Potential functional applications of extracellular vesicles: a report by the NIH Common Fund Extracellular RNA Communication Consortium
The NIH Extracellular RNA Communication Program's initiative on clinical utility of extracellular RNAs and therapeutic agents and developing scalable technologies is reviewed here. Background information and details of the projects are presented. The work has focused on modulation of target cel...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Peter J. Quesenberry [verfasserIn] Jason Aliotta [verfasserIn] Giovanni Camussi [verfasserIn] Asim B. Abdel-Mageed [verfasserIn] Sicheng Wen [verfasserIn] Laura Goldberg [verfasserIn] Huang-Ge Zhang [verfasserIn] Ciro Tetta [verfasserIn] Jeffrey Franklin [verfasserIn] Robert J. Coffey [verfasserIn] Kirsty Danielson [verfasserIn] Vinita Subramanya [verfasserIn] Ionita Ghiran [verfasserIn] Saumya Das [verfasserIn] Clark C. Chen [verfasserIn] Kae M. Pusic [verfasserIn] Aya D. Pusic [verfasserIn] Devasis Chatterjee [verfasserIn] Richard P. Kraig [verfasserIn] Leonora Balaj [verfasserIn] Mark Dooner [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Journal of Extracellular Vesicles - Wiley, 2012, 4(2015), 0, Seite 11 |
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| Übergeordnetes Werk: |
volume:4 ; year:2015 ; number:0 ; pages:11 |
| Links: |
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| DOI / URN: |
10.3402/jev.v4.27575 |
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| Katalog-ID: |
DOAJ019566263 |
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| 520 | |a The NIH Extracellular RNA Communication Program's initiative on clinical utility of extracellular RNAs and therapeutic agents and developing scalable technologies is reviewed here. Background information and details of the projects are presented. The work has focused on modulation of target cell fate by extracellular vesicles (EVs) and RNA. Work on plant-derived vesicles is of intense interest, and non-mammalian sources of vesicles may represent a very promising source for different therapeutic approaches. Retro-viral-like particles are intriguing. Clearly, EVs share pathways with the assembly machinery of several other viruses, including human endogenous retrovirals (HERVs), and this convergence may explain the observation of viral-like particles containing viral proteins and nucleic acid in EVs. Dramatic effect on regeneration of damaged bone marrow, renal, pulmonary and cardiovascular tissue is demonstrated and discussed. These studies show restoration of injured cell function and the importance of heterogeneity of different vesicle populations. The potential for neural regeneration is explored, and the capacity to promote and reverse neoplasia by EV exposure is described. The tremendous clinical potential of EVs underlies many of these projects, and the importance of regulatory issues and the necessity of general manufacturing production (GMP) studies for eventual clinical trials are emphasized. Clinical trials are already being pursued and should expand dramatically in the near future. | ||
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10.3402/jev.v4.27575 doi (DE-627)DOAJ019566263 (DE-599)DOAJe56fbab25197441eb1a243c1438a3ca6 DE-627 ger DE-627 rakwb eng QH573-671 Peter J. Quesenberry verfasserin aut Potential functional applications of extracellular vesicles: a report by the NIH Common Fund Extracellular RNA Communication Consortium 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The NIH Extracellular RNA Communication Program's initiative on clinical utility of extracellular RNAs and therapeutic agents and developing scalable technologies is reviewed here. Background information and details of the projects are presented. The work has focused on modulation of target cell fate by extracellular vesicles (EVs) and RNA. Work on plant-derived vesicles is of intense interest, and non-mammalian sources of vesicles may represent a very promising source for different therapeutic approaches. Retro-viral-like particles are intriguing. Clearly, EVs share pathways with the assembly machinery of several other viruses, including human endogenous retrovirals (HERVs), and this convergence may explain the observation of viral-like particles containing viral proteins and nucleic acid in EVs. Dramatic effect on regeneration of damaged bone marrow, renal, pulmonary and cardiovascular tissue is demonstrated and discussed. These studies show restoration of injured cell function and the importance of heterogeneity of different vesicle populations. The potential for neural regeneration is explored, and the capacity to promote and reverse neoplasia by EV exposure is described. The tremendous clinical potential of EVs underlies many of these projects, and the importance of regulatory issues and the necessity of general manufacturing production (GMP) studies for eventual clinical trials are emphasized. Clinical trials are already being pursued and should expand dramatically in the near future. extracellular vesicles cell fate change functional effects renal pulmonary heart disease cancer Cytology Jason Aliotta verfasserin aut Giovanni Camussi verfasserin aut Asim B. Abdel-Mageed verfasserin aut Sicheng Wen verfasserin aut Laura Goldberg verfasserin aut Huang-Ge Zhang verfasserin aut Ciro Tetta verfasserin aut Jeffrey Franklin verfasserin aut Robert J. Coffey verfasserin aut Kirsty Danielson verfasserin aut Vinita Subramanya verfasserin aut Ionita Ghiran verfasserin aut Saumya Das verfasserin aut Clark C. Chen verfasserin aut Kae M. Pusic verfasserin aut Aya D. Pusic verfasserin aut Devasis Chatterjee verfasserin aut Richard P. Kraig verfasserin aut Leonora Balaj verfasserin aut Mark Dooner verfasserin aut In Journal of Extracellular Vesicles Wiley, 2012 4(2015), 0, Seite 11 (DE-627)726923710 (DE-600)2683797-3 20013078 nnns volume:4 year:2015 number:0 pages:11 https://doi.org/10.3402/jev.v4.27575 kostenfrei https://doaj.org/article/e56fbab25197441eb1a243c1438a3ca6 kostenfrei http://www.journalofextracellularvesicles.net/index.php/jev/article/view/27575/pdf_38 kostenfrei https://doaj.org/toc/2001-3078 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2015 0 11 |
| spelling |
10.3402/jev.v4.27575 doi (DE-627)DOAJ019566263 (DE-599)DOAJe56fbab25197441eb1a243c1438a3ca6 DE-627 ger DE-627 rakwb eng QH573-671 Peter J. Quesenberry verfasserin aut Potential functional applications of extracellular vesicles: a report by the NIH Common Fund Extracellular RNA Communication Consortium 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The NIH Extracellular RNA Communication Program's initiative on clinical utility of extracellular RNAs and therapeutic agents and developing scalable technologies is reviewed here. Background information and details of the projects are presented. The work has focused on modulation of target cell fate by extracellular vesicles (EVs) and RNA. Work on plant-derived vesicles is of intense interest, and non-mammalian sources of vesicles may represent a very promising source for different therapeutic approaches. Retro-viral-like particles are intriguing. Clearly, EVs share pathways with the assembly machinery of several other viruses, including human endogenous retrovirals (HERVs), and this convergence may explain the observation of viral-like particles containing viral proteins and nucleic acid in EVs. Dramatic effect on regeneration of damaged bone marrow, renal, pulmonary and cardiovascular tissue is demonstrated and discussed. These studies show restoration of injured cell function and the importance of heterogeneity of different vesicle populations. The potential for neural regeneration is explored, and the capacity to promote and reverse neoplasia by EV exposure is described. The tremendous clinical potential of EVs underlies many of these projects, and the importance of regulatory issues and the necessity of general manufacturing production (GMP) studies for eventual clinical trials are emphasized. Clinical trials are already being pursued and should expand dramatically in the near future. extracellular vesicles cell fate change functional effects renal pulmonary heart disease cancer Cytology Jason Aliotta verfasserin aut Giovanni Camussi verfasserin aut Asim B. Abdel-Mageed verfasserin aut Sicheng Wen verfasserin aut Laura Goldberg verfasserin aut Huang-Ge Zhang verfasserin aut Ciro Tetta verfasserin aut Jeffrey Franklin verfasserin aut Robert J. Coffey verfasserin aut Kirsty Danielson verfasserin aut Vinita Subramanya verfasserin aut Ionita Ghiran verfasserin aut Saumya Das verfasserin aut Clark C. Chen verfasserin aut Kae M. Pusic verfasserin aut Aya D. Pusic verfasserin aut Devasis Chatterjee verfasserin aut Richard P. Kraig verfasserin aut Leonora Balaj verfasserin aut Mark Dooner verfasserin aut In Journal of Extracellular Vesicles Wiley, 2012 4(2015), 0, Seite 11 (DE-627)726923710 (DE-600)2683797-3 20013078 nnns volume:4 year:2015 number:0 pages:11 https://doi.org/10.3402/jev.v4.27575 kostenfrei https://doaj.org/article/e56fbab25197441eb1a243c1438a3ca6 kostenfrei http://www.journalofextracellularvesicles.net/index.php/jev/article/view/27575/pdf_38 kostenfrei https://doaj.org/toc/2001-3078 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2015 0 11 |
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10.3402/jev.v4.27575 doi (DE-627)DOAJ019566263 (DE-599)DOAJe56fbab25197441eb1a243c1438a3ca6 DE-627 ger DE-627 rakwb eng QH573-671 Peter J. Quesenberry verfasserin aut Potential functional applications of extracellular vesicles: a report by the NIH Common Fund Extracellular RNA Communication Consortium 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The NIH Extracellular RNA Communication Program's initiative on clinical utility of extracellular RNAs and therapeutic agents and developing scalable technologies is reviewed here. Background information and details of the projects are presented. The work has focused on modulation of target cell fate by extracellular vesicles (EVs) and RNA. Work on plant-derived vesicles is of intense interest, and non-mammalian sources of vesicles may represent a very promising source for different therapeutic approaches. Retro-viral-like particles are intriguing. Clearly, EVs share pathways with the assembly machinery of several other viruses, including human endogenous retrovirals (HERVs), and this convergence may explain the observation of viral-like particles containing viral proteins and nucleic acid in EVs. Dramatic effect on regeneration of damaged bone marrow, renal, pulmonary and cardiovascular tissue is demonstrated and discussed. These studies show restoration of injured cell function and the importance of heterogeneity of different vesicle populations. The potential for neural regeneration is explored, and the capacity to promote and reverse neoplasia by EV exposure is described. The tremendous clinical potential of EVs underlies many of these projects, and the importance of regulatory issues and the necessity of general manufacturing production (GMP) studies for eventual clinical trials are emphasized. Clinical trials are already being pursued and should expand dramatically in the near future. extracellular vesicles cell fate change functional effects renal pulmonary heart disease cancer Cytology Jason Aliotta verfasserin aut Giovanni Camussi verfasserin aut Asim B. Abdel-Mageed verfasserin aut Sicheng Wen verfasserin aut Laura Goldberg verfasserin aut Huang-Ge Zhang verfasserin aut Ciro Tetta verfasserin aut Jeffrey Franklin verfasserin aut Robert J. Coffey verfasserin aut Kirsty Danielson verfasserin aut Vinita Subramanya verfasserin aut Ionita Ghiran verfasserin aut Saumya Das verfasserin aut Clark C. Chen verfasserin aut Kae M. Pusic verfasserin aut Aya D. Pusic verfasserin aut Devasis Chatterjee verfasserin aut Richard P. Kraig verfasserin aut Leonora Balaj verfasserin aut Mark Dooner verfasserin aut In Journal of Extracellular Vesicles Wiley, 2012 4(2015), 0, Seite 11 (DE-627)726923710 (DE-600)2683797-3 20013078 nnns volume:4 year:2015 number:0 pages:11 https://doi.org/10.3402/jev.v4.27575 kostenfrei https://doaj.org/article/e56fbab25197441eb1a243c1438a3ca6 kostenfrei http://www.journalofextracellularvesicles.net/index.php/jev/article/view/27575/pdf_38 kostenfrei https://doaj.org/toc/2001-3078 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2015 0 11 |
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10.3402/jev.v4.27575 doi (DE-627)DOAJ019566263 (DE-599)DOAJe56fbab25197441eb1a243c1438a3ca6 DE-627 ger DE-627 rakwb eng QH573-671 Peter J. Quesenberry verfasserin aut Potential functional applications of extracellular vesicles: a report by the NIH Common Fund Extracellular RNA Communication Consortium 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The NIH Extracellular RNA Communication Program's initiative on clinical utility of extracellular RNAs and therapeutic agents and developing scalable technologies is reviewed here. Background information and details of the projects are presented. The work has focused on modulation of target cell fate by extracellular vesicles (EVs) and RNA. Work on plant-derived vesicles is of intense interest, and non-mammalian sources of vesicles may represent a very promising source for different therapeutic approaches. Retro-viral-like particles are intriguing. Clearly, EVs share pathways with the assembly machinery of several other viruses, including human endogenous retrovirals (HERVs), and this convergence may explain the observation of viral-like particles containing viral proteins and nucleic acid in EVs. Dramatic effect on regeneration of damaged bone marrow, renal, pulmonary and cardiovascular tissue is demonstrated and discussed. These studies show restoration of injured cell function and the importance of heterogeneity of different vesicle populations. The potential for neural regeneration is explored, and the capacity to promote and reverse neoplasia by EV exposure is described. The tremendous clinical potential of EVs underlies many of these projects, and the importance of regulatory issues and the necessity of general manufacturing production (GMP) studies for eventual clinical trials are emphasized. Clinical trials are already being pursued and should expand dramatically in the near future. extracellular vesicles cell fate change functional effects renal pulmonary heart disease cancer Cytology Jason Aliotta verfasserin aut Giovanni Camussi verfasserin aut Asim B. Abdel-Mageed verfasserin aut Sicheng Wen verfasserin aut Laura Goldberg verfasserin aut Huang-Ge Zhang verfasserin aut Ciro Tetta verfasserin aut Jeffrey Franklin verfasserin aut Robert J. Coffey verfasserin aut Kirsty Danielson verfasserin aut Vinita Subramanya verfasserin aut Ionita Ghiran verfasserin aut Saumya Das verfasserin aut Clark C. Chen verfasserin aut Kae M. Pusic verfasserin aut Aya D. Pusic verfasserin aut Devasis Chatterjee verfasserin aut Richard P. Kraig verfasserin aut Leonora Balaj verfasserin aut Mark Dooner verfasserin aut In Journal of Extracellular Vesicles Wiley, 2012 4(2015), 0, Seite 11 (DE-627)726923710 (DE-600)2683797-3 20013078 nnns volume:4 year:2015 number:0 pages:11 https://doi.org/10.3402/jev.v4.27575 kostenfrei https://doaj.org/article/e56fbab25197441eb1a243c1438a3ca6 kostenfrei http://www.journalofextracellularvesicles.net/index.php/jev/article/view/27575/pdf_38 kostenfrei https://doaj.org/toc/2001-3078 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2015 0 11 |
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10.3402/jev.v4.27575 doi (DE-627)DOAJ019566263 (DE-599)DOAJe56fbab25197441eb1a243c1438a3ca6 DE-627 ger DE-627 rakwb eng QH573-671 Peter J. Quesenberry verfasserin aut Potential functional applications of extracellular vesicles: a report by the NIH Common Fund Extracellular RNA Communication Consortium 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The NIH Extracellular RNA Communication Program's initiative on clinical utility of extracellular RNAs and therapeutic agents and developing scalable technologies is reviewed here. Background information and details of the projects are presented. The work has focused on modulation of target cell fate by extracellular vesicles (EVs) and RNA. Work on plant-derived vesicles is of intense interest, and non-mammalian sources of vesicles may represent a very promising source for different therapeutic approaches. Retro-viral-like particles are intriguing. Clearly, EVs share pathways with the assembly machinery of several other viruses, including human endogenous retrovirals (HERVs), and this convergence may explain the observation of viral-like particles containing viral proteins and nucleic acid in EVs. Dramatic effect on regeneration of damaged bone marrow, renal, pulmonary and cardiovascular tissue is demonstrated and discussed. These studies show restoration of injured cell function and the importance of heterogeneity of different vesicle populations. The potential for neural regeneration is explored, and the capacity to promote and reverse neoplasia by EV exposure is described. The tremendous clinical potential of EVs underlies many of these projects, and the importance of regulatory issues and the necessity of general manufacturing production (GMP) studies for eventual clinical trials are emphasized. Clinical trials are already being pursued and should expand dramatically in the near future. extracellular vesicles cell fate change functional effects renal pulmonary heart disease cancer Cytology Jason Aliotta verfasserin aut Giovanni Camussi verfasserin aut Asim B. Abdel-Mageed verfasserin aut Sicheng Wen verfasserin aut Laura Goldberg verfasserin aut Huang-Ge Zhang verfasserin aut Ciro Tetta verfasserin aut Jeffrey Franklin verfasserin aut Robert J. Coffey verfasserin aut Kirsty Danielson verfasserin aut Vinita Subramanya verfasserin aut Ionita Ghiran verfasserin aut Saumya Das verfasserin aut Clark C. Chen verfasserin aut Kae M. Pusic verfasserin aut Aya D. Pusic verfasserin aut Devasis Chatterjee verfasserin aut Richard P. Kraig verfasserin aut Leonora Balaj verfasserin aut Mark Dooner verfasserin aut In Journal of Extracellular Vesicles Wiley, 2012 4(2015), 0, Seite 11 (DE-627)726923710 (DE-600)2683797-3 20013078 nnns volume:4 year:2015 number:0 pages:11 https://doi.org/10.3402/jev.v4.27575 kostenfrei https://doaj.org/article/e56fbab25197441eb1a243c1438a3ca6 kostenfrei http://www.journalofextracellularvesicles.net/index.php/jev/article/view/27575/pdf_38 kostenfrei https://doaj.org/toc/2001-3078 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2015 0 11 |
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Peter J. Quesenberry @@aut@@ Jason Aliotta @@aut@@ Giovanni Camussi @@aut@@ Asim B. Abdel-Mageed @@aut@@ Sicheng Wen @@aut@@ Laura Goldberg @@aut@@ Huang-Ge Zhang @@aut@@ Ciro Tetta @@aut@@ Jeffrey Franklin @@aut@@ Robert J. Coffey @@aut@@ Kirsty Danielson @@aut@@ Vinita Subramanya @@aut@@ Ionita Ghiran @@aut@@ Saumya Das @@aut@@ Clark C. Chen @@aut@@ Kae M. Pusic @@aut@@ Aya D. Pusic @@aut@@ Devasis Chatterjee @@aut@@ Richard P. Kraig @@aut@@ Leonora Balaj @@aut@@ Mark Dooner @@aut@@ |
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Peter J. Quesenberry misc QH573-671 misc extracellular vesicles misc cell fate change misc functional effects misc renal misc pulmonary heart disease misc cancer misc Cytology Potential functional applications of extracellular vesicles: a report by the NIH Common Fund Extracellular RNA Communication Consortium |
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QH573-671 Potential functional applications of extracellular vesicles: a report by the NIH Common Fund Extracellular RNA Communication Consortium extracellular vesicles cell fate change functional effects renal pulmonary heart disease cancer |
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Peter J. Quesenberry Jason Aliotta Giovanni Camussi Asim B. Abdel-Mageed Sicheng Wen Laura Goldberg Huang-Ge Zhang Ciro Tetta Jeffrey Franklin Robert J. Coffey Kirsty Danielson Vinita Subramanya Ionita Ghiran Saumya Das Clark C. Chen Kae M. Pusic Aya D. Pusic Devasis Chatterjee Richard P. Kraig Leonora Balaj Mark Dooner |
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Potential functional applications of extracellular vesicles: a report by the NIH Common Fund Extracellular RNA Communication Consortium |
| abstract |
The NIH Extracellular RNA Communication Program's initiative on clinical utility of extracellular RNAs and therapeutic agents and developing scalable technologies is reviewed here. Background information and details of the projects are presented. The work has focused on modulation of target cell fate by extracellular vesicles (EVs) and RNA. Work on plant-derived vesicles is of intense interest, and non-mammalian sources of vesicles may represent a very promising source for different therapeutic approaches. Retro-viral-like particles are intriguing. Clearly, EVs share pathways with the assembly machinery of several other viruses, including human endogenous retrovirals (HERVs), and this convergence may explain the observation of viral-like particles containing viral proteins and nucleic acid in EVs. Dramatic effect on regeneration of damaged bone marrow, renal, pulmonary and cardiovascular tissue is demonstrated and discussed. These studies show restoration of injured cell function and the importance of heterogeneity of different vesicle populations. The potential for neural regeneration is explored, and the capacity to promote and reverse neoplasia by EV exposure is described. The tremendous clinical potential of EVs underlies many of these projects, and the importance of regulatory issues and the necessity of general manufacturing production (GMP) studies for eventual clinical trials are emphasized. Clinical trials are already being pursued and should expand dramatically in the near future. |
| abstractGer |
The NIH Extracellular RNA Communication Program's initiative on clinical utility of extracellular RNAs and therapeutic agents and developing scalable technologies is reviewed here. Background information and details of the projects are presented. The work has focused on modulation of target cell fate by extracellular vesicles (EVs) and RNA. Work on plant-derived vesicles is of intense interest, and non-mammalian sources of vesicles may represent a very promising source for different therapeutic approaches. Retro-viral-like particles are intriguing. Clearly, EVs share pathways with the assembly machinery of several other viruses, including human endogenous retrovirals (HERVs), and this convergence may explain the observation of viral-like particles containing viral proteins and nucleic acid in EVs. Dramatic effect on regeneration of damaged bone marrow, renal, pulmonary and cardiovascular tissue is demonstrated and discussed. These studies show restoration of injured cell function and the importance of heterogeneity of different vesicle populations. The potential for neural regeneration is explored, and the capacity to promote and reverse neoplasia by EV exposure is described. The tremendous clinical potential of EVs underlies many of these projects, and the importance of regulatory issues and the necessity of general manufacturing production (GMP) studies for eventual clinical trials are emphasized. Clinical trials are already being pursued and should expand dramatically in the near future. |
| abstract_unstemmed |
The NIH Extracellular RNA Communication Program's initiative on clinical utility of extracellular RNAs and therapeutic agents and developing scalable technologies is reviewed here. Background information and details of the projects are presented. The work has focused on modulation of target cell fate by extracellular vesicles (EVs) and RNA. Work on plant-derived vesicles is of intense interest, and non-mammalian sources of vesicles may represent a very promising source for different therapeutic approaches. Retro-viral-like particles are intriguing. Clearly, EVs share pathways with the assembly machinery of several other viruses, including human endogenous retrovirals (HERVs), and this convergence may explain the observation of viral-like particles containing viral proteins and nucleic acid in EVs. Dramatic effect on regeneration of damaged bone marrow, renal, pulmonary and cardiovascular tissue is demonstrated and discussed. These studies show restoration of injured cell function and the importance of heterogeneity of different vesicle populations. The potential for neural regeneration is explored, and the capacity to promote and reverse neoplasia by EV exposure is described. The tremendous clinical potential of EVs underlies many of these projects, and the importance of regulatory issues and the necessity of general manufacturing production (GMP) studies for eventual clinical trials are emphasized. Clinical trials are already being pursued and should expand dramatically in the near future. |
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Potential functional applications of extracellular vesicles: a report by the NIH Common Fund Extracellular RNA Communication Consortium |
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https://doi.org/10.3402/jev.v4.27575 https://doaj.org/article/e56fbab25197441eb1a243c1438a3ca6 http://www.journalofextracellularvesicles.net/index.php/jev/article/view/27575/pdf_38 https://doaj.org/toc/2001-3078 |
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Jason Aliotta Giovanni Camussi Asim B. Abdel-Mageed Sicheng Wen Laura Goldberg Huang-Ge Zhang Ciro Tetta Jeffrey Franklin Robert J. Coffey Kirsty Danielson Vinita Subramanya Ionita Ghiran Saumya Das Clark C. Chen Kae M. Pusic Aya D. Pusic Devasis Chatterjee Richard P. Kraig Leonora Balaj Mark Dooner |
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Jason Aliotta Giovanni Camussi Asim B. Abdel-Mageed Sicheng Wen Laura Goldberg Huang-Ge Zhang Ciro Tetta Jeffrey Franklin Robert J. Coffey Kirsty Danielson Vinita Subramanya Ionita Ghiran Saumya Das Clark C. Chen Kae M. Pusic Aya D. Pusic Devasis Chatterjee Richard P. Kraig Leonora Balaj Mark Dooner |
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2024-07-04T00:04:27.915Z |
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