Protective mechanism of flavonoids of Oxytropis falcata bunge against IPF

Aims: Total flavonoids of Oxytropis falcata bunge (FOFB) from plants medicine have anti-inflammatory and anti-fibrotic activities. The present study was to investigate the effect of FOFB on the expression of MCP-1/TNF-α/IL-1β and ICAM-1 proteins in rats with idiopathic pulmonary fibrosis(IPF). Metho...
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Autor*in:	Yan-jun Wang [verfasserIn] Xue-lin Wang [verfasserIn] Qian-kun Liang [verfasserIn] Yan-wen Chen [verfasserIn] Ling-ling Yang [verfasserIn] Hai-xia Ming [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	Total flavonoids of Oxytropis falcata bunge(FOFB) Idiopathic pulmonary fibrosis Inflammatory response Inflammatory factors

Übergeordnetes Werk:	In: Pharmacological Research - Modern Chinese Medicine - Elsevier, 2021, 1(2021), Seite 100008-
Übergeordnetes Werk:	volume:1 ; year:2021 ; pages:100008-

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.prmcm.2021.100008

Katalog-ID:	DOAJ019130465

Internformat


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520			\|a Aims: Total flavonoids of Oxytropis falcata bunge (FOFB) from plants medicine have anti-inflammatory and anti-fibrotic activities. The present study was to investigate the effect of FOFB on the expression of MCP-1/TNF-α/IL-1β and ICAM-1 proteins in rats with idiopathic pulmonary fibrosis(IPF). Methods: Fifty rats model with IPF was established by a single intratracheal instillation of bleomycin (BLM 5 mg/kg). And 10 rats were taken as the control group without any treatment. After 14 days, model rats were administered the same volume with low dose(100 mg/kg), middle dose (200 mg/kg) and high dose (400 mg/kg) of FOFB, with prednisone acetate tablet (20 mg/kg, PAT group) as the positive drug. The remaining two groups were given the same volume of normal saline once a day for 28 consecutive days. Subsequently, pathological analysis by HE and Masson staining and ultrastructure by transmission electron microscopy were performed. The expressions of cytokines including MCP-1, TNF-α, IL-1β and ICAM-1 were determined by real-time PCR and immunohistochemical staining. Results: Compared with the blank group, severe inflammation and fibrosis were found in the BLM group; The mRNA levels of MCP-1, TNF-α, IL-1β and ICAM-1 were significantly increased in the model group. However, middle or high dose of FOFB and PAT group could significantly decrease infiltration of inflammatory cells, degree of fibrosis, and expression of inflammatory cytokines levels. Conclusion: FOFB can attenuate BLM-induced IPF via inhibiting inflammatory response, reducing inflammatory infiltration, and improving the degree of fibrosis. The mechanism may be related to the inhibition the expression of MCP-1, TNF-α, IL-1β and ICAM-1 proteins.
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650		4	\|a Idiopathic pulmonary fibrosis
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700	0		\|a Xue-lin Wang \|e verfasserin \|4 aut
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700	0		\|a Ling-ling Yang \|e verfasserin \|4 aut
700	0		\|a Hai-xia Ming \|e verfasserin \|4 aut
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publishDate	2021
allfields	10.1016/j.prmcm.2021.100008 doi (DE-627)DOAJ019130465 (DE-599)DOAJ1b862b4baa574ba19de3e0d3538f02f4 DE-627 ger DE-627 rakwb eng RZ201-999 RM1-950 Yan-jun Wang verfasserin aut Protective mechanism of flavonoids of Oxytropis falcata bunge against IPF 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aims: Total flavonoids of Oxytropis falcata bunge (FOFB) from plants medicine have anti-inflammatory and anti-fibrotic activities. The present study was to investigate the effect of FOFB on the expression of MCP-1/TNF-α/IL-1β and ICAM-1 proteins in rats with idiopathic pulmonary fibrosis(IPF). Methods: Fifty rats model with IPF was established by a single intratracheal instillation of bleomycin (BLM 5 mg/kg). And 10 rats were taken as the control group without any treatment. After 14 days, model rats were administered the same volume with low dose(100 mg/kg), middle dose (200 mg/kg) and high dose (400 mg/kg) of FOFB, with prednisone acetate tablet (20 mg/kg, PAT group) as the positive drug. The remaining two groups were given the same volume of normal saline once a day for 28 consecutive days. Subsequently, pathological analysis by HE and Masson staining and ultrastructure by transmission electron microscopy were performed. The expressions of cytokines including MCP-1, TNF-α, IL-1β and ICAM-1 were determined by real-time PCR and immunohistochemical staining. Results: Compared with the blank group, severe inflammation and fibrosis were found in the BLM group; The mRNA levels of MCP-1, TNF-α, IL-1β and ICAM-1 were significantly increased in the model group. However, middle or high dose of FOFB and PAT group could significantly decrease infiltration of inflammatory cells, degree of fibrosis, and expression of inflammatory cytokines levels. Conclusion: FOFB can attenuate BLM-induced IPF via inhibiting inflammatory response, reducing inflammatory infiltration, and improving the degree of fibrosis. The mechanism may be related to the inhibition the expression of MCP-1, TNF-α, IL-1β and ICAM-1 proteins. Total flavonoids of Oxytropis falcata bunge(FOFB) Idiopathic pulmonary fibrosis Inflammatory response Inflammatory factors Other systems of medicine Therapeutics. Pharmacology Xue-lin Wang verfasserin aut Qian-kun Liang verfasserin aut Yan-wen Chen verfasserin aut Ling-ling Yang verfasserin aut Hai-xia Ming verfasserin aut In Pharmacological Research - Modern Chinese Medicine Elsevier, 2021 1(2021), Seite 100008- (DE-627)1785333399 26671425 nnns volume:1 year:2021 pages:100008- https://doi.org/10.1016/j.prmcm.2021.100008 kostenfrei https://doaj.org/article/1b862b4baa574ba19de3e0d3538f02f4 kostenfrei http://www.sciencedirect.com/science/article/pii/S2667142521000075 kostenfrei https://doaj.org/toc/2667-1425 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 1 2021 100008-
spelling	10.1016/j.prmcm.2021.100008 doi (DE-627)DOAJ019130465 (DE-599)DOAJ1b862b4baa574ba19de3e0d3538f02f4 DE-627 ger DE-627 rakwb eng RZ201-999 RM1-950 Yan-jun Wang verfasserin aut Protective mechanism of flavonoids of Oxytropis falcata bunge against IPF 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aims: Total flavonoids of Oxytropis falcata bunge (FOFB) from plants medicine have anti-inflammatory and anti-fibrotic activities. The present study was to investigate the effect of FOFB on the expression of MCP-1/TNF-α/IL-1β and ICAM-1 proteins in rats with idiopathic pulmonary fibrosis(IPF). Methods: Fifty rats model with IPF was established by a single intratracheal instillation of bleomycin (BLM 5 mg/kg). And 10 rats were taken as the control group without any treatment. After 14 days, model rats were administered the same volume with low dose(100 mg/kg), middle dose (200 mg/kg) and high dose (400 mg/kg) of FOFB, with prednisone acetate tablet (20 mg/kg, PAT group) as the positive drug. The remaining two groups were given the same volume of normal saline once a day for 28 consecutive days. Subsequently, pathological analysis by HE and Masson staining and ultrastructure by transmission electron microscopy were performed. The expressions of cytokines including MCP-1, TNF-α, IL-1β and ICAM-1 were determined by real-time PCR and immunohistochemical staining. Results: Compared with the blank group, severe inflammation and fibrosis were found in the BLM group; The mRNA levels of MCP-1, TNF-α, IL-1β and ICAM-1 were significantly increased in the model group. However, middle or high dose of FOFB and PAT group could significantly decrease infiltration of inflammatory cells, degree of fibrosis, and expression of inflammatory cytokines levels. Conclusion: FOFB can attenuate BLM-induced IPF via inhibiting inflammatory response, reducing inflammatory infiltration, and improving the degree of fibrosis. The mechanism may be related to the inhibition the expression of MCP-1, TNF-α, IL-1β and ICAM-1 proteins. Total flavonoids of Oxytropis falcata bunge(FOFB) Idiopathic pulmonary fibrosis Inflammatory response Inflammatory factors Other systems of medicine Therapeutics. Pharmacology Xue-lin Wang verfasserin aut Qian-kun Liang verfasserin aut Yan-wen Chen verfasserin aut Ling-ling Yang verfasserin aut Hai-xia Ming verfasserin aut In Pharmacological Research - Modern Chinese Medicine Elsevier, 2021 1(2021), Seite 100008- (DE-627)1785333399 26671425 nnns volume:1 year:2021 pages:100008- https://doi.org/10.1016/j.prmcm.2021.100008 kostenfrei https://doaj.org/article/1b862b4baa574ba19de3e0d3538f02f4 kostenfrei http://www.sciencedirect.com/science/article/pii/S2667142521000075 kostenfrei https://doaj.org/toc/2667-1425 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 1 2021 100008-
allfields_unstemmed	10.1016/j.prmcm.2021.100008 doi (DE-627)DOAJ019130465 (DE-599)DOAJ1b862b4baa574ba19de3e0d3538f02f4 DE-627 ger DE-627 rakwb eng RZ201-999 RM1-950 Yan-jun Wang verfasserin aut Protective mechanism of flavonoids of Oxytropis falcata bunge against IPF 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aims: Total flavonoids of Oxytropis falcata bunge (FOFB) from plants medicine have anti-inflammatory and anti-fibrotic activities. The present study was to investigate the effect of FOFB on the expression of MCP-1/TNF-α/IL-1β and ICAM-1 proteins in rats with idiopathic pulmonary fibrosis(IPF). Methods: Fifty rats model with IPF was established by a single intratracheal instillation of bleomycin (BLM 5 mg/kg). And 10 rats were taken as the control group without any treatment. After 14 days, model rats were administered the same volume with low dose(100 mg/kg), middle dose (200 mg/kg) and high dose (400 mg/kg) of FOFB, with prednisone acetate tablet (20 mg/kg, PAT group) as the positive drug. The remaining two groups were given the same volume of normal saline once a day for 28 consecutive days. Subsequently, pathological analysis by HE and Masson staining and ultrastructure by transmission electron microscopy were performed. The expressions of cytokines including MCP-1, TNF-α, IL-1β and ICAM-1 were determined by real-time PCR and immunohistochemical staining. Results: Compared with the blank group, severe inflammation and fibrosis were found in the BLM group; The mRNA levels of MCP-1, TNF-α, IL-1β and ICAM-1 were significantly increased in the model group. However, middle or high dose of FOFB and PAT group could significantly decrease infiltration of inflammatory cells, degree of fibrosis, and expression of inflammatory cytokines levels. Conclusion: FOFB can attenuate BLM-induced IPF via inhibiting inflammatory response, reducing inflammatory infiltration, and improving the degree of fibrosis. The mechanism may be related to the inhibition the expression of MCP-1, TNF-α, IL-1β and ICAM-1 proteins. Total flavonoids of Oxytropis falcata bunge(FOFB) Idiopathic pulmonary fibrosis Inflammatory response Inflammatory factors Other systems of medicine Therapeutics. Pharmacology Xue-lin Wang verfasserin aut Qian-kun Liang verfasserin aut Yan-wen Chen verfasserin aut Ling-ling Yang verfasserin aut Hai-xia Ming verfasserin aut In Pharmacological Research - Modern Chinese Medicine Elsevier, 2021 1(2021), Seite 100008- (DE-627)1785333399 26671425 nnns volume:1 year:2021 pages:100008- https://doi.org/10.1016/j.prmcm.2021.100008 kostenfrei https://doaj.org/article/1b862b4baa574ba19de3e0d3538f02f4 kostenfrei http://www.sciencedirect.com/science/article/pii/S2667142521000075 kostenfrei https://doaj.org/toc/2667-1425 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 1 2021 100008-
allfieldsGer	10.1016/j.prmcm.2021.100008 doi (DE-627)DOAJ019130465 (DE-599)DOAJ1b862b4baa574ba19de3e0d3538f02f4 DE-627 ger DE-627 rakwb eng RZ201-999 RM1-950 Yan-jun Wang verfasserin aut Protective mechanism of flavonoids of Oxytropis falcata bunge against IPF 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aims: Total flavonoids of Oxytropis falcata bunge (FOFB) from plants medicine have anti-inflammatory and anti-fibrotic activities. The present study was to investigate the effect of FOFB on the expression of MCP-1/TNF-α/IL-1β and ICAM-1 proteins in rats with idiopathic pulmonary fibrosis(IPF). Methods: Fifty rats model with IPF was established by a single intratracheal instillation of bleomycin (BLM 5 mg/kg). And 10 rats were taken as the control group without any treatment. After 14 days, model rats were administered the same volume with low dose(100 mg/kg), middle dose (200 mg/kg) and high dose (400 mg/kg) of FOFB, with prednisone acetate tablet (20 mg/kg, PAT group) as the positive drug. The remaining two groups were given the same volume of normal saline once a day for 28 consecutive days. Subsequently, pathological analysis by HE and Masson staining and ultrastructure by transmission electron microscopy were performed. The expressions of cytokines including MCP-1, TNF-α, IL-1β and ICAM-1 were determined by real-time PCR and immunohistochemical staining. Results: Compared with the blank group, severe inflammation and fibrosis were found in the BLM group; The mRNA levels of MCP-1, TNF-α, IL-1β and ICAM-1 were significantly increased in the model group. However, middle or high dose of FOFB and PAT group could significantly decrease infiltration of inflammatory cells, degree of fibrosis, and expression of inflammatory cytokines levels. Conclusion: FOFB can attenuate BLM-induced IPF via inhibiting inflammatory response, reducing inflammatory infiltration, and improving the degree of fibrosis. The mechanism may be related to the inhibition the expression of MCP-1, TNF-α, IL-1β and ICAM-1 proteins. Total flavonoids of Oxytropis falcata bunge(FOFB) Idiopathic pulmonary fibrosis Inflammatory response Inflammatory factors Other systems of medicine Therapeutics. Pharmacology Xue-lin Wang verfasserin aut Qian-kun Liang verfasserin aut Yan-wen Chen verfasserin aut Ling-ling Yang verfasserin aut Hai-xia Ming verfasserin aut In Pharmacological Research - Modern Chinese Medicine Elsevier, 2021 1(2021), Seite 100008- (DE-627)1785333399 26671425 nnns volume:1 year:2021 pages:100008- https://doi.org/10.1016/j.prmcm.2021.100008 kostenfrei https://doaj.org/article/1b862b4baa574ba19de3e0d3538f02f4 kostenfrei http://www.sciencedirect.com/science/article/pii/S2667142521000075 kostenfrei https://doaj.org/toc/2667-1425 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 1 2021 100008-
allfieldsSound	10.1016/j.prmcm.2021.100008 doi (DE-627)DOAJ019130465 (DE-599)DOAJ1b862b4baa574ba19de3e0d3538f02f4 DE-627 ger DE-627 rakwb eng RZ201-999 RM1-950 Yan-jun Wang verfasserin aut Protective mechanism of flavonoids of Oxytropis falcata bunge against IPF 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aims: Total flavonoids of Oxytropis falcata bunge (FOFB) from plants medicine have anti-inflammatory and anti-fibrotic activities. The present study was to investigate the effect of FOFB on the expression of MCP-1/TNF-α/IL-1β and ICAM-1 proteins in rats with idiopathic pulmonary fibrosis(IPF). Methods: Fifty rats model with IPF was established by a single intratracheal instillation of bleomycin (BLM 5 mg/kg). And 10 rats were taken as the control group without any treatment. After 14 days, model rats were administered the same volume with low dose(100 mg/kg), middle dose (200 mg/kg) and high dose (400 mg/kg) of FOFB, with prednisone acetate tablet (20 mg/kg, PAT group) as the positive drug. The remaining two groups were given the same volume of normal saline once a day for 28 consecutive days. Subsequently, pathological analysis by HE and Masson staining and ultrastructure by transmission electron microscopy were performed. The expressions of cytokines including MCP-1, TNF-α, IL-1β and ICAM-1 were determined by real-time PCR and immunohistochemical staining. Results: Compared with the blank group, severe inflammation and fibrosis were found in the BLM group; The mRNA levels of MCP-1, TNF-α, IL-1β and ICAM-1 were significantly increased in the model group. However, middle or high dose of FOFB and PAT group could significantly decrease infiltration of inflammatory cells, degree of fibrosis, and expression of inflammatory cytokines levels. Conclusion: FOFB can attenuate BLM-induced IPF via inhibiting inflammatory response, reducing inflammatory infiltration, and improving the degree of fibrosis. The mechanism may be related to the inhibition the expression of MCP-1, TNF-α, IL-1β and ICAM-1 proteins. Total flavonoids of Oxytropis falcata bunge(FOFB) Idiopathic pulmonary fibrosis Inflammatory response Inflammatory factors Other systems of medicine Therapeutics. Pharmacology Xue-lin Wang verfasserin aut Qian-kun Liang verfasserin aut Yan-wen Chen verfasserin aut Ling-ling Yang verfasserin aut Hai-xia Ming verfasserin aut In Pharmacological Research - Modern Chinese Medicine Elsevier, 2021 1(2021), Seite 100008- (DE-627)1785333399 26671425 nnns volume:1 year:2021 pages:100008- https://doi.org/10.1016/j.prmcm.2021.100008 kostenfrei https://doaj.org/article/1b862b4baa574ba19de3e0d3538f02f4 kostenfrei http://www.sciencedirect.com/science/article/pii/S2667142521000075 kostenfrei https://doaj.org/toc/2667-1425 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 1 2021 100008-
language	English
source	In Pharmacological Research - Modern Chinese Medicine 1(2021), Seite 100008- volume:1 year:2021 pages:100008-
sourceStr	In Pharmacological Research - Modern Chinese Medicine 1(2021), Seite 100008- volume:1 year:2021 pages:100008-
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Total flavonoids of Oxytropis falcata bunge(FOFB) Idiopathic pulmonary fibrosis Inflammatory response Inflammatory factors Other systems of medicine Therapeutics. Pharmacology
isfreeaccess_bool	true
container_title	Pharmacological Research - Modern Chinese Medicine
authorswithroles_txt_mv	Yan-jun Wang @@aut@@ Xue-lin Wang @@aut@@ Qian-kun Liang @@aut@@ Yan-wen Chen @@aut@@ Ling-ling Yang @@aut@@ Hai-xia Ming @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
hierarchy_top_id	1785333399
id	DOAJ019130465
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ019130465</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230502124834.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230226s2021 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.prmcm.2021.100008</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ019130465</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ1b862b4baa574ba19de3e0d3538f02f4</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RZ201-999</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RM1-950</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Yan-jun Wang</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Protective mechanism of flavonoids of Oxytropis falcata bunge against IPF</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2021</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Aims: Total flavonoids of Oxytropis falcata bunge (FOFB) from plants medicine have anti-inflammatory and anti-fibrotic activities. The present study was to investigate the effect of FOFB on the expression of MCP-1/TNF-α/IL-1β and ICAM-1 proteins in rats with idiopathic pulmonary fibrosis(IPF). Methods: Fifty rats model with IPF was established by a single intratracheal instillation of bleomycin (BLM 5 mg/kg). And 10 rats were taken as the control group without any treatment. After 14 days, model rats were administered the same volume with low dose(100 mg/kg), middle dose (200 mg/kg) and high dose (400 mg/kg) of FOFB, with prednisone acetate tablet (20 mg/kg, PAT group) as the positive drug. The remaining two groups were given the same volume of normal saline once a day for 28 consecutive days. Subsequently, pathological analysis by HE and Masson staining and ultrastructure by transmission electron microscopy were performed. The expressions of cytokines including MCP-1, TNF-α, IL-1β and ICAM-1 were determined by real-time PCR and immunohistochemical staining. Results: Compared with the blank group, severe inflammation and fibrosis were found in the BLM group; The mRNA levels of MCP-1, TNF-α, IL-1β and ICAM-1 were significantly increased in the model group. However, middle or high dose of FOFB and PAT group could significantly decrease infiltration of inflammatory cells, degree of fibrosis, and expression of inflammatory cytokines levels. Conclusion: FOFB can attenuate BLM-induced IPF via inhibiting inflammatory response, reducing inflammatory infiltration, and improving the degree of fibrosis. 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callnumber-first	R - Medicine
author	Yan-jun Wang
spellingShingle	Yan-jun Wang misc RZ201-999 misc RM1-950 misc Total flavonoids of Oxytropis falcata bunge(FOFB) misc Idiopathic pulmonary fibrosis misc Inflammatory response misc Inflammatory factors misc Other systems of medicine misc Therapeutics. Pharmacology Protective mechanism of flavonoids of Oxytropis falcata bunge against IPF
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topic_title	RZ201-999 RM1-950 Protective mechanism of flavonoids of Oxytropis falcata bunge against IPF Total flavonoids of Oxytropis falcata bunge(FOFB) Idiopathic pulmonary fibrosis Inflammatory response Inflammatory factors
topic	misc RZ201-999 misc RM1-950 misc Total flavonoids of Oxytropis falcata bunge(FOFB) misc Idiopathic pulmonary fibrosis misc Inflammatory response misc Inflammatory factors misc Other systems of medicine misc Therapeutics. Pharmacology
topic_unstemmed	misc RZ201-999 misc RM1-950 misc Total flavonoids of Oxytropis falcata bunge(FOFB) misc Idiopathic pulmonary fibrosis misc Inflammatory response misc Inflammatory factors misc Other systems of medicine misc Therapeutics. Pharmacology
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title	Protective mechanism of flavonoids of Oxytropis falcata bunge against IPF
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title_full	Protective mechanism of flavonoids of Oxytropis falcata bunge against IPF
author_sort	Yan-jun Wang
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title_sort	protective mechanism of flavonoids of oxytropis falcata bunge against ipf
callnumber	RZ201-999
title_auth	Protective mechanism of flavonoids of Oxytropis falcata bunge against IPF
abstract	Aims: Total flavonoids of Oxytropis falcata bunge (FOFB) from plants medicine have anti-inflammatory and anti-fibrotic activities. The present study was to investigate the effect of FOFB on the expression of MCP-1/TNF-α/IL-1β and ICAM-1 proteins in rats with idiopathic pulmonary fibrosis(IPF). Methods: Fifty rats model with IPF was established by a single intratracheal instillation of bleomycin (BLM 5 mg/kg). And 10 rats were taken as the control group without any treatment. After 14 days, model rats were administered the same volume with low dose(100 mg/kg), middle dose (200 mg/kg) and high dose (400 mg/kg) of FOFB, with prednisone acetate tablet (20 mg/kg, PAT group) as the positive drug. The remaining two groups were given the same volume of normal saline once a day for 28 consecutive days. Subsequently, pathological analysis by HE and Masson staining and ultrastructure by transmission electron microscopy were performed. The expressions of cytokines including MCP-1, TNF-α, IL-1β and ICAM-1 were determined by real-time PCR and immunohistochemical staining. Results: Compared with the blank group, severe inflammation and fibrosis were found in the BLM group; The mRNA levels of MCP-1, TNF-α, IL-1β and ICAM-1 were significantly increased in the model group. However, middle or high dose of FOFB and PAT group could significantly decrease infiltration of inflammatory cells, degree of fibrosis, and expression of inflammatory cytokines levels. Conclusion: FOFB can attenuate BLM-induced IPF via inhibiting inflammatory response, reducing inflammatory infiltration, and improving the degree of fibrosis. The mechanism may be related to the inhibition the expression of MCP-1, TNF-α, IL-1β and ICAM-1 proteins.
abstractGer	Aims: Total flavonoids of Oxytropis falcata bunge (FOFB) from plants medicine have anti-inflammatory and anti-fibrotic activities. The present study was to investigate the effect of FOFB on the expression of MCP-1/TNF-α/IL-1β and ICAM-1 proteins in rats with idiopathic pulmonary fibrosis(IPF). Methods: Fifty rats model with IPF was established by a single intratracheal instillation of bleomycin (BLM 5 mg/kg). And 10 rats were taken as the control group without any treatment. After 14 days, model rats were administered the same volume with low dose(100 mg/kg), middle dose (200 mg/kg) and high dose (400 mg/kg) of FOFB, with prednisone acetate tablet (20 mg/kg, PAT group) as the positive drug. The remaining two groups were given the same volume of normal saline once a day for 28 consecutive days. Subsequently, pathological analysis by HE and Masson staining and ultrastructure by transmission electron microscopy were performed. The expressions of cytokines including MCP-1, TNF-α, IL-1β and ICAM-1 were determined by real-time PCR and immunohistochemical staining. Results: Compared with the blank group, severe inflammation and fibrosis were found in the BLM group; The mRNA levels of MCP-1, TNF-α, IL-1β and ICAM-1 were significantly increased in the model group. However, middle or high dose of FOFB and PAT group could significantly decrease infiltration of inflammatory cells, degree of fibrosis, and expression of inflammatory cytokines levels. Conclusion: FOFB can attenuate BLM-induced IPF via inhibiting inflammatory response, reducing inflammatory infiltration, and improving the degree of fibrosis. The mechanism may be related to the inhibition the expression of MCP-1, TNF-α, IL-1β and ICAM-1 proteins.
abstract_unstemmed	Aims: Total flavonoids of Oxytropis falcata bunge (FOFB) from plants medicine have anti-inflammatory and anti-fibrotic activities. The present study was to investigate the effect of FOFB on the expression of MCP-1/TNF-α/IL-1β and ICAM-1 proteins in rats with idiopathic pulmonary fibrosis(IPF). Methods: Fifty rats model with IPF was established by a single intratracheal instillation of bleomycin (BLM 5 mg/kg). And 10 rats were taken as the control group without any treatment. After 14 days, model rats were administered the same volume with low dose(100 mg/kg), middle dose (200 mg/kg) and high dose (400 mg/kg) of FOFB, with prednisone acetate tablet (20 mg/kg, PAT group) as the positive drug. The remaining two groups were given the same volume of normal saline once a day for 28 consecutive days. Subsequently, pathological analysis by HE and Masson staining and ultrastructure by transmission electron microscopy were performed. The expressions of cytokines including MCP-1, TNF-α, IL-1β and ICAM-1 were determined by real-time PCR and immunohistochemical staining. Results: Compared with the blank group, severe inflammation and fibrosis were found in the BLM group; The mRNA levels of MCP-1, TNF-α, IL-1β and ICAM-1 were significantly increased in the model group. However, middle or high dose of FOFB and PAT group could significantly decrease infiltration of inflammatory cells, degree of fibrosis, and expression of inflammatory cytokines levels. Conclusion: FOFB can attenuate BLM-induced IPF via inhibiting inflammatory response, reducing inflammatory infiltration, and improving the degree of fibrosis. The mechanism may be related to the inhibition the expression of MCP-1, TNF-α, IL-1β and ICAM-1 proteins.
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title_short	Protective mechanism of flavonoids of Oxytropis falcata bunge against IPF
url	https://doi.org/10.1016/j.prmcm.2021.100008 https://doaj.org/article/1b862b4baa574ba19de3e0d3538f02f4 http://www.sciencedirect.com/science/article/pii/S2667142521000075 https://doaj.org/toc/2667-1425
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up_date	2024-07-03T21:57:56.750Z
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fullrecord_marcxml	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ019130465</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230502124834.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230226s2021 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.prmcm.2021.100008</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ019130465</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ1b862b4baa574ba19de3e0d3538f02f4</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RZ201-999</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RM1-950</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Yan-jun Wang</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Protective mechanism of flavonoids of Oxytropis falcata bunge against IPF</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2021</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Aims: Total flavonoids of Oxytropis falcata bunge (FOFB) from plants medicine have anti-inflammatory and anti-fibrotic activities. The present study was to investigate the effect of FOFB on the expression of MCP-1/TNF-α/IL-1β and ICAM-1 proteins in rats with idiopathic pulmonary fibrosis(IPF). Methods: Fifty rats model with IPF was established by a single intratracheal instillation of bleomycin (BLM 5 mg/kg). And 10 rats were taken as the control group without any treatment. After 14 days, model rats were administered the same volume with low dose(100 mg/kg), middle dose (200 mg/kg) and high dose (400 mg/kg) of FOFB, with prednisone acetate tablet (20 mg/kg, PAT group) as the positive drug. The remaining two groups were given the same volume of normal saline once a day for 28 consecutive days. Subsequently, pathological analysis by HE and Masson staining and ultrastructure by transmission electron microscopy were performed. The expressions of cytokines including MCP-1, TNF-α, IL-1β and ICAM-1 were determined by real-time PCR and immunohistochemical staining. Results: Compared with the blank group, severe inflammation and fibrosis were found in the BLM group; The mRNA levels of MCP-1, TNF-α, IL-1β and ICAM-1 were significantly increased in the model group. However, middle or high dose of FOFB and PAT group could significantly decrease infiltration of inflammatory cells, degree of fibrosis, and expression of inflammatory cytokines levels. Conclusion: FOFB can attenuate BLM-induced IPF via inhibiting inflammatory response, reducing inflammatory infiltration, and improving the degree of fibrosis. The mechanism may be related to the inhibition the expression of MCP-1, TNF-α, IL-1β and ICAM-1 proteins.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Total flavonoids of Oxytropis falcata bunge(FOFB)</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Idiopathic pulmonary fibrosis</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Inflammatory response</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Inflammatory factors</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Other systems of medicine</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Therapeutics. Pharmacology</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Xue-lin Wang</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Qian-kun Liang</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Yan-wen Chen</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ling-ling Yang</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Hai-xia Ming</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Pharmacological Research - Modern 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Protective mechanism of flavonoids of Oxytropis falcata bunge against IPF

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