Circulating microRNAs as promising diagnostic biomarkers for pancreatic cancer: a systematic review
Jinru Xue,1,* Erna Jia,2,* Na Ren,1 Andrew Lindsay,3,4 Haixin Yu1,51Department of Thoracic Surgery, China-Japan Union Hospital of Jilin University, Changchun, People’s Republic of China; 2Department of Gastroenterology, China-Japan Union Hospital of Jilin University, Changchun, People&...
Ausführliche Beschreibung
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Xue J [verfasserIn] Jia E [verfasserIn] Ren N [verfasserIn] Lindsay A [verfasserIn] Yu H [verfasserIn] |
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Englisch |
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2019 |
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In: OncoTargets and Therapy - Dove Medical Press, 2009, (2019), Seite 6665-6684 |
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year:2019 ; pages:6665-6684 |
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520 | |a Jinru Xue,1,* Erna Jia,2,* Na Ren,1 Andrew Lindsay,3,4 Haixin Yu1,51Department of Thoracic Surgery, China-Japan Union Hospital of Jilin University, Changchun, People’s Republic of China; 2Department of Gastroenterology, China-Japan Union Hospital of Jilin University, Changchun, People’s Republic of China; 3Major Cancer Biology, German Cancer Research Center, Heidelberg, Germany; 4Faculty of Biosciences, University of Heidelberg, Heidelberg, Germany; 5Medical Faculty Heidelberg, University of Heidelberg, Heidelberg, GermanyCorrespondence: Haixin YuDepartment of Thoracic Surgery, China-Japan Union Hospital of Jilin University, No. 126, Xiantai Avenue, Changchun 130033, People’s Republic of ChinaTel +86 1 507 232 4782Fax +86 4 318 499 5852Email 534266311qq.com*These authors contributed equally to this workAbstract: Pancreatic cancer (PC) is one of the most common forms of malignant tumors and causes of tumor-related death worldwide. The current prognosis of PC still remains poor due to the lack of effective early detection method. Recently, there is strong support that circulating miRNAs can be used as biomarkers for early detection of various cancers, including PC. The purpose of this review is to provide an overview of previous published studies on circulating miRNAs in plasma/serum for early detection of PC and summarize their diagnostic value. PubMed, Embase and Web of Science were systematically searched for eligible studies on circulating miRNAs for PC detection. Overall, 29 studies published between 2009 and 2018 evaluating 51 individual miRNAs (no P-value exceeding 0.05) and 13 miRNAs panels were included. Generally, the diagnostic performance of circulating miRNAs for PC detection was strong, with both the sensitivity and specificity of 36% individual miRNAs and 40% miRNAs panels exceeding 80%. Moreover, two promising miRNA panels were discovered and verified externally with all AUC values exceeding 0.95. Therefore, circulating miRNAs may hold potential to be used as noninvasive diagnostic biomarkers for PC, but large-scale studies are still needed to validate the promising miRNAs and optimize the miRNA panels. Since, the tremendous heterogeneity of studies in this field hampers translating miRNA markers into clinical practice, miRNA analytical procedures are also needed to be standardized in the future.Keywords: pancreatic cancer, early detection, circulating microRNAs | ||
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(DE-627)DOAJ019988745 (DE-599)DOAJ09fc63e11e5e48aa84c31c4d91a6abcd DE-627 ger DE-627 rakwb eng RC254-282 Xue J verfasserin aut Circulating microRNAs as promising diagnostic biomarkers for pancreatic cancer: a systematic review 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Jinru Xue,1,* Erna Jia,2,* Na Ren,1 Andrew Lindsay,3,4 Haixin Yu1,51Department of Thoracic Surgery, China-Japan Union Hospital of Jilin University, Changchun, People’s Republic of China; 2Department of Gastroenterology, China-Japan Union Hospital of Jilin University, Changchun, People’s Republic of China; 3Major Cancer Biology, German Cancer Research Center, Heidelberg, Germany; 4Faculty of Biosciences, University of Heidelberg, Heidelberg, Germany; 5Medical Faculty Heidelberg, University of Heidelberg, Heidelberg, GermanyCorrespondence: Haixin YuDepartment of Thoracic Surgery, China-Japan Union Hospital of Jilin University, No. 126, Xiantai Avenue, Changchun 130033, People’s Republic of ChinaTel +86 1 507 232 4782Fax +86 4 318 499 5852Email 534266311qq.com*These authors contributed equally to this workAbstract: Pancreatic cancer (PC) is one of the most common forms of malignant tumors and causes of tumor-related death worldwide. The current prognosis of PC still remains poor due to the lack of effective early detection method. Recently, there is strong support that circulating miRNAs can be used as biomarkers for early detection of various cancers, including PC. The purpose of this review is to provide an overview of previous published studies on circulating miRNAs in plasma/serum for early detection of PC and summarize their diagnostic value. PubMed, Embase and Web of Science were systematically searched for eligible studies on circulating miRNAs for PC detection. Overall, 29 studies published between 2009 and 2018 evaluating 51 individual miRNAs (no P-value exceeding 0.05) and 13 miRNAs panels were included. Generally, the diagnostic performance of circulating miRNAs for PC detection was strong, with both the sensitivity and specificity of 36% individual miRNAs and 40% miRNAs panels exceeding 80%. Moreover, two promising miRNA panels were discovered and verified externally with all AUC values exceeding 0.95. Therefore, circulating miRNAs may hold potential to be used as noninvasive diagnostic biomarkers for PC, but large-scale studies are still needed to validate the promising miRNAs and optimize the miRNA panels. Since, the tremendous heterogeneity of studies in this field hampers translating miRNA markers into clinical practice, miRNA analytical procedures are also needed to be standardized in the future.Keywords: pancreatic cancer, early detection, circulating microRNAs pancreatic cancer early detection circulating microRNAs Neoplasms. Tumors. Oncology. Including cancer and carcinogens Jia E verfasserin aut Ren N verfasserin aut Lindsay A verfasserin aut Yu H verfasserin aut In OncoTargets and Therapy Dove Medical Press, 2009 (2019), Seite 6665-6684 (DE-627)600307654 (DE-600)2495130-4 11786930 nnns year:2019 pages:6665-6684 https://doaj.org/article/09fc63e11e5e48aa84c31c4d91a6abcd kostenfrei https://www.dovepress.com/circulating-micrornas-as-promising-diagnostic-biomarkers-for-pancreati-peer-reviewed-article-OTT kostenfrei https://doaj.org/toc/1178-6930 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2019 6665-6684 |
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(DE-627)DOAJ019988745 (DE-599)DOAJ09fc63e11e5e48aa84c31c4d91a6abcd DE-627 ger DE-627 rakwb eng RC254-282 Xue J verfasserin aut Circulating microRNAs as promising diagnostic biomarkers for pancreatic cancer: a systematic review 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Jinru Xue,1,* Erna Jia,2,* Na Ren,1 Andrew Lindsay,3,4 Haixin Yu1,51Department of Thoracic Surgery, China-Japan Union Hospital of Jilin University, Changchun, People’s Republic of China; 2Department of Gastroenterology, China-Japan Union Hospital of Jilin University, Changchun, People’s Republic of China; 3Major Cancer Biology, German Cancer Research Center, Heidelberg, Germany; 4Faculty of Biosciences, University of Heidelberg, Heidelberg, Germany; 5Medical Faculty Heidelberg, University of Heidelberg, Heidelberg, GermanyCorrespondence: Haixin YuDepartment of Thoracic Surgery, China-Japan Union Hospital of Jilin University, No. 126, Xiantai Avenue, Changchun 130033, People’s Republic of ChinaTel +86 1 507 232 4782Fax +86 4 318 499 5852Email 534266311qq.com*These authors contributed equally to this workAbstract: Pancreatic cancer (PC) is one of the most common forms of malignant tumors and causes of tumor-related death worldwide. The current prognosis of PC still remains poor due to the lack of effective early detection method. Recently, there is strong support that circulating miRNAs can be used as biomarkers for early detection of various cancers, including PC. The purpose of this review is to provide an overview of previous published studies on circulating miRNAs in plasma/serum for early detection of PC and summarize their diagnostic value. PubMed, Embase and Web of Science were systematically searched for eligible studies on circulating miRNAs for PC detection. Overall, 29 studies published between 2009 and 2018 evaluating 51 individual miRNAs (no P-value exceeding 0.05) and 13 miRNAs panels were included. Generally, the diagnostic performance of circulating miRNAs for PC detection was strong, with both the sensitivity and specificity of 36% individual miRNAs and 40% miRNAs panels exceeding 80%. Moreover, two promising miRNA panels were discovered and verified externally with all AUC values exceeding 0.95. Therefore, circulating miRNAs may hold potential to be used as noninvasive diagnostic biomarkers for PC, but large-scale studies are still needed to validate the promising miRNAs and optimize the miRNA panels. Since, the tremendous heterogeneity of studies in this field hampers translating miRNA markers into clinical practice, miRNA analytical procedures are also needed to be standardized in the future.Keywords: pancreatic cancer, early detection, circulating microRNAs pancreatic cancer early detection circulating microRNAs Neoplasms. Tumors. Oncology. Including cancer and carcinogens Jia E verfasserin aut Ren N verfasserin aut Lindsay A verfasserin aut Yu H verfasserin aut In OncoTargets and Therapy Dove Medical Press, 2009 (2019), Seite 6665-6684 (DE-627)600307654 (DE-600)2495130-4 11786930 nnns year:2019 pages:6665-6684 https://doaj.org/article/09fc63e11e5e48aa84c31c4d91a6abcd kostenfrei https://www.dovepress.com/circulating-micrornas-as-promising-diagnostic-biomarkers-for-pancreati-peer-reviewed-article-OTT kostenfrei https://doaj.org/toc/1178-6930 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2019 6665-6684 |
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(DE-627)DOAJ019988745 (DE-599)DOAJ09fc63e11e5e48aa84c31c4d91a6abcd DE-627 ger DE-627 rakwb eng RC254-282 Xue J verfasserin aut Circulating microRNAs as promising diagnostic biomarkers for pancreatic cancer: a systematic review 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Jinru Xue,1,* Erna Jia,2,* Na Ren,1 Andrew Lindsay,3,4 Haixin Yu1,51Department of Thoracic Surgery, China-Japan Union Hospital of Jilin University, Changchun, People’s Republic of China; 2Department of Gastroenterology, China-Japan Union Hospital of Jilin University, Changchun, People’s Republic of China; 3Major Cancer Biology, German Cancer Research Center, Heidelberg, Germany; 4Faculty of Biosciences, University of Heidelberg, Heidelberg, Germany; 5Medical Faculty Heidelberg, University of Heidelberg, Heidelberg, GermanyCorrespondence: Haixin YuDepartment of Thoracic Surgery, China-Japan Union Hospital of Jilin University, No. 126, Xiantai Avenue, Changchun 130033, People’s Republic of ChinaTel +86 1 507 232 4782Fax +86 4 318 499 5852Email 534266311qq.com*These authors contributed equally to this workAbstract: Pancreatic cancer (PC) is one of the most common forms of malignant tumors and causes of tumor-related death worldwide. The current prognosis of PC still remains poor due to the lack of effective early detection method. Recently, there is strong support that circulating miRNAs can be used as biomarkers for early detection of various cancers, including PC. The purpose of this review is to provide an overview of previous published studies on circulating miRNAs in plasma/serum for early detection of PC and summarize their diagnostic value. PubMed, Embase and Web of Science were systematically searched for eligible studies on circulating miRNAs for PC detection. Overall, 29 studies published between 2009 and 2018 evaluating 51 individual miRNAs (no P-value exceeding 0.05) and 13 miRNAs panels were included. Generally, the diagnostic performance of circulating miRNAs for PC detection was strong, with both the sensitivity and specificity of 36% individual miRNAs and 40% miRNAs panels exceeding 80%. Moreover, two promising miRNA panels were discovered and verified externally with all AUC values exceeding 0.95. Therefore, circulating miRNAs may hold potential to be used as noninvasive diagnostic biomarkers for PC, but large-scale studies are still needed to validate the promising miRNAs and optimize the miRNA panels. Since, the tremendous heterogeneity of studies in this field hampers translating miRNA markers into clinical practice, miRNA analytical procedures are also needed to be standardized in the future.Keywords: pancreatic cancer, early detection, circulating microRNAs pancreatic cancer early detection circulating microRNAs Neoplasms. Tumors. Oncology. Including cancer and carcinogens Jia E verfasserin aut Ren N verfasserin aut Lindsay A verfasserin aut Yu H verfasserin aut In OncoTargets and Therapy Dove Medical Press, 2009 (2019), Seite 6665-6684 (DE-627)600307654 (DE-600)2495130-4 11786930 nnns year:2019 pages:6665-6684 https://doaj.org/article/09fc63e11e5e48aa84c31c4d91a6abcd kostenfrei https://www.dovepress.com/circulating-micrornas-as-promising-diagnostic-biomarkers-for-pancreati-peer-reviewed-article-OTT kostenfrei https://doaj.org/toc/1178-6930 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2019 6665-6684 |
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(DE-627)DOAJ019988745 (DE-599)DOAJ09fc63e11e5e48aa84c31c4d91a6abcd DE-627 ger DE-627 rakwb eng RC254-282 Xue J verfasserin aut Circulating microRNAs as promising diagnostic biomarkers for pancreatic cancer: a systematic review 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Jinru Xue,1,* Erna Jia,2,* Na Ren,1 Andrew Lindsay,3,4 Haixin Yu1,51Department of Thoracic Surgery, China-Japan Union Hospital of Jilin University, Changchun, People’s Republic of China; 2Department of Gastroenterology, China-Japan Union Hospital of Jilin University, Changchun, People’s Republic of China; 3Major Cancer Biology, German Cancer Research Center, Heidelberg, Germany; 4Faculty of Biosciences, University of Heidelberg, Heidelberg, Germany; 5Medical Faculty Heidelberg, University of Heidelberg, Heidelberg, GermanyCorrespondence: Haixin YuDepartment of Thoracic Surgery, China-Japan Union Hospital of Jilin University, No. 126, Xiantai Avenue, Changchun 130033, People’s Republic of ChinaTel +86 1 507 232 4782Fax +86 4 318 499 5852Email 534266311qq.com*These authors contributed equally to this workAbstract: Pancreatic cancer (PC) is one of the most common forms of malignant tumors and causes of tumor-related death worldwide. The current prognosis of PC still remains poor due to the lack of effective early detection method. Recently, there is strong support that circulating miRNAs can be used as biomarkers for early detection of various cancers, including PC. The purpose of this review is to provide an overview of previous published studies on circulating miRNAs in plasma/serum for early detection of PC and summarize their diagnostic value. PubMed, Embase and Web of Science were systematically searched for eligible studies on circulating miRNAs for PC detection. Overall, 29 studies published between 2009 and 2018 evaluating 51 individual miRNAs (no P-value exceeding 0.05) and 13 miRNAs panels were included. Generally, the diagnostic performance of circulating miRNAs for PC detection was strong, with both the sensitivity and specificity of 36% individual miRNAs and 40% miRNAs panels exceeding 80%. Moreover, two promising miRNA panels were discovered and verified externally with all AUC values exceeding 0.95. Therefore, circulating miRNAs may hold potential to be used as noninvasive diagnostic biomarkers for PC, but large-scale studies are still needed to validate the promising miRNAs and optimize the miRNA panels. Since, the tremendous heterogeneity of studies in this field hampers translating miRNA markers into clinical practice, miRNA analytical procedures are also needed to be standardized in the future.Keywords: pancreatic cancer, early detection, circulating microRNAs pancreatic cancer early detection circulating microRNAs Neoplasms. Tumors. Oncology. Including cancer and carcinogens Jia E verfasserin aut Ren N verfasserin aut Lindsay A verfasserin aut Yu H verfasserin aut In OncoTargets and Therapy Dove Medical Press, 2009 (2019), Seite 6665-6684 (DE-627)600307654 (DE-600)2495130-4 11786930 nnns year:2019 pages:6665-6684 https://doaj.org/article/09fc63e11e5e48aa84c31c4d91a6abcd kostenfrei https://www.dovepress.com/circulating-micrornas-as-promising-diagnostic-biomarkers-for-pancreati-peer-reviewed-article-OTT kostenfrei https://doaj.org/toc/1178-6930 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2019 6665-6684 |
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(DE-627)DOAJ019988745 (DE-599)DOAJ09fc63e11e5e48aa84c31c4d91a6abcd DE-627 ger DE-627 rakwb eng RC254-282 Xue J verfasserin aut Circulating microRNAs as promising diagnostic biomarkers for pancreatic cancer: a systematic review 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Jinru Xue,1,* Erna Jia,2,* Na Ren,1 Andrew Lindsay,3,4 Haixin Yu1,51Department of Thoracic Surgery, China-Japan Union Hospital of Jilin University, Changchun, People’s Republic of China; 2Department of Gastroenterology, China-Japan Union Hospital of Jilin University, Changchun, People’s Republic of China; 3Major Cancer Biology, German Cancer Research Center, Heidelberg, Germany; 4Faculty of Biosciences, University of Heidelberg, Heidelberg, Germany; 5Medical Faculty Heidelberg, University of Heidelberg, Heidelberg, GermanyCorrespondence: Haixin YuDepartment of Thoracic Surgery, China-Japan Union Hospital of Jilin University, No. 126, Xiantai Avenue, Changchun 130033, People’s Republic of ChinaTel +86 1 507 232 4782Fax +86 4 318 499 5852Email 534266311qq.com*These authors contributed equally to this workAbstract: Pancreatic cancer (PC) is one of the most common forms of malignant tumors and causes of tumor-related death worldwide. The current prognosis of PC still remains poor due to the lack of effective early detection method. Recently, there is strong support that circulating miRNAs can be used as biomarkers for early detection of various cancers, including PC. The purpose of this review is to provide an overview of previous published studies on circulating miRNAs in plasma/serum for early detection of PC and summarize their diagnostic value. PubMed, Embase and Web of Science were systematically searched for eligible studies on circulating miRNAs for PC detection. Overall, 29 studies published between 2009 and 2018 evaluating 51 individual miRNAs (no P-value exceeding 0.05) and 13 miRNAs panels were included. Generally, the diagnostic performance of circulating miRNAs for PC detection was strong, with both the sensitivity and specificity of 36% individual miRNAs and 40% miRNAs panels exceeding 80%. Moreover, two promising miRNA panels were discovered and verified externally with all AUC values exceeding 0.95. Therefore, circulating miRNAs may hold potential to be used as noninvasive diagnostic biomarkers for PC, but large-scale studies are still needed to validate the promising miRNAs and optimize the miRNA panels. Since, the tremendous heterogeneity of studies in this field hampers translating miRNA markers into clinical practice, miRNA analytical procedures are also needed to be standardized in the future.Keywords: pancreatic cancer, early detection, circulating microRNAs pancreatic cancer early detection circulating microRNAs Neoplasms. Tumors. Oncology. Including cancer and carcinogens Jia E verfasserin aut Ren N verfasserin aut Lindsay A verfasserin aut Yu H verfasserin aut In OncoTargets and Therapy Dove Medical Press, 2009 (2019), Seite 6665-6684 (DE-627)600307654 (DE-600)2495130-4 11786930 nnns year:2019 pages:6665-6684 https://doaj.org/article/09fc63e11e5e48aa84c31c4d91a6abcd kostenfrei https://www.dovepress.com/circulating-micrornas-as-promising-diagnostic-biomarkers-for-pancreati-peer-reviewed-article-OTT kostenfrei https://doaj.org/toc/1178-6930 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2019 6665-6684 |
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Jinru Xue,1,* Erna Jia,2,* Na Ren,1 Andrew Lindsay,3,4 Haixin Yu1,51Department of Thoracic Surgery, China-Japan Union Hospital of Jilin University, Changchun, People’s Republic of China; 2Department of Gastroenterology, China-Japan Union Hospital of Jilin University, Changchun, People’s Republic of China; 3Major Cancer Biology, German Cancer Research Center, Heidelberg, Germany; 4Faculty of Biosciences, University of Heidelberg, Heidelberg, Germany; 5Medical Faculty Heidelberg, University of Heidelberg, Heidelberg, GermanyCorrespondence: Haixin YuDepartment of Thoracic Surgery, China-Japan Union Hospital of Jilin University, No. 126, Xiantai Avenue, Changchun 130033, People’s Republic of ChinaTel +86 1 507 232 4782Fax +86 4 318 499 5852Email 534266311qq.com*These authors contributed equally to this workAbstract: Pancreatic cancer (PC) is one of the most common forms of malignant tumors and causes of tumor-related death worldwide. The current prognosis of PC still remains poor due to the lack of effective early detection method. Recently, there is strong support that circulating miRNAs can be used as biomarkers for early detection of various cancers, including PC. The purpose of this review is to provide an overview of previous published studies on circulating miRNAs in plasma/serum for early detection of PC and summarize their diagnostic value. PubMed, Embase and Web of Science were systematically searched for eligible studies on circulating miRNAs for PC detection. Overall, 29 studies published between 2009 and 2018 evaluating 51 individual miRNAs (no P-value exceeding 0.05) and 13 miRNAs panels were included. Generally, the diagnostic performance of circulating miRNAs for PC detection was strong, with both the sensitivity and specificity of 36% individual miRNAs and 40% miRNAs panels exceeding 80%. Moreover, two promising miRNA panels were discovered and verified externally with all AUC values exceeding 0.95. Therefore, circulating miRNAs may hold potential to be used as noninvasive diagnostic biomarkers for PC, but large-scale studies are still needed to validate the promising miRNAs and optimize the miRNA panels. Since, the tremendous heterogeneity of studies in this field hampers translating miRNA markers into clinical practice, miRNA analytical procedures are also needed to be standardized in the future.Keywords: pancreatic cancer, early detection, circulating microRNAs |
abstractGer |
Jinru Xue,1,* Erna Jia,2,* Na Ren,1 Andrew Lindsay,3,4 Haixin Yu1,51Department of Thoracic Surgery, China-Japan Union Hospital of Jilin University, Changchun, People’s Republic of China; 2Department of Gastroenterology, China-Japan Union Hospital of Jilin University, Changchun, People’s Republic of China; 3Major Cancer Biology, German Cancer Research Center, Heidelberg, Germany; 4Faculty of Biosciences, University of Heidelberg, Heidelberg, Germany; 5Medical Faculty Heidelberg, University of Heidelberg, Heidelberg, GermanyCorrespondence: Haixin YuDepartment of Thoracic Surgery, China-Japan Union Hospital of Jilin University, No. 126, Xiantai Avenue, Changchun 130033, People’s Republic of ChinaTel +86 1 507 232 4782Fax +86 4 318 499 5852Email 534266311qq.com*These authors contributed equally to this workAbstract: Pancreatic cancer (PC) is one of the most common forms of malignant tumors and causes of tumor-related death worldwide. The current prognosis of PC still remains poor due to the lack of effective early detection method. Recently, there is strong support that circulating miRNAs can be used as biomarkers for early detection of various cancers, including PC. The purpose of this review is to provide an overview of previous published studies on circulating miRNAs in plasma/serum for early detection of PC and summarize their diagnostic value. PubMed, Embase and Web of Science were systematically searched for eligible studies on circulating miRNAs for PC detection. Overall, 29 studies published between 2009 and 2018 evaluating 51 individual miRNAs (no P-value exceeding 0.05) and 13 miRNAs panels were included. Generally, the diagnostic performance of circulating miRNAs for PC detection was strong, with both the sensitivity and specificity of 36% individual miRNAs and 40% miRNAs panels exceeding 80%. Moreover, two promising miRNA panels were discovered and verified externally with all AUC values exceeding 0.95. Therefore, circulating miRNAs may hold potential to be used as noninvasive diagnostic biomarkers for PC, but large-scale studies are still needed to validate the promising miRNAs and optimize the miRNA panels. Since, the tremendous heterogeneity of studies in this field hampers translating miRNA markers into clinical practice, miRNA analytical procedures are also needed to be standardized in the future.Keywords: pancreatic cancer, early detection, circulating microRNAs |
abstract_unstemmed |
Jinru Xue,1,* Erna Jia,2,* Na Ren,1 Andrew Lindsay,3,4 Haixin Yu1,51Department of Thoracic Surgery, China-Japan Union Hospital of Jilin University, Changchun, People’s Republic of China; 2Department of Gastroenterology, China-Japan Union Hospital of Jilin University, Changchun, People’s Republic of China; 3Major Cancer Biology, German Cancer Research Center, Heidelberg, Germany; 4Faculty of Biosciences, University of Heidelberg, Heidelberg, Germany; 5Medical Faculty Heidelberg, University of Heidelberg, Heidelberg, GermanyCorrespondence: Haixin YuDepartment of Thoracic Surgery, China-Japan Union Hospital of Jilin University, No. 126, Xiantai Avenue, Changchun 130033, People’s Republic of ChinaTel +86 1 507 232 4782Fax +86 4 318 499 5852Email 534266311qq.com*These authors contributed equally to this workAbstract: Pancreatic cancer (PC) is one of the most common forms of malignant tumors and causes of tumor-related death worldwide. The current prognosis of PC still remains poor due to the lack of effective early detection method. Recently, there is strong support that circulating miRNAs can be used as biomarkers for early detection of various cancers, including PC. The purpose of this review is to provide an overview of previous published studies on circulating miRNAs in plasma/serum for early detection of PC and summarize their diagnostic value. PubMed, Embase and Web of Science were systematically searched for eligible studies on circulating miRNAs for PC detection. Overall, 29 studies published between 2009 and 2018 evaluating 51 individual miRNAs (no P-value exceeding 0.05) and 13 miRNAs panels were included. Generally, the diagnostic performance of circulating miRNAs for PC detection was strong, with both the sensitivity and specificity of 36% individual miRNAs and 40% miRNAs panels exceeding 80%. Moreover, two promising miRNA panels were discovered and verified externally with all AUC values exceeding 0.95. Therefore, circulating miRNAs may hold potential to be used as noninvasive diagnostic biomarkers for PC, but large-scale studies are still needed to validate the promising miRNAs and optimize the miRNA panels. Since, the tremendous heterogeneity of studies in this field hampers translating miRNA markers into clinical practice, miRNA analytical procedures are also needed to be standardized in the future.Keywords: pancreatic cancer, early detection, circulating microRNAs |
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