Psoriatic Dermal-derived Mesenchymal Stem Cells Reduce Keratinocyte Junctions, and Increase Glycolysis

Although it is known that psoriatic dermal-derived mesenchymal stem cells (DMSCs) dysregulate keratinocyte proliferation, the biological activity profile of keratinocytes influenced by psoriatic DMSCs remain unknown. In the present study, we assessed the impact of psoriatic DMSCs on keratinocyte pro...
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Autor*in:	Junqin Li [verfasserIn] Jianxiao Xing [verfasserIn] Funa Lu [verfasserIn] Wenjuan Chang [verfasserIn] Nannan Liang [verfasserIn] Juan Li [verfasserIn] Ying Wang [verfasserIn] Xiaofang Li [verfasserIn] Xincheng Zhao [verfasserIn] Ruixia Hou [verfasserIn] Maoqiang Man [verfasserIn] Guohua Yin [verfasserIn] Xinhua Li [verfasserIn] Kaiming Zhang [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	psoriasis dermal mesenchymal stem cells keratinocytes cell junctions cell proliferation glycolysis

Übergeordnetes Werk:	In: Acta Dermato-Venereologica - Medical Journals Sweden, 2011, 100(2020), 8, p adv00122
Übergeordnetes Werk:	volume:100 ; year:2020 ; number:8, p adv00122

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.2340/00015555-3480

Katalog-ID:	DOAJ019665865

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520			\|a Although it is known that psoriatic dermal-derived mesenchymal stem cells (DMSCs) dysregulate keratinocyte proliferation, the biological activity profile of keratinocytes influenced by psoriatic DMSCs remain unknown. In the present study, we assessed the impact of psoriatic DMSCs on keratinocyte proliferation, differentiation, and glucose metabolism in normal human epidermal keratinocytes co-cultured with or without psoriatic DMSCs. Co-culture of normal human epidermal keratinocytes with psoriatic DMSCs downregulated expression levels of proteins associated with cell junction assembly (alpha-actinin-1, catenin beta-1, poliovirus receptor-related protein 4 and procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2), while upregulating proteins associated with keratinocyte proliferation and differentiation (involucrin, isoform 2 of Histone-binding protein, isoform 3 of Telomeric repeat-binding factor 2 and keratin 13). Moreover, co-culture of normal human epidermal keratinocytes with psoriatic DMSCs stimulated keratinocyte proliferation and glycolysis, but reduced keratinocyte junctions. Taken together, these results demonstrate that psoriatic DMSCs increase keratinocyte proliferation and glycolysis, and reduce cell junctions, suggesting a pathogenic role of psoriatic DMSCs in epidermal hyperplasia, aberrant differentiation, and reduction in turnover time of keratinocytes in psoriasis.
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allfields	10.2340/00015555-3480 doi (DE-627)DOAJ019665865 (DE-599)DOAJe7128f6080134a8984330ef35ff0f6b5 DE-627 ger DE-627 rakwb eng RL1-803 Junqin Li verfasserin aut Psoriatic Dermal-derived Mesenchymal Stem Cells Reduce Keratinocyte Junctions, and Increase Glycolysis 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Although it is known that psoriatic dermal-derived mesenchymal stem cells (DMSCs) dysregulate keratinocyte proliferation, the biological activity profile of keratinocytes influenced by psoriatic DMSCs remain unknown. In the present study, we assessed the impact of psoriatic DMSCs on keratinocyte proliferation, differentiation, and glucose metabolism in normal human epidermal keratinocytes co-cultured with or without psoriatic DMSCs. Co-culture of normal human epidermal keratinocytes with psoriatic DMSCs downregulated expression levels of proteins associated with cell junction assembly (alpha-actinin-1, catenin beta-1, poliovirus receptor-related protein 4 and procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2), while upregulating proteins associated with keratinocyte proliferation and differentiation (involucrin, isoform 2 of Histone-binding protein, isoform 3 of Telomeric repeat-binding factor 2 and keratin 13). Moreover, co-culture of normal human epidermal keratinocytes with psoriatic DMSCs stimulated keratinocyte proliferation and glycolysis, but reduced keratinocyte junctions. Taken together, these results demonstrate that psoriatic DMSCs increase keratinocyte proliferation and glycolysis, and reduce cell junctions, suggesting a pathogenic role of psoriatic DMSCs in epidermal hyperplasia, aberrant differentiation, and reduction in turnover time of keratinocytes in psoriasis. psoriasis dermal mesenchymal stem cells keratinocytes cell junctions cell proliferation glycolysis Dermatology Jianxiao Xing verfasserin aut Funa Lu verfasserin aut Wenjuan Chang verfasserin aut Nannan Liang verfasserin aut Juan Li verfasserin aut Ying Wang verfasserin aut Xiaofang Li verfasserin aut Xincheng Zhao verfasserin aut Ruixia Hou verfasserin aut Maoqiang Man verfasserin aut Guohua Yin verfasserin aut Xinhua Li verfasserin aut Kaiming Zhang verfasserin aut In Acta Dermato-Venereologica Medical Journals Sweden, 2011 100(2020), 8, p adv00122 (DE-627)302725431 (DE-600)1492617-9 16512057 nnns volume:100 year:2020 number:8, p adv00122 https://doi.org/10.2340/00015555-3480 kostenfrei https://doaj.org/article/e7128f6080134a8984330ef35ff0f6b5 kostenfrei https://www.medicaljournals.se/acta/content/html/10.2340/00015555-3480 kostenfrei https://doaj.org/toc/0001-5555 Journal toc kostenfrei https://doaj.org/toc/1651-2057 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 100 2020 8, p adv00122
spelling	10.2340/00015555-3480 doi (DE-627)DOAJ019665865 (DE-599)DOAJe7128f6080134a8984330ef35ff0f6b5 DE-627 ger DE-627 rakwb eng RL1-803 Junqin Li verfasserin aut Psoriatic Dermal-derived Mesenchymal Stem Cells Reduce Keratinocyte Junctions, and Increase Glycolysis 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Although it is known that psoriatic dermal-derived mesenchymal stem cells (DMSCs) dysregulate keratinocyte proliferation, the biological activity profile of keratinocytes influenced by psoriatic DMSCs remain unknown. In the present study, we assessed the impact of psoriatic DMSCs on keratinocyte proliferation, differentiation, and glucose metabolism in normal human epidermal keratinocytes co-cultured with or without psoriatic DMSCs. Co-culture of normal human epidermal keratinocytes with psoriatic DMSCs downregulated expression levels of proteins associated with cell junction assembly (alpha-actinin-1, catenin beta-1, poliovirus receptor-related protein 4 and procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2), while upregulating proteins associated with keratinocyte proliferation and differentiation (involucrin, isoform 2 of Histone-binding protein, isoform 3 of Telomeric repeat-binding factor 2 and keratin 13). Moreover, co-culture of normal human epidermal keratinocytes with psoriatic DMSCs stimulated keratinocyte proliferation and glycolysis, but reduced keratinocyte junctions. Taken together, these results demonstrate that psoriatic DMSCs increase keratinocyte proliferation and glycolysis, and reduce cell junctions, suggesting a pathogenic role of psoriatic DMSCs in epidermal hyperplasia, aberrant differentiation, and reduction in turnover time of keratinocytes in psoriasis. psoriasis dermal mesenchymal stem cells keratinocytes cell junctions cell proliferation glycolysis Dermatology Jianxiao Xing verfasserin aut Funa Lu verfasserin aut Wenjuan Chang verfasserin aut Nannan Liang verfasserin aut Juan Li verfasserin aut Ying Wang verfasserin aut Xiaofang Li verfasserin aut Xincheng Zhao verfasserin aut Ruixia Hou verfasserin aut Maoqiang Man verfasserin aut Guohua Yin verfasserin aut Xinhua Li verfasserin aut Kaiming Zhang verfasserin aut In Acta Dermato-Venereologica Medical Journals Sweden, 2011 100(2020), 8, p adv00122 (DE-627)302725431 (DE-600)1492617-9 16512057 nnns volume:100 year:2020 number:8, p adv00122 https://doi.org/10.2340/00015555-3480 kostenfrei https://doaj.org/article/e7128f6080134a8984330ef35ff0f6b5 kostenfrei https://www.medicaljournals.se/acta/content/html/10.2340/00015555-3480 kostenfrei https://doaj.org/toc/0001-5555 Journal toc kostenfrei https://doaj.org/toc/1651-2057 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 100 2020 8, p adv00122
allfields_unstemmed	10.2340/00015555-3480 doi (DE-627)DOAJ019665865 (DE-599)DOAJe7128f6080134a8984330ef35ff0f6b5 DE-627 ger DE-627 rakwb eng RL1-803 Junqin Li verfasserin aut Psoriatic Dermal-derived Mesenchymal Stem Cells Reduce Keratinocyte Junctions, and Increase Glycolysis 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Although it is known that psoriatic dermal-derived mesenchymal stem cells (DMSCs) dysregulate keratinocyte proliferation, the biological activity profile of keratinocytes influenced by psoriatic DMSCs remain unknown. In the present study, we assessed the impact of psoriatic DMSCs on keratinocyte proliferation, differentiation, and glucose metabolism in normal human epidermal keratinocytes co-cultured with or without psoriatic DMSCs. Co-culture of normal human epidermal keratinocytes with psoriatic DMSCs downregulated expression levels of proteins associated with cell junction assembly (alpha-actinin-1, catenin beta-1, poliovirus receptor-related protein 4 and procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2), while upregulating proteins associated with keratinocyte proliferation and differentiation (involucrin, isoform 2 of Histone-binding protein, isoform 3 of Telomeric repeat-binding factor 2 and keratin 13). Moreover, co-culture of normal human epidermal keratinocytes with psoriatic DMSCs stimulated keratinocyte proliferation and glycolysis, but reduced keratinocyte junctions. Taken together, these results demonstrate that psoriatic DMSCs increase keratinocyte proliferation and glycolysis, and reduce cell junctions, suggesting a pathogenic role of psoriatic DMSCs in epidermal hyperplasia, aberrant differentiation, and reduction in turnover time of keratinocytes in psoriasis. psoriasis dermal mesenchymal stem cells keratinocytes cell junctions cell proliferation glycolysis Dermatology Jianxiao Xing verfasserin aut Funa Lu verfasserin aut Wenjuan Chang verfasserin aut Nannan Liang verfasserin aut Juan Li verfasserin aut Ying Wang verfasserin aut Xiaofang Li verfasserin aut Xincheng Zhao verfasserin aut Ruixia Hou verfasserin aut Maoqiang Man verfasserin aut Guohua Yin verfasserin aut Xinhua Li verfasserin aut Kaiming Zhang verfasserin aut In Acta Dermato-Venereologica Medical Journals Sweden, 2011 100(2020), 8, p adv00122 (DE-627)302725431 (DE-600)1492617-9 16512057 nnns volume:100 year:2020 number:8, p adv00122 https://doi.org/10.2340/00015555-3480 kostenfrei https://doaj.org/article/e7128f6080134a8984330ef35ff0f6b5 kostenfrei https://www.medicaljournals.se/acta/content/html/10.2340/00015555-3480 kostenfrei https://doaj.org/toc/0001-5555 Journal toc kostenfrei https://doaj.org/toc/1651-2057 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 100 2020 8, p adv00122
allfieldsGer	10.2340/00015555-3480 doi (DE-627)DOAJ019665865 (DE-599)DOAJe7128f6080134a8984330ef35ff0f6b5 DE-627 ger DE-627 rakwb eng RL1-803 Junqin Li verfasserin aut Psoriatic Dermal-derived Mesenchymal Stem Cells Reduce Keratinocyte Junctions, and Increase Glycolysis 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Although it is known that psoriatic dermal-derived mesenchymal stem cells (DMSCs) dysregulate keratinocyte proliferation, the biological activity profile of keratinocytes influenced by psoriatic DMSCs remain unknown. In the present study, we assessed the impact of psoriatic DMSCs on keratinocyte proliferation, differentiation, and glucose metabolism in normal human epidermal keratinocytes co-cultured with or without psoriatic DMSCs. Co-culture of normal human epidermal keratinocytes with psoriatic DMSCs downregulated expression levels of proteins associated with cell junction assembly (alpha-actinin-1, catenin beta-1, poliovirus receptor-related protein 4 and procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2), while upregulating proteins associated with keratinocyte proliferation and differentiation (involucrin, isoform 2 of Histone-binding protein, isoform 3 of Telomeric repeat-binding factor 2 and keratin 13). Moreover, co-culture of normal human epidermal keratinocytes with psoriatic DMSCs stimulated keratinocyte proliferation and glycolysis, but reduced keratinocyte junctions. Taken together, these results demonstrate that psoriatic DMSCs increase keratinocyte proliferation and glycolysis, and reduce cell junctions, suggesting a pathogenic role of psoriatic DMSCs in epidermal hyperplasia, aberrant differentiation, and reduction in turnover time of keratinocytes in psoriasis. psoriasis dermal mesenchymal stem cells keratinocytes cell junctions cell proliferation glycolysis Dermatology Jianxiao Xing verfasserin aut Funa Lu verfasserin aut Wenjuan Chang verfasserin aut Nannan Liang verfasserin aut Juan Li verfasserin aut Ying Wang verfasserin aut Xiaofang Li verfasserin aut Xincheng Zhao verfasserin aut Ruixia Hou verfasserin aut Maoqiang Man verfasserin aut Guohua Yin verfasserin aut Xinhua Li verfasserin aut Kaiming Zhang verfasserin aut In Acta Dermato-Venereologica Medical Journals Sweden, 2011 100(2020), 8, p adv00122 (DE-627)302725431 (DE-600)1492617-9 16512057 nnns volume:100 year:2020 number:8, p adv00122 https://doi.org/10.2340/00015555-3480 kostenfrei https://doaj.org/article/e7128f6080134a8984330ef35ff0f6b5 kostenfrei https://www.medicaljournals.se/acta/content/html/10.2340/00015555-3480 kostenfrei https://doaj.org/toc/0001-5555 Journal toc kostenfrei https://doaj.org/toc/1651-2057 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 100 2020 8, p adv00122
allfieldsSound	10.2340/00015555-3480 doi (DE-627)DOAJ019665865 (DE-599)DOAJe7128f6080134a8984330ef35ff0f6b5 DE-627 ger DE-627 rakwb eng RL1-803 Junqin Li verfasserin aut Psoriatic Dermal-derived Mesenchymal Stem Cells Reduce Keratinocyte Junctions, and Increase Glycolysis 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Although it is known that psoriatic dermal-derived mesenchymal stem cells (DMSCs) dysregulate keratinocyte proliferation, the biological activity profile of keratinocytes influenced by psoriatic DMSCs remain unknown. In the present study, we assessed the impact of psoriatic DMSCs on keratinocyte proliferation, differentiation, and glucose metabolism in normal human epidermal keratinocytes co-cultured with or without psoriatic DMSCs. Co-culture of normal human epidermal keratinocytes with psoriatic DMSCs downregulated expression levels of proteins associated with cell junction assembly (alpha-actinin-1, catenin beta-1, poliovirus receptor-related protein 4 and procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2), while upregulating proteins associated with keratinocyte proliferation and differentiation (involucrin, isoform 2 of Histone-binding protein, isoform 3 of Telomeric repeat-binding factor 2 and keratin 13). Moreover, co-culture of normal human epidermal keratinocytes with psoriatic DMSCs stimulated keratinocyte proliferation and glycolysis, but reduced keratinocyte junctions. Taken together, these results demonstrate that psoriatic DMSCs increase keratinocyte proliferation and glycolysis, and reduce cell junctions, suggesting a pathogenic role of psoriatic DMSCs in epidermal hyperplasia, aberrant differentiation, and reduction in turnover time of keratinocytes in psoriasis. psoriasis dermal mesenchymal stem cells keratinocytes cell junctions cell proliferation glycolysis Dermatology Jianxiao Xing verfasserin aut Funa Lu verfasserin aut Wenjuan Chang verfasserin aut Nannan Liang verfasserin aut Juan Li verfasserin aut Ying Wang verfasserin aut Xiaofang Li verfasserin aut Xincheng Zhao verfasserin aut Ruixia Hou verfasserin aut Maoqiang Man verfasserin aut Guohua Yin verfasserin aut Xinhua Li verfasserin aut Kaiming Zhang verfasserin aut In Acta Dermato-Venereologica Medical Journals Sweden, 2011 100(2020), 8, p adv00122 (DE-627)302725431 (DE-600)1492617-9 16512057 nnns volume:100 year:2020 number:8, p adv00122 https://doi.org/10.2340/00015555-3480 kostenfrei https://doaj.org/article/e7128f6080134a8984330ef35ff0f6b5 kostenfrei https://www.medicaljournals.se/acta/content/html/10.2340/00015555-3480 kostenfrei https://doaj.org/toc/0001-5555 Journal toc kostenfrei https://doaj.org/toc/1651-2057 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 100 2020 8, p adv00122
language	English
source	In Acta Dermato-Venereologica 100(2020), 8, p adv00122 volume:100 year:2020 number:8, p adv00122
sourceStr	In Acta Dermato-Venereologica 100(2020), 8, p adv00122 volume:100 year:2020 number:8, p adv00122
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	psoriasis dermal mesenchymal stem cells keratinocytes cell junctions cell proliferation glycolysis Dermatology
isfreeaccess_bool	true
container_title	Acta Dermato-Venereologica
authorswithroles_txt_mv	Junqin Li @@aut@@ Jianxiao Xing @@aut@@ Funa Lu @@aut@@ Wenjuan Chang @@aut@@ Nannan Liang @@aut@@ Juan Li @@aut@@ Ying Wang @@aut@@ Xiaofang Li @@aut@@ Xincheng Zhao @@aut@@ Ruixia Hou @@aut@@ Maoqiang Man @@aut@@ Guohua Yin @@aut@@ Xinhua Li @@aut@@ Kaiming Zhang @@aut@@
publishDateDaySort_date	2020-01-01T00:00:00Z
hierarchy_top_id	302725431
id	DOAJ019665865
language_de	englisch
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callnumber-first	R - Medicine
author	Junqin Li
spellingShingle	Junqin Li misc RL1-803 misc psoriasis misc dermal mesenchymal stem cells misc keratinocytes misc cell junctions misc cell proliferation misc glycolysis misc Dermatology Psoriatic Dermal-derived Mesenchymal Stem Cells Reduce Keratinocyte Junctions, and Increase Glycolysis
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topic_title	RL1-803 Psoriatic Dermal-derived Mesenchymal Stem Cells Reduce Keratinocyte Junctions, and Increase Glycolysis psoriasis dermal mesenchymal stem cells keratinocytes cell junctions cell proliferation glycolysis
topic	misc RL1-803 misc psoriasis misc dermal mesenchymal stem cells misc keratinocytes misc cell junctions misc cell proliferation misc glycolysis misc Dermatology
topic_unstemmed	misc RL1-803 misc psoriasis misc dermal mesenchymal stem cells misc keratinocytes misc cell junctions misc cell proliferation misc glycolysis misc Dermatology
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title	Psoriatic Dermal-derived Mesenchymal Stem Cells Reduce Keratinocyte Junctions, and Increase Glycolysis
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title_full	Psoriatic Dermal-derived Mesenchymal Stem Cells Reduce Keratinocyte Junctions, and Increase Glycolysis
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author_browse	Junqin Li Jianxiao Xing Funa Lu Wenjuan Chang Nannan Liang Juan Li Ying Wang Xiaofang Li Xincheng Zhao Ruixia Hou Maoqiang Man Guohua Yin Xinhua Li Kaiming Zhang
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title_sort	psoriatic dermal-derived mesenchymal stem cells reduce keratinocyte junctions, and increase glycolysis
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title_auth	Psoriatic Dermal-derived Mesenchymal Stem Cells Reduce Keratinocyte Junctions, and Increase Glycolysis
abstract	Although it is known that psoriatic dermal-derived mesenchymal stem cells (DMSCs) dysregulate keratinocyte proliferation, the biological activity profile of keratinocytes influenced by psoriatic DMSCs remain unknown. In the present study, we assessed the impact of psoriatic DMSCs on keratinocyte proliferation, differentiation, and glucose metabolism in normal human epidermal keratinocytes co-cultured with or without psoriatic DMSCs. Co-culture of normal human epidermal keratinocytes with psoriatic DMSCs downregulated expression levels of proteins associated with cell junction assembly (alpha-actinin-1, catenin beta-1, poliovirus receptor-related protein 4 and procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2), while upregulating proteins associated with keratinocyte proliferation and differentiation (involucrin, isoform 2 of Histone-binding protein, isoform 3 of Telomeric repeat-binding factor 2 and keratin 13). Moreover, co-culture of normal human epidermal keratinocytes with psoriatic DMSCs stimulated keratinocyte proliferation and glycolysis, but reduced keratinocyte junctions. Taken together, these results demonstrate that psoriatic DMSCs increase keratinocyte proliferation and glycolysis, and reduce cell junctions, suggesting a pathogenic role of psoriatic DMSCs in epidermal hyperplasia, aberrant differentiation, and reduction in turnover time of keratinocytes in psoriasis.
abstractGer	Although it is known that psoriatic dermal-derived mesenchymal stem cells (DMSCs) dysregulate keratinocyte proliferation, the biological activity profile of keratinocytes influenced by psoriatic DMSCs remain unknown. In the present study, we assessed the impact of psoriatic DMSCs on keratinocyte proliferation, differentiation, and glucose metabolism in normal human epidermal keratinocytes co-cultured with or without psoriatic DMSCs. Co-culture of normal human epidermal keratinocytes with psoriatic DMSCs downregulated expression levels of proteins associated with cell junction assembly (alpha-actinin-1, catenin beta-1, poliovirus receptor-related protein 4 and procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2), while upregulating proteins associated with keratinocyte proliferation and differentiation (involucrin, isoform 2 of Histone-binding protein, isoform 3 of Telomeric repeat-binding factor 2 and keratin 13). Moreover, co-culture of normal human epidermal keratinocytes with psoriatic DMSCs stimulated keratinocyte proliferation and glycolysis, but reduced keratinocyte junctions. Taken together, these results demonstrate that psoriatic DMSCs increase keratinocyte proliferation and glycolysis, and reduce cell junctions, suggesting a pathogenic role of psoriatic DMSCs in epidermal hyperplasia, aberrant differentiation, and reduction in turnover time of keratinocytes in psoriasis.
abstract_unstemmed	Although it is known that psoriatic dermal-derived mesenchymal stem cells (DMSCs) dysregulate keratinocyte proliferation, the biological activity profile of keratinocytes influenced by psoriatic DMSCs remain unknown. In the present study, we assessed the impact of psoriatic DMSCs on keratinocyte proliferation, differentiation, and glucose metabolism in normal human epidermal keratinocytes co-cultured with or without psoriatic DMSCs. Co-culture of normal human epidermal keratinocytes with psoriatic DMSCs downregulated expression levels of proteins associated with cell junction assembly (alpha-actinin-1, catenin beta-1, poliovirus receptor-related protein 4 and procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2), while upregulating proteins associated with keratinocyte proliferation and differentiation (involucrin, isoform 2 of Histone-binding protein, isoform 3 of Telomeric repeat-binding factor 2 and keratin 13). Moreover, co-culture of normal human epidermal keratinocytes with psoriatic DMSCs stimulated keratinocyte proliferation and glycolysis, but reduced keratinocyte junctions. Taken together, these results demonstrate that psoriatic DMSCs increase keratinocyte proliferation and glycolysis, and reduce cell junctions, suggesting a pathogenic role of psoriatic DMSCs in epidermal hyperplasia, aberrant differentiation, and reduction in turnover time of keratinocytes in psoriasis.
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title_short	Psoriatic Dermal-derived Mesenchymal Stem Cells Reduce Keratinocyte Junctions, and Increase Glycolysis
url	https://doi.org/10.2340/00015555-3480 https://doaj.org/article/e7128f6080134a8984330ef35ff0f6b5 https://www.medicaljournals.se/acta/content/html/10.2340/00015555-3480 https://doaj.org/toc/0001-5555 https://doaj.org/toc/1651-2057
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Psoriatic Dermal-derived Mesenchymal Stem Cells Reduce Keratinocyte Junctions, and Increase Glycolysis

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