Hyperferritinemic sepsis: an opportunity for earlier diagnosis and intervention?

We describe a case of an infant with HSV meningitis and septic shock who demonstrated a remarkably high serum ferritin level. Aggressive pediatric intensive care and the administration of high dose glucocorticoids were not able to reverse the multiple organ dysfunctions. Subsequent autopsy identifi...
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Gespeichert in:

Autor*in:	E. Scott Halstead [verfasserIn] Surender Rajasekaran [verfasserIn] Julie C. Fitzgerald [verfasserIn] Scott L. Weiss [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2016

Schlagwörter:	Sepsis hsv Hemophagocytic lymphohistiocytosis (HLH) Macrophage Activation Syndrome (MAS) ferritin Cytokine storm

Übergeordnetes Werk:	In: Frontiers in Pediatrics - Frontiers Media S.A., 2013, 4(2016)
Übergeordnetes Werk:	volume:4 ; year:2016

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fped.2016.00077

Katalog-ID:	DOAJ019205295

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allfieldsSound	10.3389/fped.2016.00077 doi (DE-627)DOAJ019205295 (DE-599)DOAJf58fe20b4a584226a6d53bbf8b2457d3 DE-627 ger DE-627 rakwb eng RJ1-570 E. Scott Halstead verfasserin aut Hyperferritinemic sepsis: an opportunity for earlier diagnosis and intervention? 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier We describe a case of an infant with HSV meningitis and septic shock who demonstrated a remarkably high serum ferritin level. Aggressive pediatric intensive care and the administration of high dose glucocorticoids were not able to reverse the multiple organ dysfunctions. Subsequent autopsy identified the presence of hemophagocytosis, thus the patient fulfilled hemophagocytic lymphohistiocytosis (HLH) criteria post-mortem. This case highlights that serum ferritin may be in important early indicator of mortality in sepsis due to a cytokine storm similar to macrophage activation syndrome (MAS) and HLH. Sepsis hsv Hemophagocytic lymphohistiocytosis (HLH) Macrophage Activation Syndrome (MAS) ferritin Cytokine storm Pediatrics Surender Rajasekaran verfasserin aut Julie C. Fitzgerald verfasserin aut Scott L. Weiss verfasserin aut In Frontiers in Pediatrics Frontiers Media S.A., 2013 4(2016) (DE-627)742738744 (DE-600)2711999-3 22962360 nnns volume:4 year:2016 https://doi.org/10.3389/fped.2016.00077 kostenfrei https://doaj.org/article/f58fe20b4a584226a6d53bbf8b2457d3 kostenfrei http://journal.frontiersin.org/Journal/10.3389/fped.2016.00077/full kostenfrei https://doaj.org/toc/2296-2360 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2016
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callnumber-first	R - Medicine
author	E. Scott Halstead
spellingShingle	E. Scott Halstead misc RJ1-570 misc Sepsis misc hsv misc Hemophagocytic lymphohistiocytosis (HLH) misc Macrophage Activation Syndrome (MAS) misc ferritin misc Cytokine storm misc Pediatrics Hyperferritinemic sepsis: an opportunity for earlier diagnosis and intervention?
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topic_title	RJ1-570 Hyperferritinemic sepsis: an opportunity for earlier diagnosis and intervention? Sepsis hsv Hemophagocytic lymphohistiocytosis (HLH) Macrophage Activation Syndrome (MAS) ferritin Cytokine storm
topic	misc RJ1-570 misc Sepsis misc hsv misc Hemophagocytic lymphohistiocytosis (HLH) misc Macrophage Activation Syndrome (MAS) misc ferritin misc Cytokine storm misc Pediatrics
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title	Hyperferritinemic sepsis: an opportunity for earlier diagnosis and intervention?
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title_full	Hyperferritinemic sepsis: an opportunity for earlier diagnosis and intervention?
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author_browse	E. Scott Halstead Surender Rajasekaran Julie C. Fitzgerald Scott L. Weiss
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title_sort	hyperferritinemic sepsis: an opportunity for earlier diagnosis and intervention?
callnumber	RJ1-570
title_auth	Hyperferritinemic sepsis: an opportunity for earlier diagnosis and intervention?
abstract	We describe a case of an infant with HSV meningitis and septic shock who demonstrated a remarkably high serum ferritin level. Aggressive pediatric intensive care and the administration of high dose glucocorticoids were not able to reverse the multiple organ dysfunctions. Subsequent autopsy identified the presence of hemophagocytosis, thus the patient fulfilled hemophagocytic lymphohistiocytosis (HLH) criteria post-mortem. This case highlights that serum ferritin may be in important early indicator of mortality in sepsis due to a cytokine storm similar to macrophage activation syndrome (MAS) and HLH.
abstractGer	We describe a case of an infant with HSV meningitis and septic shock who demonstrated a remarkably high serum ferritin level. Aggressive pediatric intensive care and the administration of high dose glucocorticoids were not able to reverse the multiple organ dysfunctions. Subsequent autopsy identified the presence of hemophagocytosis, thus the patient fulfilled hemophagocytic lymphohistiocytosis (HLH) criteria post-mortem. This case highlights that serum ferritin may be in important early indicator of mortality in sepsis due to a cytokine storm similar to macrophage activation syndrome (MAS) and HLH.
abstract_unstemmed	We describe a case of an infant with HSV meningitis and septic shock who demonstrated a remarkably high serum ferritin level. Aggressive pediatric intensive care and the administration of high dose glucocorticoids were not able to reverse the multiple organ dysfunctions. Subsequent autopsy identified the presence of hemophagocytosis, thus the patient fulfilled hemophagocytic lymphohistiocytosis (HLH) criteria post-mortem. This case highlights that serum ferritin may be in important early indicator of mortality in sepsis due to a cytokine storm similar to macrophage activation syndrome (MAS) and HLH.
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title_short	Hyperferritinemic sepsis: an opportunity for earlier diagnosis and intervention?
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