Antimicrobial activity of Buchenavia tetraphylla against Candida albicans strains isolated from vaginal secretions

Context: Buchenavia tetraphylla (Aubl.) RA Howard (Combretaceae: Combretoideae) is an ethnomedicinal plant with reported antifungal action. Objective: This study evaluates the antimicrobial activity of B. tetraphylla leaf extracts against clinical isolates of Candida albicans. The morphological alte...
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Autor*in:	José Robson Neves Cavalcanti Filho [verfasserIn] Tiago Fonseca Silva [verfasserIn] Woah Queiroz Nobre [verfasserIn] Larissa Isabela Oliveira de Souza [verfasserIn] Cristiane Santos Silva e Silva Figueiredo [verfasserIn] Regina Celia Bressan Queiroz de Figueiredo [verfasserIn] Norma Buarque de Gusmão [verfasserIn] Márcia Vanusa Silva [verfasserIn] Luís Cláudio Nascimento da Silva [verfasserIn] Maria Tereza dos Santos Correia [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	antifungal agents natural products caatinga biome

Übergeordnetes Werk:	In: Pharmaceutical Biology - Taylor & Francis Group, 2017, 55(2017), 1, Seite 1521-1527
Übergeordnetes Werk:	volume:55 ; year:2017 ; number:1 ; pages:1521-1527

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.1080/13880209.2017.1304427

Katalog-ID:	DOAJ019818955

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520			\|a Context: Buchenavia tetraphylla (Aubl.) RA Howard (Combretaceae: Combretoideae) is an ethnomedicinal plant with reported antifungal action. Objective: This study evaluates the antimicrobial activity of B. tetraphylla leaf extracts against clinical isolates of Candida albicans. The morphological alterations, combinatory effects with fluconazole and the cytotoxicity of the active extract were analyzed. Materials and methods: Extracts were obtained using different solvents (hexane: BTHE; chloroform: BTCE; ethyl acetate: BTEE; and methanol: BTME). Antimicrobial activity was determined by the broth microdilution method using nine strains of C. albicans isolated from vaginal secretions and one standard strain (UFPEDA 1007). Results: All extracts showed anti-C. albicans activity, including against the azole-resistant strains. The MIC values ranged from 156 to 2500 μg/mL for the BTHE; 156 to 1250 μg/mL for the BTCE; 625 to 1250 μg/mL for the BTME and 625 μg/mL to 2500 μg/mL for the BTEE. BTME showed the best anti-C. albicans activity. This extract demonstrated additive/synergistic interactions with fluconazole. Scanning electron microscopy analysis suggested that the BTME interferes with the cell division and development of C. albicans. BTME showed IC50 values of 981 and 3935 μg/mL, against J774 macrophages and human erythrocytes, respectively. This extract also enhanced the production of nitric oxide by J774 macrophages. Discussion and conclusion: Buchenavia tetraphylla methanolic extract (BTME) is a great source of antimicrobial compounds that are able to enhance the action of fluconazole against different C. albicans strains; this action seems related to inhibition of cell division.
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700	0		\|a Luís Cláudio Nascimento da Silva \|e verfasserin \|4 aut
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allfields	10.1080/13880209.2017.1304427 doi (DE-627)DOAJ019818955 (DE-599)DOAJ0363c062d2fa46dc84512faea6d9c2f4 DE-627 ger DE-627 rakwb eng RM1-950 José Robson Neves Cavalcanti Filho verfasserin aut Antimicrobial activity of Buchenavia tetraphylla against Candida albicans strains isolated from vaginal secretions 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Context: Buchenavia tetraphylla (Aubl.) RA Howard (Combretaceae: Combretoideae) is an ethnomedicinal plant with reported antifungal action. Objective: This study evaluates the antimicrobial activity of B. tetraphylla leaf extracts against clinical isolates of Candida albicans. The morphological alterations, combinatory effects with fluconazole and the cytotoxicity of the active extract were analyzed. Materials and methods: Extracts were obtained using different solvents (hexane: BTHE; chloroform: BTCE; ethyl acetate: BTEE; and methanol: BTME). Antimicrobial activity was determined by the broth microdilution method using nine strains of C. albicans isolated from vaginal secretions and one standard strain (UFPEDA 1007). Results: All extracts showed anti-C. albicans activity, including against the azole-resistant strains. The MIC values ranged from 156 to 2500 μg/mL for the BTHE; 156 to 1250 μg/mL for the BTCE; 625 to 1250 μg/mL for the BTME and 625 μg/mL to 2500 μg/mL for the BTEE. BTME showed the best anti-C. albicans activity. This extract demonstrated additive/synergistic interactions with fluconazole. Scanning electron microscopy analysis suggested that the BTME interferes with the cell division and development of C. albicans. BTME showed IC50 values of 981 and 3935 μg/mL, against J774 macrophages and human erythrocytes, respectively. This extract also enhanced the production of nitric oxide by J774 macrophages. Discussion and conclusion: Buchenavia tetraphylla methanolic extract (BTME) is a great source of antimicrobial compounds that are able to enhance the action of fluconazole against different C. albicans strains; this action seems related to inhibition of cell division. antifungal agents natural products caatinga biome Therapeutics. Pharmacology Tiago Fonseca Silva verfasserin aut Woah Queiroz Nobre verfasserin aut Larissa Isabela Oliveira de Souza verfasserin aut Cristiane Santos Silva e Silva Figueiredo verfasserin aut Regina Celia Bressan Queiroz de Figueiredo verfasserin aut Norma Buarque de Gusmão verfasserin aut Márcia Vanusa Silva verfasserin aut Luís Cláudio Nascimento da Silva verfasserin aut Maria Tereza dos Santos Correia verfasserin aut In Pharmaceutical Biology Taylor & Francis Group, 2017 55(2017), 1, Seite 1521-1527 (DE-627)300595905 (DE-600)1483151-X 17445116 nnns volume:55 year:2017 number:1 pages:1521-1527 https://doi.org/10.1080/13880209.2017.1304427 kostenfrei https://doaj.org/article/0363c062d2fa46dc84512faea6d9c2f4 kostenfrei http://dx.doi.org/10.1080/13880209.2017.1304427 kostenfrei https://doaj.org/toc/1388-0209 Journal toc kostenfrei https://doaj.org/toc/1744-5116 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_1200 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 55 2017 1 1521-1527
spelling	10.1080/13880209.2017.1304427 doi (DE-627)DOAJ019818955 (DE-599)DOAJ0363c062d2fa46dc84512faea6d9c2f4 DE-627 ger DE-627 rakwb eng RM1-950 José Robson Neves Cavalcanti Filho verfasserin aut Antimicrobial activity of Buchenavia tetraphylla against Candida albicans strains isolated from vaginal secretions 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Context: Buchenavia tetraphylla (Aubl.) RA Howard (Combretaceae: Combretoideae) is an ethnomedicinal plant with reported antifungal action. Objective: This study evaluates the antimicrobial activity of B. tetraphylla leaf extracts against clinical isolates of Candida albicans. The morphological alterations, combinatory effects with fluconazole and the cytotoxicity of the active extract were analyzed. Materials and methods: Extracts were obtained using different solvents (hexane: BTHE; chloroform: BTCE; ethyl acetate: BTEE; and methanol: BTME). Antimicrobial activity was determined by the broth microdilution method using nine strains of C. albicans isolated from vaginal secretions and one standard strain (UFPEDA 1007). Results: All extracts showed anti-C. albicans activity, including against the azole-resistant strains. The MIC values ranged from 156 to 2500 μg/mL for the BTHE; 156 to 1250 μg/mL for the BTCE; 625 to 1250 μg/mL for the BTME and 625 μg/mL to 2500 μg/mL for the BTEE. BTME showed the best anti-C. albicans activity. This extract demonstrated additive/synergistic interactions with fluconazole. Scanning electron microscopy analysis suggested that the BTME interferes with the cell division and development of C. albicans. BTME showed IC50 values of 981 and 3935 μg/mL, against J774 macrophages and human erythrocytes, respectively. This extract also enhanced the production of nitric oxide by J774 macrophages. Discussion and conclusion: Buchenavia tetraphylla methanolic extract (BTME) is a great source of antimicrobial compounds that are able to enhance the action of fluconazole against different C. albicans strains; this action seems related to inhibition of cell division. antifungal agents natural products caatinga biome Therapeutics. Pharmacology Tiago Fonseca Silva verfasserin aut Woah Queiroz Nobre verfasserin aut Larissa Isabela Oliveira de Souza verfasserin aut Cristiane Santos Silva e Silva Figueiredo verfasserin aut Regina Celia Bressan Queiroz de Figueiredo verfasserin aut Norma Buarque de Gusmão verfasserin aut Márcia Vanusa Silva verfasserin aut Luís Cláudio Nascimento da Silva verfasserin aut Maria Tereza dos Santos Correia verfasserin aut In Pharmaceutical Biology Taylor & Francis Group, 2017 55(2017), 1, Seite 1521-1527 (DE-627)300595905 (DE-600)1483151-X 17445116 nnns volume:55 year:2017 number:1 pages:1521-1527 https://doi.org/10.1080/13880209.2017.1304427 kostenfrei https://doaj.org/article/0363c062d2fa46dc84512faea6d9c2f4 kostenfrei http://dx.doi.org/10.1080/13880209.2017.1304427 kostenfrei https://doaj.org/toc/1388-0209 Journal toc kostenfrei https://doaj.org/toc/1744-5116 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_1200 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 55 2017 1 1521-1527
allfields_unstemmed	10.1080/13880209.2017.1304427 doi (DE-627)DOAJ019818955 (DE-599)DOAJ0363c062d2fa46dc84512faea6d9c2f4 DE-627 ger DE-627 rakwb eng RM1-950 José Robson Neves Cavalcanti Filho verfasserin aut Antimicrobial activity of Buchenavia tetraphylla against Candida albicans strains isolated from vaginal secretions 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Context: Buchenavia tetraphylla (Aubl.) RA Howard (Combretaceae: Combretoideae) is an ethnomedicinal plant with reported antifungal action. Objective: This study evaluates the antimicrobial activity of B. tetraphylla leaf extracts against clinical isolates of Candida albicans. The morphological alterations, combinatory effects with fluconazole and the cytotoxicity of the active extract were analyzed. Materials and methods: Extracts were obtained using different solvents (hexane: BTHE; chloroform: BTCE; ethyl acetate: BTEE; and methanol: BTME). Antimicrobial activity was determined by the broth microdilution method using nine strains of C. albicans isolated from vaginal secretions and one standard strain (UFPEDA 1007). Results: All extracts showed anti-C. albicans activity, including against the azole-resistant strains. The MIC values ranged from 156 to 2500 μg/mL for the BTHE; 156 to 1250 μg/mL for the BTCE; 625 to 1250 μg/mL for the BTME and 625 μg/mL to 2500 μg/mL for the BTEE. BTME showed the best anti-C. albicans activity. This extract demonstrated additive/synergistic interactions with fluconazole. Scanning electron microscopy analysis suggested that the BTME interferes with the cell division and development of C. albicans. BTME showed IC50 values of 981 and 3935 μg/mL, against J774 macrophages and human erythrocytes, respectively. This extract also enhanced the production of nitric oxide by J774 macrophages. Discussion and conclusion: Buchenavia tetraphylla methanolic extract (BTME) is a great source of antimicrobial compounds that are able to enhance the action of fluconazole against different C. albicans strains; this action seems related to inhibition of cell division. antifungal agents natural products caatinga biome Therapeutics. Pharmacology Tiago Fonseca Silva verfasserin aut Woah Queiroz Nobre verfasserin aut Larissa Isabela Oliveira de Souza verfasserin aut Cristiane Santos Silva e Silva Figueiredo verfasserin aut Regina Celia Bressan Queiroz de Figueiredo verfasserin aut Norma Buarque de Gusmão verfasserin aut Márcia Vanusa Silva verfasserin aut Luís Cláudio Nascimento da Silva verfasserin aut Maria Tereza dos Santos Correia verfasserin aut In Pharmaceutical Biology Taylor & Francis Group, 2017 55(2017), 1, Seite 1521-1527 (DE-627)300595905 (DE-600)1483151-X 17445116 nnns volume:55 year:2017 number:1 pages:1521-1527 https://doi.org/10.1080/13880209.2017.1304427 kostenfrei https://doaj.org/article/0363c062d2fa46dc84512faea6d9c2f4 kostenfrei http://dx.doi.org/10.1080/13880209.2017.1304427 kostenfrei https://doaj.org/toc/1388-0209 Journal toc kostenfrei https://doaj.org/toc/1744-5116 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_1200 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 55 2017 1 1521-1527
allfieldsGer	10.1080/13880209.2017.1304427 doi (DE-627)DOAJ019818955 (DE-599)DOAJ0363c062d2fa46dc84512faea6d9c2f4 DE-627 ger DE-627 rakwb eng RM1-950 José Robson Neves Cavalcanti Filho verfasserin aut Antimicrobial activity of Buchenavia tetraphylla against Candida albicans strains isolated from vaginal secretions 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Context: Buchenavia tetraphylla (Aubl.) RA Howard (Combretaceae: Combretoideae) is an ethnomedicinal plant with reported antifungal action. Objective: This study evaluates the antimicrobial activity of B. tetraphylla leaf extracts against clinical isolates of Candida albicans. The morphological alterations, combinatory effects with fluconazole and the cytotoxicity of the active extract were analyzed. Materials and methods: Extracts were obtained using different solvents (hexane: BTHE; chloroform: BTCE; ethyl acetate: BTEE; and methanol: BTME). Antimicrobial activity was determined by the broth microdilution method using nine strains of C. albicans isolated from vaginal secretions and one standard strain (UFPEDA 1007). Results: All extracts showed anti-C. albicans activity, including against the azole-resistant strains. The MIC values ranged from 156 to 2500 μg/mL for the BTHE; 156 to 1250 μg/mL for the BTCE; 625 to 1250 μg/mL for the BTME and 625 μg/mL to 2500 μg/mL for the BTEE. BTME showed the best anti-C. albicans activity. This extract demonstrated additive/synergistic interactions with fluconazole. Scanning electron microscopy analysis suggested that the BTME interferes with the cell division and development of C. albicans. BTME showed IC50 values of 981 and 3935 μg/mL, against J774 macrophages and human erythrocytes, respectively. This extract also enhanced the production of nitric oxide by J774 macrophages. Discussion and conclusion: Buchenavia tetraphylla methanolic extract (BTME) is a great source of antimicrobial compounds that are able to enhance the action of fluconazole against different C. albicans strains; this action seems related to inhibition of cell division. antifungal agents natural products caatinga biome Therapeutics. Pharmacology Tiago Fonseca Silva verfasserin aut Woah Queiroz Nobre verfasserin aut Larissa Isabela Oliveira de Souza verfasserin aut Cristiane Santos Silva e Silva Figueiredo verfasserin aut Regina Celia Bressan Queiroz de Figueiredo verfasserin aut Norma Buarque de Gusmão verfasserin aut Márcia Vanusa Silva verfasserin aut Luís Cláudio Nascimento da Silva verfasserin aut Maria Tereza dos Santos Correia verfasserin aut In Pharmaceutical Biology Taylor & Francis Group, 2017 55(2017), 1, Seite 1521-1527 (DE-627)300595905 (DE-600)1483151-X 17445116 nnns volume:55 year:2017 number:1 pages:1521-1527 https://doi.org/10.1080/13880209.2017.1304427 kostenfrei https://doaj.org/article/0363c062d2fa46dc84512faea6d9c2f4 kostenfrei http://dx.doi.org/10.1080/13880209.2017.1304427 kostenfrei https://doaj.org/toc/1388-0209 Journal toc kostenfrei https://doaj.org/toc/1744-5116 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_1200 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 55 2017 1 1521-1527
allfieldsSound	10.1080/13880209.2017.1304427 doi (DE-627)DOAJ019818955 (DE-599)DOAJ0363c062d2fa46dc84512faea6d9c2f4 DE-627 ger DE-627 rakwb eng RM1-950 José Robson Neves Cavalcanti Filho verfasserin aut Antimicrobial activity of Buchenavia tetraphylla against Candida albicans strains isolated from vaginal secretions 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Context: Buchenavia tetraphylla (Aubl.) RA Howard (Combretaceae: Combretoideae) is an ethnomedicinal plant with reported antifungal action. Objective: This study evaluates the antimicrobial activity of B. tetraphylla leaf extracts against clinical isolates of Candida albicans. The morphological alterations, combinatory effects with fluconazole and the cytotoxicity of the active extract were analyzed. Materials and methods: Extracts were obtained using different solvents (hexane: BTHE; chloroform: BTCE; ethyl acetate: BTEE; and methanol: BTME). Antimicrobial activity was determined by the broth microdilution method using nine strains of C. albicans isolated from vaginal secretions and one standard strain (UFPEDA 1007). Results: All extracts showed anti-C. albicans activity, including against the azole-resistant strains. The MIC values ranged from 156 to 2500 μg/mL for the BTHE; 156 to 1250 μg/mL for the BTCE; 625 to 1250 μg/mL for the BTME and 625 μg/mL to 2500 μg/mL for the BTEE. BTME showed the best anti-C. albicans activity. This extract demonstrated additive/synergistic interactions with fluconazole. Scanning electron microscopy analysis suggested that the BTME interferes with the cell division and development of C. albicans. BTME showed IC50 values of 981 and 3935 μg/mL, against J774 macrophages and human erythrocytes, respectively. This extract also enhanced the production of nitric oxide by J774 macrophages. Discussion and conclusion: Buchenavia tetraphylla methanolic extract (BTME) is a great source of antimicrobial compounds that are able to enhance the action of fluconazole against different C. albicans strains; this action seems related to inhibition of cell division. antifungal agents natural products caatinga biome Therapeutics. Pharmacology Tiago Fonseca Silva verfasserin aut Woah Queiroz Nobre verfasserin aut Larissa Isabela Oliveira de Souza verfasserin aut Cristiane Santos Silva e Silva Figueiredo verfasserin aut Regina Celia Bressan Queiroz de Figueiredo verfasserin aut Norma Buarque de Gusmão verfasserin aut Márcia Vanusa Silva verfasserin aut Luís Cláudio Nascimento da Silva verfasserin aut Maria Tereza dos Santos Correia verfasserin aut In Pharmaceutical Biology Taylor & Francis Group, 2017 55(2017), 1, Seite 1521-1527 (DE-627)300595905 (DE-600)1483151-X 17445116 nnns volume:55 year:2017 number:1 pages:1521-1527 https://doi.org/10.1080/13880209.2017.1304427 kostenfrei https://doaj.org/article/0363c062d2fa46dc84512faea6d9c2f4 kostenfrei http://dx.doi.org/10.1080/13880209.2017.1304427 kostenfrei https://doaj.org/toc/1388-0209 Journal toc kostenfrei https://doaj.org/toc/1744-5116 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_1200 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 55 2017 1 1521-1527
language	English
source	In Pharmaceutical Biology 55(2017), 1, Seite 1521-1527 volume:55 year:2017 number:1 pages:1521-1527
sourceStr	In Pharmaceutical Biology 55(2017), 1, Seite 1521-1527 volume:55 year:2017 number:1 pages:1521-1527
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	antifungal agents natural products caatinga biome Therapeutics. Pharmacology
isfreeaccess_bool	true
container_title	Pharmaceutical Biology
authorswithroles_txt_mv	José Robson Neves Cavalcanti Filho @@aut@@ Tiago Fonseca Silva @@aut@@ Woah Queiroz Nobre @@aut@@ Larissa Isabela Oliveira de Souza @@aut@@ Cristiane Santos Silva e Silva Figueiredo @@aut@@ Regina Celia Bressan Queiroz de Figueiredo @@aut@@ Norma Buarque de Gusmão @@aut@@ Márcia Vanusa Silva @@aut@@ Luís Cláudio Nascimento da Silva @@aut@@ Maria Tereza dos Santos Correia @@aut@@
publishDateDaySort_date	2017-01-01T00:00:00Z
hierarchy_top_id	300595905
id	DOAJ019818955
language_de	englisch
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RA Howard (Combretaceae: Combretoideae) is an ethnomedicinal plant with reported antifungal action. Objective: This study evaluates the antimicrobial activity of B. tetraphylla leaf extracts against clinical isolates of Candida albicans. The morphological alterations, combinatory effects with fluconazole and the cytotoxicity of the active extract were analyzed. Materials and methods: Extracts were obtained using different solvents (hexane: BTHE; chloroform: BTCE; ethyl acetate: BTEE; and methanol: BTME). Antimicrobial activity was determined by the broth microdilution method using nine strains of C. albicans isolated from vaginal secretions and one standard strain (UFPEDA 1007). Results: All extracts showed anti-C. albicans activity, including against the azole-resistant strains. The MIC values ranged from 156 to 2500 μg/mL for the BTHE; 156 to 1250 μg/mL for the BTCE; 625 to 1250 μg/mL for the BTME and 625 μg/mL to 2500 μg/mL for the BTEE. 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callnumber-first	R - Medicine
author	José Robson Neves Cavalcanti Filho
spellingShingle	José Robson Neves Cavalcanti Filho misc RM1-950 misc antifungal agents misc natural products misc caatinga biome misc Therapeutics. Pharmacology Antimicrobial activity of Buchenavia tetraphylla against Candida albicans strains isolated from vaginal secretions
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topic_title	RM1-950 Antimicrobial activity of Buchenavia tetraphylla against Candida albicans strains isolated from vaginal secretions antifungal agents natural products caatinga biome
topic	misc RM1-950 misc antifungal agents misc natural products misc caatinga biome misc Therapeutics. Pharmacology
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title	Antimicrobial activity of Buchenavia tetraphylla against Candida albicans strains isolated from vaginal secretions
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title_full	Antimicrobial activity of Buchenavia tetraphylla against Candida albicans strains isolated from vaginal secretions
author_sort	José Robson Neves Cavalcanti Filho
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author_browse	José Robson Neves Cavalcanti Filho Tiago Fonseca Silva Woah Queiroz Nobre Larissa Isabela Oliveira de Souza Cristiane Santos Silva e Silva Figueiredo Regina Celia Bressan Queiroz de Figueiredo Norma Buarque de Gusmão Márcia Vanusa Silva Luís Cláudio Nascimento da Silva Maria Tereza dos Santos Correia
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title_sort	antimicrobial activity of buchenavia tetraphylla against candida albicans strains isolated from vaginal secretions
callnumber	RM1-950
title_auth	Antimicrobial activity of Buchenavia tetraphylla against Candida albicans strains isolated from vaginal secretions
abstract	Context: Buchenavia tetraphylla (Aubl.) RA Howard (Combretaceae: Combretoideae) is an ethnomedicinal plant with reported antifungal action. Objective: This study evaluates the antimicrobial activity of B. tetraphylla leaf extracts against clinical isolates of Candida albicans. The morphological alterations, combinatory effects with fluconazole and the cytotoxicity of the active extract were analyzed. Materials and methods: Extracts were obtained using different solvents (hexane: BTHE; chloroform: BTCE; ethyl acetate: BTEE; and methanol: BTME). Antimicrobial activity was determined by the broth microdilution method using nine strains of C. albicans isolated from vaginal secretions and one standard strain (UFPEDA 1007). Results: All extracts showed anti-C. albicans activity, including against the azole-resistant strains. The MIC values ranged from 156 to 2500 μg/mL for the BTHE; 156 to 1250 μg/mL for the BTCE; 625 to 1250 μg/mL for the BTME and 625 μg/mL to 2500 μg/mL for the BTEE. BTME showed the best anti-C. albicans activity. This extract demonstrated additive/synergistic interactions with fluconazole. Scanning electron microscopy analysis suggested that the BTME interferes with the cell division and development of C. albicans. BTME showed IC50 values of 981 and 3935 μg/mL, against J774 macrophages and human erythrocytes, respectively. This extract also enhanced the production of nitric oxide by J774 macrophages. Discussion and conclusion: Buchenavia tetraphylla methanolic extract (BTME) is a great source of antimicrobial compounds that are able to enhance the action of fluconazole against different C. albicans strains; this action seems related to inhibition of cell division.
abstractGer	Context: Buchenavia tetraphylla (Aubl.) RA Howard (Combretaceae: Combretoideae) is an ethnomedicinal plant with reported antifungal action. Objective: This study evaluates the antimicrobial activity of B. tetraphylla leaf extracts against clinical isolates of Candida albicans. The morphological alterations, combinatory effects with fluconazole and the cytotoxicity of the active extract were analyzed. Materials and methods: Extracts were obtained using different solvents (hexane: BTHE; chloroform: BTCE; ethyl acetate: BTEE; and methanol: BTME). Antimicrobial activity was determined by the broth microdilution method using nine strains of C. albicans isolated from vaginal secretions and one standard strain (UFPEDA 1007). Results: All extracts showed anti-C. albicans activity, including against the azole-resistant strains. The MIC values ranged from 156 to 2500 μg/mL for the BTHE; 156 to 1250 μg/mL for the BTCE; 625 to 1250 μg/mL for the BTME and 625 μg/mL to 2500 μg/mL for the BTEE. BTME showed the best anti-C. albicans activity. This extract demonstrated additive/synergistic interactions with fluconazole. Scanning electron microscopy analysis suggested that the BTME interferes with the cell division and development of C. albicans. BTME showed IC50 values of 981 and 3935 μg/mL, against J774 macrophages and human erythrocytes, respectively. This extract also enhanced the production of nitric oxide by J774 macrophages. Discussion and conclusion: Buchenavia tetraphylla methanolic extract (BTME) is a great source of antimicrobial compounds that are able to enhance the action of fluconazole against different C. albicans strains; this action seems related to inhibition of cell division.
abstract_unstemmed	Context: Buchenavia tetraphylla (Aubl.) RA Howard (Combretaceae: Combretoideae) is an ethnomedicinal plant with reported antifungal action. Objective: This study evaluates the antimicrobial activity of B. tetraphylla leaf extracts against clinical isolates of Candida albicans. The morphological alterations, combinatory effects with fluconazole and the cytotoxicity of the active extract were analyzed. Materials and methods: Extracts were obtained using different solvents (hexane: BTHE; chloroform: BTCE; ethyl acetate: BTEE; and methanol: BTME). Antimicrobial activity was determined by the broth microdilution method using nine strains of C. albicans isolated from vaginal secretions and one standard strain (UFPEDA 1007). Results: All extracts showed anti-C. albicans activity, including against the azole-resistant strains. The MIC values ranged from 156 to 2500 μg/mL for the BTHE; 156 to 1250 μg/mL for the BTCE; 625 to 1250 μg/mL for the BTME and 625 μg/mL to 2500 μg/mL for the BTEE. BTME showed the best anti-C. albicans activity. This extract demonstrated additive/synergistic interactions with fluconazole. Scanning electron microscopy analysis suggested that the BTME interferes with the cell division and development of C. albicans. BTME showed IC50 values of 981 and 3935 μg/mL, against J774 macrophages and human erythrocytes, respectively. This extract also enhanced the production of nitric oxide by J774 macrophages. Discussion and conclusion: Buchenavia tetraphylla methanolic extract (BTME) is a great source of antimicrobial compounds that are able to enhance the action of fluconazole against different C. albicans strains; this action seems related to inhibition of cell division.
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title_short	Antimicrobial activity of Buchenavia tetraphylla against Candida albicans strains isolated from vaginal secretions
url	https://doi.org/10.1080/13880209.2017.1304427 https://doaj.org/article/0363c062d2fa46dc84512faea6d9c2f4 http://dx.doi.org/10.1080/13880209.2017.1304427 https://doaj.org/toc/1388-0209 https://doaj.org/toc/1744-5116
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author2Str	Tiago Fonseca Silva Woah Queiroz Nobre Larissa Isabela Oliveira de Souza Cristiane Santos Silva e Silva Figueiredo Regina Celia Bressan Queiroz de Figueiredo Norma Buarque de Gusmão Márcia Vanusa Silva Luís Cláudio Nascimento da Silva Maria Tereza dos Santos Correia
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BTME showed the best anti-C. albicans activity. This extract demonstrated additive/synergistic interactions with fluconazole. Scanning electron microscopy analysis suggested that the BTME interferes with the cell division and development of C. albicans. BTME showed IC50 values of 981 and 3935 μg/mL, against J774 macrophages and human erythrocytes, respectively. This extract also enhanced the production of nitric oxide by J774 macrophages. 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Antimicrobial activity of Buchenavia tetraphylla against Candida albicans strains isolated from vaginal secretions

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