MIFlowCyt-EV: a framework for standardized reporting of extracellular vesicle flow cytometry experiments
Extracellular vesicles (EVs) are small, heterogeneous and difficult to measure. Flow cytometry (FC) is a key technology for the measurement of individual particles, but its application to the analysis of EVs and other submicron particles has presented many challenges and has produced a number of con...
Ausführliche Beschreibung
Autor*in: |
Joshua A. Welsh [verfasserIn] Edwin Van Der Pol [verfasserIn] Ger J.A. Arkesteijn [verfasserIn] Michel Bremer [verfasserIn] Alain Brisson [verfasserIn] Frank Coumans [verfasserIn] Françoise Dignat-George [verfasserIn] Erika Duggan [verfasserIn] Ionita Ghiran [verfasserIn] Bernd Giebel [verfasserIn] André Görgens [verfasserIn] An Hendrix [verfasserIn] Romaric Lacroix [verfasserIn] Joanne Lannigan [verfasserIn] Sten F.W.M. Libregts [verfasserIn] Estefanía Lozano-Andrés [verfasserIn] Aizea Morales-Kastresana [verfasserIn] Stephane Robert [verfasserIn] Leonie De Rond [verfasserIn] Tobias Tertel [verfasserIn] John Tigges [verfasserIn] Olivier De Wever [verfasserIn] Xiaomei Yan [verfasserIn] Rienk Nieuwland [verfasserIn] Marca H.M. Wauben [verfasserIn] John P. Nolan [verfasserIn] Jennifer C. Jones [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2020 |
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Übergeordnetes Werk: |
In: Journal of Extracellular Vesicles - Wiley, 2012, 9(2020), 1 |
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Übergeordnetes Werk: |
volume:9 ; year:2020 ; number:1 |
Links: |
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DOI / URN: |
10.1080/20013078.2020.1713526 |
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Katalog-ID: |
DOAJ018338925 |
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520 | |a Extracellular vesicles (EVs) are small, heterogeneous and difficult to measure. Flow cytometry (FC) is a key technology for the measurement of individual particles, but its application to the analysis of EVs and other submicron particles has presented many challenges and has produced a number of controversial results, in part due to limitations of instrument detection, lack of robust methods and ambiguities in how data should be interpreted. These complications are exacerbated by the field’s lack of a robust reporting framework, and many EV-FC manuscripts include incomplete descriptions of methods and results, contain artefacts stemming from an insufficient instrument sensitivity and inappropriate experimental design and lack appropriate calibration and standardization. To address these issues, a working group (WG) of EV-FC researchers from ISEV, ISAC and ISTH, worked together as an EV-FC WG and developed a consensus framework for the minimum information that should be provided regarding EV-FC. This framework incorporates the existing Minimum Information for Studies of EVs (MISEV) guidelines and Minimum Information about a FC experiment (MIFlowCyt) standard in an EV-FC-specific reporting framework (MIFlowCyt-EV) that supports reporting of critical information related to sample staining, EV detection and measurement and experimental design in manuscripts that report EV-FC data. MIFlowCyt-EV provides a structure for sharing EV-FC results, but it does not prescribe specific protocols, as there will continue to be rapid evolution of instruments and methods for the foreseeable future. MIFlowCyt-EV accommodates this evolution, while providing information needed to evaluate and compare different approaches. Because MIFlowCyt-EV will ensure consistency in the manner of reporting of EV-FC studies, over time we expect that adoption of MIFlowCyt-EV as a standard for reporting EV- FC studies will improve the ability to quantitatively compare results from different laboratories and to support the development of new instruments and assays for improved measurement of EVs. | ||
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650 | 4 | |a flow cytometry | |
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700 | 0 | |a Edwin Van Der Pol |e verfasserin |4 aut | |
700 | 0 | |a Ger J.A. Arkesteijn |e verfasserin |4 aut | |
700 | 0 | |a Michel Bremer |e verfasserin |4 aut | |
700 | 0 | |a Alain Brisson |e verfasserin |4 aut | |
700 | 0 | |a Frank Coumans |e verfasserin |4 aut | |
700 | 0 | |a Françoise Dignat-George |e verfasserin |4 aut | |
700 | 0 | |a Erika Duggan |e verfasserin |4 aut | |
700 | 0 | |a Ionita Ghiran |e verfasserin |4 aut | |
700 | 0 | |a Bernd Giebel |e verfasserin |4 aut | |
700 | 0 | |a André Görgens |e verfasserin |4 aut | |
700 | 0 | |a An Hendrix |e verfasserin |4 aut | |
700 | 0 | |a Romaric Lacroix |e verfasserin |4 aut | |
700 | 0 | |a Joanne Lannigan |e verfasserin |4 aut | |
700 | 0 | |a Sten F.W.M. Libregts |e verfasserin |4 aut | |
700 | 0 | |a Estefanía Lozano-Andrés |e verfasserin |4 aut | |
700 | 0 | |a Aizea Morales-Kastresana |e verfasserin |4 aut | |
700 | 0 | |a Stephane Robert |e verfasserin |4 aut | |
700 | 0 | |a Leonie De Rond |e verfasserin |4 aut | |
700 | 0 | |a Tobias Tertel |e verfasserin |4 aut | |
700 | 0 | |a John Tigges |e verfasserin |4 aut | |
700 | 0 | |a Olivier De Wever |e verfasserin |4 aut | |
700 | 0 | |a Xiaomei Yan |e verfasserin |4 aut | |
700 | 0 | |a Rienk Nieuwland |e verfasserin |4 aut | |
700 | 0 | |a Marca H.M. Wauben |e verfasserin |4 aut | |
700 | 0 | |a John P. Nolan |e verfasserin |4 aut | |
700 | 0 | |a Jennifer C. Jones |e verfasserin |4 aut | |
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10.1080/20013078.2020.1713526 doi (DE-627)DOAJ018338925 (DE-599)DOAJ8a246264520d49b19361915e0bafee96 DE-627 ger DE-627 rakwb eng QH573-671 Joshua A. Welsh verfasserin aut MIFlowCyt-EV: a framework for standardized reporting of extracellular vesicle flow cytometry experiments 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Extracellular vesicles (EVs) are small, heterogeneous and difficult to measure. Flow cytometry (FC) is a key technology for the measurement of individual particles, but its application to the analysis of EVs and other submicron particles has presented many challenges and has produced a number of controversial results, in part due to limitations of instrument detection, lack of robust methods and ambiguities in how data should be interpreted. These complications are exacerbated by the field’s lack of a robust reporting framework, and many EV-FC manuscripts include incomplete descriptions of methods and results, contain artefacts stemming from an insufficient instrument sensitivity and inappropriate experimental design and lack appropriate calibration and standardization. To address these issues, a working group (WG) of EV-FC researchers from ISEV, ISAC and ISTH, worked together as an EV-FC WG and developed a consensus framework for the minimum information that should be provided regarding EV-FC. This framework incorporates the existing Minimum Information for Studies of EVs (MISEV) guidelines and Minimum Information about a FC experiment (MIFlowCyt) standard in an EV-FC-specific reporting framework (MIFlowCyt-EV) that supports reporting of critical information related to sample staining, EV detection and measurement and experimental design in manuscripts that report EV-FC data. MIFlowCyt-EV provides a structure for sharing EV-FC results, but it does not prescribe specific protocols, as there will continue to be rapid evolution of instruments and methods for the foreseeable future. MIFlowCyt-EV accommodates this evolution, while providing information needed to evaluate and compare different approaches. Because MIFlowCyt-EV will ensure consistency in the manner of reporting of EV-FC studies, over time we expect that adoption of MIFlowCyt-EV as a standard for reporting EV- FC studies will improve the ability to quantitatively compare results from different laboratories and to support the development of new instruments and assays for improved measurement of EVs. extracellular vesicles flow cytometry framework reporting standardization Cytology Edwin Van Der Pol verfasserin aut Ger J.A. Arkesteijn verfasserin aut Michel Bremer verfasserin aut Alain Brisson verfasserin aut Frank Coumans verfasserin aut Françoise Dignat-George verfasserin aut Erika Duggan verfasserin aut Ionita Ghiran verfasserin aut Bernd Giebel verfasserin aut André Görgens verfasserin aut An Hendrix verfasserin aut Romaric Lacroix verfasserin aut Joanne Lannigan verfasserin aut Sten F.W.M. Libregts verfasserin aut Estefanía Lozano-Andrés verfasserin aut Aizea Morales-Kastresana verfasserin aut Stephane Robert verfasserin aut Leonie De Rond verfasserin aut Tobias Tertel verfasserin aut John Tigges verfasserin aut Olivier De Wever verfasserin aut Xiaomei Yan verfasserin aut Rienk Nieuwland verfasserin aut Marca H.M. Wauben verfasserin aut John P. Nolan verfasserin aut Jennifer C. Jones verfasserin aut In Journal of Extracellular Vesicles Wiley, 2012 9(2020), 1 (DE-627)726923710 (DE-600)2683797-3 20013078 nnns volume:9 year:2020 number:1 https://doi.org/10.1080/20013078.2020.1713526 kostenfrei https://doaj.org/article/8a246264520d49b19361915e0bafee96 kostenfrei http://dx.doi.org/10.1080/20013078.2020.1713526 kostenfrei https://doaj.org/toc/2001-3078 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 1 |
spelling |
10.1080/20013078.2020.1713526 doi (DE-627)DOAJ018338925 (DE-599)DOAJ8a246264520d49b19361915e0bafee96 DE-627 ger DE-627 rakwb eng QH573-671 Joshua A. Welsh verfasserin aut MIFlowCyt-EV: a framework for standardized reporting of extracellular vesicle flow cytometry experiments 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Extracellular vesicles (EVs) are small, heterogeneous and difficult to measure. Flow cytometry (FC) is a key technology for the measurement of individual particles, but its application to the analysis of EVs and other submicron particles has presented many challenges and has produced a number of controversial results, in part due to limitations of instrument detection, lack of robust methods and ambiguities in how data should be interpreted. These complications are exacerbated by the field’s lack of a robust reporting framework, and many EV-FC manuscripts include incomplete descriptions of methods and results, contain artefacts stemming from an insufficient instrument sensitivity and inappropriate experimental design and lack appropriate calibration and standardization. To address these issues, a working group (WG) of EV-FC researchers from ISEV, ISAC and ISTH, worked together as an EV-FC WG and developed a consensus framework for the minimum information that should be provided regarding EV-FC. This framework incorporates the existing Minimum Information for Studies of EVs (MISEV) guidelines and Minimum Information about a FC experiment (MIFlowCyt) standard in an EV-FC-specific reporting framework (MIFlowCyt-EV) that supports reporting of critical information related to sample staining, EV detection and measurement and experimental design in manuscripts that report EV-FC data. MIFlowCyt-EV provides a structure for sharing EV-FC results, but it does not prescribe specific protocols, as there will continue to be rapid evolution of instruments and methods for the foreseeable future. MIFlowCyt-EV accommodates this evolution, while providing information needed to evaluate and compare different approaches. Because MIFlowCyt-EV will ensure consistency in the manner of reporting of EV-FC studies, over time we expect that adoption of MIFlowCyt-EV as a standard for reporting EV- FC studies will improve the ability to quantitatively compare results from different laboratories and to support the development of new instruments and assays for improved measurement of EVs. extracellular vesicles flow cytometry framework reporting standardization Cytology Edwin Van Der Pol verfasserin aut Ger J.A. Arkesteijn verfasserin aut Michel Bremer verfasserin aut Alain Brisson verfasserin aut Frank Coumans verfasserin aut Françoise Dignat-George verfasserin aut Erika Duggan verfasserin aut Ionita Ghiran verfasserin aut Bernd Giebel verfasserin aut André Görgens verfasserin aut An Hendrix verfasserin aut Romaric Lacroix verfasserin aut Joanne Lannigan verfasserin aut Sten F.W.M. Libregts verfasserin aut Estefanía Lozano-Andrés verfasserin aut Aizea Morales-Kastresana verfasserin aut Stephane Robert verfasserin aut Leonie De Rond verfasserin aut Tobias Tertel verfasserin aut John Tigges verfasserin aut Olivier De Wever verfasserin aut Xiaomei Yan verfasserin aut Rienk Nieuwland verfasserin aut Marca H.M. Wauben verfasserin aut John P. Nolan verfasserin aut Jennifer C. Jones verfasserin aut In Journal of Extracellular Vesicles Wiley, 2012 9(2020), 1 (DE-627)726923710 (DE-600)2683797-3 20013078 nnns volume:9 year:2020 number:1 https://doi.org/10.1080/20013078.2020.1713526 kostenfrei https://doaj.org/article/8a246264520d49b19361915e0bafee96 kostenfrei http://dx.doi.org/10.1080/20013078.2020.1713526 kostenfrei https://doaj.org/toc/2001-3078 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 1 |
allfields_unstemmed |
10.1080/20013078.2020.1713526 doi (DE-627)DOAJ018338925 (DE-599)DOAJ8a246264520d49b19361915e0bafee96 DE-627 ger DE-627 rakwb eng QH573-671 Joshua A. Welsh verfasserin aut MIFlowCyt-EV: a framework for standardized reporting of extracellular vesicle flow cytometry experiments 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Extracellular vesicles (EVs) are small, heterogeneous and difficult to measure. Flow cytometry (FC) is a key technology for the measurement of individual particles, but its application to the analysis of EVs and other submicron particles has presented many challenges and has produced a number of controversial results, in part due to limitations of instrument detection, lack of robust methods and ambiguities in how data should be interpreted. These complications are exacerbated by the field’s lack of a robust reporting framework, and many EV-FC manuscripts include incomplete descriptions of methods and results, contain artefacts stemming from an insufficient instrument sensitivity and inappropriate experimental design and lack appropriate calibration and standardization. To address these issues, a working group (WG) of EV-FC researchers from ISEV, ISAC and ISTH, worked together as an EV-FC WG and developed a consensus framework for the minimum information that should be provided regarding EV-FC. This framework incorporates the existing Minimum Information for Studies of EVs (MISEV) guidelines and Minimum Information about a FC experiment (MIFlowCyt) standard in an EV-FC-specific reporting framework (MIFlowCyt-EV) that supports reporting of critical information related to sample staining, EV detection and measurement and experimental design in manuscripts that report EV-FC data. MIFlowCyt-EV provides a structure for sharing EV-FC results, but it does not prescribe specific protocols, as there will continue to be rapid evolution of instruments and methods for the foreseeable future. MIFlowCyt-EV accommodates this evolution, while providing information needed to evaluate and compare different approaches. Because MIFlowCyt-EV will ensure consistency in the manner of reporting of EV-FC studies, over time we expect that adoption of MIFlowCyt-EV as a standard for reporting EV- FC studies will improve the ability to quantitatively compare results from different laboratories and to support the development of new instruments and assays for improved measurement of EVs. extracellular vesicles flow cytometry framework reporting standardization Cytology Edwin Van Der Pol verfasserin aut Ger J.A. Arkesteijn verfasserin aut Michel Bremer verfasserin aut Alain Brisson verfasserin aut Frank Coumans verfasserin aut Françoise Dignat-George verfasserin aut Erika Duggan verfasserin aut Ionita Ghiran verfasserin aut Bernd Giebel verfasserin aut André Görgens verfasserin aut An Hendrix verfasserin aut Romaric Lacroix verfasserin aut Joanne Lannigan verfasserin aut Sten F.W.M. Libregts verfasserin aut Estefanía Lozano-Andrés verfasserin aut Aizea Morales-Kastresana verfasserin aut Stephane Robert verfasserin aut Leonie De Rond verfasserin aut Tobias Tertel verfasserin aut John Tigges verfasserin aut Olivier De Wever verfasserin aut Xiaomei Yan verfasserin aut Rienk Nieuwland verfasserin aut Marca H.M. Wauben verfasserin aut John P. Nolan verfasserin aut Jennifer C. Jones verfasserin aut In Journal of Extracellular Vesicles Wiley, 2012 9(2020), 1 (DE-627)726923710 (DE-600)2683797-3 20013078 nnns volume:9 year:2020 number:1 https://doi.org/10.1080/20013078.2020.1713526 kostenfrei https://doaj.org/article/8a246264520d49b19361915e0bafee96 kostenfrei http://dx.doi.org/10.1080/20013078.2020.1713526 kostenfrei https://doaj.org/toc/2001-3078 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 1 |
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10.1080/20013078.2020.1713526 doi (DE-627)DOAJ018338925 (DE-599)DOAJ8a246264520d49b19361915e0bafee96 DE-627 ger DE-627 rakwb eng QH573-671 Joshua A. Welsh verfasserin aut MIFlowCyt-EV: a framework for standardized reporting of extracellular vesicle flow cytometry experiments 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Extracellular vesicles (EVs) are small, heterogeneous and difficult to measure. Flow cytometry (FC) is a key technology for the measurement of individual particles, but its application to the analysis of EVs and other submicron particles has presented many challenges and has produced a number of controversial results, in part due to limitations of instrument detection, lack of robust methods and ambiguities in how data should be interpreted. These complications are exacerbated by the field’s lack of a robust reporting framework, and many EV-FC manuscripts include incomplete descriptions of methods and results, contain artefacts stemming from an insufficient instrument sensitivity and inappropriate experimental design and lack appropriate calibration and standardization. To address these issues, a working group (WG) of EV-FC researchers from ISEV, ISAC and ISTH, worked together as an EV-FC WG and developed a consensus framework for the minimum information that should be provided regarding EV-FC. This framework incorporates the existing Minimum Information for Studies of EVs (MISEV) guidelines and Minimum Information about a FC experiment (MIFlowCyt) standard in an EV-FC-specific reporting framework (MIFlowCyt-EV) that supports reporting of critical information related to sample staining, EV detection and measurement and experimental design in manuscripts that report EV-FC data. MIFlowCyt-EV provides a structure for sharing EV-FC results, but it does not prescribe specific protocols, as there will continue to be rapid evolution of instruments and methods for the foreseeable future. MIFlowCyt-EV accommodates this evolution, while providing information needed to evaluate and compare different approaches. Because MIFlowCyt-EV will ensure consistency in the manner of reporting of EV-FC studies, over time we expect that adoption of MIFlowCyt-EV as a standard for reporting EV- FC studies will improve the ability to quantitatively compare results from different laboratories and to support the development of new instruments and assays for improved measurement of EVs. extracellular vesicles flow cytometry framework reporting standardization Cytology Edwin Van Der Pol verfasserin aut Ger J.A. Arkesteijn verfasserin aut Michel Bremer verfasserin aut Alain Brisson verfasserin aut Frank Coumans verfasserin aut Françoise Dignat-George verfasserin aut Erika Duggan verfasserin aut Ionita Ghiran verfasserin aut Bernd Giebel verfasserin aut André Görgens verfasserin aut An Hendrix verfasserin aut Romaric Lacroix verfasserin aut Joanne Lannigan verfasserin aut Sten F.W.M. Libregts verfasserin aut Estefanía Lozano-Andrés verfasserin aut Aizea Morales-Kastresana verfasserin aut Stephane Robert verfasserin aut Leonie De Rond verfasserin aut Tobias Tertel verfasserin aut John Tigges verfasserin aut Olivier De Wever verfasserin aut Xiaomei Yan verfasserin aut Rienk Nieuwland verfasserin aut Marca H.M. Wauben verfasserin aut John P. Nolan verfasserin aut Jennifer C. Jones verfasserin aut In Journal of Extracellular Vesicles Wiley, 2012 9(2020), 1 (DE-627)726923710 (DE-600)2683797-3 20013078 nnns volume:9 year:2020 number:1 https://doi.org/10.1080/20013078.2020.1713526 kostenfrei https://doaj.org/article/8a246264520d49b19361915e0bafee96 kostenfrei http://dx.doi.org/10.1080/20013078.2020.1713526 kostenfrei https://doaj.org/toc/2001-3078 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 1 |
allfieldsSound |
10.1080/20013078.2020.1713526 doi (DE-627)DOAJ018338925 (DE-599)DOAJ8a246264520d49b19361915e0bafee96 DE-627 ger DE-627 rakwb eng QH573-671 Joshua A. Welsh verfasserin aut MIFlowCyt-EV: a framework for standardized reporting of extracellular vesicle flow cytometry experiments 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Extracellular vesicles (EVs) are small, heterogeneous and difficult to measure. Flow cytometry (FC) is a key technology for the measurement of individual particles, but its application to the analysis of EVs and other submicron particles has presented many challenges and has produced a number of controversial results, in part due to limitations of instrument detection, lack of robust methods and ambiguities in how data should be interpreted. These complications are exacerbated by the field’s lack of a robust reporting framework, and many EV-FC manuscripts include incomplete descriptions of methods and results, contain artefacts stemming from an insufficient instrument sensitivity and inappropriate experimental design and lack appropriate calibration and standardization. To address these issues, a working group (WG) of EV-FC researchers from ISEV, ISAC and ISTH, worked together as an EV-FC WG and developed a consensus framework for the minimum information that should be provided regarding EV-FC. This framework incorporates the existing Minimum Information for Studies of EVs (MISEV) guidelines and Minimum Information about a FC experiment (MIFlowCyt) standard in an EV-FC-specific reporting framework (MIFlowCyt-EV) that supports reporting of critical information related to sample staining, EV detection and measurement and experimental design in manuscripts that report EV-FC data. MIFlowCyt-EV provides a structure for sharing EV-FC results, but it does not prescribe specific protocols, as there will continue to be rapid evolution of instruments and methods for the foreseeable future. MIFlowCyt-EV accommodates this evolution, while providing information needed to evaluate and compare different approaches. Because MIFlowCyt-EV will ensure consistency in the manner of reporting of EV-FC studies, over time we expect that adoption of MIFlowCyt-EV as a standard for reporting EV- FC studies will improve the ability to quantitatively compare results from different laboratories and to support the development of new instruments and assays for improved measurement of EVs. extracellular vesicles flow cytometry framework reporting standardization Cytology Edwin Van Der Pol verfasserin aut Ger J.A. Arkesteijn verfasserin aut Michel Bremer verfasserin aut Alain Brisson verfasserin aut Frank Coumans verfasserin aut Françoise Dignat-George verfasserin aut Erika Duggan verfasserin aut Ionita Ghiran verfasserin aut Bernd Giebel verfasserin aut André Görgens verfasserin aut An Hendrix verfasserin aut Romaric Lacroix verfasserin aut Joanne Lannigan verfasserin aut Sten F.W.M. Libregts verfasserin aut Estefanía Lozano-Andrés verfasserin aut Aizea Morales-Kastresana verfasserin aut Stephane Robert verfasserin aut Leonie De Rond verfasserin aut Tobias Tertel verfasserin aut John Tigges verfasserin aut Olivier De Wever verfasserin aut Xiaomei Yan verfasserin aut Rienk Nieuwland verfasserin aut Marca H.M. Wauben verfasserin aut John P. Nolan verfasserin aut Jennifer C. Jones verfasserin aut In Journal of Extracellular Vesicles Wiley, 2012 9(2020), 1 (DE-627)726923710 (DE-600)2683797-3 20013078 nnns volume:9 year:2020 number:1 https://doi.org/10.1080/20013078.2020.1713526 kostenfrei https://doaj.org/article/8a246264520d49b19361915e0bafee96 kostenfrei http://dx.doi.org/10.1080/20013078.2020.1713526 kostenfrei https://doaj.org/toc/2001-3078 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 1 |
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Joshua A. Welsh @@aut@@ Edwin Van Der Pol @@aut@@ Ger J.A. Arkesteijn @@aut@@ Michel Bremer @@aut@@ Alain Brisson @@aut@@ Frank Coumans @@aut@@ Françoise Dignat-George @@aut@@ Erika Duggan @@aut@@ Ionita Ghiran @@aut@@ Bernd Giebel @@aut@@ André Görgens @@aut@@ An Hendrix @@aut@@ Romaric Lacroix @@aut@@ Joanne Lannigan @@aut@@ Sten F.W.M. Libregts @@aut@@ Estefanía Lozano-Andrés @@aut@@ Aizea Morales-Kastresana @@aut@@ Stephane Robert @@aut@@ Leonie De Rond @@aut@@ Tobias Tertel @@aut@@ John Tigges @@aut@@ Olivier De Wever @@aut@@ Xiaomei Yan @@aut@@ Rienk Nieuwland @@aut@@ Marca H.M. Wauben @@aut@@ John P. Nolan @@aut@@ Jennifer C. Jones @@aut@@ |
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Joshua A. Welsh |
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Joshua A. Welsh misc QH573-671 misc extracellular vesicles misc flow cytometry misc framework misc reporting misc standardization misc Cytology MIFlowCyt-EV: a framework for standardized reporting of extracellular vesicle flow cytometry experiments |
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Joshua A. Welsh Edwin Van Der Pol Ger J.A. Arkesteijn Michel Bremer Alain Brisson Frank Coumans Françoise Dignat-George Erika Duggan Ionita Ghiran Bernd Giebel André Görgens An Hendrix Romaric Lacroix Joanne Lannigan Sten F.W.M. Libregts Estefanía Lozano-Andrés Aizea Morales-Kastresana Stephane Robert Leonie De Rond Tobias Tertel John Tigges Olivier De Wever Xiaomei Yan Rienk Nieuwland Marca H.M. Wauben John P. Nolan Jennifer C. Jones |
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miflowcyt-ev: a framework for standardized reporting of extracellular vesicle flow cytometry experiments |
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MIFlowCyt-EV: a framework for standardized reporting of extracellular vesicle flow cytometry experiments |
abstract |
Extracellular vesicles (EVs) are small, heterogeneous and difficult to measure. Flow cytometry (FC) is a key technology for the measurement of individual particles, but its application to the analysis of EVs and other submicron particles has presented many challenges and has produced a number of controversial results, in part due to limitations of instrument detection, lack of robust methods and ambiguities in how data should be interpreted. These complications are exacerbated by the field’s lack of a robust reporting framework, and many EV-FC manuscripts include incomplete descriptions of methods and results, contain artefacts stemming from an insufficient instrument sensitivity and inappropriate experimental design and lack appropriate calibration and standardization. To address these issues, a working group (WG) of EV-FC researchers from ISEV, ISAC and ISTH, worked together as an EV-FC WG and developed a consensus framework for the minimum information that should be provided regarding EV-FC. This framework incorporates the existing Minimum Information for Studies of EVs (MISEV) guidelines and Minimum Information about a FC experiment (MIFlowCyt) standard in an EV-FC-specific reporting framework (MIFlowCyt-EV) that supports reporting of critical information related to sample staining, EV detection and measurement and experimental design in manuscripts that report EV-FC data. MIFlowCyt-EV provides a structure for sharing EV-FC results, but it does not prescribe specific protocols, as there will continue to be rapid evolution of instruments and methods for the foreseeable future. MIFlowCyt-EV accommodates this evolution, while providing information needed to evaluate and compare different approaches. Because MIFlowCyt-EV will ensure consistency in the manner of reporting of EV-FC studies, over time we expect that adoption of MIFlowCyt-EV as a standard for reporting EV- FC studies will improve the ability to quantitatively compare results from different laboratories and to support the development of new instruments and assays for improved measurement of EVs. |
abstractGer |
Extracellular vesicles (EVs) are small, heterogeneous and difficult to measure. Flow cytometry (FC) is a key technology for the measurement of individual particles, but its application to the analysis of EVs and other submicron particles has presented many challenges and has produced a number of controversial results, in part due to limitations of instrument detection, lack of robust methods and ambiguities in how data should be interpreted. These complications are exacerbated by the field’s lack of a robust reporting framework, and many EV-FC manuscripts include incomplete descriptions of methods and results, contain artefacts stemming from an insufficient instrument sensitivity and inappropriate experimental design and lack appropriate calibration and standardization. To address these issues, a working group (WG) of EV-FC researchers from ISEV, ISAC and ISTH, worked together as an EV-FC WG and developed a consensus framework for the minimum information that should be provided regarding EV-FC. This framework incorporates the existing Minimum Information for Studies of EVs (MISEV) guidelines and Minimum Information about a FC experiment (MIFlowCyt) standard in an EV-FC-specific reporting framework (MIFlowCyt-EV) that supports reporting of critical information related to sample staining, EV detection and measurement and experimental design in manuscripts that report EV-FC data. MIFlowCyt-EV provides a structure for sharing EV-FC results, but it does not prescribe specific protocols, as there will continue to be rapid evolution of instruments and methods for the foreseeable future. MIFlowCyt-EV accommodates this evolution, while providing information needed to evaluate and compare different approaches. Because MIFlowCyt-EV will ensure consistency in the manner of reporting of EV-FC studies, over time we expect that adoption of MIFlowCyt-EV as a standard for reporting EV- FC studies will improve the ability to quantitatively compare results from different laboratories and to support the development of new instruments and assays for improved measurement of EVs. |
abstract_unstemmed |
Extracellular vesicles (EVs) are small, heterogeneous and difficult to measure. Flow cytometry (FC) is a key technology for the measurement of individual particles, but its application to the analysis of EVs and other submicron particles has presented many challenges and has produced a number of controversial results, in part due to limitations of instrument detection, lack of robust methods and ambiguities in how data should be interpreted. These complications are exacerbated by the field’s lack of a robust reporting framework, and many EV-FC manuscripts include incomplete descriptions of methods and results, contain artefacts stemming from an insufficient instrument sensitivity and inappropriate experimental design and lack appropriate calibration and standardization. To address these issues, a working group (WG) of EV-FC researchers from ISEV, ISAC and ISTH, worked together as an EV-FC WG and developed a consensus framework for the minimum information that should be provided regarding EV-FC. This framework incorporates the existing Minimum Information for Studies of EVs (MISEV) guidelines and Minimum Information about a FC experiment (MIFlowCyt) standard in an EV-FC-specific reporting framework (MIFlowCyt-EV) that supports reporting of critical information related to sample staining, EV detection and measurement and experimental design in manuscripts that report EV-FC data. MIFlowCyt-EV provides a structure for sharing EV-FC results, but it does not prescribe specific protocols, as there will continue to be rapid evolution of instruments and methods for the foreseeable future. MIFlowCyt-EV accommodates this evolution, while providing information needed to evaluate and compare different approaches. Because MIFlowCyt-EV will ensure consistency in the manner of reporting of EV-FC studies, over time we expect that adoption of MIFlowCyt-EV as a standard for reporting EV- FC studies will improve the ability to quantitatively compare results from different laboratories and to support the development of new instruments and assays for improved measurement of EVs. |
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title_short |
MIFlowCyt-EV: a framework for standardized reporting of extracellular vesicle flow cytometry experiments |
url |
https://doi.org/10.1080/20013078.2020.1713526 https://doaj.org/article/8a246264520d49b19361915e0bafee96 http://dx.doi.org/10.1080/20013078.2020.1713526 https://doaj.org/toc/2001-3078 |
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author2 |
Edwin Van Der Pol Ger J.A. Arkesteijn Michel Bremer Alain Brisson Frank Coumans Françoise Dignat-George Erika Duggan Ionita Ghiran Bernd Giebel André Görgens An Hendrix Romaric Lacroix Joanne Lannigan Sten F.W.M. Libregts Estefanía Lozano-Andrés Aizea Morales-Kastresana Stephane Robert Leonie De Rond Tobias Tertel John Tigges Olivier De Wever Xiaomei Yan Rienk Nieuwland Marca H.M. Wauben John P. Nolan Jennifer C. Jones |
author2Str |
Edwin Van Der Pol Ger J.A. Arkesteijn Michel Bremer Alain Brisson Frank Coumans Françoise Dignat-George Erika Duggan Ionita Ghiran Bernd Giebel André Görgens An Hendrix Romaric Lacroix Joanne Lannigan Sten F.W.M. Libregts Estefanía Lozano-Andrés Aizea Morales-Kastresana Stephane Robert Leonie De Rond Tobias Tertel John Tigges Olivier De Wever Xiaomei Yan Rienk Nieuwland Marca H.M. Wauben John P. Nolan Jennifer C. Jones |
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QH - Natural History and Biology |
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doi_str |
10.1080/20013078.2020.1713526 |
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up_date |
2024-07-03T17:20:34.984Z |
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|
score |
7.400099 |