Levels of Cortisol in CSF Are Associated With SNAP-25 and Tau Pathology but Not Amyloid-β

Objective: Preclinical studies have found both hyperactivity of hypothalamic- pituitary- adrenal (HPA) axis and synaptic degeneration are involved in the pathogenesis of Alzheimer’s disease (AD). However, the data on the relationship of activity of HPA axis and synaptic degeneration in humans are li...
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Autor*in:	Qing Wang [verfasserIn] Wenjun Zhou [verfasserIn] Jie Zhang [verfasserIn] The Alzheimer’s Disease Neuroimaging Initiative [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	cortisol SNAP-25 Alzheimer’s disease tau pathology synapse degeneration mild cognitive impairment

Übergeordnetes Werk:	In: Frontiers in Aging Neuroscience - Frontiers Media S.A., 2010, 10(2018)
Übergeordnetes Werk:	volume:10 ; year:2018

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fnagi.2018.00383

Katalog-ID:	DOAJ019181426

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520			\|a Objective: Preclinical studies have found both hyperactivity of hypothalamic- pituitary- adrenal (HPA) axis and synaptic degeneration are involved in the pathogenesis of Alzheimer’s disease (AD). However, the data on the relationship of activity of HPA axis and synaptic degeneration in humans are limited.Methods: We compared CSF cortisol levels in 310 subjects, including 92 cognitively normal older people, 149 patients with mild cognitive impairment (MCI), and 69 patients with mild AD. Several linear and logistic regression models were conducted to investigate associations between CSF cortisol and synaptosomal-associated protein 25 (SNAP-25, reflecting synaptic degeneration) and other AD-related biomarkers.Results: We found that levels of cortisol in CSF were associated with SNAP-25 levels and tau pathologies but not amyloid-β protein. However, there were no significant differences in CSF cortisol levels among the three diagnostic groups.Conclusion: The HPA axis may play a crucial role in synaptic degeneration in AD pathogenesis.
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allfields	10.3389/fnagi.2018.00383 doi (DE-627)DOAJ019181426 (DE-599)DOAJbf177e301fb04cc387f97910b5aa7b5f DE-627 ger DE-627 rakwb eng RC321-571 Qing Wang verfasserin aut Levels of Cortisol in CSF Are Associated With SNAP-25 and Tau Pathology but Not Amyloid-β 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: Preclinical studies have found both hyperactivity of hypothalamic- pituitary- adrenal (HPA) axis and synaptic degeneration are involved in the pathogenesis of Alzheimer’s disease (AD). However, the data on the relationship of activity of HPA axis and synaptic degeneration in humans are limited.Methods: We compared CSF cortisol levels in 310 subjects, including 92 cognitively normal older people, 149 patients with mild cognitive impairment (MCI), and 69 patients with mild AD. Several linear and logistic regression models were conducted to investigate associations between CSF cortisol and synaptosomal-associated protein 25 (SNAP-25, reflecting synaptic degeneration) and other AD-related biomarkers.Results: We found that levels of cortisol in CSF were associated with SNAP-25 levels and tau pathologies but not amyloid-β protein. However, there were no significant differences in CSF cortisol levels among the three diagnostic groups.Conclusion: The HPA axis may play a crucial role in synaptic degeneration in AD pathogenesis. cortisol SNAP-25 Alzheimer’s disease tau pathology synapse degeneration mild cognitive impairment Neurosciences. Biological psychiatry. Neuropsychiatry Wenjun Zhou verfasserin aut Jie Zhang verfasserin aut The Alzheimer’s Disease Neuroimaging Initiative verfasserin aut In Frontiers in Aging Neuroscience Frontiers Media S.A., 2010 10(2018) (DE-627)629834350 (DE-600)2558898-9 16634365 nnns volume:10 year:2018 https://doi.org/10.3389/fnagi.2018.00383 kostenfrei https://doaj.org/article/bf177e301fb04cc387f97910b5aa7b5f kostenfrei https://www.frontiersin.org/article/10.3389/fnagi.2018.00383/full kostenfrei https://doaj.org/toc/1663-4365 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2018
spelling	10.3389/fnagi.2018.00383 doi (DE-627)DOAJ019181426 (DE-599)DOAJbf177e301fb04cc387f97910b5aa7b5f DE-627 ger DE-627 rakwb eng RC321-571 Qing Wang verfasserin aut Levels of Cortisol in CSF Are Associated With SNAP-25 and Tau Pathology but Not Amyloid-β 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: Preclinical studies have found both hyperactivity of hypothalamic- pituitary- adrenal (HPA) axis and synaptic degeneration are involved in the pathogenesis of Alzheimer’s disease (AD). However, the data on the relationship of activity of HPA axis and synaptic degeneration in humans are limited.Methods: We compared CSF cortisol levels in 310 subjects, including 92 cognitively normal older people, 149 patients with mild cognitive impairment (MCI), and 69 patients with mild AD. Several linear and logistic regression models were conducted to investigate associations between CSF cortisol and synaptosomal-associated protein 25 (SNAP-25, reflecting synaptic degeneration) and other AD-related biomarkers.Results: We found that levels of cortisol in CSF were associated with SNAP-25 levels and tau pathologies but not amyloid-β protein. However, there were no significant differences in CSF cortisol levels among the three diagnostic groups.Conclusion: The HPA axis may play a crucial role in synaptic degeneration in AD pathogenesis. cortisol SNAP-25 Alzheimer’s disease tau pathology synapse degeneration mild cognitive impairment Neurosciences. Biological psychiatry. Neuropsychiatry Wenjun Zhou verfasserin aut Jie Zhang verfasserin aut The Alzheimer’s Disease Neuroimaging Initiative verfasserin aut In Frontiers in Aging Neuroscience Frontiers Media S.A., 2010 10(2018) (DE-627)629834350 (DE-600)2558898-9 16634365 nnns volume:10 year:2018 https://doi.org/10.3389/fnagi.2018.00383 kostenfrei https://doaj.org/article/bf177e301fb04cc387f97910b5aa7b5f kostenfrei https://www.frontiersin.org/article/10.3389/fnagi.2018.00383/full kostenfrei https://doaj.org/toc/1663-4365 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2018
allfields_unstemmed	10.3389/fnagi.2018.00383 doi (DE-627)DOAJ019181426 (DE-599)DOAJbf177e301fb04cc387f97910b5aa7b5f DE-627 ger DE-627 rakwb eng RC321-571 Qing Wang verfasserin aut Levels of Cortisol in CSF Are Associated With SNAP-25 and Tau Pathology but Not Amyloid-β 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: Preclinical studies have found both hyperactivity of hypothalamic- pituitary- adrenal (HPA) axis and synaptic degeneration are involved in the pathogenesis of Alzheimer’s disease (AD). However, the data on the relationship of activity of HPA axis and synaptic degeneration in humans are limited.Methods: We compared CSF cortisol levels in 310 subjects, including 92 cognitively normal older people, 149 patients with mild cognitive impairment (MCI), and 69 patients with mild AD. Several linear and logistic regression models were conducted to investigate associations between CSF cortisol and synaptosomal-associated protein 25 (SNAP-25, reflecting synaptic degeneration) and other AD-related biomarkers.Results: We found that levels of cortisol in CSF were associated with SNAP-25 levels and tau pathologies but not amyloid-β protein. However, there were no significant differences in CSF cortisol levels among the three diagnostic groups.Conclusion: The HPA axis may play a crucial role in synaptic degeneration in AD pathogenesis. cortisol SNAP-25 Alzheimer’s disease tau pathology synapse degeneration mild cognitive impairment Neurosciences. Biological psychiatry. Neuropsychiatry Wenjun Zhou verfasserin aut Jie Zhang verfasserin aut The Alzheimer’s Disease Neuroimaging Initiative verfasserin aut In Frontiers in Aging Neuroscience Frontiers Media S.A., 2010 10(2018) (DE-627)629834350 (DE-600)2558898-9 16634365 nnns volume:10 year:2018 https://doi.org/10.3389/fnagi.2018.00383 kostenfrei https://doaj.org/article/bf177e301fb04cc387f97910b5aa7b5f kostenfrei https://www.frontiersin.org/article/10.3389/fnagi.2018.00383/full kostenfrei https://doaj.org/toc/1663-4365 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2018
allfieldsGer	10.3389/fnagi.2018.00383 doi (DE-627)DOAJ019181426 (DE-599)DOAJbf177e301fb04cc387f97910b5aa7b5f DE-627 ger DE-627 rakwb eng RC321-571 Qing Wang verfasserin aut Levels of Cortisol in CSF Are Associated With SNAP-25 and Tau Pathology but Not Amyloid-β 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: Preclinical studies have found both hyperactivity of hypothalamic- pituitary- adrenal (HPA) axis and synaptic degeneration are involved in the pathogenesis of Alzheimer’s disease (AD). However, the data on the relationship of activity of HPA axis and synaptic degeneration in humans are limited.Methods: We compared CSF cortisol levels in 310 subjects, including 92 cognitively normal older people, 149 patients with mild cognitive impairment (MCI), and 69 patients with mild AD. Several linear and logistic regression models were conducted to investigate associations between CSF cortisol and synaptosomal-associated protein 25 (SNAP-25, reflecting synaptic degeneration) and other AD-related biomarkers.Results: We found that levels of cortisol in CSF were associated with SNAP-25 levels and tau pathologies but not amyloid-β protein. However, there were no significant differences in CSF cortisol levels among the three diagnostic groups.Conclusion: The HPA axis may play a crucial role in synaptic degeneration in AD pathogenesis. cortisol SNAP-25 Alzheimer’s disease tau pathology synapse degeneration mild cognitive impairment Neurosciences. Biological psychiatry. Neuropsychiatry Wenjun Zhou verfasserin aut Jie Zhang verfasserin aut The Alzheimer’s Disease Neuroimaging Initiative verfasserin aut In Frontiers in Aging Neuroscience Frontiers Media S.A., 2010 10(2018) (DE-627)629834350 (DE-600)2558898-9 16634365 nnns volume:10 year:2018 https://doi.org/10.3389/fnagi.2018.00383 kostenfrei https://doaj.org/article/bf177e301fb04cc387f97910b5aa7b5f kostenfrei https://www.frontiersin.org/article/10.3389/fnagi.2018.00383/full kostenfrei https://doaj.org/toc/1663-4365 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2018
allfieldsSound	10.3389/fnagi.2018.00383 doi (DE-627)DOAJ019181426 (DE-599)DOAJbf177e301fb04cc387f97910b5aa7b5f DE-627 ger DE-627 rakwb eng RC321-571 Qing Wang verfasserin aut Levels of Cortisol in CSF Are Associated With SNAP-25 and Tau Pathology but Not Amyloid-β 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: Preclinical studies have found both hyperactivity of hypothalamic- pituitary- adrenal (HPA) axis and synaptic degeneration are involved in the pathogenesis of Alzheimer’s disease (AD). However, the data on the relationship of activity of HPA axis and synaptic degeneration in humans are limited.Methods: We compared CSF cortisol levels in 310 subjects, including 92 cognitively normal older people, 149 patients with mild cognitive impairment (MCI), and 69 patients with mild AD. Several linear and logistic regression models were conducted to investigate associations between CSF cortisol and synaptosomal-associated protein 25 (SNAP-25, reflecting synaptic degeneration) and other AD-related biomarkers.Results: We found that levels of cortisol in CSF were associated with SNAP-25 levels and tau pathologies but not amyloid-β protein. However, there were no significant differences in CSF cortisol levels among the three diagnostic groups.Conclusion: The HPA axis may play a crucial role in synaptic degeneration in AD pathogenesis. cortisol SNAP-25 Alzheimer’s disease tau pathology synapse degeneration mild cognitive impairment Neurosciences. Biological psychiatry. Neuropsychiatry Wenjun Zhou verfasserin aut Jie Zhang verfasserin aut The Alzheimer’s Disease Neuroimaging Initiative verfasserin aut In Frontiers in Aging Neuroscience Frontiers Media S.A., 2010 10(2018) (DE-627)629834350 (DE-600)2558898-9 16634365 nnns volume:10 year:2018 https://doi.org/10.3389/fnagi.2018.00383 kostenfrei https://doaj.org/article/bf177e301fb04cc387f97910b5aa7b5f kostenfrei https://www.frontiersin.org/article/10.3389/fnagi.2018.00383/full kostenfrei https://doaj.org/toc/1663-4365 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2018
language	English
source	In Frontiers in Aging Neuroscience 10(2018) volume:10 year:2018
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topic_facet	cortisol SNAP-25 Alzheimer’s disease tau pathology synapse degeneration mild cognitive impairment Neurosciences. Biological psychiatry. Neuropsychiatry
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container_title	Frontiers in Aging Neuroscience
authorswithroles_txt_mv	Qing Wang @@aut@@ Wenjun Zhou @@aut@@ Jie Zhang @@aut@@ The Alzheimer’s Disease Neuroimaging Initiative @@aut@@
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callnumber-first	R - Medicine
author	Qing Wang
spellingShingle	Qing Wang misc RC321-571 misc cortisol misc SNAP-25 misc Alzheimer’s disease misc tau pathology misc synapse degeneration misc mild cognitive impairment misc Neurosciences. Biological psychiatry. Neuropsychiatry Levels of Cortisol in CSF Are Associated With SNAP-25 and Tau Pathology but Not Amyloid-β
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topic_title	RC321-571 Levels of Cortisol in CSF Are Associated With SNAP-25 and Tau Pathology but Not Amyloid-β cortisol SNAP-25 Alzheimer’s disease tau pathology synapse degeneration mild cognitive impairment
topic	misc RC321-571 misc cortisol misc SNAP-25 misc Alzheimer’s disease misc tau pathology misc synapse degeneration misc mild cognitive impairment misc Neurosciences. Biological psychiatry. Neuropsychiatry
topic_unstemmed	misc RC321-571 misc cortisol misc SNAP-25 misc Alzheimer’s disease misc tau pathology misc synapse degeneration misc mild cognitive impairment misc Neurosciences. Biological psychiatry. Neuropsychiatry
topic_browse	misc RC321-571 misc cortisol misc SNAP-25 misc Alzheimer’s disease misc tau pathology misc synapse degeneration misc mild cognitive impairment misc Neurosciences. Biological psychiatry. Neuropsychiatry
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title	Levels of Cortisol in CSF Are Associated With SNAP-25 and Tau Pathology but Not Amyloid-β
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title_full	Levels of Cortisol in CSF Are Associated With SNAP-25 and Tau Pathology but Not Amyloid-β
author_sort	Qing Wang
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title_sort	levels of cortisol in csf are associated with snap-25 and tau pathology but not amyloid-β
callnumber	RC321-571
title_auth	Levels of Cortisol in CSF Are Associated With SNAP-25 and Tau Pathology but Not Amyloid-β
abstract	Objective: Preclinical studies have found both hyperactivity of hypothalamic- pituitary- adrenal (HPA) axis and synaptic degeneration are involved in the pathogenesis of Alzheimer’s disease (AD). However, the data on the relationship of activity of HPA axis and synaptic degeneration in humans are limited.Methods: We compared CSF cortisol levels in 310 subjects, including 92 cognitively normal older people, 149 patients with mild cognitive impairment (MCI), and 69 patients with mild AD. Several linear and logistic regression models were conducted to investigate associations between CSF cortisol and synaptosomal-associated protein 25 (SNAP-25, reflecting synaptic degeneration) and other AD-related biomarkers.Results: We found that levels of cortisol in CSF were associated with SNAP-25 levels and tau pathologies but not amyloid-β protein. However, there were no significant differences in CSF cortisol levels among the three diagnostic groups.Conclusion: The HPA axis may play a crucial role in synaptic degeneration in AD pathogenesis.
abstractGer	Objective: Preclinical studies have found both hyperactivity of hypothalamic- pituitary- adrenal (HPA) axis and synaptic degeneration are involved in the pathogenesis of Alzheimer’s disease (AD). However, the data on the relationship of activity of HPA axis and synaptic degeneration in humans are limited.Methods: We compared CSF cortisol levels in 310 subjects, including 92 cognitively normal older people, 149 patients with mild cognitive impairment (MCI), and 69 patients with mild AD. Several linear and logistic regression models were conducted to investigate associations between CSF cortisol and synaptosomal-associated protein 25 (SNAP-25, reflecting synaptic degeneration) and other AD-related biomarkers.Results: We found that levels of cortisol in CSF were associated with SNAP-25 levels and tau pathologies but not amyloid-β protein. However, there were no significant differences in CSF cortisol levels among the three diagnostic groups.Conclusion: The HPA axis may play a crucial role in synaptic degeneration in AD pathogenesis.
abstract_unstemmed	Objective: Preclinical studies have found both hyperactivity of hypothalamic- pituitary- adrenal (HPA) axis and synaptic degeneration are involved in the pathogenesis of Alzheimer’s disease (AD). However, the data on the relationship of activity of HPA axis and synaptic degeneration in humans are limited.Methods: We compared CSF cortisol levels in 310 subjects, including 92 cognitively normal older people, 149 patients with mild cognitive impairment (MCI), and 69 patients with mild AD. Several linear and logistic regression models were conducted to investigate associations between CSF cortisol and synaptosomal-associated protein 25 (SNAP-25, reflecting synaptic degeneration) and other AD-related biomarkers.Results: We found that levels of cortisol in CSF were associated with SNAP-25 levels and tau pathologies but not amyloid-β protein. However, there were no significant differences in CSF cortisol levels among the three diagnostic groups.Conclusion: The HPA axis may play a crucial role in synaptic degeneration in AD pathogenesis.
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title_short	Levels of Cortisol in CSF Are Associated With SNAP-25 and Tau Pathology but Not Amyloid-β
url	https://doi.org/10.3389/fnagi.2018.00383 https://doaj.org/article/bf177e301fb04cc387f97910b5aa7b5f https://www.frontiersin.org/article/10.3389/fnagi.2018.00383/full https://doaj.org/toc/1663-4365
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up_date	2024-07-03T22:14:21.304Z
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