Expression Patterns of Circulating MicroRNAs in the Risk Stratification of Bicuspid Aortopathy

Objective: Aortic size-based criteria are of limited value in the prediction of aortic events, while most aortic events occur in patients with proximal aortic diameters < 50 mm. Serological biomarkers and especially circulating microRNAs (miRNAs) have been proposed as an elegant tool to improve risk stratification in patients with different aortopathies. Therefore, we aimed to evaluate the levels of circulating miRNAs in a surgical cohort of patients presenting with bicuspid aortic valve disease and distinct valvulo-aortic phenotypes. Methods: We prospectively examined a consecutive cohort of 145 patients referred for aortic valve surgery: (1) Sixty three patients (mean age 47 ± 11 years, 92% male) with bicuspid aortic valve regurgitation and root dilatation (BAV-AR), (2) thirty two patients (mean age 59 ± 11 years, 73% male) with bicuspid aortic valve stenosis (BAV-AS), and (3) fifty patients (mean age 56 ± 14 years, 55% male) with tricuspid aortic valve stenosis and normal aortic root diameters (TAV-AS) who underwent aortic valve+/-proximal aortic surgery at a single institution. MicroRNAs analysis included 11 miRNAs, all published previously in association with aortopathies. Endpoints of our study were (1) correlation between circulating miRNAs and aortic diameter and (2) comparison of circulating miRNAs in distinct valvulo-aortic phenotypes. Results: We found a significant inverse linear correlation between circulating miRNAs levels and proximal aortic diameter in the whole study cohort. The strongest correlation was found for miR-17 (<i<r</i< = −0.42, <i<p</i< < 0.001), miR-20a (<i<r</i< = −0.37, <i<p</i< < 0.001), and miR-106a (<i<r</i< = −0.32, <i<p</i< < 0.001). All miRNAs were significantly downregulated in BAV vs. TAV with normal aortic root dimensions Conclusions: Our data demonstrate a significant inverse correlation between circulating miRNAs levels and the maximal aortic diameter in BAV aortopathy. When comparing miRNAs expression patterns in BAV vs. TAV patients with normal aortic root dimensions, BAV patients showed significant downregulation of analyzed miRNAs as compared to their TAV counterparts. Further multicenter studies in larger cohorts are needed to further validate these results. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Evaldas Girdauskas [verfasserIn] Niklas Neumann [verfasserIn] Johannes Petersen [verfasserIn] Tatiana Sequeira-Gross [verfasserIn] Shiho Naito [verfasserIn] Maria von Stumm [verfasserIn] Yskert von Kodolitsch [verfasserIn] Hermann Reichenspurner [verfasserIn] Tanja Zeller [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	biomarkers circulating micrornas aortopathy bicuspid aortic valve

Übergeordnetes Werk:	In: Journal of Clinical Medicine - MDPI AG, 2013, 9(2020), 1, p 276
Übergeordnetes Werk:	volume:9 ; year:2020 ; number:1, p 276

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/jcm9010276

Katalog-ID:	DOAJ019419473

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allfields	10.3390/jcm9010276 doi (DE-627)DOAJ019419473 (DE-599)DOAJef99c186cfd64f2d856b301f3240f4e6 DE-627 ger DE-627 rakwb eng Evaldas Girdauskas verfasserin aut Expression Patterns of Circulating MicroRNAs in the Risk Stratification of Bicuspid Aortopathy 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: Aortic size-based criteria are of limited value in the prediction of aortic events, while most aortic events occur in patients with proximal aortic diameters < 50 mm. Serological biomarkers and especially circulating microRNAs (miRNAs) have been proposed as an elegant tool to improve risk stratification in patients with different aortopathies. Therefore, we aimed to evaluate the levels of circulating miRNAs in a surgical cohort of patients presenting with bicuspid aortic valve disease and distinct valvulo-aortic phenotypes. Methods: We prospectively examined a consecutive cohort of 145 patients referred for aortic valve surgery: (1) Sixty three patients (mean age 47 ± 11 years, 92% male) with bicuspid aortic valve regurgitation and root dilatation (BAV-AR), (2) thirty two patients (mean age 59 ± 11 years, 73% male) with bicuspid aortic valve stenosis (BAV-AS), and (3) fifty patients (mean age 56 ± 14 years, 55% male) with tricuspid aortic valve stenosis and normal aortic root diameters (TAV-AS) who underwent aortic valve+/-proximal aortic surgery at a single institution. MicroRNAs analysis included 11 miRNAs, all published previously in association with aortopathies. Endpoints of our study were (1) correlation between circulating miRNAs and aortic diameter and (2) comparison of circulating miRNAs in distinct valvulo-aortic phenotypes. Results: We found a significant inverse linear correlation between circulating miRNAs levels and proximal aortic diameter in the whole study cohort. The strongest correlation was found for miR-17 (<i<r</i< = −0.42, <i<p</i< < 0.001), miR-20a (<i<r</i< = −0.37, <i<p</i< < 0.001), and miR-106a (<i<r</i< = −0.32, <i<p</i< < 0.001). All miRNAs were significantly downregulated in BAV vs. TAV with normal aortic root dimensions Conclusions: Our data demonstrate a significant inverse correlation between circulating miRNAs levels and the maximal aortic diameter in BAV aortopathy. When comparing miRNAs expression patterns in BAV vs. TAV patients with normal aortic root dimensions, BAV patients showed significant downregulation of analyzed miRNAs as compared to their TAV counterparts. Further multicenter studies in larger cohorts are needed to further validate these results. biomarkers circulating micrornas aortopathy bicuspid aortic valve Medicine R Niklas Neumann verfasserin aut Johannes Petersen verfasserin aut Tatiana Sequeira-Gross verfasserin aut Shiho Naito verfasserin aut Maria von Stumm verfasserin aut Yskert von Kodolitsch verfasserin aut Hermann Reichenspurner verfasserin aut Tanja Zeller verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 9(2020), 1, p 276 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:9 year:2020 number:1, p 276 https://doi.org/10.3390/jcm9010276 kostenfrei https://doaj.org/article/ef99c186cfd64f2d856b301f3240f4e6 kostenfrei https://www.mdpi.com/2077-0383/9/1/276 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 1, p 276
spelling	10.3390/jcm9010276 doi (DE-627)DOAJ019419473 (DE-599)DOAJef99c186cfd64f2d856b301f3240f4e6 DE-627 ger DE-627 rakwb eng Evaldas Girdauskas verfasserin aut Expression Patterns of Circulating MicroRNAs in the Risk Stratification of Bicuspid Aortopathy 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: Aortic size-based criteria are of limited value in the prediction of aortic events, while most aortic events occur in patients with proximal aortic diameters < 50 mm. Serological biomarkers and especially circulating microRNAs (miRNAs) have been proposed as an elegant tool to improve risk stratification in patients with different aortopathies. Therefore, we aimed to evaluate the levels of circulating miRNAs in a surgical cohort of patients presenting with bicuspid aortic valve disease and distinct valvulo-aortic phenotypes. Methods: We prospectively examined a consecutive cohort of 145 patients referred for aortic valve surgery: (1) Sixty three patients (mean age 47 ± 11 years, 92% male) with bicuspid aortic valve regurgitation and root dilatation (BAV-AR), (2) thirty two patients (mean age 59 ± 11 years, 73% male) with bicuspid aortic valve stenosis (BAV-AS), and (3) fifty patients (mean age 56 ± 14 years, 55% male) with tricuspid aortic valve stenosis and normal aortic root diameters (TAV-AS) who underwent aortic valve+/-proximal aortic surgery at a single institution. MicroRNAs analysis included 11 miRNAs, all published previously in association with aortopathies. Endpoints of our study were (1) correlation between circulating miRNAs and aortic diameter and (2) comparison of circulating miRNAs in distinct valvulo-aortic phenotypes. Results: We found a significant inverse linear correlation between circulating miRNAs levels and proximal aortic diameter in the whole study cohort. The strongest correlation was found for miR-17 (<i<r</i< = −0.42, <i<p</i< < 0.001), miR-20a (<i<r</i< = −0.37, <i<p</i< < 0.001), and miR-106a (<i<r</i< = −0.32, <i<p</i< < 0.001). All miRNAs were significantly downregulated in BAV vs. TAV with normal aortic root dimensions Conclusions: Our data demonstrate a significant inverse correlation between circulating miRNAs levels and the maximal aortic diameter in BAV aortopathy. When comparing miRNAs expression patterns in BAV vs. TAV patients with normal aortic root dimensions, BAV patients showed significant downregulation of analyzed miRNAs as compared to their TAV counterparts. Further multicenter studies in larger cohorts are needed to further validate these results. biomarkers circulating micrornas aortopathy bicuspid aortic valve Medicine R Niklas Neumann verfasserin aut Johannes Petersen verfasserin aut Tatiana Sequeira-Gross verfasserin aut Shiho Naito verfasserin aut Maria von Stumm verfasserin aut Yskert von Kodolitsch verfasserin aut Hermann Reichenspurner verfasserin aut Tanja Zeller verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 9(2020), 1, p 276 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:9 year:2020 number:1, p 276 https://doi.org/10.3390/jcm9010276 kostenfrei https://doaj.org/article/ef99c186cfd64f2d856b301f3240f4e6 kostenfrei https://www.mdpi.com/2077-0383/9/1/276 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 1, p 276
allfields_unstemmed	10.3390/jcm9010276 doi (DE-627)DOAJ019419473 (DE-599)DOAJef99c186cfd64f2d856b301f3240f4e6 DE-627 ger DE-627 rakwb eng Evaldas Girdauskas verfasserin aut Expression Patterns of Circulating MicroRNAs in the Risk Stratification of Bicuspid Aortopathy 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: Aortic size-based criteria are of limited value in the prediction of aortic events, while most aortic events occur in patients with proximal aortic diameters < 50 mm. Serological biomarkers and especially circulating microRNAs (miRNAs) have been proposed as an elegant tool to improve risk stratification in patients with different aortopathies. Therefore, we aimed to evaluate the levels of circulating miRNAs in a surgical cohort of patients presenting with bicuspid aortic valve disease and distinct valvulo-aortic phenotypes. Methods: We prospectively examined a consecutive cohort of 145 patients referred for aortic valve surgery: (1) Sixty three patients (mean age 47 ± 11 years, 92% male) with bicuspid aortic valve regurgitation and root dilatation (BAV-AR), (2) thirty two patients (mean age 59 ± 11 years, 73% male) with bicuspid aortic valve stenosis (BAV-AS), and (3) fifty patients (mean age 56 ± 14 years, 55% male) with tricuspid aortic valve stenosis and normal aortic root diameters (TAV-AS) who underwent aortic valve+/-proximal aortic surgery at a single institution. MicroRNAs analysis included 11 miRNAs, all published previously in association with aortopathies. Endpoints of our study were (1) correlation between circulating miRNAs and aortic diameter and (2) comparison of circulating miRNAs in distinct valvulo-aortic phenotypes. Results: We found a significant inverse linear correlation between circulating miRNAs levels and proximal aortic diameter in the whole study cohort. The strongest correlation was found for miR-17 (<i<r</i< = −0.42, <i<p</i< < 0.001), miR-20a (<i<r</i< = −0.37, <i<p</i< < 0.001), and miR-106a (<i<r</i< = −0.32, <i<p</i< < 0.001). All miRNAs were significantly downregulated in BAV vs. TAV with normal aortic root dimensions Conclusions: Our data demonstrate a significant inverse correlation between circulating miRNAs levels and the maximal aortic diameter in BAV aortopathy. When comparing miRNAs expression patterns in BAV vs. TAV patients with normal aortic root dimensions, BAV patients showed significant downregulation of analyzed miRNAs as compared to their TAV counterparts. Further multicenter studies in larger cohorts are needed to further validate these results. biomarkers circulating micrornas aortopathy bicuspid aortic valve Medicine R Niklas Neumann verfasserin aut Johannes Petersen verfasserin aut Tatiana Sequeira-Gross verfasserin aut Shiho Naito verfasserin aut Maria von Stumm verfasserin aut Yskert von Kodolitsch verfasserin aut Hermann Reichenspurner verfasserin aut Tanja Zeller verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 9(2020), 1, p 276 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:9 year:2020 number:1, p 276 https://doi.org/10.3390/jcm9010276 kostenfrei https://doaj.org/article/ef99c186cfd64f2d856b301f3240f4e6 kostenfrei https://www.mdpi.com/2077-0383/9/1/276 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 1, p 276
allfieldsGer	10.3390/jcm9010276 doi (DE-627)DOAJ019419473 (DE-599)DOAJef99c186cfd64f2d856b301f3240f4e6 DE-627 ger DE-627 rakwb eng Evaldas Girdauskas verfasserin aut Expression Patterns of Circulating MicroRNAs in the Risk Stratification of Bicuspid Aortopathy 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: Aortic size-based criteria are of limited value in the prediction of aortic events, while most aortic events occur in patients with proximal aortic diameters < 50 mm. Serological biomarkers and especially circulating microRNAs (miRNAs) have been proposed as an elegant tool to improve risk stratification in patients with different aortopathies. Therefore, we aimed to evaluate the levels of circulating miRNAs in a surgical cohort of patients presenting with bicuspid aortic valve disease and distinct valvulo-aortic phenotypes. Methods: We prospectively examined a consecutive cohort of 145 patients referred for aortic valve surgery: (1) Sixty three patients (mean age 47 ± 11 years, 92% male) with bicuspid aortic valve regurgitation and root dilatation (BAV-AR), (2) thirty two patients (mean age 59 ± 11 years, 73% male) with bicuspid aortic valve stenosis (BAV-AS), and (3) fifty patients (mean age 56 ± 14 years, 55% male) with tricuspid aortic valve stenosis and normal aortic root diameters (TAV-AS) who underwent aortic valve+/-proximal aortic surgery at a single institution. MicroRNAs analysis included 11 miRNAs, all published previously in association with aortopathies. Endpoints of our study were (1) correlation between circulating miRNAs and aortic diameter and (2) comparison of circulating miRNAs in distinct valvulo-aortic phenotypes. Results: We found a significant inverse linear correlation between circulating miRNAs levels and proximal aortic diameter in the whole study cohort. The strongest correlation was found for miR-17 (<i<r</i< = −0.42, <i<p</i< < 0.001), miR-20a (<i<r</i< = −0.37, <i<p</i< < 0.001), and miR-106a (<i<r</i< = −0.32, <i<p</i< < 0.001). All miRNAs were significantly downregulated in BAV vs. TAV with normal aortic root dimensions Conclusions: Our data demonstrate a significant inverse correlation between circulating miRNAs levels and the maximal aortic diameter in BAV aortopathy. When comparing miRNAs expression patterns in BAV vs. TAV patients with normal aortic root dimensions, BAV patients showed significant downregulation of analyzed miRNAs as compared to their TAV counterparts. Further multicenter studies in larger cohorts are needed to further validate these results. biomarkers circulating micrornas aortopathy bicuspid aortic valve Medicine R Niklas Neumann verfasserin aut Johannes Petersen verfasserin aut Tatiana Sequeira-Gross verfasserin aut Shiho Naito verfasserin aut Maria von Stumm verfasserin aut Yskert von Kodolitsch verfasserin aut Hermann Reichenspurner verfasserin aut Tanja Zeller verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 9(2020), 1, p 276 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:9 year:2020 number:1, p 276 https://doi.org/10.3390/jcm9010276 kostenfrei https://doaj.org/article/ef99c186cfd64f2d856b301f3240f4e6 kostenfrei https://www.mdpi.com/2077-0383/9/1/276 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 1, p 276
allfieldsSound	10.3390/jcm9010276 doi (DE-627)DOAJ019419473 (DE-599)DOAJef99c186cfd64f2d856b301f3240f4e6 DE-627 ger DE-627 rakwb eng Evaldas Girdauskas verfasserin aut Expression Patterns of Circulating MicroRNAs in the Risk Stratification of Bicuspid Aortopathy 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: Aortic size-based criteria are of limited value in the prediction of aortic events, while most aortic events occur in patients with proximal aortic diameters < 50 mm. Serological biomarkers and especially circulating microRNAs (miRNAs) have been proposed as an elegant tool to improve risk stratification in patients with different aortopathies. Therefore, we aimed to evaluate the levels of circulating miRNAs in a surgical cohort of patients presenting with bicuspid aortic valve disease and distinct valvulo-aortic phenotypes. Methods: We prospectively examined a consecutive cohort of 145 patients referred for aortic valve surgery: (1) Sixty three patients (mean age 47 ± 11 years, 92% male) with bicuspid aortic valve regurgitation and root dilatation (BAV-AR), (2) thirty two patients (mean age 59 ± 11 years, 73% male) with bicuspid aortic valve stenosis (BAV-AS), and (3) fifty patients (mean age 56 ± 14 years, 55% male) with tricuspid aortic valve stenosis and normal aortic root diameters (TAV-AS) who underwent aortic valve+/-proximal aortic surgery at a single institution. MicroRNAs analysis included 11 miRNAs, all published previously in association with aortopathies. Endpoints of our study were (1) correlation between circulating miRNAs and aortic diameter and (2) comparison of circulating miRNAs in distinct valvulo-aortic phenotypes. Results: We found a significant inverse linear correlation between circulating miRNAs levels and proximal aortic diameter in the whole study cohort. The strongest correlation was found for miR-17 (<i<r</i< = −0.42, <i<p</i< < 0.001), miR-20a (<i<r</i< = −0.37, <i<p</i< < 0.001), and miR-106a (<i<r</i< = −0.32, <i<p</i< < 0.001). All miRNAs were significantly downregulated in BAV vs. TAV with normal aortic root dimensions Conclusions: Our data demonstrate a significant inverse correlation between circulating miRNAs levels and the maximal aortic diameter in BAV aortopathy. When comparing miRNAs expression patterns in BAV vs. TAV patients with normal aortic root dimensions, BAV patients showed significant downregulation of analyzed miRNAs as compared to their TAV counterparts. Further multicenter studies in larger cohorts are needed to further validate these results. biomarkers circulating micrornas aortopathy bicuspid aortic valve Medicine R Niklas Neumann verfasserin aut Johannes Petersen verfasserin aut Tatiana Sequeira-Gross verfasserin aut Shiho Naito verfasserin aut Maria von Stumm verfasserin aut Yskert von Kodolitsch verfasserin aut Hermann Reichenspurner verfasserin aut Tanja Zeller verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 9(2020), 1, p 276 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:9 year:2020 number:1, p 276 https://doi.org/10.3390/jcm9010276 kostenfrei https://doaj.org/article/ef99c186cfd64f2d856b301f3240f4e6 kostenfrei https://www.mdpi.com/2077-0383/9/1/276 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 1, p 276
language	English
source	In Journal of Clinical Medicine 9(2020), 1, p 276 volume:9 year:2020 number:1, p 276
sourceStr	In Journal of Clinical Medicine 9(2020), 1, p 276 volume:9 year:2020 number:1, p 276
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	biomarkers circulating micrornas aortopathy bicuspid aortic valve Medicine R
isfreeaccess_bool	true
container_title	Journal of Clinical Medicine
authorswithroles_txt_mv	Evaldas Girdauskas @@aut@@ Niklas Neumann @@aut@@ Johannes Petersen @@aut@@ Tatiana Sequeira-Gross @@aut@@ Shiho Naito @@aut@@ Maria von Stumm @@aut@@ Yskert von Kodolitsch @@aut@@ Hermann Reichenspurner @@aut@@ Tanja Zeller @@aut@@
publishDateDaySort_date	2020-01-01T00:00:00Z
hierarchy_top_id	718632478
id	DOAJ019419473
language_de	englisch
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Serological biomarkers and especially circulating microRNAs (miRNAs) have been proposed as an elegant tool to improve risk stratification in patients with different aortopathies. Therefore, we aimed to evaluate the levels of circulating miRNAs in a surgical cohort of patients presenting with bicuspid aortic valve disease and distinct valvulo-aortic phenotypes. Methods: We prospectively examined a consecutive cohort of 145 patients referred for aortic valve surgery: (1) Sixty three patients (mean age 47 ± 11 years, 92% male) with bicuspid aortic valve regurgitation and root dilatation (BAV-AR), (2) thirty two patients (mean age 59 ± 11 years, 73% male) with bicuspid aortic valve stenosis (BAV-AS), and (3) fifty patients (mean age 56 ± 14 years, 55% male) with tricuspid aortic valve stenosis and normal aortic root diameters (TAV-AS) who underwent aortic valve+/-proximal aortic surgery at a single institution. MicroRNAs analysis included 11 miRNAs, all published previously in association with aortopathies. Endpoints of our study were (1) correlation between circulating miRNAs and aortic diameter and (2) comparison of circulating miRNAs in distinct valvulo-aortic phenotypes. Results: We found a significant inverse linear correlation between circulating miRNAs levels and proximal aortic diameter in the whole study cohort. The strongest correlation was found for miR-17 (<i<r</i< = −0.42, <i<p</i< &lt; 0.001), miR-20a (<i<r</i< = −0.37, <i<p</i< &lt; 0.001), and miR-106a (<i<r</i< = −0.32, <i<p</i< &lt; 0.001). All miRNAs were significantly downregulated in BAV vs. TAV with normal aortic root dimensions Conclusions: Our data demonstrate a significant inverse correlation between circulating miRNAs levels and the maximal aortic diameter in BAV aortopathy. When comparing miRNAs expression patterns in BAV vs. TAV patients with normal aortic root dimensions, BAV patients showed significant downregulation of analyzed miRNAs as compared to their TAV counterparts. 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author	Evaldas Girdauskas
spellingShingle	Evaldas Girdauskas misc biomarkers misc circulating micrornas misc aortopathy misc bicuspid aortic valve misc Medicine misc R Expression Patterns of Circulating MicroRNAs in the Risk Stratification of Bicuspid Aortopathy
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topic_title	Expression Patterns of Circulating MicroRNAs in the Risk Stratification of Bicuspid Aortopathy biomarkers circulating micrornas aortopathy bicuspid aortic valve
topic	misc biomarkers misc circulating micrornas misc aortopathy misc bicuspid aortic valve misc Medicine misc R
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title	Expression Patterns of Circulating MicroRNAs in the Risk Stratification of Bicuspid Aortopathy
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title_full	Expression Patterns of Circulating MicroRNAs in the Risk Stratification of Bicuspid Aortopathy
author_sort	Evaldas Girdauskas
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author_browse	Evaldas Girdauskas Niklas Neumann Johannes Petersen Tatiana Sequeira-Gross Shiho Naito Maria von Stumm Yskert von Kodolitsch Hermann Reichenspurner Tanja Zeller
container_volume	9
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doi_str_mv	10.3390/jcm9010276
author2-role	verfasserin
title_sort	expression patterns of circulating micrornas in the risk stratification of bicuspid aortopathy
title_auth	Expression Patterns of Circulating MicroRNAs in the Risk Stratification of Bicuspid Aortopathy
abstract	Objective: Aortic size-based criteria are of limited value in the prediction of aortic events, while most aortic events occur in patients with proximal aortic diameters < 50 mm. Serological biomarkers and especially circulating microRNAs (miRNAs) have been proposed as an elegant tool to improve risk stratification in patients with different aortopathies. Therefore, we aimed to evaluate the levels of circulating miRNAs in a surgical cohort of patients presenting with bicuspid aortic valve disease and distinct valvulo-aortic phenotypes. Methods: We prospectively examined a consecutive cohort of 145 patients referred for aortic valve surgery: (1) Sixty three patients (mean age 47 ± 11 years, 92% male) with bicuspid aortic valve regurgitation and root dilatation (BAV-AR), (2) thirty two patients (mean age 59 ± 11 years, 73% male) with bicuspid aortic valve stenosis (BAV-AS), and (3) fifty patients (mean age 56 ± 14 years, 55% male) with tricuspid aortic valve stenosis and normal aortic root diameters (TAV-AS) who underwent aortic valve+/-proximal aortic surgery at a single institution. MicroRNAs analysis included 11 miRNAs, all published previously in association with aortopathies. Endpoints of our study were (1) correlation between circulating miRNAs and aortic diameter and (2) comparison of circulating miRNAs in distinct valvulo-aortic phenotypes. Results: We found a significant inverse linear correlation between circulating miRNAs levels and proximal aortic diameter in the whole study cohort. The strongest correlation was found for miR-17 (<i<r</i< = −0.42, <i<p</i< < 0.001), miR-20a (<i<r</i< = −0.37, <i<p</i< < 0.001), and miR-106a (<i<r</i< = −0.32, <i<p</i< < 0.001). All miRNAs were significantly downregulated in BAV vs. TAV with normal aortic root dimensions Conclusions: Our data demonstrate a significant inverse correlation between circulating miRNAs levels and the maximal aortic diameter in BAV aortopathy. When comparing miRNAs expression patterns in BAV vs. TAV patients with normal aortic root dimensions, BAV patients showed significant downregulation of analyzed miRNAs as compared to their TAV counterparts. Further multicenter studies in larger cohorts are needed to further validate these results.
abstractGer	Objective: Aortic size-based criteria are of limited value in the prediction of aortic events, while most aortic events occur in patients with proximal aortic diameters < 50 mm. Serological biomarkers and especially circulating microRNAs (miRNAs) have been proposed as an elegant tool to improve risk stratification in patients with different aortopathies. Therefore, we aimed to evaluate the levels of circulating miRNAs in a surgical cohort of patients presenting with bicuspid aortic valve disease and distinct valvulo-aortic phenotypes. Methods: We prospectively examined a consecutive cohort of 145 patients referred for aortic valve surgery: (1) Sixty three patients (mean age 47 ± 11 years, 92% male) with bicuspid aortic valve regurgitation and root dilatation (BAV-AR), (2) thirty two patients (mean age 59 ± 11 years, 73% male) with bicuspid aortic valve stenosis (BAV-AS), and (3) fifty patients (mean age 56 ± 14 years, 55% male) with tricuspid aortic valve stenosis and normal aortic root diameters (TAV-AS) who underwent aortic valve+/-proximal aortic surgery at a single institution. MicroRNAs analysis included 11 miRNAs, all published previously in association with aortopathies. Endpoints of our study were (1) correlation between circulating miRNAs and aortic diameter and (2) comparison of circulating miRNAs in distinct valvulo-aortic phenotypes. Results: We found a significant inverse linear correlation between circulating miRNAs levels and proximal aortic diameter in the whole study cohort. The strongest correlation was found for miR-17 (<i<r</i< = −0.42, <i<p</i< < 0.001), miR-20a (<i<r</i< = −0.37, <i<p</i< < 0.001), and miR-106a (<i<r</i< = −0.32, <i<p</i< < 0.001). All miRNAs were significantly downregulated in BAV vs. TAV with normal aortic root dimensions Conclusions: Our data demonstrate a significant inverse correlation between circulating miRNAs levels and the maximal aortic diameter in BAV aortopathy. When comparing miRNAs expression patterns in BAV vs. TAV patients with normal aortic root dimensions, BAV patients showed significant downregulation of analyzed miRNAs as compared to their TAV counterparts. Further multicenter studies in larger cohorts are needed to further validate these results.
abstract_unstemmed	Objective: Aortic size-based criteria are of limited value in the prediction of aortic events, while most aortic events occur in patients with proximal aortic diameters < 50 mm. Serological biomarkers and especially circulating microRNAs (miRNAs) have been proposed as an elegant tool to improve risk stratification in patients with different aortopathies. Therefore, we aimed to evaluate the levels of circulating miRNAs in a surgical cohort of patients presenting with bicuspid aortic valve disease and distinct valvulo-aortic phenotypes. Methods: We prospectively examined a consecutive cohort of 145 patients referred for aortic valve surgery: (1) Sixty three patients (mean age 47 ± 11 years, 92% male) with bicuspid aortic valve regurgitation and root dilatation (BAV-AR), (2) thirty two patients (mean age 59 ± 11 years, 73% male) with bicuspid aortic valve stenosis (BAV-AS), and (3) fifty patients (mean age 56 ± 14 years, 55% male) with tricuspid aortic valve stenosis and normal aortic root diameters (TAV-AS) who underwent aortic valve+/-proximal aortic surgery at a single institution. MicroRNAs analysis included 11 miRNAs, all published previously in association with aortopathies. Endpoints of our study were (1) correlation between circulating miRNAs and aortic diameter and (2) comparison of circulating miRNAs in distinct valvulo-aortic phenotypes. Results: We found a significant inverse linear correlation between circulating miRNAs levels and proximal aortic diameter in the whole study cohort. The strongest correlation was found for miR-17 (<i<r</i< = −0.42, <i<p</i< < 0.001), miR-20a (<i<r</i< = −0.37, <i<p</i< < 0.001), and miR-106a (<i<r</i< = −0.32, <i<p</i< < 0.001). All miRNAs were significantly downregulated in BAV vs. TAV with normal aortic root dimensions Conclusions: Our data demonstrate a significant inverse correlation between circulating miRNAs levels and the maximal aortic diameter in BAV aortopathy. When comparing miRNAs expression patterns in BAV vs. TAV patients with normal aortic root dimensions, BAV patients showed significant downregulation of analyzed miRNAs as compared to their TAV counterparts. Further multicenter studies in larger cohorts are needed to further validate these results.
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title_short	Expression Patterns of Circulating MicroRNAs in the Risk Stratification of Bicuspid Aortopathy
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author2	Niklas Neumann Johannes Petersen Tatiana Sequeira-Gross Shiho Naito Maria von Stumm Yskert von Kodolitsch Hermann Reichenspurner Tanja Zeller
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