Biphasic Temporal Relationship between Cancers and Systemic Sclerosis: A Clinical Series from Montpellier University Hospital and Review of the Literature

Cancer among patients with systemic sclerosis (SSc) would appear to be more prevalent than in the general population. Pathophysiological hypotheses are multiple, involving intertwined factors such as immune system antitumoral response, oxygen species dysregulation, and immunosuppressive treatments....
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Autor*in:	Léo Partouche [verfasserIn] Radjiv Goulabchand [verfasserIn] Alexandre Thibault Jacques Maria [verfasserIn] Sophie Rivière [verfasserIn] Christian Jorgensen [verfasserIn] Valérie Rigau [verfasserIn] Céline Bourgier [verfasserIn] Didier Bessis [verfasserIn] Alain Le Quellec [verfasserIn] Isabelle Quere [verfasserIn] Jacques Morel [verfasserIn] Philippe Guilpain [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	systemic sclerosis scleroderma breast cancer lung cancer cancer occurrence

Übergeordnetes Werk:	In: Journal of Clinical Medicine - MDPI AG, 2013, 9(2020), 3, p 853
Übergeordnetes Werk:	volume:9 ; year:2020 ; number:3, p 853

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/jcm9030853

Katalog-ID:	DOAJ019718470

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allfields	10.3390/jcm9030853 doi (DE-627)DOAJ019718470 (DE-599)DOAJ96b16f2830df431f8196d13e91c03010 DE-627 ger DE-627 rakwb eng Léo Partouche verfasserin aut Biphasic Temporal Relationship between Cancers and Systemic Sclerosis: A Clinical Series from Montpellier University Hospital and Review of the Literature 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Cancer among patients with systemic sclerosis (SSc) would appear to be more prevalent than in the general population. Pathophysiological hypotheses are multiple, involving intertwined factors such as immune system antitumoral response, oxygen species dysregulation, and immunosuppressive treatments. We aimed to identify SSc patients with cancer monitored at our center, describing their clinical and immunological characteristics, such as cancer-specific outcomes. We focused in particular on the temporal relationships between cancer onset and SSc diagnosis. A retrospective study was conducted on SSc patients from Montpellier University Hospital from 2003 to 2018. Clinical characteristics and outcomes of each SSc patient with cancer were recorded. Fifty-five patients with SSc and at least one cancer was included (median age 56 years (47−66)), with a median follow-up time of 11 years (4−15). Sixty-four metachronous malignancies were identified (12 patients had two cancers). Among them, early-onset cancer occurrences (±5 years from SSc diagnosis) included 23 cancers (39% breast cancers, 13% lung cancers, and 13% gastro-intestinal tract cancers). Twenty-two cancers occurred 10 years (±5 years) after SSc diagnosis (14% breast cancers, 23% gastrointestinal (GI) tract cancers, and 18% lung cancers). Patients without any of the two autoantibodies (anti-centromere (ACA) and anti-topoisomerase (ATA-scl70) antibodies) were more prevalent in the early-onset cancer subgroup (14 vs. 6, <i<p</i< = 0.02). This study brought to light two peaks of cancer occurrence in SSc patients. Early-onset cancers were associated with SSc with a specific immunological signature. Late-onset cancers might be the consequence of a subtle interplay between repeated target organ inflammation, immunosuppressant use, mesenchymal cell dysfunction and subsequent genetic alterations. systemic sclerosis scleroderma breast cancer lung cancer cancer occurrence Medicine R Radjiv Goulabchand verfasserin aut Alexandre Thibault Jacques Maria verfasserin aut Sophie Rivière verfasserin aut Christian Jorgensen verfasserin aut Valérie Rigau verfasserin aut Céline Bourgier verfasserin aut Didier Bessis verfasserin aut Alain Le Quellec verfasserin aut Isabelle Quere verfasserin aut Jacques Morel verfasserin aut Philippe Guilpain verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 9(2020), 3, p 853 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:9 year:2020 number:3, p 853 https://doi.org/10.3390/jcm9030853 kostenfrei https://doaj.org/article/96b16f2830df431f8196d13e91c03010 kostenfrei https://www.mdpi.com/2077-0383/9/3/853 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 3, p 853
spelling	10.3390/jcm9030853 doi (DE-627)DOAJ019718470 (DE-599)DOAJ96b16f2830df431f8196d13e91c03010 DE-627 ger DE-627 rakwb eng Léo Partouche verfasserin aut Biphasic Temporal Relationship between Cancers and Systemic Sclerosis: A Clinical Series from Montpellier University Hospital and Review of the Literature 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Cancer among patients with systemic sclerosis (SSc) would appear to be more prevalent than in the general population. Pathophysiological hypotheses are multiple, involving intertwined factors such as immune system antitumoral response, oxygen species dysregulation, and immunosuppressive treatments. We aimed to identify SSc patients with cancer monitored at our center, describing their clinical and immunological characteristics, such as cancer-specific outcomes. We focused in particular on the temporal relationships between cancer onset and SSc diagnosis. A retrospective study was conducted on SSc patients from Montpellier University Hospital from 2003 to 2018. Clinical characteristics and outcomes of each SSc patient with cancer were recorded. Fifty-five patients with SSc and at least one cancer was included (median age 56 years (47−66)), with a median follow-up time of 11 years (4−15). Sixty-four metachronous malignancies were identified (12 patients had two cancers). Among them, early-onset cancer occurrences (±5 years from SSc diagnosis) included 23 cancers (39% breast cancers, 13% lung cancers, and 13% gastro-intestinal tract cancers). Twenty-two cancers occurred 10 years (±5 years) after SSc diagnosis (14% breast cancers, 23% gastrointestinal (GI) tract cancers, and 18% lung cancers). Patients without any of the two autoantibodies (anti-centromere (ACA) and anti-topoisomerase (ATA-scl70) antibodies) were more prevalent in the early-onset cancer subgroup (14 vs. 6, <i<p</i< = 0.02). This study brought to light two peaks of cancer occurrence in SSc patients. Early-onset cancers were associated with SSc with a specific immunological signature. Late-onset cancers might be the consequence of a subtle interplay between repeated target organ inflammation, immunosuppressant use, mesenchymal cell dysfunction and subsequent genetic alterations. systemic sclerosis scleroderma breast cancer lung cancer cancer occurrence Medicine R Radjiv Goulabchand verfasserin aut Alexandre Thibault Jacques Maria verfasserin aut Sophie Rivière verfasserin aut Christian Jorgensen verfasserin aut Valérie Rigau verfasserin aut Céline Bourgier verfasserin aut Didier Bessis verfasserin aut Alain Le Quellec verfasserin aut Isabelle Quere verfasserin aut Jacques Morel verfasserin aut Philippe Guilpain verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 9(2020), 3, p 853 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:9 year:2020 number:3, p 853 https://doi.org/10.3390/jcm9030853 kostenfrei https://doaj.org/article/96b16f2830df431f8196d13e91c03010 kostenfrei https://www.mdpi.com/2077-0383/9/3/853 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 3, p 853
allfields_unstemmed	10.3390/jcm9030853 doi (DE-627)DOAJ019718470 (DE-599)DOAJ96b16f2830df431f8196d13e91c03010 DE-627 ger DE-627 rakwb eng Léo Partouche verfasserin aut Biphasic Temporal Relationship between Cancers and Systemic Sclerosis: A Clinical Series from Montpellier University Hospital and Review of the Literature 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Cancer among patients with systemic sclerosis (SSc) would appear to be more prevalent than in the general population. Pathophysiological hypotheses are multiple, involving intertwined factors such as immune system antitumoral response, oxygen species dysregulation, and immunosuppressive treatments. We aimed to identify SSc patients with cancer monitored at our center, describing their clinical and immunological characteristics, such as cancer-specific outcomes. We focused in particular on the temporal relationships between cancer onset and SSc diagnosis. A retrospective study was conducted on SSc patients from Montpellier University Hospital from 2003 to 2018. Clinical characteristics and outcomes of each SSc patient with cancer were recorded. Fifty-five patients with SSc and at least one cancer was included (median age 56 years (47−66)), with a median follow-up time of 11 years (4−15). Sixty-four metachronous malignancies were identified (12 patients had two cancers). Among them, early-onset cancer occurrences (±5 years from SSc diagnosis) included 23 cancers (39% breast cancers, 13% lung cancers, and 13% gastro-intestinal tract cancers). Twenty-two cancers occurred 10 years (±5 years) after SSc diagnosis (14% breast cancers, 23% gastrointestinal (GI) tract cancers, and 18% lung cancers). Patients without any of the two autoantibodies (anti-centromere (ACA) and anti-topoisomerase (ATA-scl70) antibodies) were more prevalent in the early-onset cancer subgroup (14 vs. 6, <i<p</i< = 0.02). This study brought to light two peaks of cancer occurrence in SSc patients. Early-onset cancers were associated with SSc with a specific immunological signature. Late-onset cancers might be the consequence of a subtle interplay between repeated target organ inflammation, immunosuppressant use, mesenchymal cell dysfunction and subsequent genetic alterations. systemic sclerosis scleroderma breast cancer lung cancer cancer occurrence Medicine R Radjiv Goulabchand verfasserin aut Alexandre Thibault Jacques Maria verfasserin aut Sophie Rivière verfasserin aut Christian Jorgensen verfasserin aut Valérie Rigau verfasserin aut Céline Bourgier verfasserin aut Didier Bessis verfasserin aut Alain Le Quellec verfasserin aut Isabelle Quere verfasserin aut Jacques Morel verfasserin aut Philippe Guilpain verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 9(2020), 3, p 853 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:9 year:2020 number:3, p 853 https://doi.org/10.3390/jcm9030853 kostenfrei https://doaj.org/article/96b16f2830df431f8196d13e91c03010 kostenfrei https://www.mdpi.com/2077-0383/9/3/853 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 3, p 853
allfieldsGer	10.3390/jcm9030853 doi (DE-627)DOAJ019718470 (DE-599)DOAJ96b16f2830df431f8196d13e91c03010 DE-627 ger DE-627 rakwb eng Léo Partouche verfasserin aut Biphasic Temporal Relationship between Cancers and Systemic Sclerosis: A Clinical Series from Montpellier University Hospital and Review of the Literature 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Cancer among patients with systemic sclerosis (SSc) would appear to be more prevalent than in the general population. Pathophysiological hypotheses are multiple, involving intertwined factors such as immune system antitumoral response, oxygen species dysregulation, and immunosuppressive treatments. We aimed to identify SSc patients with cancer monitored at our center, describing their clinical and immunological characteristics, such as cancer-specific outcomes. We focused in particular on the temporal relationships between cancer onset and SSc diagnosis. A retrospective study was conducted on SSc patients from Montpellier University Hospital from 2003 to 2018. Clinical characteristics and outcomes of each SSc patient with cancer were recorded. Fifty-five patients with SSc and at least one cancer was included (median age 56 years (47−66)), with a median follow-up time of 11 years (4−15). Sixty-four metachronous malignancies were identified (12 patients had two cancers). Among them, early-onset cancer occurrences (±5 years from SSc diagnosis) included 23 cancers (39% breast cancers, 13% lung cancers, and 13% gastro-intestinal tract cancers). Twenty-two cancers occurred 10 years (±5 years) after SSc diagnosis (14% breast cancers, 23% gastrointestinal (GI) tract cancers, and 18% lung cancers). Patients without any of the two autoantibodies (anti-centromere (ACA) and anti-topoisomerase (ATA-scl70) antibodies) were more prevalent in the early-onset cancer subgroup (14 vs. 6, <i<p</i< = 0.02). This study brought to light two peaks of cancer occurrence in SSc patients. Early-onset cancers were associated with SSc with a specific immunological signature. Late-onset cancers might be the consequence of a subtle interplay between repeated target organ inflammation, immunosuppressant use, mesenchymal cell dysfunction and subsequent genetic alterations. systemic sclerosis scleroderma breast cancer lung cancer cancer occurrence Medicine R Radjiv Goulabchand verfasserin aut Alexandre Thibault Jacques Maria verfasserin aut Sophie Rivière verfasserin aut Christian Jorgensen verfasserin aut Valérie Rigau verfasserin aut Céline Bourgier verfasserin aut Didier Bessis verfasserin aut Alain Le Quellec verfasserin aut Isabelle Quere verfasserin aut Jacques Morel verfasserin aut Philippe Guilpain verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 9(2020), 3, p 853 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:9 year:2020 number:3, p 853 https://doi.org/10.3390/jcm9030853 kostenfrei https://doaj.org/article/96b16f2830df431f8196d13e91c03010 kostenfrei https://www.mdpi.com/2077-0383/9/3/853 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 3, p 853
allfieldsSound	10.3390/jcm9030853 doi (DE-627)DOAJ019718470 (DE-599)DOAJ96b16f2830df431f8196d13e91c03010 DE-627 ger DE-627 rakwb eng Léo Partouche verfasserin aut Biphasic Temporal Relationship between Cancers and Systemic Sclerosis: A Clinical Series from Montpellier University Hospital and Review of the Literature 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Cancer among patients with systemic sclerosis (SSc) would appear to be more prevalent than in the general population. Pathophysiological hypotheses are multiple, involving intertwined factors such as immune system antitumoral response, oxygen species dysregulation, and immunosuppressive treatments. We aimed to identify SSc patients with cancer monitored at our center, describing their clinical and immunological characteristics, such as cancer-specific outcomes. We focused in particular on the temporal relationships between cancer onset and SSc diagnosis. A retrospective study was conducted on SSc patients from Montpellier University Hospital from 2003 to 2018. Clinical characteristics and outcomes of each SSc patient with cancer were recorded. Fifty-five patients with SSc and at least one cancer was included (median age 56 years (47−66)), with a median follow-up time of 11 years (4−15). Sixty-four metachronous malignancies were identified (12 patients had two cancers). Among them, early-onset cancer occurrences (±5 years from SSc diagnosis) included 23 cancers (39% breast cancers, 13% lung cancers, and 13% gastro-intestinal tract cancers). Twenty-two cancers occurred 10 years (±5 years) after SSc diagnosis (14% breast cancers, 23% gastrointestinal (GI) tract cancers, and 18% lung cancers). Patients without any of the two autoantibodies (anti-centromere (ACA) and anti-topoisomerase (ATA-scl70) antibodies) were more prevalent in the early-onset cancer subgroup (14 vs. 6, <i<p</i< = 0.02). This study brought to light two peaks of cancer occurrence in SSc patients. Early-onset cancers were associated with SSc with a specific immunological signature. Late-onset cancers might be the consequence of a subtle interplay between repeated target organ inflammation, immunosuppressant use, mesenchymal cell dysfunction and subsequent genetic alterations. systemic sclerosis scleroderma breast cancer lung cancer cancer occurrence Medicine R Radjiv Goulabchand verfasserin aut Alexandre Thibault Jacques Maria verfasserin aut Sophie Rivière verfasserin aut Christian Jorgensen verfasserin aut Valérie Rigau verfasserin aut Céline Bourgier verfasserin aut Didier Bessis verfasserin aut Alain Le Quellec verfasserin aut Isabelle Quere verfasserin aut Jacques Morel verfasserin aut Philippe Guilpain verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 9(2020), 3, p 853 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:9 year:2020 number:3, p 853 https://doi.org/10.3390/jcm9030853 kostenfrei https://doaj.org/article/96b16f2830df431f8196d13e91c03010 kostenfrei https://www.mdpi.com/2077-0383/9/3/853 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 3, p 853
language	English
source	In Journal of Clinical Medicine 9(2020), 3, p 853 volume:9 year:2020 number:3, p 853
sourceStr	In Journal of Clinical Medicine 9(2020), 3, p 853 volume:9 year:2020 number:3, p 853
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	systemic sclerosis scleroderma breast cancer lung cancer cancer occurrence Medicine R
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container_title	Journal of Clinical Medicine
authorswithroles_txt_mv	Léo Partouche @@aut@@ Radjiv Goulabchand @@aut@@ Alexandre Thibault Jacques Maria @@aut@@ Sophie Rivière @@aut@@ Christian Jorgensen @@aut@@ Valérie Rigau @@aut@@ Céline Bourgier @@aut@@ Didier Bessis @@aut@@ Alain Le Quellec @@aut@@ Isabelle Quere @@aut@@ Jacques Morel @@aut@@ Philippe Guilpain @@aut@@
publishDateDaySort_date	2020-01-01T00:00:00Z
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author	Léo Partouche
spellingShingle	Léo Partouche misc systemic sclerosis misc scleroderma misc breast cancer misc lung cancer misc cancer occurrence misc Medicine misc R Biphasic Temporal Relationship between Cancers and Systemic Sclerosis: A Clinical Series from Montpellier University Hospital and Review of the Literature
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topic_title	Biphasic Temporal Relationship between Cancers and Systemic Sclerosis: A Clinical Series from Montpellier University Hospital and Review of the Literature systemic sclerosis scleroderma breast cancer lung cancer cancer occurrence
topic	misc systemic sclerosis misc scleroderma misc breast cancer misc lung cancer misc cancer occurrence misc Medicine misc R
topic_unstemmed	misc systemic sclerosis misc scleroderma misc breast cancer misc lung cancer misc cancer occurrence misc Medicine misc R
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title	Biphasic Temporal Relationship between Cancers and Systemic Sclerosis: A Clinical Series from Montpellier University Hospital and Review of the Literature
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title_full	Biphasic Temporal Relationship between Cancers and Systemic Sclerosis: A Clinical Series from Montpellier University Hospital and Review of the Literature
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author_browse	Léo Partouche Radjiv Goulabchand Alexandre Thibault Jacques Maria Sophie Rivière Christian Jorgensen Valérie Rigau Céline Bourgier Didier Bessis Alain Le Quellec Isabelle Quere Jacques Morel Philippe Guilpain
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title_sort	biphasic temporal relationship between cancers and systemic sclerosis: a clinical series from montpellier university hospital and review of the literature
title_auth	Biphasic Temporal Relationship between Cancers and Systemic Sclerosis: A Clinical Series from Montpellier University Hospital and Review of the Literature
abstract	Cancer among patients with systemic sclerosis (SSc) would appear to be more prevalent than in the general population. Pathophysiological hypotheses are multiple, involving intertwined factors such as immune system antitumoral response, oxygen species dysregulation, and immunosuppressive treatments. We aimed to identify SSc patients with cancer monitored at our center, describing their clinical and immunological characteristics, such as cancer-specific outcomes. We focused in particular on the temporal relationships between cancer onset and SSc diagnosis. A retrospective study was conducted on SSc patients from Montpellier University Hospital from 2003 to 2018. Clinical characteristics and outcomes of each SSc patient with cancer were recorded. Fifty-five patients with SSc and at least one cancer was included (median age 56 years (47−66)), with a median follow-up time of 11 years (4−15). Sixty-four metachronous malignancies were identified (12 patients had two cancers). Among them, early-onset cancer occurrences (±5 years from SSc diagnosis) included 23 cancers (39% breast cancers, 13% lung cancers, and 13% gastro-intestinal tract cancers). Twenty-two cancers occurred 10 years (±5 years) after SSc diagnosis (14% breast cancers, 23% gastrointestinal (GI) tract cancers, and 18% lung cancers). Patients without any of the two autoantibodies (anti-centromere (ACA) and anti-topoisomerase (ATA-scl70) antibodies) were more prevalent in the early-onset cancer subgroup (14 vs. 6, <i<p</i< = 0.02). This study brought to light two peaks of cancer occurrence in SSc patients. Early-onset cancers were associated with SSc with a specific immunological signature. Late-onset cancers might be the consequence of a subtle interplay between repeated target organ inflammation, immunosuppressant use, mesenchymal cell dysfunction and subsequent genetic alterations.
abstractGer	Cancer among patients with systemic sclerosis (SSc) would appear to be more prevalent than in the general population. Pathophysiological hypotheses are multiple, involving intertwined factors such as immune system antitumoral response, oxygen species dysregulation, and immunosuppressive treatments. We aimed to identify SSc patients with cancer monitored at our center, describing their clinical and immunological characteristics, such as cancer-specific outcomes. We focused in particular on the temporal relationships between cancer onset and SSc diagnosis. A retrospective study was conducted on SSc patients from Montpellier University Hospital from 2003 to 2018. Clinical characteristics and outcomes of each SSc patient with cancer were recorded. Fifty-five patients with SSc and at least one cancer was included (median age 56 years (47−66)), with a median follow-up time of 11 years (4−15). Sixty-four metachronous malignancies were identified (12 patients had two cancers). Among them, early-onset cancer occurrences (±5 years from SSc diagnosis) included 23 cancers (39% breast cancers, 13% lung cancers, and 13% gastro-intestinal tract cancers). Twenty-two cancers occurred 10 years (±5 years) after SSc diagnosis (14% breast cancers, 23% gastrointestinal (GI) tract cancers, and 18% lung cancers). Patients without any of the two autoantibodies (anti-centromere (ACA) and anti-topoisomerase (ATA-scl70) antibodies) were more prevalent in the early-onset cancer subgroup (14 vs. 6, <i<p</i< = 0.02). This study brought to light two peaks of cancer occurrence in SSc patients. Early-onset cancers were associated with SSc with a specific immunological signature. Late-onset cancers might be the consequence of a subtle interplay between repeated target organ inflammation, immunosuppressant use, mesenchymal cell dysfunction and subsequent genetic alterations.
abstract_unstemmed	Cancer among patients with systemic sclerosis (SSc) would appear to be more prevalent than in the general population. Pathophysiological hypotheses are multiple, involving intertwined factors such as immune system antitumoral response, oxygen species dysregulation, and immunosuppressive treatments. We aimed to identify SSc patients with cancer monitored at our center, describing their clinical and immunological characteristics, such as cancer-specific outcomes. We focused in particular on the temporal relationships between cancer onset and SSc diagnosis. A retrospective study was conducted on SSc patients from Montpellier University Hospital from 2003 to 2018. Clinical characteristics and outcomes of each SSc patient with cancer were recorded. Fifty-five patients with SSc and at least one cancer was included (median age 56 years (47−66)), with a median follow-up time of 11 years (4−15). Sixty-four metachronous malignancies were identified (12 patients had two cancers). Among them, early-onset cancer occurrences (±5 years from SSc diagnosis) included 23 cancers (39% breast cancers, 13% lung cancers, and 13% gastro-intestinal tract cancers). Twenty-two cancers occurred 10 years (±5 years) after SSc diagnosis (14% breast cancers, 23% gastrointestinal (GI) tract cancers, and 18% lung cancers). Patients without any of the two autoantibodies (anti-centromere (ACA) and anti-topoisomerase (ATA-scl70) antibodies) were more prevalent in the early-onset cancer subgroup (14 vs. 6, <i<p</i< = 0.02). This study brought to light two peaks of cancer occurrence in SSc patients. Early-onset cancers were associated with SSc with a specific immunological signature. Late-onset cancers might be the consequence of a subtle interplay between repeated target organ inflammation, immunosuppressant use, mesenchymal cell dysfunction and subsequent genetic alterations.
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title_short	Biphasic Temporal Relationship between Cancers and Systemic Sclerosis: A Clinical Series from Montpellier University Hospital and Review of the Literature
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