Circadian Oscillations in the Murine Preoptic Area Are Reset by Temperature, but Not Light

Mammals maintain their internal body temperature within a physiologically optimal range. This involves the regulation of core body temperature in response to changing environmental temperatures and a natural circadian oscillation of internal temperatures. The preoptic area (POA) of the hypothalamus...
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Autor*in:	Nicolás M. Díaz [verfasserIn] Shannon A. Gordon [verfasserIn] Richard A. Lang [verfasserIn] Ethan D. Buhr [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	preoptic area circadian rhythm Opn5 neuropsin temperature

Übergeordnetes Werk:	In: Frontiers in Physiology - Frontiers Media S.A., 2011, 13(2022)
Übergeordnetes Werk:	volume:13 ; year:2022

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fphys.2022.934591

Katalog-ID:	DOAJ020150873

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callnumber-first	Q - Science
author	Nicolás M. Díaz
spellingShingle	Nicolás M. Díaz misc QP1-981 misc preoptic area misc circadian rhythm misc Opn5 misc neuropsin misc temperature misc Physiology Circadian Oscillations in the Murine Preoptic Area Are Reset by Temperature, but Not Light
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topic_title	QP1-981 Circadian Oscillations in the Murine Preoptic Area Are Reset by Temperature, but Not Light preoptic area circadian rhythm Opn5 neuropsin temperature
topic	misc QP1-981 misc preoptic area misc circadian rhythm misc Opn5 misc neuropsin misc temperature misc Physiology
topic_unstemmed	misc QP1-981 misc preoptic area misc circadian rhythm misc Opn5 misc neuropsin misc temperature misc Physiology
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title	Circadian Oscillations in the Murine Preoptic Area Are Reset by Temperature, but Not Light
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title_full	Circadian Oscillations in the Murine Preoptic Area Are Reset by Temperature, but Not Light
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author_browse	Nicolás M. Díaz Shannon A. Gordon Richard A. Lang Ethan D. Buhr
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title_sort	circadian oscillations in the murine preoptic area are reset by temperature, but not light
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title_auth	Circadian Oscillations in the Murine Preoptic Area Are Reset by Temperature, but Not Light
abstract	Mammals maintain their internal body temperature within a physiologically optimal range. This involves the regulation of core body temperature in response to changing environmental temperatures and a natural circadian oscillation of internal temperatures. The preoptic area (POA) of the hypothalamus coordinates body temperature by responding to both external temperature cues and internal brain temperature. Here we describe an autonomous circadian clock system in the murine ventromedial POA (VMPO) in close proximity to cells which express the atypical violet-light sensitive opsin, Opn5. We analyzed the light-sensitivity and thermal-sensitivity of the VMPO circadian clocks ex vivo. The phase of the VMPO circadian oscillations was not influenced by light. However, the VMPO clocks were reset by temperature changes within the physiological internal temperature range. This thermal-sensitivity of the VMPO circadian clock did not require functional Opn5 expression or a functional circadian clock within the Opn5-expressing cells. The presence of temperature-sensitive circadian clocks in the VMPO provides an advancement in the understanding of mechanisms involved in the dynamic regulation of core body temperature.
abstractGer	Mammals maintain their internal body temperature within a physiologically optimal range. This involves the regulation of core body temperature in response to changing environmental temperatures and a natural circadian oscillation of internal temperatures. The preoptic area (POA) of the hypothalamus coordinates body temperature by responding to both external temperature cues and internal brain temperature. Here we describe an autonomous circadian clock system in the murine ventromedial POA (VMPO) in close proximity to cells which express the atypical violet-light sensitive opsin, Opn5. We analyzed the light-sensitivity and thermal-sensitivity of the VMPO circadian clocks ex vivo. The phase of the VMPO circadian oscillations was not influenced by light. However, the VMPO clocks were reset by temperature changes within the physiological internal temperature range. This thermal-sensitivity of the VMPO circadian clock did not require functional Opn5 expression or a functional circadian clock within the Opn5-expressing cells. The presence of temperature-sensitive circadian clocks in the VMPO provides an advancement in the understanding of mechanisms involved in the dynamic regulation of core body temperature.
abstract_unstemmed	Mammals maintain their internal body temperature within a physiologically optimal range. This involves the regulation of core body temperature in response to changing environmental temperatures and a natural circadian oscillation of internal temperatures. The preoptic area (POA) of the hypothalamus coordinates body temperature by responding to both external temperature cues and internal brain temperature. Here we describe an autonomous circadian clock system in the murine ventromedial POA (VMPO) in close proximity to cells which express the atypical violet-light sensitive opsin, Opn5. We analyzed the light-sensitivity and thermal-sensitivity of the VMPO circadian clocks ex vivo. The phase of the VMPO circadian oscillations was not influenced by light. However, the VMPO clocks were reset by temperature changes within the physiological internal temperature range. This thermal-sensitivity of the VMPO circadian clock did not require functional Opn5 expression or a functional circadian clock within the Opn5-expressing cells. The presence of temperature-sensitive circadian clocks in the VMPO provides an advancement in the understanding of mechanisms involved in the dynamic regulation of core body temperature.
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title_short	Circadian Oscillations in the Murine Preoptic Area Are Reset by Temperature, but Not Light
url	https://doi.org/10.3389/fphys.2022.934591 https://doaj.org/article/a10c255f1b0b460c8d713cba72631655 https://www.frontiersin.org/articles/10.3389/fphys.2022.934591/full https://doaj.org/toc/1664-042X
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Circadian Oscillations in the Murine Preoptic Area Are Reset by Temperature, but Not Light

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