A simple randomized prospective study comparing catheter-directed thrombolysis versus systemic thrombolysis in patients with massive and submassive pulmonary embolism

Context: Catheter-directed thrombolysis (CDT) is a novel mode of thrombolysis where thrombolytic agents are directed through catheter to a specific area of interest; hence, low-dose thrombolytic agent will be required to produce satisfactory thrombolysis results. This will subsequently decrease the...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Suyash Tated [verfasserIn] Dinesh Joshi [verfasserIn] Anand Shukla [verfasserIn] Pratik Raval [verfasserIn] Karthik Natrajan [verfasserIn] Kewal Kanabar [verfasserIn] Surender Kumar [verfasserIn] Jigneshkumar Patel [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	catheter-directed thrombolysis pulmonary embolism systemic thrombolysis

Übergeordnetes Werk:	In: Heart India - Wolters Kluwer Medknow Publications, 2017, 9(2021), 3, Seite 169-173
Übergeordnetes Werk:	volume:9 ; year:2021 ; number:3 ; pages:169-173

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.4103/heartindia.heartindia_96_21

Katalog-ID:	DOAJ019103646

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245	1	2	\|a A simple randomized prospective study comparing catheter-directed thrombolysis versus systemic thrombolysis in patients with massive and submassive pulmonary embolism
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520			\|a Context: Catheter-directed thrombolysis (CDT) is a novel mode of thrombolysis where thrombolytic agents are directed through catheter to a specific area of interest; hence, low-dose thrombolytic agent will be required to produce satisfactory thrombolysis results. This will subsequently decrease the bleeding complications. With this postulation, a study was conducted to compare the outcome of CDT versus systemic thrombolysis (ST) in patients with massive and submassive pulmonary embolism (PE). Methods: The present study prospectively included the cases of massive and submassive (high-risk) PE and randomly distributed 25 patients into two groups each: Group A underwent CDT, whereas Group B underwent ST. The outcomes of both the groups were studied including mortality and bleeding complications, and patients were followed up for 6 months. At the end of the study, data were analyzed, and outcomes of both the groups were compared. Results: Baseline characteristics were similar in both the groups. The success rate was 90.4% in Group A (CDT) and 75% in Group B (ST) among patients with massive PE (P = 0.95). The mortality rate was numerically higher in the ST group (12%) than in the CDT group (8%). Bleeding complications were higher in the ST group (20%) than in the CDT group (8%). Conclusion: CDT was found to be noninferior to ST with respect to primary outcomes of mortality and success rate of thrombolysis. CDT had lower occurrence of bleeding episodes. CDT can be considered viable alternative to ST in patients with high bleeding risk.
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allfields	10.4103/heartindia.heartindia_96_21 doi (DE-627)DOAJ019103646 (DE-599)DOAJc3674ade03b2473eb7126225d12222b7 DE-627 ger DE-627 rakwb eng RC666-701 Suyash Tated verfasserin aut A simple randomized prospective study comparing catheter-directed thrombolysis versus systemic thrombolysis in patients with massive and submassive pulmonary embolism 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Context: Catheter-directed thrombolysis (CDT) is a novel mode of thrombolysis where thrombolytic agents are directed through catheter to a specific area of interest; hence, low-dose thrombolytic agent will be required to produce satisfactory thrombolysis results. This will subsequently decrease the bleeding complications. With this postulation, a study was conducted to compare the outcome of CDT versus systemic thrombolysis (ST) in patients with massive and submassive pulmonary embolism (PE). Methods: The present study prospectively included the cases of massive and submassive (high-risk) PE and randomly distributed 25 patients into two groups each: Group A underwent CDT, whereas Group B underwent ST. The outcomes of both the groups were studied including mortality and bleeding complications, and patients were followed up for 6 months. At the end of the study, data were analyzed, and outcomes of both the groups were compared. Results: Baseline characteristics were similar in both the groups. The success rate was 90.4% in Group A (CDT) and 75% in Group B (ST) among patients with massive PE (P = 0.95). The mortality rate was numerically higher in the ST group (12%) than in the CDT group (8%). Bleeding complications were higher in the ST group (20%) than in the CDT group (8%). Conclusion: CDT was found to be noninferior to ST with respect to primary outcomes of mortality and success rate of thrombolysis. CDT had lower occurrence of bleeding episodes. CDT can be considered viable alternative to ST in patients with high bleeding risk. catheter-directed thrombolysis pulmonary embolism systemic thrombolysis Diseases of the circulatory (Cardiovascular) system Dinesh Joshi verfasserin aut Anand Shukla verfasserin aut Pratik Raval verfasserin aut Karthik Natrajan verfasserin aut Kewal Kanabar verfasserin aut Surender Kumar verfasserin aut Jigneshkumar Patel verfasserin aut In Heart India Wolters Kluwer Medknow Publications, 2017 9(2021), 3, Seite 169-173 (DE-627)168235749X 23216638 nnns volume:9 year:2021 number:3 pages:169-173 https://doi.org/10.4103/heartindia.heartindia_96_21 kostenfrei https://doaj.org/article/c3674ade03b2473eb7126225d12222b7 kostenfrei http://www.heartindia.net/article.asp?issn=2321-449x;year=2021;volume=9;issue=3;spage=169;epage=173;aulast=Tated kostenfrei https://doaj.org/toc/2321-449X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2021 3 169-173
spelling	10.4103/heartindia.heartindia_96_21 doi (DE-627)DOAJ019103646 (DE-599)DOAJc3674ade03b2473eb7126225d12222b7 DE-627 ger DE-627 rakwb eng RC666-701 Suyash Tated verfasserin aut A simple randomized prospective study comparing catheter-directed thrombolysis versus systemic thrombolysis in patients with massive and submassive pulmonary embolism 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Context: Catheter-directed thrombolysis (CDT) is a novel mode of thrombolysis where thrombolytic agents are directed through catheter to a specific area of interest; hence, low-dose thrombolytic agent will be required to produce satisfactory thrombolysis results. This will subsequently decrease the bleeding complications. With this postulation, a study was conducted to compare the outcome of CDT versus systemic thrombolysis (ST) in patients with massive and submassive pulmonary embolism (PE). Methods: The present study prospectively included the cases of massive and submassive (high-risk) PE and randomly distributed 25 patients into two groups each: Group A underwent CDT, whereas Group B underwent ST. The outcomes of both the groups were studied including mortality and bleeding complications, and patients were followed up for 6 months. At the end of the study, data were analyzed, and outcomes of both the groups were compared. Results: Baseline characteristics were similar in both the groups. The success rate was 90.4% in Group A (CDT) and 75% in Group B (ST) among patients with massive PE (P = 0.95). The mortality rate was numerically higher in the ST group (12%) than in the CDT group (8%). Bleeding complications were higher in the ST group (20%) than in the CDT group (8%). Conclusion: CDT was found to be noninferior to ST with respect to primary outcomes of mortality and success rate of thrombolysis. CDT had lower occurrence of bleeding episodes. CDT can be considered viable alternative to ST in patients with high bleeding risk. catheter-directed thrombolysis pulmonary embolism systemic thrombolysis Diseases of the circulatory (Cardiovascular) system Dinesh Joshi verfasserin aut Anand Shukla verfasserin aut Pratik Raval verfasserin aut Karthik Natrajan verfasserin aut Kewal Kanabar verfasserin aut Surender Kumar verfasserin aut Jigneshkumar Patel verfasserin aut In Heart India Wolters Kluwer Medknow Publications, 2017 9(2021), 3, Seite 169-173 (DE-627)168235749X 23216638 nnns volume:9 year:2021 number:3 pages:169-173 https://doi.org/10.4103/heartindia.heartindia_96_21 kostenfrei https://doaj.org/article/c3674ade03b2473eb7126225d12222b7 kostenfrei http://www.heartindia.net/article.asp?issn=2321-449x;year=2021;volume=9;issue=3;spage=169;epage=173;aulast=Tated kostenfrei https://doaj.org/toc/2321-449X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2021 3 169-173
allfields_unstemmed	10.4103/heartindia.heartindia_96_21 doi (DE-627)DOAJ019103646 (DE-599)DOAJc3674ade03b2473eb7126225d12222b7 DE-627 ger DE-627 rakwb eng RC666-701 Suyash Tated verfasserin aut A simple randomized prospective study comparing catheter-directed thrombolysis versus systemic thrombolysis in patients with massive and submassive pulmonary embolism 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Context: Catheter-directed thrombolysis (CDT) is a novel mode of thrombolysis where thrombolytic agents are directed through catheter to a specific area of interest; hence, low-dose thrombolytic agent will be required to produce satisfactory thrombolysis results. This will subsequently decrease the bleeding complications. With this postulation, a study was conducted to compare the outcome of CDT versus systemic thrombolysis (ST) in patients with massive and submassive pulmonary embolism (PE). Methods: The present study prospectively included the cases of massive and submassive (high-risk) PE and randomly distributed 25 patients into two groups each: Group A underwent CDT, whereas Group B underwent ST. The outcomes of both the groups were studied including mortality and bleeding complications, and patients were followed up for 6 months. At the end of the study, data were analyzed, and outcomes of both the groups were compared. Results: Baseline characteristics were similar in both the groups. The success rate was 90.4% in Group A (CDT) and 75% in Group B (ST) among patients with massive PE (P = 0.95). The mortality rate was numerically higher in the ST group (12%) than in the CDT group (8%). Bleeding complications were higher in the ST group (20%) than in the CDT group (8%). Conclusion: CDT was found to be noninferior to ST with respect to primary outcomes of mortality and success rate of thrombolysis. CDT had lower occurrence of bleeding episodes. CDT can be considered viable alternative to ST in patients with high bleeding risk. catheter-directed thrombolysis pulmonary embolism systemic thrombolysis Diseases of the circulatory (Cardiovascular) system Dinesh Joshi verfasserin aut Anand Shukla verfasserin aut Pratik Raval verfasserin aut Karthik Natrajan verfasserin aut Kewal Kanabar verfasserin aut Surender Kumar verfasserin aut Jigneshkumar Patel verfasserin aut In Heart India Wolters Kluwer Medknow Publications, 2017 9(2021), 3, Seite 169-173 (DE-627)168235749X 23216638 nnns volume:9 year:2021 number:3 pages:169-173 https://doi.org/10.4103/heartindia.heartindia_96_21 kostenfrei https://doaj.org/article/c3674ade03b2473eb7126225d12222b7 kostenfrei http://www.heartindia.net/article.asp?issn=2321-449x;year=2021;volume=9;issue=3;spage=169;epage=173;aulast=Tated kostenfrei https://doaj.org/toc/2321-449X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2021 3 169-173
allfieldsGer	10.4103/heartindia.heartindia_96_21 doi (DE-627)DOAJ019103646 (DE-599)DOAJc3674ade03b2473eb7126225d12222b7 DE-627 ger DE-627 rakwb eng RC666-701 Suyash Tated verfasserin aut A simple randomized prospective study comparing catheter-directed thrombolysis versus systemic thrombolysis in patients with massive and submassive pulmonary embolism 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Context: Catheter-directed thrombolysis (CDT) is a novel mode of thrombolysis where thrombolytic agents are directed through catheter to a specific area of interest; hence, low-dose thrombolytic agent will be required to produce satisfactory thrombolysis results. This will subsequently decrease the bleeding complications. With this postulation, a study was conducted to compare the outcome of CDT versus systemic thrombolysis (ST) in patients with massive and submassive pulmonary embolism (PE). Methods: The present study prospectively included the cases of massive and submassive (high-risk) PE and randomly distributed 25 patients into two groups each: Group A underwent CDT, whereas Group B underwent ST. The outcomes of both the groups were studied including mortality and bleeding complications, and patients were followed up for 6 months. At the end of the study, data were analyzed, and outcomes of both the groups were compared. Results: Baseline characteristics were similar in both the groups. The success rate was 90.4% in Group A (CDT) and 75% in Group B (ST) among patients with massive PE (P = 0.95). The mortality rate was numerically higher in the ST group (12%) than in the CDT group (8%). Bleeding complications were higher in the ST group (20%) than in the CDT group (8%). Conclusion: CDT was found to be noninferior to ST with respect to primary outcomes of mortality and success rate of thrombolysis. CDT had lower occurrence of bleeding episodes. CDT can be considered viable alternative to ST in patients with high bleeding risk. catheter-directed thrombolysis pulmonary embolism systemic thrombolysis Diseases of the circulatory (Cardiovascular) system Dinesh Joshi verfasserin aut Anand Shukla verfasserin aut Pratik Raval verfasserin aut Karthik Natrajan verfasserin aut Kewal Kanabar verfasserin aut Surender Kumar verfasserin aut Jigneshkumar Patel verfasserin aut In Heart India Wolters Kluwer Medknow Publications, 2017 9(2021), 3, Seite 169-173 (DE-627)168235749X 23216638 nnns volume:9 year:2021 number:3 pages:169-173 https://doi.org/10.4103/heartindia.heartindia_96_21 kostenfrei https://doaj.org/article/c3674ade03b2473eb7126225d12222b7 kostenfrei http://www.heartindia.net/article.asp?issn=2321-449x;year=2021;volume=9;issue=3;spage=169;epage=173;aulast=Tated kostenfrei https://doaj.org/toc/2321-449X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2021 3 169-173
allfieldsSound	10.4103/heartindia.heartindia_96_21 doi (DE-627)DOAJ019103646 (DE-599)DOAJc3674ade03b2473eb7126225d12222b7 DE-627 ger DE-627 rakwb eng RC666-701 Suyash Tated verfasserin aut A simple randomized prospective study comparing catheter-directed thrombolysis versus systemic thrombolysis in patients with massive and submassive pulmonary embolism 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Context: Catheter-directed thrombolysis (CDT) is a novel mode of thrombolysis where thrombolytic agents are directed through catheter to a specific area of interest; hence, low-dose thrombolytic agent will be required to produce satisfactory thrombolysis results. This will subsequently decrease the bleeding complications. With this postulation, a study was conducted to compare the outcome of CDT versus systemic thrombolysis (ST) in patients with massive and submassive pulmonary embolism (PE). Methods: The present study prospectively included the cases of massive and submassive (high-risk) PE and randomly distributed 25 patients into two groups each: Group A underwent CDT, whereas Group B underwent ST. The outcomes of both the groups were studied including mortality and bleeding complications, and patients were followed up for 6 months. At the end of the study, data were analyzed, and outcomes of both the groups were compared. Results: Baseline characteristics were similar in both the groups. The success rate was 90.4% in Group A (CDT) and 75% in Group B (ST) among patients with massive PE (P = 0.95). The mortality rate was numerically higher in the ST group (12%) than in the CDT group (8%). Bleeding complications were higher in the ST group (20%) than in the CDT group (8%). Conclusion: CDT was found to be noninferior to ST with respect to primary outcomes of mortality and success rate of thrombolysis. CDT had lower occurrence of bleeding episodes. CDT can be considered viable alternative to ST in patients with high bleeding risk. catheter-directed thrombolysis pulmonary embolism systemic thrombolysis Diseases of the circulatory (Cardiovascular) system Dinesh Joshi verfasserin aut Anand Shukla verfasserin aut Pratik Raval verfasserin aut Karthik Natrajan verfasserin aut Kewal Kanabar verfasserin aut Surender Kumar verfasserin aut Jigneshkumar Patel verfasserin aut In Heart India Wolters Kluwer Medknow Publications, 2017 9(2021), 3, Seite 169-173 (DE-627)168235749X 23216638 nnns volume:9 year:2021 number:3 pages:169-173 https://doi.org/10.4103/heartindia.heartindia_96_21 kostenfrei https://doaj.org/article/c3674ade03b2473eb7126225d12222b7 kostenfrei http://www.heartindia.net/article.asp?issn=2321-449x;year=2021;volume=9;issue=3;spage=169;epage=173;aulast=Tated kostenfrei https://doaj.org/toc/2321-449X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2021 3 169-173
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authorswithroles_txt_mv	Suyash Tated @@aut@@ Dinesh Joshi @@aut@@ Anand Shukla @@aut@@ Pratik Raval @@aut@@ Karthik Natrajan @@aut@@ Kewal Kanabar @@aut@@ Surender Kumar @@aut@@ Jigneshkumar Patel @@aut@@
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callnumber-first	R - Medicine
author	Suyash Tated
spellingShingle	Suyash Tated misc RC666-701 misc catheter-directed thrombolysis misc pulmonary embolism misc systemic thrombolysis misc Diseases of the circulatory (Cardiovascular) system A simple randomized prospective study comparing catheter-directed thrombolysis versus systemic thrombolysis in patients with massive and submassive pulmonary embolism
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topic_title	RC666-701 A simple randomized prospective study comparing catheter-directed thrombolysis versus systemic thrombolysis in patients with massive and submassive pulmonary embolism catheter-directed thrombolysis pulmonary embolism systemic thrombolysis
topic	misc RC666-701 misc catheter-directed thrombolysis misc pulmonary embolism misc systemic thrombolysis misc Diseases of the circulatory (Cardiovascular) system
topic_unstemmed	misc RC666-701 misc catheter-directed thrombolysis misc pulmonary embolism misc systemic thrombolysis misc Diseases of the circulatory (Cardiovascular) system
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title	A simple randomized prospective study comparing catheter-directed thrombolysis versus systemic thrombolysis in patients with massive and submassive pulmonary embolism
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title_full	A simple randomized prospective study comparing catheter-directed thrombolysis versus systemic thrombolysis in patients with massive and submassive pulmonary embolism
author_sort	Suyash Tated
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author_browse	Suyash Tated Dinesh Joshi Anand Shukla Pratik Raval Karthik Natrajan Kewal Kanabar Surender Kumar Jigneshkumar Patel
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doi_str_mv	10.4103/heartindia.heartindia_96_21
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title_sort	simple randomized prospective study comparing catheter-directed thrombolysis versus systemic thrombolysis in patients with massive and submassive pulmonary embolism
callnumber	RC666-701
title_auth	A simple randomized prospective study comparing catheter-directed thrombolysis versus systemic thrombolysis in patients with massive and submassive pulmonary embolism
abstract	Context: Catheter-directed thrombolysis (CDT) is a novel mode of thrombolysis where thrombolytic agents are directed through catheter to a specific area of interest; hence, low-dose thrombolytic agent will be required to produce satisfactory thrombolysis results. This will subsequently decrease the bleeding complications. With this postulation, a study was conducted to compare the outcome of CDT versus systemic thrombolysis (ST) in patients with massive and submassive pulmonary embolism (PE). Methods: The present study prospectively included the cases of massive and submassive (high-risk) PE and randomly distributed 25 patients into two groups each: Group A underwent CDT, whereas Group B underwent ST. The outcomes of both the groups were studied including mortality and bleeding complications, and patients were followed up for 6 months. At the end of the study, data were analyzed, and outcomes of both the groups were compared. Results: Baseline characteristics were similar in both the groups. The success rate was 90.4% in Group A (CDT) and 75% in Group B (ST) among patients with massive PE (P = 0.95). The mortality rate was numerically higher in the ST group (12%) than in the CDT group (8%). Bleeding complications were higher in the ST group (20%) than in the CDT group (8%). Conclusion: CDT was found to be noninferior to ST with respect to primary outcomes of mortality and success rate of thrombolysis. CDT had lower occurrence of bleeding episodes. CDT can be considered viable alternative to ST in patients with high bleeding risk.
abstractGer	Context: Catheter-directed thrombolysis (CDT) is a novel mode of thrombolysis where thrombolytic agents are directed through catheter to a specific area of interest; hence, low-dose thrombolytic agent will be required to produce satisfactory thrombolysis results. This will subsequently decrease the bleeding complications. With this postulation, a study was conducted to compare the outcome of CDT versus systemic thrombolysis (ST) in patients with massive and submassive pulmonary embolism (PE). Methods: The present study prospectively included the cases of massive and submassive (high-risk) PE and randomly distributed 25 patients into two groups each: Group A underwent CDT, whereas Group B underwent ST. The outcomes of both the groups were studied including mortality and bleeding complications, and patients were followed up for 6 months. At the end of the study, data were analyzed, and outcomes of both the groups were compared. Results: Baseline characteristics were similar in both the groups. The success rate was 90.4% in Group A (CDT) and 75% in Group B (ST) among patients with massive PE (P = 0.95). The mortality rate was numerically higher in the ST group (12%) than in the CDT group (8%). Bleeding complications were higher in the ST group (20%) than in the CDT group (8%). Conclusion: CDT was found to be noninferior to ST with respect to primary outcomes of mortality and success rate of thrombolysis. CDT had lower occurrence of bleeding episodes. CDT can be considered viable alternative to ST in patients with high bleeding risk.
abstract_unstemmed	Context: Catheter-directed thrombolysis (CDT) is a novel mode of thrombolysis where thrombolytic agents are directed through catheter to a specific area of interest; hence, low-dose thrombolytic agent will be required to produce satisfactory thrombolysis results. This will subsequently decrease the bleeding complications. With this postulation, a study was conducted to compare the outcome of CDT versus systemic thrombolysis (ST) in patients with massive and submassive pulmonary embolism (PE). Methods: The present study prospectively included the cases of massive and submassive (high-risk) PE and randomly distributed 25 patients into two groups each: Group A underwent CDT, whereas Group B underwent ST. The outcomes of both the groups were studied including mortality and bleeding complications, and patients were followed up for 6 months. At the end of the study, data were analyzed, and outcomes of both the groups were compared. Results: Baseline characteristics were similar in both the groups. The success rate was 90.4% in Group A (CDT) and 75% in Group B (ST) among patients with massive PE (P = 0.95). The mortality rate was numerically higher in the ST group (12%) than in the CDT group (8%). Bleeding complications were higher in the ST group (20%) than in the CDT group (8%). Conclusion: CDT was found to be noninferior to ST with respect to primary outcomes of mortality and success rate of thrombolysis. CDT had lower occurrence of bleeding episodes. CDT can be considered viable alternative to ST in patients with high bleeding risk.
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title_short	A simple randomized prospective study comparing catheter-directed thrombolysis versus systemic thrombolysis in patients with massive and submassive pulmonary embolism
url	https://doi.org/10.4103/heartindia.heartindia_96_21 https://doaj.org/article/c3674ade03b2473eb7126225d12222b7 http://www.heartindia.net/article.asp?issn=2321-449x;year=2021;volume=9;issue=3;spage=169;epage=173;aulast=Tated https://doaj.org/toc/2321-449X
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author2	Dinesh Joshi Anand Shukla Pratik Raval Karthik Natrajan Kewal Kanabar Surender Kumar Jigneshkumar Patel
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doi_str	10.4103/heartindia.heartindia_96_21
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up_date	2024-07-03T21:48:39.633Z
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Bleeding complications were higher in the ST group (20%) than in the CDT group (8%). Conclusion: CDT was found to be noninferior to ST with respect to primary outcomes of mortality and success rate of thrombolysis. CDT had lower occurrence of bleeding episodes. 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A simple randomized prospective study comparing catheter-directed thrombolysis versus systemic thrombolysis in patients with massive and submassive pulmonary embolism

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