Vertebral Fractures as a Manifestation of Phosphaturic Mesenchymal Tumor-Induced Osteomalacia

Background. The rarity of the disease and, in this regard, the lack of doctors awareness about the pathology, late diagnosis and severe complications of the musculoskeletal system emphasize the relevance of clinical case demonstrating. The uniqueness of the case lies in the fact that hypopho...
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Autor*in:	S. S. Rodionova [verfasserIn] Yu. V. Buklemishev [verfasserIn] I. N. Karpov [verfasserIn] O. B. Shugaeva [verfasserIn] A. N. Torgashin [verfasserIn]

Format:	E-Artikel
Sprache:	Russisch

Erschienen:	2021

Schlagwörter:	phosphaturic oncogenic osteomalacia, fgf-23 secreting tumor, phosphaturic mesenchymal tumor, pathological

Übergeordnetes Werk:	In: Travmatologiâ i Ortopediâ Rossii - Vreden Russian Research Institute of Traumatology and Orthopedics, 2016, 27(2021), 2, Seite 114-123
Übergeordnetes Werk:	volume:27 ; year:2021 ; number:2 ; pages:114-123

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.21823/2311-2905-2021-27-2-114-123

Katalog-ID:	DOAJ019489153

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callnumber-first	R - Medicine
author	S. S. Rodionova
spellingShingle	S. S. Rodionova misc RD701-811 misc phosphaturic oncogenic osteomalacia, fgf-23 secreting tumor, phosphaturic mesenchymal tumor, pathological misc Orthopedic surgery Vertebral Fractures as a Manifestation of Phosphaturic Mesenchymal Tumor-Induced Osteomalacia
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topic_title	RD701-811 Vertebral Fractures as a Manifestation of Phosphaturic Mesenchymal Tumor-Induced Osteomalacia phosphaturic oncogenic osteomalacia, fgf-23 secreting tumor, phosphaturic mesenchymal tumor, pathological
topic	misc RD701-811 misc phosphaturic oncogenic osteomalacia, fgf-23 secreting tumor, phosphaturic mesenchymal tumor, pathological misc Orthopedic surgery
topic_unstemmed	misc RD701-811 misc phosphaturic oncogenic osteomalacia, fgf-23 secreting tumor, phosphaturic mesenchymal tumor, pathological misc Orthopedic surgery
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title	Vertebral Fractures as a Manifestation of Phosphaturic Mesenchymal Tumor-Induced Osteomalacia
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title_full	Vertebral Fractures as a Manifestation of Phosphaturic Mesenchymal Tumor-Induced Osteomalacia
author_sort	S. S. Rodionova
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author_browse	S. S. Rodionova Yu. V. Buklemishev I. N. Karpov O. B. Shugaeva A. N. Torgashin
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title_sort	vertebral fractures as a manifestation of phosphaturic mesenchymal tumor-induced osteomalacia
callnumber	RD701-811
title_auth	Vertebral Fractures as a Manifestation of Phosphaturic Mesenchymal Tumor-Induced Osteomalacia
abstract	Background. The rarity of the disease and, in this regard, the lack of doctors awareness about the pathology, late diagnosis and severe complications of the musculoskeletal system emphasize the relevance of clinical case demonstrating. The uniqueness of the case lies in the fact that hypophosphatemia, noted 3 years after the disease debut, was not taken into account. Case description. A 45-year-old patient with complaints of muscle weakness, gait disorders, torso deformity and multiple vertebral body fractures that appeared against the background of any somatic diseases absence, a differential diagnosis of metastatic vertebral bodies lesions and secondary osteoporosis complicated by vertebral body fractures was carried out for four years in various hospitals, and was even treated with bisphosphonates. Against this background, the chest deformity increased, kyphosis and remodeling fractures of other bones appeared. The assessment of calcium and phosphorus homeostasis was first performed at the 4th year of the disease, but the detected hypophosphatemia was not regarded as a manifestation of hypophosphatemic osteomalacia. Conclusion. Among adult patients with multiple low-energy fractures, severe muscle weakness and bone pain that appeared against the background of complete health, to exclude hypophosphatemic osteomalacia induced by mesenchymal tumor, it is necessary to include the level of phosphorus in blood and daily urine assessment in the diagnostic algorithm.
abstractGer	Background. The rarity of the disease and, in this regard, the lack of doctors awareness about the pathology, late diagnosis and severe complications of the musculoskeletal system emphasize the relevance of clinical case demonstrating. The uniqueness of the case lies in the fact that hypophosphatemia, noted 3 years after the disease debut, was not taken into account. Case description. A 45-year-old patient with complaints of muscle weakness, gait disorders, torso deformity and multiple vertebral body fractures that appeared against the background of any somatic diseases absence, a differential diagnosis of metastatic vertebral bodies lesions and secondary osteoporosis complicated by vertebral body fractures was carried out for four years in various hospitals, and was even treated with bisphosphonates. Against this background, the chest deformity increased, kyphosis and remodeling fractures of other bones appeared. The assessment of calcium and phosphorus homeostasis was first performed at the 4th year of the disease, but the detected hypophosphatemia was not regarded as a manifestation of hypophosphatemic osteomalacia. Conclusion. Among adult patients with multiple low-energy fractures, severe muscle weakness and bone pain that appeared against the background of complete health, to exclude hypophosphatemic osteomalacia induced by mesenchymal tumor, it is necessary to include the level of phosphorus in blood and daily urine assessment in the diagnostic algorithm.
abstract_unstemmed	Background. The rarity of the disease and, in this regard, the lack of doctors awareness about the pathology, late diagnosis and severe complications of the musculoskeletal system emphasize the relevance of clinical case demonstrating. The uniqueness of the case lies in the fact that hypophosphatemia, noted 3 years after the disease debut, was not taken into account. Case description. A 45-year-old patient with complaints of muscle weakness, gait disorders, torso deformity and multiple vertebral body fractures that appeared against the background of any somatic diseases absence, a differential diagnosis of metastatic vertebral bodies lesions and secondary osteoporosis complicated by vertebral body fractures was carried out for four years in various hospitals, and was even treated with bisphosphonates. Against this background, the chest deformity increased, kyphosis and remodeling fractures of other bones appeared. The assessment of calcium and phosphorus homeostasis was first performed at the 4th year of the disease, but the detected hypophosphatemia was not regarded as a manifestation of hypophosphatemic osteomalacia. Conclusion. Among adult patients with multiple low-energy fractures, severe muscle weakness and bone pain that appeared against the background of complete health, to exclude hypophosphatemic osteomalacia induced by mesenchymal tumor, it is necessary to include the level of phosphorus in blood and daily urine assessment in the diagnostic algorithm.
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title_short	Vertebral Fractures as a Manifestation of Phosphaturic Mesenchymal Tumor-Induced Osteomalacia
url	https://doi.org/10.21823/2311-2905-2021-27-2-114-123 https://doaj.org/article/3dae5cc2a2c146bf914ee39969432462 https://journal.rniito.org/jour/article/viewFile/1597/1101 https://doaj.org/toc/2311-2905 https://doaj.org/toc/2542-0933
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