In Cell Death and Disease Nature Publishing Group, 2010 13(2022), 3, Seite 11 (DE-627)620145250 (DE-600)2541626-1 20414889 nnns volume:13 year:2022 number:3 pages:11 https://doi.org/10.1038/s41419-022-04672-5 kostenfrei https://doaj.org/article/c70f9966a99040c29796d841b6286abb kostenfrei https://doi.org/10.1038/s41419-022-04672-5 kostenfrei https://doaj.org/toc/2041-4889 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022 3 11
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topic_title	QH573-671 YTHDF1 promotes breast cancer cell growth, DNA damage repair and chemoresistance
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title	YTHDF1 promotes breast cancer cell growth, DNA damage repair and chemoresistance
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title_sort	ythdf1 promotes breast cancer cell growth, dna damage repair and chemoresistance
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title_auth	YTHDF1 promotes breast cancer cell growth, DNA damage repair and chemoresistance
abstract	Abstract Chemoresistance represents a major obstacle to the treatment of human cancers. Increased DNA repair capacity is one of the important mechanisms underlying chemoresistance. In silico analysis indicated that YTHDF1, an m6A binding protein, is a putative tumor promoter in breast cancer. Loss of function studies further showed that YTHDF1 promotes breast cancer cell growth in vitro and in vivo. YTHDF1 facilitates S-phase entry, DNA replication and DNA damage repair, and accordingly YTHDF1 knockdown sensitizes breast cancer cells to Adriamycin and Cisplatin as well as Olaparib, a PARP inhibitor. E2F8 is a target molecule by YTHDF1 which modulates E2F8 mRNA stability and DNA damage repair in a METTL14-dependent manner. These data demonstrate that YTHDF1 has a tumor-promoting role in breast cancer, and is a novel target to overcome chemoresistance.
abstractGer	Abstract Chemoresistance represents a major obstacle to the treatment of human cancers. Increased DNA repair capacity is one of the important mechanisms underlying chemoresistance. In silico analysis indicated that YTHDF1, an m6A binding protein, is a putative tumor promoter in breast cancer. Loss of function studies further showed that YTHDF1 promotes breast cancer cell growth in vitro and in vivo. YTHDF1 facilitates S-phase entry, DNA replication and DNA damage repair, and accordingly YTHDF1 knockdown sensitizes breast cancer cells to Adriamycin and Cisplatin as well as Olaparib, a PARP inhibitor. E2F8 is a target molecule by YTHDF1 which modulates E2F8 mRNA stability and DNA damage repair in a METTL14-dependent manner. These data demonstrate that YTHDF1 has a tumor-promoting role in breast cancer, and is a novel target to overcome chemoresistance.
abstract_unstemmed	Abstract Chemoresistance represents a major obstacle to the treatment of human cancers. Increased DNA repair capacity is one of the important mechanisms underlying chemoresistance. In silico analysis indicated that YTHDF1, an m6A binding protein, is a putative tumor promoter in breast cancer. Loss of function studies further showed that YTHDF1 promotes breast cancer cell growth in vitro and in vivo. YTHDF1 facilitates S-phase entry, DNA replication and DNA damage repair, and accordingly YTHDF1 knockdown sensitizes breast cancer cells to Adriamycin and Cisplatin as well as Olaparib, a PARP inhibitor. E2F8 is a target molecule by YTHDF1 which modulates E2F8 mRNA stability and DNA damage repair in a METTL14-dependent manner. These data demonstrate that YTHDF1 has a tumor-promoting role in breast cancer, and is a novel target to overcome chemoresistance.
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title_short	YTHDF1 promotes breast cancer cell growth, DNA damage repair and chemoresistance
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