Angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to Henoch–Schönlein purpura: a meta-analysis

Objective: Meta-analysis was performed in the current study to evaluate the relationship of the angiotensin-converting enzyme insertion/deletion polymorphism with the risk of the incidence of Henoch–Schönlein purpura. Methods: The electronic databases, including Embase, PubMed and Google scholar, we...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Xiaoqing Zhang [verfasserIn] Lin Wu [verfasserIn] Minglei Chai [verfasserIn] Xiaofang Huang [verfasserIn] Jiajin Zhu [verfasserIn] Shaojun Li [verfasserIn] Jun Zhang [verfasserIn] Huahong Zhang [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Übergeordnetes Werk:	In: Journal of the Renin-Angiotensin-Aldosterone System - SAGE Publications, 2014, 20(2019)
Übergeordnetes Werk:	volume:20 ; year:2019

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1177/1470320319836302

Katalog-ID:	DOAJ019933975

Internformat


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allfields	10.1177/1470320319836302 doi (DE-627)DOAJ019933975 (DE-599)DOAJa194c281af4247d7bdb50439b46c6969 DE-627 ger DE-627 rakwb eng R5-920 Xiaoqing Zhang verfasserin aut Angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to Henoch–Schönlein purpura: a meta-analysis 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: Meta-analysis was performed in the current study to evaluate the relationship of the angiotensin-converting enzyme insertion/deletion polymorphism with the risk of the incidence of Henoch–Schönlein purpura. Methods: The electronic databases, including Embase, PubMed and Google scholar, were systemically retrieved to search for related articles. Meanwhile, statistical analysis was performed using the odds ratio and the corresponding 95% confidence interval. Results: A total of six articles enrolling 504 patients and 706 healthy controls was enrolled into the current meta-analysis. Results of the meta-analysis suggested that the angiotensin-converting enzyme D allele was markedly correlated with the risk of the incidence of Henoch–Schönlein purpura among the general population (deletion (D) vs. insertion (I): odds ratio (OR) 1.42, 95% confidence interval (CI) 1.05–1.93; DD vs. II: OR 2.23, 95% CI 1.06–4.70; DI vs. II: OR 1.36, 95% CI 1.00–1.85; dominant model: OR 1.56, 95% CI 1.00–2.42; recessive model: OR 1.83, 95% CI 1.06–3.16). Moreover, such a polymorphism was found to correlate with the susceptibility to Henoch–Schönlein purpura when studies were stratified according to the sample size of over 200. In addition, such a polymorphism was recognised to be remarkably associated with the susceptibility to Henoch–Schönlein purpura in the Caucasian population, which was not found in the Asian population. Conclusions: The results of the current meta-analysis indicate that the angiotensin-converting enzyme D allele might be a risk factor against the risk of Henoch–Schönlein purpura, especially in Caucasians. Medicine (General) Lin Wu verfasserin aut Minglei Chai verfasserin aut Xiaofang Huang verfasserin aut Jiajin Zhu verfasserin aut Shaojun Li verfasserin aut Jun Zhang verfasserin aut Huahong Zhang verfasserin aut In Journal of the Renin-Angiotensin-Aldosterone System SAGE Publications, 2014 20(2019) (DE-627)52147485X (DE-600)2261873-9 17528976 nnns volume:20 year:2019 https://doi.org/10.1177/1470320319836302 kostenfrei https://doaj.org/article/a194c281af4247d7bdb50439b46c6969 kostenfrei https://doi.org/10.1177/1470320319836302 kostenfrei https://doaj.org/toc/1752-8976 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2704 GBV_ILN_2707 GBV_ILN_2889 GBV_ILN_2890 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2019
spelling	10.1177/1470320319836302 doi (DE-627)DOAJ019933975 (DE-599)DOAJa194c281af4247d7bdb50439b46c6969 DE-627 ger DE-627 rakwb eng R5-920 Xiaoqing Zhang verfasserin aut Angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to Henoch–Schönlein purpura: a meta-analysis 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: Meta-analysis was performed in the current study to evaluate the relationship of the angiotensin-converting enzyme insertion/deletion polymorphism with the risk of the incidence of Henoch–Schönlein purpura. Methods: The electronic databases, including Embase, PubMed and Google scholar, were systemically retrieved to search for related articles. Meanwhile, statistical analysis was performed using the odds ratio and the corresponding 95% confidence interval. Results: A total of six articles enrolling 504 patients and 706 healthy controls was enrolled into the current meta-analysis. Results of the meta-analysis suggested that the angiotensin-converting enzyme D allele was markedly correlated with the risk of the incidence of Henoch–Schönlein purpura among the general population (deletion (D) vs. insertion (I): odds ratio (OR) 1.42, 95% confidence interval (CI) 1.05–1.93; DD vs. II: OR 2.23, 95% CI 1.06–4.70; DI vs. II: OR 1.36, 95% CI 1.00–1.85; dominant model: OR 1.56, 95% CI 1.00–2.42; recessive model: OR 1.83, 95% CI 1.06–3.16). Moreover, such a polymorphism was found to correlate with the susceptibility to Henoch–Schönlein purpura when studies were stratified according to the sample size of over 200. In addition, such a polymorphism was recognised to be remarkably associated with the susceptibility to Henoch–Schönlein purpura in the Caucasian population, which was not found in the Asian population. Conclusions: The results of the current meta-analysis indicate that the angiotensin-converting enzyme D allele might be a risk factor against the risk of Henoch–Schönlein purpura, especially in Caucasians. Medicine (General) Lin Wu verfasserin aut Minglei Chai verfasserin aut Xiaofang Huang verfasserin aut Jiajin Zhu verfasserin aut Shaojun Li verfasserin aut Jun Zhang verfasserin aut Huahong Zhang verfasserin aut In Journal of the Renin-Angiotensin-Aldosterone System SAGE Publications, 2014 20(2019) (DE-627)52147485X (DE-600)2261873-9 17528976 nnns volume:20 year:2019 https://doi.org/10.1177/1470320319836302 kostenfrei https://doaj.org/article/a194c281af4247d7bdb50439b46c6969 kostenfrei https://doi.org/10.1177/1470320319836302 kostenfrei https://doaj.org/toc/1752-8976 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2704 GBV_ILN_2707 GBV_ILN_2889 GBV_ILN_2890 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2019
allfields_unstemmed	10.1177/1470320319836302 doi (DE-627)DOAJ019933975 (DE-599)DOAJa194c281af4247d7bdb50439b46c6969 DE-627 ger DE-627 rakwb eng R5-920 Xiaoqing Zhang verfasserin aut Angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to Henoch–Schönlein purpura: a meta-analysis 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: Meta-analysis was performed in the current study to evaluate the relationship of the angiotensin-converting enzyme insertion/deletion polymorphism with the risk of the incidence of Henoch–Schönlein purpura. Methods: The electronic databases, including Embase, PubMed and Google scholar, were systemically retrieved to search for related articles. Meanwhile, statistical analysis was performed using the odds ratio and the corresponding 95% confidence interval. Results: A total of six articles enrolling 504 patients and 706 healthy controls was enrolled into the current meta-analysis. Results of the meta-analysis suggested that the angiotensin-converting enzyme D allele was markedly correlated with the risk of the incidence of Henoch–Schönlein purpura among the general population (deletion (D) vs. insertion (I): odds ratio (OR) 1.42, 95% confidence interval (CI) 1.05–1.93; DD vs. II: OR 2.23, 95% CI 1.06–4.70; DI vs. II: OR 1.36, 95% CI 1.00–1.85; dominant model: OR 1.56, 95% CI 1.00–2.42; recessive model: OR 1.83, 95% CI 1.06–3.16). Moreover, such a polymorphism was found to correlate with the susceptibility to Henoch–Schönlein purpura when studies were stratified according to the sample size of over 200. In addition, such a polymorphism was recognised to be remarkably associated with the susceptibility to Henoch–Schönlein purpura in the Caucasian population, which was not found in the Asian population. Conclusions: The results of the current meta-analysis indicate that the angiotensin-converting enzyme D allele might be a risk factor against the risk of Henoch–Schönlein purpura, especially in Caucasians. Medicine (General) Lin Wu verfasserin aut Minglei Chai verfasserin aut Xiaofang Huang verfasserin aut Jiajin Zhu verfasserin aut Shaojun Li verfasserin aut Jun Zhang verfasserin aut Huahong Zhang verfasserin aut In Journal of the Renin-Angiotensin-Aldosterone System SAGE Publications, 2014 20(2019) (DE-627)52147485X (DE-600)2261873-9 17528976 nnns volume:20 year:2019 https://doi.org/10.1177/1470320319836302 kostenfrei https://doaj.org/article/a194c281af4247d7bdb50439b46c6969 kostenfrei https://doi.org/10.1177/1470320319836302 kostenfrei https://doaj.org/toc/1752-8976 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2704 GBV_ILN_2707 GBV_ILN_2889 GBV_ILN_2890 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2019
allfieldsGer	10.1177/1470320319836302 doi (DE-627)DOAJ019933975 (DE-599)DOAJa194c281af4247d7bdb50439b46c6969 DE-627 ger DE-627 rakwb eng R5-920 Xiaoqing Zhang verfasserin aut Angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to Henoch–Schönlein purpura: a meta-analysis 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: Meta-analysis was performed in the current study to evaluate the relationship of the angiotensin-converting enzyme insertion/deletion polymorphism with the risk of the incidence of Henoch–Schönlein purpura. Methods: The electronic databases, including Embase, PubMed and Google scholar, were systemically retrieved to search for related articles. Meanwhile, statistical analysis was performed using the odds ratio and the corresponding 95% confidence interval. Results: A total of six articles enrolling 504 patients and 706 healthy controls was enrolled into the current meta-analysis. Results of the meta-analysis suggested that the angiotensin-converting enzyme D allele was markedly correlated with the risk of the incidence of Henoch–Schönlein purpura among the general population (deletion (D) vs. insertion (I): odds ratio (OR) 1.42, 95% confidence interval (CI) 1.05–1.93; DD vs. II: OR 2.23, 95% CI 1.06–4.70; DI vs. II: OR 1.36, 95% CI 1.00–1.85; dominant model: OR 1.56, 95% CI 1.00–2.42; recessive model: OR 1.83, 95% CI 1.06–3.16). Moreover, such a polymorphism was found to correlate with the susceptibility to Henoch–Schönlein purpura when studies were stratified according to the sample size of over 200. In addition, such a polymorphism was recognised to be remarkably associated with the susceptibility to Henoch–Schönlein purpura in the Caucasian population, which was not found in the Asian population. Conclusions: The results of the current meta-analysis indicate that the angiotensin-converting enzyme D allele might be a risk factor against the risk of Henoch–Schönlein purpura, especially in Caucasians. Medicine (General) Lin Wu verfasserin aut Minglei Chai verfasserin aut Xiaofang Huang verfasserin aut Jiajin Zhu verfasserin aut Shaojun Li verfasserin aut Jun Zhang verfasserin aut Huahong Zhang verfasserin aut In Journal of the Renin-Angiotensin-Aldosterone System SAGE Publications, 2014 20(2019) (DE-627)52147485X (DE-600)2261873-9 17528976 nnns volume:20 year:2019 https://doi.org/10.1177/1470320319836302 kostenfrei https://doaj.org/article/a194c281af4247d7bdb50439b46c6969 kostenfrei https://doi.org/10.1177/1470320319836302 kostenfrei https://doaj.org/toc/1752-8976 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2704 GBV_ILN_2707 GBV_ILN_2889 GBV_ILN_2890 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2019
allfieldsSound	10.1177/1470320319836302 doi (DE-627)DOAJ019933975 (DE-599)DOAJa194c281af4247d7bdb50439b46c6969 DE-627 ger DE-627 rakwb eng R5-920 Xiaoqing Zhang verfasserin aut Angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to Henoch–Schönlein purpura: a meta-analysis 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: Meta-analysis was performed in the current study to evaluate the relationship of the angiotensin-converting enzyme insertion/deletion polymorphism with the risk of the incidence of Henoch–Schönlein purpura. Methods: The electronic databases, including Embase, PubMed and Google scholar, were systemically retrieved to search for related articles. Meanwhile, statistical analysis was performed using the odds ratio and the corresponding 95% confidence interval. Results: A total of six articles enrolling 504 patients and 706 healthy controls was enrolled into the current meta-analysis. Results of the meta-analysis suggested that the angiotensin-converting enzyme D allele was markedly correlated with the risk of the incidence of Henoch–Schönlein purpura among the general population (deletion (D) vs. insertion (I): odds ratio (OR) 1.42, 95% confidence interval (CI) 1.05–1.93; DD vs. II: OR 2.23, 95% CI 1.06–4.70; DI vs. II: OR 1.36, 95% CI 1.00–1.85; dominant model: OR 1.56, 95% CI 1.00–2.42; recessive model: OR 1.83, 95% CI 1.06–3.16). Moreover, such a polymorphism was found to correlate with the susceptibility to Henoch–Schönlein purpura when studies were stratified according to the sample size of over 200. In addition, such a polymorphism was recognised to be remarkably associated with the susceptibility to Henoch–Schönlein purpura in the Caucasian population, which was not found in the Asian population. Conclusions: The results of the current meta-analysis indicate that the angiotensin-converting enzyme D allele might be a risk factor against the risk of Henoch–Schönlein purpura, especially in Caucasians. Medicine (General) Lin Wu verfasserin aut Minglei Chai verfasserin aut Xiaofang Huang verfasserin aut Jiajin Zhu verfasserin aut Shaojun Li verfasserin aut Jun Zhang verfasserin aut Huahong Zhang verfasserin aut In Journal of the Renin-Angiotensin-Aldosterone System SAGE Publications, 2014 20(2019) (DE-627)52147485X (DE-600)2261873-9 17528976 nnns volume:20 year:2019 https://doi.org/10.1177/1470320319836302 kostenfrei https://doaj.org/article/a194c281af4247d7bdb50439b46c6969 kostenfrei https://doi.org/10.1177/1470320319836302 kostenfrei https://doaj.org/toc/1752-8976 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2704 GBV_ILN_2707 GBV_ILN_2889 GBV_ILN_2890 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2019
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author	Xiaoqing Zhang
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topic_title	R5-920 Angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to Henoch–Schönlein purpura: a meta-analysis
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title	Angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to Henoch–Schönlein purpura: a meta-analysis
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title_full	Angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to Henoch–Schönlein purpura: a meta-analysis
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author_browse	Xiaoqing Zhang Lin Wu Minglei Chai Xiaofang Huang Jiajin Zhu Shaojun Li Jun Zhang Huahong Zhang
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title_sort	angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to henoch–schönlein purpura: a meta-analysis
callnumber	R5-920
title_auth	Angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to Henoch–Schönlein purpura: a meta-analysis
abstract	Objective: Meta-analysis was performed in the current study to evaluate the relationship of the angiotensin-converting enzyme insertion/deletion polymorphism with the risk of the incidence of Henoch–Schönlein purpura. Methods: The electronic databases, including Embase, PubMed and Google scholar, were systemically retrieved to search for related articles. Meanwhile, statistical analysis was performed using the odds ratio and the corresponding 95% confidence interval. Results: A total of six articles enrolling 504 patients and 706 healthy controls was enrolled into the current meta-analysis. Results of the meta-analysis suggested that the angiotensin-converting enzyme D allele was markedly correlated with the risk of the incidence of Henoch–Schönlein purpura among the general population (deletion (D) vs. insertion (I): odds ratio (OR) 1.42, 95% confidence interval (CI) 1.05–1.93; DD vs. II: OR 2.23, 95% CI 1.06–4.70; DI vs. II: OR 1.36, 95% CI 1.00–1.85; dominant model: OR 1.56, 95% CI 1.00–2.42; recessive model: OR 1.83, 95% CI 1.06–3.16). Moreover, such a polymorphism was found to correlate with the susceptibility to Henoch–Schönlein purpura when studies were stratified according to the sample size of over 200. In addition, such a polymorphism was recognised to be remarkably associated with the susceptibility to Henoch–Schönlein purpura in the Caucasian population, which was not found in the Asian population. Conclusions: The results of the current meta-analysis indicate that the angiotensin-converting enzyme D allele might be a risk factor against the risk of Henoch–Schönlein purpura, especially in Caucasians.
abstractGer	Objective: Meta-analysis was performed in the current study to evaluate the relationship of the angiotensin-converting enzyme insertion/deletion polymorphism with the risk of the incidence of Henoch–Schönlein purpura. Methods: The electronic databases, including Embase, PubMed and Google scholar, were systemically retrieved to search for related articles. Meanwhile, statistical analysis was performed using the odds ratio and the corresponding 95% confidence interval. Results: A total of six articles enrolling 504 patients and 706 healthy controls was enrolled into the current meta-analysis. Results of the meta-analysis suggested that the angiotensin-converting enzyme D allele was markedly correlated with the risk of the incidence of Henoch–Schönlein purpura among the general population (deletion (D) vs. insertion (I): odds ratio (OR) 1.42, 95% confidence interval (CI) 1.05–1.93; DD vs. II: OR 2.23, 95% CI 1.06–4.70; DI vs. II: OR 1.36, 95% CI 1.00–1.85; dominant model: OR 1.56, 95% CI 1.00–2.42; recessive model: OR 1.83, 95% CI 1.06–3.16). Moreover, such a polymorphism was found to correlate with the susceptibility to Henoch–Schönlein purpura when studies were stratified according to the sample size of over 200. In addition, such a polymorphism was recognised to be remarkably associated with the susceptibility to Henoch–Schönlein purpura in the Caucasian population, which was not found in the Asian population. Conclusions: The results of the current meta-analysis indicate that the angiotensin-converting enzyme D allele might be a risk factor against the risk of Henoch–Schönlein purpura, especially in Caucasians.
abstract_unstemmed	Objective: Meta-analysis was performed in the current study to evaluate the relationship of the angiotensin-converting enzyme insertion/deletion polymorphism with the risk of the incidence of Henoch–Schönlein purpura. Methods: The electronic databases, including Embase, PubMed and Google scholar, were systemically retrieved to search for related articles. Meanwhile, statistical analysis was performed using the odds ratio and the corresponding 95% confidence interval. Results: A total of six articles enrolling 504 patients and 706 healthy controls was enrolled into the current meta-analysis. Results of the meta-analysis suggested that the angiotensin-converting enzyme D allele was markedly correlated with the risk of the incidence of Henoch–Schönlein purpura among the general population (deletion (D) vs. insertion (I): odds ratio (OR) 1.42, 95% confidence interval (CI) 1.05–1.93; DD vs. II: OR 2.23, 95% CI 1.06–4.70; DI vs. II: OR 1.36, 95% CI 1.00–1.85; dominant model: OR 1.56, 95% CI 1.00–2.42; recessive model: OR 1.83, 95% CI 1.06–3.16). Moreover, such a polymorphism was found to correlate with the susceptibility to Henoch–Schönlein purpura when studies were stratified according to the sample size of over 200. In addition, such a polymorphism was recognised to be remarkably associated with the susceptibility to Henoch–Schönlein purpura in the Caucasian population, which was not found in the Asian population. Conclusions: The results of the current meta-analysis indicate that the angiotensin-converting enzyme D allele might be a risk factor against the risk of Henoch–Schönlein purpura, especially in Caucasians.
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title_short	Angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to Henoch–Schönlein purpura: a meta-analysis
url	https://doi.org/10.1177/1470320319836302 https://doaj.org/article/a194c281af4247d7bdb50439b46c6969 https://doaj.org/toc/1752-8976
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Moreover, such a polymorphism was found to correlate with the susceptibility to Henoch–Schönlein purpura when studies were stratified according to the sample size of over 200. In addition, such a polymorphism was recognised to be remarkably associated with the susceptibility to Henoch–Schönlein purpura in the Caucasian population, which was not found in the Asian population. Conclusions: The results of the current meta-analysis indicate that the angiotensin-converting enzyme D allele might be a risk factor against the risk of Henoch–Schönlein purpura, especially in Caucasians.</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Medicine (General)</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Lin Wu</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Minglei Chai</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Xiaofang Huang</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jiajin Zhu</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Shaojun Li</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jun Zhang</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Huahong Zhang</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Journal of the Renin-Angiotensin-Aldosterone System</subfield><subfield code="d">SAGE Publications, 2014</subfield><subfield code="g">20(2019)</subfield><subfield code="w">(DE-627)52147485X</subfield><subfield code="w">(DE-600)2261873-9</subfield><subfield code="x">17528976</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:20</subfield><subfield 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Angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to Henoch–Schönlein purpura: a meta-analysis

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