Knowledge Gaps in the Fetal to Neonatal Transition of Infants With a Congenital Diaphragmatic Hernia

Clinical research for infants born with a congenital diaphragmatic hernia (CDH) has until recently mainly focused on advances in prenatal and postnatal treatment. However, during the early perinatal transition period there are major physiological adaptations. For most infants these changes will happ...
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Autor*in:	Philip L. J. DeKoninck [verfasserIn] Emily J. J. Horn-Oudshoorn [verfasserIn] Ronny Knol [verfasserIn] Kelly J. Crossley [verfasserIn] Irwin K. M. Reiss [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	congenital diaphragmatic hernia birth cord clamping neonatal transition oxygen respiratory monitoring

Übergeordnetes Werk:	In: Frontiers in Pediatrics - Frontiers Media S.A., 2013, 9(2021)
Übergeordnetes Werk:	volume:9 ; year:2021

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fped.2021.784810

Katalog-ID:	DOAJ019767749

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allfieldsSound	10.3389/fped.2021.784810 doi (DE-627)DOAJ019767749 (DE-599)DOAJ45d692337f4a49c8942b1e54297fbb62 DE-627 ger DE-627 rakwb eng RJ1-570 Philip L. J. DeKoninck verfasserin aut Knowledge Gaps in the Fetal to Neonatal Transition of Infants With a Congenital Diaphragmatic Hernia 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Clinical research for infants born with a congenital diaphragmatic hernia (CDH) has until recently mainly focused on advances in prenatal and postnatal treatment. However, during the early perinatal transition period there are major physiological adaptations. For most infants these changes will happen uneventfully, but for CDH infants this marks the beginning of serious respiratory complications. In recent years, there is emerging evidence that the clinical management during the perinatal stabilization period in the delivery room may influence postnatal outcomes. Herein, we discuss major knowledge gaps and novel concepts that aim to optimize fetal to neonatal transition for infants with CDH. One such novel and interesting approach is performing resuscitation with an intact umbilical cord, the efficacy of this procedure is currently being investigated in several clinical trials. Furthermore, close evaluation of neonatal physiological parameters in the first 24 h of life might provide early clues concerning the severity of lung hypoplasia and the risk of adverse outcomes. We will provide an overview of trending concepts and discuss potential areas for future research. congenital diaphragmatic hernia birth cord clamping neonatal transition oxygen respiratory monitoring Pediatrics Philip L. J. DeKoninck verfasserin aut Emily J. J. Horn-Oudshoorn verfasserin aut Ronny Knol verfasserin aut Kelly J. Crossley verfasserin aut Kelly J. Crossley verfasserin aut Irwin K. M. Reiss verfasserin aut In Frontiers in Pediatrics Frontiers Media S.A., 2013 9(2021) (DE-627)742738744 (DE-600)2711999-3 22962360 nnns volume:9 year:2021 https://doi.org/10.3389/fped.2021.784810 kostenfrei https://doaj.org/article/45d692337f4a49c8942b1e54297fbb62 kostenfrei https://www.frontiersin.org/articles/10.3389/fped.2021.784810/full kostenfrei https://doaj.org/toc/2296-2360 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2021
language	English
source	In Frontiers in Pediatrics 9(2021) volume:9 year:2021
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topic_facet	congenital diaphragmatic hernia birth cord clamping neonatal transition oxygen respiratory monitoring Pediatrics
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container_title	Frontiers in Pediatrics
authorswithroles_txt_mv	Philip L. J. DeKoninck @@aut@@ Emily J. J. Horn-Oudshoorn @@aut@@ Ronny Knol @@aut@@ Kelly J. Crossley @@aut@@ Irwin K. M. Reiss @@aut@@
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callnumber-first	R - Medicine
author	Philip L. J. DeKoninck
spellingShingle	Philip L. J. DeKoninck misc RJ1-570 misc congenital diaphragmatic hernia misc birth misc cord clamping misc neonatal transition misc oxygen misc respiratory monitoring misc Pediatrics Knowledge Gaps in the Fetal to Neonatal Transition of Infants With a Congenital Diaphragmatic Hernia
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topic_title	RJ1-570 Knowledge Gaps in the Fetal to Neonatal Transition of Infants With a Congenital Diaphragmatic Hernia congenital diaphragmatic hernia birth cord clamping neonatal transition oxygen respiratory monitoring
topic	misc RJ1-570 misc congenital diaphragmatic hernia misc birth misc cord clamping misc neonatal transition misc oxygen misc respiratory monitoring misc Pediatrics
topic_unstemmed	misc RJ1-570 misc congenital diaphragmatic hernia misc birth misc cord clamping misc neonatal transition misc oxygen misc respiratory monitoring misc Pediatrics
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title	Knowledge Gaps in the Fetal to Neonatal Transition of Infants With a Congenital Diaphragmatic Hernia
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title_full	Knowledge Gaps in the Fetal to Neonatal Transition of Infants With a Congenital Diaphragmatic Hernia
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title_sort	knowledge gaps in the fetal to neonatal transition of infants with a congenital diaphragmatic hernia
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title_auth	Knowledge Gaps in the Fetal to Neonatal Transition of Infants With a Congenital Diaphragmatic Hernia
abstract	Clinical research for infants born with a congenital diaphragmatic hernia (CDH) has until recently mainly focused on advances in prenatal and postnatal treatment. However, during the early perinatal transition period there are major physiological adaptations. For most infants these changes will happen uneventfully, but for CDH infants this marks the beginning of serious respiratory complications. In recent years, there is emerging evidence that the clinical management during the perinatal stabilization period in the delivery room may influence postnatal outcomes. Herein, we discuss major knowledge gaps and novel concepts that aim to optimize fetal to neonatal transition for infants with CDH. One such novel and interesting approach is performing resuscitation with an intact umbilical cord, the efficacy of this procedure is currently being investigated in several clinical trials. Furthermore, close evaluation of neonatal physiological parameters in the first 24 h of life might provide early clues concerning the severity of lung hypoplasia and the risk of adverse outcomes. We will provide an overview of trending concepts and discuss potential areas for future research.
abstractGer	Clinical research for infants born with a congenital diaphragmatic hernia (CDH) has until recently mainly focused on advances in prenatal and postnatal treatment. However, during the early perinatal transition period there are major physiological adaptations. For most infants these changes will happen uneventfully, but for CDH infants this marks the beginning of serious respiratory complications. In recent years, there is emerging evidence that the clinical management during the perinatal stabilization period in the delivery room may influence postnatal outcomes. Herein, we discuss major knowledge gaps and novel concepts that aim to optimize fetal to neonatal transition for infants with CDH. One such novel and interesting approach is performing resuscitation with an intact umbilical cord, the efficacy of this procedure is currently being investigated in several clinical trials. Furthermore, close evaluation of neonatal physiological parameters in the first 24 h of life might provide early clues concerning the severity of lung hypoplasia and the risk of adverse outcomes. We will provide an overview of trending concepts and discuss potential areas for future research.
abstract_unstemmed	Clinical research for infants born with a congenital diaphragmatic hernia (CDH) has until recently mainly focused on advances in prenatal and postnatal treatment. However, during the early perinatal transition period there are major physiological adaptations. For most infants these changes will happen uneventfully, but for CDH infants this marks the beginning of serious respiratory complications. In recent years, there is emerging evidence that the clinical management during the perinatal stabilization period in the delivery room may influence postnatal outcomes. Herein, we discuss major knowledge gaps and novel concepts that aim to optimize fetal to neonatal transition for infants with CDH. One such novel and interesting approach is performing resuscitation with an intact umbilical cord, the efficacy of this procedure is currently being investigated in several clinical trials. Furthermore, close evaluation of neonatal physiological parameters in the first 24 h of life might provide early clues concerning the severity of lung hypoplasia and the risk of adverse outcomes. We will provide an overview of trending concepts and discuss potential areas for future research.
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title_short	Knowledge Gaps in the Fetal to Neonatal Transition of Infants With a Congenital Diaphragmatic Hernia
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