An Efficient Synthesis of Novel Dispirooxindole Derivatives via One-Pot Three-Component 1,3-Dipolar Cycloaddition Reactions

A series of novel dispirooxindoles have been synthesized through three-component 1,3-dipolar cycloaddition of azomethine ylides generated in situ by the decarboxylative condensation of isatin and an α-amino acid with the dipolarophile 5-benzylidene-1,3-dimethylpyrimidine-2,4,6-trione. This method ha...
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Autor*in:	Yucheng Wang [verfasserIn] Juxian Wang [verfasserIn] Hongtao Liu [verfasserIn] Huiyuan Wang [verfasserIn] Wei Lin [verfasserIn] Lexing Xu [verfasserIn] Zhibin Huang [verfasserIn] Gang Chen [verfasserIn] Qian Zhao [verfasserIn] Daqing Shi [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2012

Schlagwörter:	dispirooxindole three-component reaction 1,3-dipolar cycloaddition azomethine ylide

Übergeordnetes Werk:	In: Molecules - MDPI AG, 2003, 17(2012), 11, Seite 12704-12717
Übergeordnetes Werk:	volume:17 ; year:2012 ; number:11 ; pages:12704-12717

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/molecules171112704

Katalog-ID:	DOAJ020057822

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520			\|a A series of novel dispirooxindoles have been synthesized through three-component 1,3-dipolar cycloaddition of azomethine ylides generated in situ by the decarboxylative condensation of isatin and an α-amino acid with the dipolarophile 5-benzylidene-1,3-dimethylpyrimidine-2,4,6-trione. This method has the advantages of mild reaction conditions, high atom economy, excellent yields, and high regio- and stereo-selectivity.
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allfields	10.3390/molecules171112704 doi (DE-627)DOAJ020057822 (DE-599)DOAJbc35ec9cd1e34d37a953d1aef05e1aff DE-627 ger DE-627 rakwb eng QD241-441 Yucheng Wang verfasserin aut An Efficient Synthesis of Novel Dispirooxindole Derivatives via One-Pot Three-Component 1,3-Dipolar Cycloaddition Reactions 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A series of novel dispirooxindoles have been synthesized through three-component 1,3-dipolar cycloaddition of azomethine ylides generated in situ by the decarboxylative condensation of isatin and an α-amino acid with the dipolarophile 5-benzylidene-1,3-dimethylpyrimidine-2,4,6-trione. This method has the advantages of mild reaction conditions, high atom economy, excellent yields, and high regio- and stereo-selectivity. dispirooxindole three-component reaction 1,3-dipolar cycloaddition azomethine ylide Organic chemistry Juxian Wang verfasserin aut Hongtao Liu verfasserin aut Huiyuan Wang verfasserin aut Wei Lin verfasserin aut Lexing Xu verfasserin aut Zhibin Huang verfasserin aut Gang Chen verfasserin aut Qian Zhao verfasserin aut Daqing Shi verfasserin aut In Molecules MDPI AG, 2003 17(2012), 11, Seite 12704-12717 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:17 year:2012 number:11 pages:12704-12717 https://doi.org/10.3390/molecules171112704 kostenfrei https://doaj.org/article/bc35ec9cd1e34d37a953d1aef05e1aff kostenfrei http://www.mdpi.com/1420-3049/17/11/12704 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2012 11 12704-12717
spelling	10.3390/molecules171112704 doi (DE-627)DOAJ020057822 (DE-599)DOAJbc35ec9cd1e34d37a953d1aef05e1aff DE-627 ger DE-627 rakwb eng QD241-441 Yucheng Wang verfasserin aut An Efficient Synthesis of Novel Dispirooxindole Derivatives via One-Pot Three-Component 1,3-Dipolar Cycloaddition Reactions 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A series of novel dispirooxindoles have been synthesized through three-component 1,3-dipolar cycloaddition of azomethine ylides generated in situ by the decarboxylative condensation of isatin and an α-amino acid with the dipolarophile 5-benzylidene-1,3-dimethylpyrimidine-2,4,6-trione. This method has the advantages of mild reaction conditions, high atom economy, excellent yields, and high regio- and stereo-selectivity. dispirooxindole three-component reaction 1,3-dipolar cycloaddition azomethine ylide Organic chemistry Juxian Wang verfasserin aut Hongtao Liu verfasserin aut Huiyuan Wang verfasserin aut Wei Lin verfasserin aut Lexing Xu verfasserin aut Zhibin Huang verfasserin aut Gang Chen verfasserin aut Qian Zhao verfasserin aut Daqing Shi verfasserin aut In Molecules MDPI AG, 2003 17(2012), 11, Seite 12704-12717 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:17 year:2012 number:11 pages:12704-12717 https://doi.org/10.3390/molecules171112704 kostenfrei https://doaj.org/article/bc35ec9cd1e34d37a953d1aef05e1aff kostenfrei http://www.mdpi.com/1420-3049/17/11/12704 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2012 11 12704-12717
allfields_unstemmed	10.3390/molecules171112704 doi (DE-627)DOAJ020057822 (DE-599)DOAJbc35ec9cd1e34d37a953d1aef05e1aff DE-627 ger DE-627 rakwb eng QD241-441 Yucheng Wang verfasserin aut An Efficient Synthesis of Novel Dispirooxindole Derivatives via One-Pot Three-Component 1,3-Dipolar Cycloaddition Reactions 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A series of novel dispirooxindoles have been synthesized through three-component 1,3-dipolar cycloaddition of azomethine ylides generated in situ by the decarboxylative condensation of isatin and an α-amino acid with the dipolarophile 5-benzylidene-1,3-dimethylpyrimidine-2,4,6-trione. This method has the advantages of mild reaction conditions, high atom economy, excellent yields, and high regio- and stereo-selectivity. dispirooxindole three-component reaction 1,3-dipolar cycloaddition azomethine ylide Organic chemistry Juxian Wang verfasserin aut Hongtao Liu verfasserin aut Huiyuan Wang verfasserin aut Wei Lin verfasserin aut Lexing Xu verfasserin aut Zhibin Huang verfasserin aut Gang Chen verfasserin aut Qian Zhao verfasserin aut Daqing Shi verfasserin aut In Molecules MDPI AG, 2003 17(2012), 11, Seite 12704-12717 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:17 year:2012 number:11 pages:12704-12717 https://doi.org/10.3390/molecules171112704 kostenfrei https://doaj.org/article/bc35ec9cd1e34d37a953d1aef05e1aff kostenfrei http://www.mdpi.com/1420-3049/17/11/12704 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2012 11 12704-12717
allfieldsGer	10.3390/molecules171112704 doi (DE-627)DOAJ020057822 (DE-599)DOAJbc35ec9cd1e34d37a953d1aef05e1aff DE-627 ger DE-627 rakwb eng QD241-441 Yucheng Wang verfasserin aut An Efficient Synthesis of Novel Dispirooxindole Derivatives via One-Pot Three-Component 1,3-Dipolar Cycloaddition Reactions 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A series of novel dispirooxindoles have been synthesized through three-component 1,3-dipolar cycloaddition of azomethine ylides generated in situ by the decarboxylative condensation of isatin and an α-amino acid with the dipolarophile 5-benzylidene-1,3-dimethylpyrimidine-2,4,6-trione. This method has the advantages of mild reaction conditions, high atom economy, excellent yields, and high regio- and stereo-selectivity. dispirooxindole three-component reaction 1,3-dipolar cycloaddition azomethine ylide Organic chemistry Juxian Wang verfasserin aut Hongtao Liu verfasserin aut Huiyuan Wang verfasserin aut Wei Lin verfasserin aut Lexing Xu verfasserin aut Zhibin Huang verfasserin aut Gang Chen verfasserin aut Qian Zhao verfasserin aut Daqing Shi verfasserin aut In Molecules MDPI AG, 2003 17(2012), 11, Seite 12704-12717 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:17 year:2012 number:11 pages:12704-12717 https://doi.org/10.3390/molecules171112704 kostenfrei https://doaj.org/article/bc35ec9cd1e34d37a953d1aef05e1aff kostenfrei http://www.mdpi.com/1420-3049/17/11/12704 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2012 11 12704-12717
allfieldsSound	10.3390/molecules171112704 doi (DE-627)DOAJ020057822 (DE-599)DOAJbc35ec9cd1e34d37a953d1aef05e1aff DE-627 ger DE-627 rakwb eng QD241-441 Yucheng Wang verfasserin aut An Efficient Synthesis of Novel Dispirooxindole Derivatives via One-Pot Three-Component 1,3-Dipolar Cycloaddition Reactions 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A series of novel dispirooxindoles have been synthesized through three-component 1,3-dipolar cycloaddition of azomethine ylides generated in situ by the decarboxylative condensation of isatin and an α-amino acid with the dipolarophile 5-benzylidene-1,3-dimethylpyrimidine-2,4,6-trione. This method has the advantages of mild reaction conditions, high atom economy, excellent yields, and high regio- and stereo-selectivity. dispirooxindole three-component reaction 1,3-dipolar cycloaddition azomethine ylide Organic chemistry Juxian Wang verfasserin aut Hongtao Liu verfasserin aut Huiyuan Wang verfasserin aut Wei Lin verfasserin aut Lexing Xu verfasserin aut Zhibin Huang verfasserin aut Gang Chen verfasserin aut Qian Zhao verfasserin aut Daqing Shi verfasserin aut In Molecules MDPI AG, 2003 17(2012), 11, Seite 12704-12717 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:17 year:2012 number:11 pages:12704-12717 https://doi.org/10.3390/molecules171112704 kostenfrei https://doaj.org/article/bc35ec9cd1e34d37a953d1aef05e1aff kostenfrei http://www.mdpi.com/1420-3049/17/11/12704 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2012 11 12704-12717
language	English
source	In Molecules 17(2012), 11, Seite 12704-12717 volume:17 year:2012 number:11 pages:12704-12717
sourceStr	In Molecules 17(2012), 11, Seite 12704-12717 volume:17 year:2012 number:11 pages:12704-12717
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	dispirooxindole three-component reaction 1,3-dipolar cycloaddition azomethine ylide Organic chemistry
isfreeaccess_bool	true
container_title	Molecules
authorswithroles_txt_mv	Yucheng Wang @@aut@@ Juxian Wang @@aut@@ Hongtao Liu @@aut@@ Huiyuan Wang @@aut@@ Wei Lin @@aut@@ Lexing Xu @@aut@@ Zhibin Huang @@aut@@ Gang Chen @@aut@@ Qian Zhao @@aut@@ Daqing Shi @@aut@@
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callnumber-first	Q - Science
author	Yucheng Wang
spellingShingle	Yucheng Wang misc QD241-441 misc dispirooxindole misc three-component reaction misc 1,3-dipolar cycloaddition misc azomethine ylide misc Organic chemistry An Efficient Synthesis of Novel Dispirooxindole Derivatives via One-Pot Three-Component 1,3-Dipolar Cycloaddition Reactions
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topic_title	QD241-441 An Efficient Synthesis of Novel Dispirooxindole Derivatives via One-Pot Three-Component 1,3-Dipolar Cycloaddition Reactions dispirooxindole three-component reaction 1,3-dipolar cycloaddition azomethine ylide
topic	misc QD241-441 misc dispirooxindole misc three-component reaction misc 1,3-dipolar cycloaddition misc azomethine ylide misc Organic chemistry
topic_unstemmed	misc QD241-441 misc dispirooxindole misc three-component reaction misc 1,3-dipolar cycloaddition misc azomethine ylide misc Organic chemistry
topic_browse	misc QD241-441 misc dispirooxindole misc three-component reaction misc 1,3-dipolar cycloaddition misc azomethine ylide misc Organic chemistry
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title	An Efficient Synthesis of Novel Dispirooxindole Derivatives via One-Pot Three-Component 1,3-Dipolar Cycloaddition Reactions
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title_full	An Efficient Synthesis of Novel Dispirooxindole Derivatives via One-Pot Three-Component 1,3-Dipolar Cycloaddition Reactions
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journal	Molecules
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author_browse	Yucheng Wang Juxian Wang Hongtao Liu Huiyuan Wang Wei Lin Lexing Xu Zhibin Huang Gang Chen Qian Zhao Daqing Shi
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title_sort	efficient synthesis of novel dispirooxindole derivatives via one-pot three-component 1,3-dipolar cycloaddition reactions
callnumber	QD241-441
title_auth	An Efficient Synthesis of Novel Dispirooxindole Derivatives via One-Pot Three-Component 1,3-Dipolar Cycloaddition Reactions
abstract	A series of novel dispirooxindoles have been synthesized through three-component 1,3-dipolar cycloaddition of azomethine ylides generated in situ by the decarboxylative condensation of isatin and an α-amino acid with the dipolarophile 5-benzylidene-1,3-dimethylpyrimidine-2,4,6-trione. This method has the advantages of mild reaction conditions, high atom economy, excellent yields, and high regio- and stereo-selectivity.
abstractGer	A series of novel dispirooxindoles have been synthesized through three-component 1,3-dipolar cycloaddition of azomethine ylides generated in situ by the decarboxylative condensation of isatin and an α-amino acid with the dipolarophile 5-benzylidene-1,3-dimethylpyrimidine-2,4,6-trione. This method has the advantages of mild reaction conditions, high atom economy, excellent yields, and high regio- and stereo-selectivity.
abstract_unstemmed	A series of novel dispirooxindoles have been synthesized through three-component 1,3-dipolar cycloaddition of azomethine ylides generated in situ by the decarboxylative condensation of isatin and an α-amino acid with the dipolarophile 5-benzylidene-1,3-dimethylpyrimidine-2,4,6-trione. This method has the advantages of mild reaction conditions, high atom economy, excellent yields, and high regio- and stereo-selectivity.
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container_issue	11
title_short	An Efficient Synthesis of Novel Dispirooxindole Derivatives via One-Pot Three-Component 1,3-Dipolar Cycloaddition Reactions
url	https://doi.org/10.3390/molecules171112704 https://doaj.org/article/bc35ec9cd1e34d37a953d1aef05e1aff http://www.mdpi.com/1420-3049/17/11/12704 https://doaj.org/toc/1420-3049
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author2	Juxian Wang Hongtao Liu Huiyuan Wang Wei Lin Lexing Xu Zhibin Huang Gang Chen Qian Zhao Daqing Shi
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up_date	2024-07-04T01:56:38.165Z
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