MFN1 and MFN2 Are Dispensable for Sperm Development and Functions in Mice

MFN1 (Mitofusin 1) and MFN2 (Mitofusin 2) are GTPases essential for mitochondrial fusion. Published studies revealed crucial roles of both Mitofusins during embryonic development. Despite the unique mitochondrial organization in sperm flagella, the biological requirement in sperm development and fun...
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Autor*in:	Junru Miao [verfasserIn] Wei Chen [verfasserIn] Pengxiang Wang [verfasserIn] Xin Zhang [verfasserIn] Lei Wang [verfasserIn] Shuai Wang [verfasserIn] Yuan Wang [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	MFN1 MFN2 haploid spermatids male fertility sperm functions

Übergeordnetes Werk:	In: International Journal of Molecular Sciences - MDPI AG, 2003, 22(2021), 24, p 13507
Übergeordnetes Werk:	volume:22 ; year:2021 ; number:24, p 13507

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.3390/ijms222413507

Katalog-ID:	DOAJ018689078

Internformat


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allfields	10.3390/ijms222413507 doi (DE-627)DOAJ018689078 (DE-599)DOAJ6df3155eda064cbd9695e9953f0553a6 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Junru Miao verfasserin aut MFN1 and MFN2 Are Dispensable for Sperm Development and Functions in Mice 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier MFN1 (Mitofusin 1) and MFN2 (Mitofusin 2) are GTPases essential for mitochondrial fusion. Published studies revealed crucial roles of both Mitofusins during embryonic development. Despite the unique mitochondrial organization in sperm flagella, the biological requirement in sperm development and functions remain undefined. Here, using sperm-specific Cre drivers, we show that either <i<Mfn1</i< or <i<Mfn2</i< knockout in haploid germ cells does not affect male fertility. The <i<Mfn1</i< and <i<Mfn2</i< double knockout mice were further analyzed. We found no differences in testis morphology and weight between <i<Mfn</i<-deficient mice and their wild-type littermate controls. Spermatogenesis was normal in <i<Mfn</i< double knockout mice, in which properly developed TRA98+ germ cells, SYCP3+ spermatocytes, and TNP1+ spermatids/spermatozoa were detected in seminiferous tubules, indicating that sperm formation was not disrupted upon MFN deficiency. Collectively, our findings reveal that both MFN1 and MFN2 are dispensable for sperm development and functions in mice. MFN1 MFN2 haploid spermatids male fertility sperm functions Biology (General) Chemistry Wei Chen verfasserin aut Pengxiang Wang verfasserin aut Xin Zhang verfasserin aut Lei Wang verfasserin aut Shuai Wang verfasserin aut Yuan Wang verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 22(2021), 24, p 13507 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:22 year:2021 number:24, p 13507 https://doi.org/10.3390/ijms222413507 kostenfrei https://doaj.org/article/6df3155eda064cbd9695e9953f0553a6 kostenfrei https://www.mdpi.com/1422-0067/22/24/13507 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2021 24, p 13507
spelling	10.3390/ijms222413507 doi (DE-627)DOAJ018689078 (DE-599)DOAJ6df3155eda064cbd9695e9953f0553a6 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Junru Miao verfasserin aut MFN1 and MFN2 Are Dispensable for Sperm Development and Functions in Mice 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier MFN1 (Mitofusin 1) and MFN2 (Mitofusin 2) are GTPases essential for mitochondrial fusion. Published studies revealed crucial roles of both Mitofusins during embryonic development. Despite the unique mitochondrial organization in sperm flagella, the biological requirement in sperm development and functions remain undefined. Here, using sperm-specific Cre drivers, we show that either <i<Mfn1</i< or <i<Mfn2</i< knockout in haploid germ cells does not affect male fertility. The <i<Mfn1</i< and <i<Mfn2</i< double knockout mice were further analyzed. We found no differences in testis morphology and weight between <i<Mfn</i<-deficient mice and their wild-type littermate controls. Spermatogenesis was normal in <i<Mfn</i< double knockout mice, in which properly developed TRA98+ germ cells, SYCP3+ spermatocytes, and TNP1+ spermatids/spermatozoa were detected in seminiferous tubules, indicating that sperm formation was not disrupted upon MFN deficiency. Collectively, our findings reveal that both MFN1 and MFN2 are dispensable for sperm development and functions in mice. MFN1 MFN2 haploid spermatids male fertility sperm functions Biology (General) Chemistry Wei Chen verfasserin aut Pengxiang Wang verfasserin aut Xin Zhang verfasserin aut Lei Wang verfasserin aut Shuai Wang verfasserin aut Yuan Wang verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 22(2021), 24, p 13507 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:22 year:2021 number:24, p 13507 https://doi.org/10.3390/ijms222413507 kostenfrei https://doaj.org/article/6df3155eda064cbd9695e9953f0553a6 kostenfrei https://www.mdpi.com/1422-0067/22/24/13507 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2021 24, p 13507
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allfieldsGer	10.3390/ijms222413507 doi (DE-627)DOAJ018689078 (DE-599)DOAJ6df3155eda064cbd9695e9953f0553a6 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Junru Miao verfasserin aut MFN1 and MFN2 Are Dispensable for Sperm Development and Functions in Mice 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier MFN1 (Mitofusin 1) and MFN2 (Mitofusin 2) are GTPases essential for mitochondrial fusion. Published studies revealed crucial roles of both Mitofusins during embryonic development. Despite the unique mitochondrial organization in sperm flagella, the biological requirement in sperm development and functions remain undefined. Here, using sperm-specific Cre drivers, we show that either <i<Mfn1</i< or <i<Mfn2</i< knockout in haploid germ cells does not affect male fertility. The <i<Mfn1</i< and <i<Mfn2</i< double knockout mice were further analyzed. We found no differences in testis morphology and weight between <i<Mfn</i<-deficient mice and their wild-type littermate controls. Spermatogenesis was normal in <i<Mfn</i< double knockout mice, in which properly developed TRA98+ germ cells, SYCP3+ spermatocytes, and TNP1+ spermatids/spermatozoa were detected in seminiferous tubules, indicating that sperm formation was not disrupted upon MFN deficiency. Collectively, our findings reveal that both MFN1 and MFN2 are dispensable for sperm development and functions in mice. MFN1 MFN2 haploid spermatids male fertility sperm functions Biology (General) Chemistry Wei Chen verfasserin aut Pengxiang Wang verfasserin aut Xin Zhang verfasserin aut Lei Wang verfasserin aut Shuai Wang verfasserin aut Yuan Wang verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 22(2021), 24, p 13507 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:22 year:2021 number:24, p 13507 https://doi.org/10.3390/ijms222413507 kostenfrei https://doaj.org/article/6df3155eda064cbd9695e9953f0553a6 kostenfrei https://www.mdpi.com/1422-0067/22/24/13507 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2021 24, p 13507
allfieldsSound	10.3390/ijms222413507 doi (DE-627)DOAJ018689078 (DE-599)DOAJ6df3155eda064cbd9695e9953f0553a6 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Junru Miao verfasserin aut MFN1 and MFN2 Are Dispensable for Sperm Development and Functions in Mice 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier MFN1 (Mitofusin 1) and MFN2 (Mitofusin 2) are GTPases essential for mitochondrial fusion. Published studies revealed crucial roles of both Mitofusins during embryonic development. Despite the unique mitochondrial organization in sperm flagella, the biological requirement in sperm development and functions remain undefined. Here, using sperm-specific Cre drivers, we show that either <i<Mfn1</i< or <i<Mfn2</i< knockout in haploid germ cells does not affect male fertility. The <i<Mfn1</i< and <i<Mfn2</i< double knockout mice were further analyzed. We found no differences in testis morphology and weight between <i<Mfn</i<-deficient mice and their wild-type littermate controls. Spermatogenesis was normal in <i<Mfn</i< double knockout mice, in which properly developed TRA98+ germ cells, SYCP3+ spermatocytes, and TNP1+ spermatids/spermatozoa were detected in seminiferous tubules, indicating that sperm formation was not disrupted upon MFN deficiency. Collectively, our findings reveal that both MFN1 and MFN2 are dispensable for sperm development and functions in mice. MFN1 MFN2 haploid spermatids male fertility sperm functions Biology (General) Chemistry Wei Chen verfasserin aut Pengxiang Wang verfasserin aut Xin Zhang verfasserin aut Lei Wang verfasserin aut Shuai Wang verfasserin aut Yuan Wang verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 22(2021), 24, p 13507 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:22 year:2021 number:24, p 13507 https://doi.org/10.3390/ijms222413507 kostenfrei https://doaj.org/article/6df3155eda064cbd9695e9953f0553a6 kostenfrei https://www.mdpi.com/1422-0067/22/24/13507 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2021 24, p 13507
language	English
source	In International Journal of Molecular Sciences 22(2021), 24, p 13507 volume:22 year:2021 number:24, p 13507
sourceStr	In International Journal of Molecular Sciences 22(2021), 24, p 13507 volume:22 year:2021 number:24, p 13507
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topic_facet	MFN1 MFN2 haploid spermatids male fertility sperm functions Biology (General) Chemistry
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container_title	International Journal of Molecular Sciences
authorswithroles_txt_mv	Junru Miao @@aut@@ Wei Chen @@aut@@ Pengxiang Wang @@aut@@ Xin Zhang @@aut@@ Lei Wang @@aut@@ Shuai Wang @@aut@@ Yuan Wang @@aut@@
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callnumber-first	Q - Science
author	Junru Miao
spellingShingle	Junru Miao misc QH301-705.5 misc QD1-999 misc MFN1 misc MFN2 misc haploid spermatids misc male fertility misc sperm functions misc Biology (General) misc Chemistry MFN1 and MFN2 Are Dispensable for Sperm Development and Functions in Mice
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topic_title	QH301-705.5 QD1-999 MFN1 and MFN2 Are Dispensable for Sperm Development and Functions in Mice MFN1 MFN2 haploid spermatids male fertility sperm functions
topic	misc QH301-705.5 misc QD1-999 misc MFN1 misc MFN2 misc haploid spermatids misc male fertility misc sperm functions misc Biology (General) misc Chemistry
topic_unstemmed	misc QH301-705.5 misc QD1-999 misc MFN1 misc MFN2 misc haploid spermatids misc male fertility misc sperm functions misc Biology (General) misc Chemistry
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title	MFN1 and MFN2 Are Dispensable for Sperm Development and Functions in Mice
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title_full	MFN1 and MFN2 Are Dispensable for Sperm Development and Functions in Mice
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title_sort	mfn1 and mfn2 are dispensable for sperm development and functions in mice
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title_auth	MFN1 and MFN2 Are Dispensable for Sperm Development and Functions in Mice
abstract	MFN1 (Mitofusin 1) and MFN2 (Mitofusin 2) are GTPases essential for mitochondrial fusion. Published studies revealed crucial roles of both Mitofusins during embryonic development. Despite the unique mitochondrial organization in sperm flagella, the biological requirement in sperm development and functions remain undefined. Here, using sperm-specific Cre drivers, we show that either <i<Mfn1</i< or <i<Mfn2</i< knockout in haploid germ cells does not affect male fertility. The <i<Mfn1</i< and <i<Mfn2</i< double knockout mice were further analyzed. We found no differences in testis morphology and weight between <i<Mfn</i<-deficient mice and their wild-type littermate controls. Spermatogenesis was normal in <i<Mfn</i< double knockout mice, in which properly developed TRA98+ germ cells, SYCP3+ spermatocytes, and TNP1+ spermatids/spermatozoa were detected in seminiferous tubules, indicating that sperm formation was not disrupted upon MFN deficiency. Collectively, our findings reveal that both MFN1 and MFN2 are dispensable for sperm development and functions in mice.
abstractGer	MFN1 (Mitofusin 1) and MFN2 (Mitofusin 2) are GTPases essential for mitochondrial fusion. Published studies revealed crucial roles of both Mitofusins during embryonic development. Despite the unique mitochondrial organization in sperm flagella, the biological requirement in sperm development and functions remain undefined. Here, using sperm-specific Cre drivers, we show that either <i<Mfn1</i< or <i<Mfn2</i< knockout in haploid germ cells does not affect male fertility. The <i<Mfn1</i< and <i<Mfn2</i< double knockout mice were further analyzed. We found no differences in testis morphology and weight between <i<Mfn</i<-deficient mice and their wild-type littermate controls. Spermatogenesis was normal in <i<Mfn</i< double knockout mice, in which properly developed TRA98+ germ cells, SYCP3+ spermatocytes, and TNP1+ spermatids/spermatozoa were detected in seminiferous tubules, indicating that sperm formation was not disrupted upon MFN deficiency. Collectively, our findings reveal that both MFN1 and MFN2 are dispensable for sperm development and functions in mice.
abstract_unstemmed	MFN1 (Mitofusin 1) and MFN2 (Mitofusin 2) are GTPases essential for mitochondrial fusion. Published studies revealed crucial roles of both Mitofusins during embryonic development. Despite the unique mitochondrial organization in sperm flagella, the biological requirement in sperm development and functions remain undefined. Here, using sperm-specific Cre drivers, we show that either <i<Mfn1</i< or <i<Mfn2</i< knockout in haploid germ cells does not affect male fertility. The <i<Mfn1</i< and <i<Mfn2</i< double knockout mice were further analyzed. We found no differences in testis morphology and weight between <i<Mfn</i<-deficient mice and their wild-type littermate controls. Spermatogenesis was normal in <i<Mfn</i< double knockout mice, in which properly developed TRA98+ germ cells, SYCP3+ spermatocytes, and TNP1+ spermatids/spermatozoa were detected in seminiferous tubules, indicating that sperm formation was not disrupted upon MFN deficiency. Collectively, our findings reveal that both MFN1 and MFN2 are dispensable for sperm development and functions in mice.
collection_details	GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700
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title_short	MFN1 and MFN2 Are Dispensable for Sperm Development and Functions in Mice
url	https://doi.org/10.3390/ijms222413507 https://doaj.org/article/6df3155eda064cbd9695e9953f0553a6 https://www.mdpi.com/1422-0067/22/24/13507 https://doaj.org/toc/1661-6596 https://doaj.org/toc/1422-0067
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up_date	2024-07-03T19:21:00.976Z
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Published studies revealed crucial roles of both Mitofusins during embryonic development. Despite the unique mitochondrial organization in sperm flagella, the biological requirement in sperm development and functions remain undefined. Here, using sperm-specific Cre drivers, we show that either <i<Mfn1</i< or <i<Mfn2</i< knockout in haploid germ cells does not affect male fertility. The <i<Mfn1</i< and <i<Mfn2</i< double knockout mice were further analyzed. We found no differences in testis morphology and weight between <i<Mfn</i<-deficient mice and their wild-type littermate controls. Spermatogenesis was normal in <i<Mfn</i< double knockout mice, in which properly developed TRA98+ germ cells, SYCP3+ spermatocytes, and TNP1+ spermatids/spermatozoa were detected in seminiferous tubules, indicating that sperm formation was not disrupted upon MFN deficiency. 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code="a">Pengxiang Wang</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Xin Zhang</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Lei Wang</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Shuai Wang</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Yuan Wang</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">International Journal of Molecular Sciences</subfield><subfield code="d">MDPI AG, 2003</subfield><subfield code="g">22(2021), 24, p 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MFN1 and MFN2 Are Dispensable for Sperm Development and Functions in Mice

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