Kamishoyosan reduces conditioned fear-induced freezing behavior in socially isolated ovariectomized rats
In the present study, we investigated the effect of kamishoyosan (KSS) on conditioned fear-induced freezing in ovariectomized (OVX) rats. Socially isolated OVX rats showed the longest freezing time among the following four groups: group-housed sham-operated (Sham), isolated Sham, group-housed OVX, a...
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| Autor*in: |
Nobuaki Egashira [verfasserIn] Hikari Iba [verfasserIn] Haruna Kuwano [verfasserIn] Rikako Kawanaka [verfasserIn] Masaki Nagao [verfasserIn] Hiroshi Moriyama [verfasserIn] Takuya Watanabe [verfasserIn] Kaori Kubota [verfasserIn] Shutaro Katsurabayashi [verfasserIn] Katsunori Iwasaki [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2016 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Journal of Pharmacological Sciences - Elsevier, 2017, 131(2016), 4, Seite 279-283 |
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| Übergeordnetes Werk: |
volume:131 ; year:2016 ; number:4 ; pages:279-283 |
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| DOI / URN: |
10.1016/j.jphs.2016.07.007 |
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DOAJ019208464 |
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| 520 | |a In the present study, we investigated the effect of kamishoyosan (KSS) on conditioned fear-induced freezing in ovariectomized (OVX) rats. Socially isolated OVX rats showed the longest freezing time among the following four groups: group-housed sham-operated (Sham), isolated Sham, group-housed OVX, and isolated OVX rats. Repeated oral administration of KSS (30–300 mg/kg) reduced conditioned fear-induced freezing in socially isolated OVX rats. The reduction of freezing by KSS was reversed by flumazenil (3 mg/kg) and bicuculline (3 mg/kg). These findings suggest that the GABAA-benzodiazepine receptor complex is involved in the anxiolytic effect of KSS in socially isolated OVX rats. | ||
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Nobuaki Egashira Hikari Iba Haruna Kuwano Rikako Kawanaka Masaki Nagao Hiroshi Moriyama Takuya Watanabe Kaori Kubota Shutaro Katsurabayashi Katsunori Iwasaki |
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Elektronische Aufsätze |
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Nobuaki Egashira |
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kamishoyosan reduces conditioned fear-induced freezing behavior in socially isolated ovariectomized rats |
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RM1-950 |
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Kamishoyosan reduces conditioned fear-induced freezing behavior in socially isolated ovariectomized rats |
| abstract |
In the present study, we investigated the effect of kamishoyosan (KSS) on conditioned fear-induced freezing in ovariectomized (OVX) rats. Socially isolated OVX rats showed the longest freezing time among the following four groups: group-housed sham-operated (Sham), isolated Sham, group-housed OVX, and isolated OVX rats. Repeated oral administration of KSS (30–300 mg/kg) reduced conditioned fear-induced freezing in socially isolated OVX rats. The reduction of freezing by KSS was reversed by flumazenil (3 mg/kg) and bicuculline (3 mg/kg). These findings suggest that the GABAA-benzodiazepine receptor complex is involved in the anxiolytic effect of KSS in socially isolated OVX rats. |
| abstractGer |
In the present study, we investigated the effect of kamishoyosan (KSS) on conditioned fear-induced freezing in ovariectomized (OVX) rats. Socially isolated OVX rats showed the longest freezing time among the following four groups: group-housed sham-operated (Sham), isolated Sham, group-housed OVX, and isolated OVX rats. Repeated oral administration of KSS (30–300 mg/kg) reduced conditioned fear-induced freezing in socially isolated OVX rats. The reduction of freezing by KSS was reversed by flumazenil (3 mg/kg) and bicuculline (3 mg/kg). These findings suggest that the GABAA-benzodiazepine receptor complex is involved in the anxiolytic effect of KSS in socially isolated OVX rats. |
| abstract_unstemmed |
In the present study, we investigated the effect of kamishoyosan (KSS) on conditioned fear-induced freezing in ovariectomized (OVX) rats. Socially isolated OVX rats showed the longest freezing time among the following four groups: group-housed sham-operated (Sham), isolated Sham, group-housed OVX, and isolated OVX rats. Repeated oral administration of KSS (30–300 mg/kg) reduced conditioned fear-induced freezing in socially isolated OVX rats. The reduction of freezing by KSS was reversed by flumazenil (3 mg/kg) and bicuculline (3 mg/kg). These findings suggest that the GABAA-benzodiazepine receptor complex is involved in the anxiolytic effect of KSS in socially isolated OVX rats. |
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Kamishoyosan reduces conditioned fear-induced freezing behavior in socially isolated ovariectomized rats |
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https://doi.org/10.1016/j.jphs.2016.07.007 https://doaj.org/article/b77b48959d0844489f05705150c068f2 http://www.sciencedirect.com/science/article/pii/S1347861316300895 https://doaj.org/toc/1347-8613 |
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Hikari Iba Haruna Kuwano Rikako Kawanaka Masaki Nagao Hiroshi Moriyama Takuya Watanabe Kaori Kubota Shutaro Katsurabayashi Katsunori Iwasaki |
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Hikari Iba Haruna Kuwano Rikako Kawanaka Masaki Nagao Hiroshi Moriyama Takuya Watanabe Kaori Kubota Shutaro Katsurabayashi Katsunori Iwasaki |
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RM - Therapeutics and Pharmacology |
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