Pregnancy is accompanied by larger high density lipoprotein particles and compositionally distinct subspecies

Pregnancy is accompanied by significant physiological changes, which can impact the health and development of the fetus and mother. Pregnancy-induced changes in plasma lipoproteins are well documented, with modest to no impact observed on the generic measure of high density lipoprotein (HDL) cholest...
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Autor*in:	John T. Melchior [verfasserIn] Debi K. Swertfeger [verfasserIn] Jamie Morris [verfasserIn] Scott E. Street [verfasserIn] Carri R. Warshak [verfasserIn] Jeffrey A. Welge [verfasserIn] Alan T. Remaley [verfasserIn] Janet M. Catov [verfasserIn] W. Sean Davidson [verfasserIn] Laura A. Woollett [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	dyslipidemia nuclear magnetic resonance spectroscopy lipoprotein proteomics mass spectrometry pregnancy

Übergeordnetes Werk:	In: Journal of Lipid Research - Elsevier, 2021, 62(2021), Seite 100107-
Übergeordnetes Werk:	volume:62 ; year:2021 ; pages:100107-

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.jlr.2021.100107

Katalog-ID:	DOAJ019443676

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allfieldsSound	10.1016/j.jlr.2021.100107 doi (DE-627)DOAJ019443676 (DE-599)DOAJ5826d53782b841698497b93ac7f63d14 DE-627 ger DE-627 rakwb eng QD415-436 John T. Melchior verfasserin aut Pregnancy is accompanied by larger high density lipoprotein particles and compositionally distinct subspecies 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Pregnancy is accompanied by significant physiological changes, which can impact the health and development of the fetus and mother. Pregnancy-induced changes in plasma lipoproteins are well documented, with modest to no impact observed on the generic measure of high density lipoprotein (HDL) cholesterol. However, the impact of pregnancy on the concentration and composition of HDL subspecies has not been examined in depth. In this prospective study, we collected plasma from 24 nonpregnant and 19 pregnant women in their second trimester. Using nuclear magnetic resonance (NMR), we quantified 11 different lipoprotein subspecies from plasma by size, including three in the HDL class. We observed an increase in the number of larger HDL particles in pregnant women, which were confirmed by tracking phospholipids across lipoproteins using high-resolution gel-filtration chromatography. Using liquid chromatography-mass spectrometry (LC-MS), we identified 87 lipid-associated proteins across size-speciated fractions. We report drastic shifts in multiple protein clusters across different HDL size fractions in pregnant females compared with nonpregnant controls that have major implications on HDL function. These findings significantly elevate our understanding of how changes in lipoprotein metabolism during pregnancy could impact the health of both the fetus and the mother. dyslipidemia nuclear magnetic resonance spectroscopy lipoprotein proteomics mass spectrometry pregnancy Biochemistry Debi K. Swertfeger verfasserin aut Jamie Morris verfasserin aut Scott E. Street verfasserin aut Carri R. Warshak verfasserin aut Jeffrey A. Welge verfasserin aut Alan T. Remaley verfasserin aut Janet M. Catov verfasserin aut W. Sean Davidson verfasserin aut Laura A. Woollett verfasserin aut In Journal of Lipid Research Elsevier, 2021 62(2021), Seite 100107- (DE-627)26601593X (DE-600)1466675-3 15397262 nnns volume:62 year:2021 pages:100107- https://doi.org/10.1016/j.jlr.2021.100107 kostenfrei https://doaj.org/article/5826d53782b841698497b93ac7f63d14 kostenfrei http://www.sciencedirect.com/science/article/pii/S0022227521000894 kostenfrei https://doaj.org/toc/0022-2275 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2006 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 62 2021 100107-
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callnumber-first	Q - Science
author	John T. Melchior
spellingShingle	John T. Melchior misc QD415-436 misc dyslipidemia misc nuclear magnetic resonance spectroscopy misc lipoprotein misc proteomics misc mass spectrometry misc pregnancy misc Biochemistry Pregnancy is accompanied by larger high density lipoprotein particles and compositionally distinct subspecies
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topic_title	QD415-436 Pregnancy is accompanied by larger high density lipoprotein particles and compositionally distinct subspecies dyslipidemia nuclear magnetic resonance spectroscopy lipoprotein proteomics mass spectrometry pregnancy
topic	misc QD415-436 misc dyslipidemia misc nuclear magnetic resonance spectroscopy misc lipoprotein misc proteomics misc mass spectrometry misc pregnancy misc Biochemistry
topic_unstemmed	misc QD415-436 misc dyslipidemia misc nuclear magnetic resonance spectroscopy misc lipoprotein misc proteomics misc mass spectrometry misc pregnancy misc Biochemistry
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title	Pregnancy is accompanied by larger high density lipoprotein particles and compositionally distinct subspecies
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title_full	Pregnancy is accompanied by larger high density lipoprotein particles and compositionally distinct subspecies
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author_browse	John T. Melchior Debi K. Swertfeger Jamie Morris Scott E. Street Carri R. Warshak Jeffrey A. Welge Alan T. Remaley Janet M. Catov W. Sean Davidson Laura A. Woollett
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title_sort	pregnancy is accompanied by larger high density lipoprotein particles and compositionally distinct subspecies
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title_auth	Pregnancy is accompanied by larger high density lipoprotein particles and compositionally distinct subspecies
abstract	Pregnancy is accompanied by significant physiological changes, which can impact the health and development of the fetus and mother. Pregnancy-induced changes in plasma lipoproteins are well documented, with modest to no impact observed on the generic measure of high density lipoprotein (HDL) cholesterol. However, the impact of pregnancy on the concentration and composition of HDL subspecies has not been examined in depth. In this prospective study, we collected plasma from 24 nonpregnant and 19 pregnant women in their second trimester. Using nuclear magnetic resonance (NMR), we quantified 11 different lipoprotein subspecies from plasma by size, including three in the HDL class. We observed an increase in the number of larger HDL particles in pregnant women, which were confirmed by tracking phospholipids across lipoproteins using high-resolution gel-filtration chromatography. Using liquid chromatography-mass spectrometry (LC-MS), we identified 87 lipid-associated proteins across size-speciated fractions. We report drastic shifts in multiple protein clusters across different HDL size fractions in pregnant females compared with nonpregnant controls that have major implications on HDL function. These findings significantly elevate our understanding of how changes in lipoprotein metabolism during pregnancy could impact the health of both the fetus and the mother.
abstractGer	Pregnancy is accompanied by significant physiological changes, which can impact the health and development of the fetus and mother. Pregnancy-induced changes in plasma lipoproteins are well documented, with modest to no impact observed on the generic measure of high density lipoprotein (HDL) cholesterol. However, the impact of pregnancy on the concentration and composition of HDL subspecies has not been examined in depth. In this prospective study, we collected plasma from 24 nonpregnant and 19 pregnant women in their second trimester. Using nuclear magnetic resonance (NMR), we quantified 11 different lipoprotein subspecies from plasma by size, including three in the HDL class. We observed an increase in the number of larger HDL particles in pregnant women, which were confirmed by tracking phospholipids across lipoproteins using high-resolution gel-filtration chromatography. Using liquid chromatography-mass spectrometry (LC-MS), we identified 87 lipid-associated proteins across size-speciated fractions. We report drastic shifts in multiple protein clusters across different HDL size fractions in pregnant females compared with nonpregnant controls that have major implications on HDL function. These findings significantly elevate our understanding of how changes in lipoprotein metabolism during pregnancy could impact the health of both the fetus and the mother.
abstract_unstemmed	Pregnancy is accompanied by significant physiological changes, which can impact the health and development of the fetus and mother. Pregnancy-induced changes in plasma lipoproteins are well documented, with modest to no impact observed on the generic measure of high density lipoprotein (HDL) cholesterol. However, the impact of pregnancy on the concentration and composition of HDL subspecies has not been examined in depth. In this prospective study, we collected plasma from 24 nonpregnant and 19 pregnant women in their second trimester. Using nuclear magnetic resonance (NMR), we quantified 11 different lipoprotein subspecies from plasma by size, including three in the HDL class. We observed an increase in the number of larger HDL particles in pregnant women, which were confirmed by tracking phospholipids across lipoproteins using high-resolution gel-filtration chromatography. Using liquid chromatography-mass spectrometry (LC-MS), we identified 87 lipid-associated proteins across size-speciated fractions. We report drastic shifts in multiple protein clusters across different HDL size fractions in pregnant females compared with nonpregnant controls that have major implications on HDL function. These findings significantly elevate our understanding of how changes in lipoprotein metabolism during pregnancy could impact the health of both the fetus and the mother.
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title_short	Pregnancy is accompanied by larger high density lipoprotein particles and compositionally distinct subspecies
url	https://doi.org/10.1016/j.jlr.2021.100107 https://doaj.org/article/5826d53782b841698497b93ac7f63d14 http://www.sciencedirect.com/science/article/pii/S0022227521000894 https://doaj.org/toc/0022-2275
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