Differentiation, functions, and roles of T follicular regulatory cells in autoimmune diseases

Abstract T follicular helper cells participate in stimulating germinal center (GC) formation and supporting B cell differentiation and autoantibody production. However, T follicular regulatory (Tfr) cells suppress B cell activation. Since changes in the number and functions of Tfr cells lead to dysr...
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Autor*in:	He Hao [verfasserIn] Shingo Nakayamada [verfasserIn] Yoshiya Tanaka [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	T follicular regulatory cells Differentiation T follicular helper cells Therapeutic targets Autoimmune diseases

Übergeordnetes Werk:	In: Inflammation and Regeneration - BMC, 2016, 41(2021), 1, Seite 8
Übergeordnetes Werk:	volume:41 ; year:2021 ; number:1 ; pages:8

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s41232-021-00164-9

Katalog-ID:	DOAJ020092857

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520			\|a Abstract T follicular helper cells participate in stimulating germinal center (GC) formation and supporting B cell differentiation and autoantibody production. However, T follicular regulatory (Tfr) cells suppress B cell activation. Since changes in the number and functions of Tfr cells lead to dysregulated GC reaction and autoantibody response, targeting Tfr cells may benefit the treatment of autoimmune diseases. Differentiation of Tfr cells is a multistage and multifactorial process with various positive and negative regulators. Therefore, understanding the signals regulating Tfr cell generation is crucial for the development of targeted therapies. In this review, we discuss recent studies that have elucidated the roles of Tfr cells in autoimmune diseases and investigated the modulators of Tfr cell differentiation. Additionally, potential immunotherapies targeting Tfr cells are highlighted.
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spelling	10.1186/s41232-021-00164-9 doi (DE-627)DOAJ020092857 (DE-599)DOAJ83e87aa4f2a142d69d34751a2c332075 DE-627 ger DE-627 rakwb eng RB1-214 He Hao verfasserin aut Differentiation, functions, and roles of T follicular regulatory cells in autoimmune diseases 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract T follicular helper cells participate in stimulating germinal center (GC) formation and supporting B cell differentiation and autoantibody production. However, T follicular regulatory (Tfr) cells suppress B cell activation. Since changes in the number and functions of Tfr cells lead to dysregulated GC reaction and autoantibody response, targeting Tfr cells may benefit the treatment of autoimmune diseases. Differentiation of Tfr cells is a multistage and multifactorial process with various positive and negative regulators. Therefore, understanding the signals regulating Tfr cell generation is crucial for the development of targeted therapies. In this review, we discuss recent studies that have elucidated the roles of Tfr cells in autoimmune diseases and investigated the modulators of Tfr cell differentiation. Additionally, potential immunotherapies targeting Tfr cells are highlighted. T follicular regulatory cells Differentiation T follicular helper cells Therapeutic targets Autoimmune diseases Pathology Shingo Nakayamada verfasserin aut Yoshiya Tanaka verfasserin aut In Inflammation and Regeneration BMC, 2016 41(2021), 1, Seite 8 (DE-627)559080913 (DE-600)2411877-1 18808190 nnns volume:41 year:2021 number:1 pages:8 https://doi.org/10.1186/s41232-021-00164-9 kostenfrei https://doaj.org/article/83e87aa4f2a142d69d34751a2c332075 kostenfrei https://doi.org/10.1186/s41232-021-00164-9 kostenfrei https://doaj.org/toc/1880-8190 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 41 2021 1 8
allfields_unstemmed	10.1186/s41232-021-00164-9 doi (DE-627)DOAJ020092857 (DE-599)DOAJ83e87aa4f2a142d69d34751a2c332075 DE-627 ger DE-627 rakwb eng RB1-214 He Hao verfasserin aut Differentiation, functions, and roles of T follicular regulatory cells in autoimmune diseases 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract T follicular helper cells participate in stimulating germinal center (GC) formation and supporting B cell differentiation and autoantibody production. However, T follicular regulatory (Tfr) cells suppress B cell activation. Since changes in the number and functions of Tfr cells lead to dysregulated GC reaction and autoantibody response, targeting Tfr cells may benefit the treatment of autoimmune diseases. Differentiation of Tfr cells is a multistage and multifactorial process with various positive and negative regulators. Therefore, understanding the signals regulating Tfr cell generation is crucial for the development of targeted therapies. In this review, we discuss recent studies that have elucidated the roles of Tfr cells in autoimmune diseases and investigated the modulators of Tfr cell differentiation. Additionally, potential immunotherapies targeting Tfr cells are highlighted. T follicular regulatory cells Differentiation T follicular helper cells Therapeutic targets Autoimmune diseases Pathology Shingo Nakayamada verfasserin aut Yoshiya Tanaka verfasserin aut In Inflammation and Regeneration BMC, 2016 41(2021), 1, Seite 8 (DE-627)559080913 (DE-600)2411877-1 18808190 nnns volume:41 year:2021 number:1 pages:8 https://doi.org/10.1186/s41232-021-00164-9 kostenfrei https://doaj.org/article/83e87aa4f2a142d69d34751a2c332075 kostenfrei https://doi.org/10.1186/s41232-021-00164-9 kostenfrei https://doaj.org/toc/1880-8190 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 41 2021 1 8
allfieldsGer	10.1186/s41232-021-00164-9 doi (DE-627)DOAJ020092857 (DE-599)DOAJ83e87aa4f2a142d69d34751a2c332075 DE-627 ger DE-627 rakwb eng RB1-214 He Hao verfasserin aut Differentiation, functions, and roles of T follicular regulatory cells in autoimmune diseases 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract T follicular helper cells participate in stimulating germinal center (GC) formation and supporting B cell differentiation and autoantibody production. However, T follicular regulatory (Tfr) cells suppress B cell activation. Since changes in the number and functions of Tfr cells lead to dysregulated GC reaction and autoantibody response, targeting Tfr cells may benefit the treatment of autoimmune diseases. Differentiation of Tfr cells is a multistage and multifactorial process with various positive and negative regulators. Therefore, understanding the signals regulating Tfr cell generation is crucial for the development of targeted therapies. In this review, we discuss recent studies that have elucidated the roles of Tfr cells in autoimmune diseases and investigated the modulators of Tfr cell differentiation. Additionally, potential immunotherapies targeting Tfr cells are highlighted. T follicular regulatory cells Differentiation T follicular helper cells Therapeutic targets Autoimmune diseases Pathology Shingo Nakayamada verfasserin aut Yoshiya Tanaka verfasserin aut In Inflammation and Regeneration BMC, 2016 41(2021), 1, Seite 8 (DE-627)559080913 (DE-600)2411877-1 18808190 nnns volume:41 year:2021 number:1 pages:8 https://doi.org/10.1186/s41232-021-00164-9 kostenfrei https://doaj.org/article/83e87aa4f2a142d69d34751a2c332075 kostenfrei https://doi.org/10.1186/s41232-021-00164-9 kostenfrei https://doaj.org/toc/1880-8190 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 41 2021 1 8
allfieldsSound	10.1186/s41232-021-00164-9 doi (DE-627)DOAJ020092857 (DE-599)DOAJ83e87aa4f2a142d69d34751a2c332075 DE-627 ger DE-627 rakwb eng RB1-214 He Hao verfasserin aut Differentiation, functions, and roles of T follicular regulatory cells in autoimmune diseases 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract T follicular helper cells participate in stimulating germinal center (GC) formation and supporting B cell differentiation and autoantibody production. However, T follicular regulatory (Tfr) cells suppress B cell activation. Since changes in the number and functions of Tfr cells lead to dysregulated GC reaction and autoantibody response, targeting Tfr cells may benefit the treatment of autoimmune diseases. Differentiation of Tfr cells is a multistage and multifactorial process with various positive and negative regulators. Therefore, understanding the signals regulating Tfr cell generation is crucial for the development of targeted therapies. In this review, we discuss recent studies that have elucidated the roles of Tfr cells in autoimmune diseases and investigated the modulators of Tfr cell differentiation. Additionally, potential immunotherapies targeting Tfr cells are highlighted. T follicular regulatory cells Differentiation T follicular helper cells Therapeutic targets Autoimmune diseases Pathology Shingo Nakayamada verfasserin aut Yoshiya Tanaka verfasserin aut In Inflammation and Regeneration BMC, 2016 41(2021), 1, Seite 8 (DE-627)559080913 (DE-600)2411877-1 18808190 nnns volume:41 year:2021 number:1 pages:8 https://doi.org/10.1186/s41232-021-00164-9 kostenfrei https://doaj.org/article/83e87aa4f2a142d69d34751a2c332075 kostenfrei https://doi.org/10.1186/s41232-021-00164-9 kostenfrei https://doaj.org/toc/1880-8190 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 41 2021 1 8
language	English
source	In Inflammation and Regeneration 41(2021), 1, Seite 8 volume:41 year:2021 number:1 pages:8
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topic_facet	T follicular regulatory cells Differentiation T follicular helper cells Therapeutic targets Autoimmune diseases Pathology
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author	He Hao
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topic_title	RB1-214 Differentiation, functions, and roles of T follicular regulatory cells in autoimmune diseases T follicular regulatory cells Differentiation T follicular helper cells Therapeutic targets Autoimmune diseases
topic	misc RB1-214 misc T follicular regulatory cells misc Differentiation misc T follicular helper cells misc Therapeutic targets misc Autoimmune diseases misc Pathology
topic_unstemmed	misc RB1-214 misc T follicular regulatory cells misc Differentiation misc T follicular helper cells misc Therapeutic targets misc Autoimmune diseases misc Pathology
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title	Differentiation, functions, and roles of T follicular regulatory cells in autoimmune diseases
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title_sort	differentiation, functions, and roles of t follicular regulatory cells in autoimmune diseases
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title_auth	Differentiation, functions, and roles of T follicular regulatory cells in autoimmune diseases
abstract	Abstract T follicular helper cells participate in stimulating germinal center (GC) formation and supporting B cell differentiation and autoantibody production. However, T follicular regulatory (Tfr) cells suppress B cell activation. Since changes in the number and functions of Tfr cells lead to dysregulated GC reaction and autoantibody response, targeting Tfr cells may benefit the treatment of autoimmune diseases. Differentiation of Tfr cells is a multistage and multifactorial process with various positive and negative regulators. Therefore, understanding the signals regulating Tfr cell generation is crucial for the development of targeted therapies. In this review, we discuss recent studies that have elucidated the roles of Tfr cells in autoimmune diseases and investigated the modulators of Tfr cell differentiation. Additionally, potential immunotherapies targeting Tfr cells are highlighted.
abstractGer	Abstract T follicular helper cells participate in stimulating germinal center (GC) formation and supporting B cell differentiation and autoantibody production. However, T follicular regulatory (Tfr) cells suppress B cell activation. Since changes in the number and functions of Tfr cells lead to dysregulated GC reaction and autoantibody response, targeting Tfr cells may benefit the treatment of autoimmune diseases. Differentiation of Tfr cells is a multistage and multifactorial process with various positive and negative regulators. Therefore, understanding the signals regulating Tfr cell generation is crucial for the development of targeted therapies. In this review, we discuss recent studies that have elucidated the roles of Tfr cells in autoimmune diseases and investigated the modulators of Tfr cell differentiation. Additionally, potential immunotherapies targeting Tfr cells are highlighted.
abstract_unstemmed	Abstract T follicular helper cells participate in stimulating germinal center (GC) formation and supporting B cell differentiation and autoantibody production. However, T follicular regulatory (Tfr) cells suppress B cell activation. Since changes in the number and functions of Tfr cells lead to dysregulated GC reaction and autoantibody response, targeting Tfr cells may benefit the treatment of autoimmune diseases. Differentiation of Tfr cells is a multistage and multifactorial process with various positive and negative regulators. Therefore, understanding the signals regulating Tfr cell generation is crucial for the development of targeted therapies. In this review, we discuss recent studies that have elucidated the roles of Tfr cells in autoimmune diseases and investigated the modulators of Tfr cell differentiation. Additionally, potential immunotherapies targeting Tfr cells are highlighted.
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title_short	Differentiation, functions, and roles of T follicular regulatory cells in autoimmune diseases
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