A mathematical model of chromosome recombination-induced drug resistance in cancer therapy

Cytotoxic chemotherapeutics are common treatment methods of many cancers, and patients are often dosed at maximum tolerated dose (MTD), which is trying to eliminate cancer cells as much as possible. However, highly doses chemotherapy may induce unexpected gene mutations or DNA recombinations, which...
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Autor*in:	Hongli Yang [verfasserIn] Jinzhi Lei [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	delay differential equation genomic disorder non-clonal chromosome aberrations chemotherapy drug resistance

Übergeordnetes Werk:	In: Mathematical Biosciences and Engineering - AIMS Press, 2020, 16(2019), 6, Seite 7098-7111
Übergeordnetes Werk:	volume:16 ; year:2019 ; number:6 ; pages:7098-7111

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3934/mbe.2019356

Katalog-ID:	DOAJ020151985

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callnumber-first	T - Technology
author	Hongli Yang
spellingShingle	Hongli Yang misc TP248.13-248.65 misc QA1-939 misc delay differential equation misc genomic disorder misc non-clonal chromosome aberrations misc chemotherapy misc drug resistance misc Biotechnology misc Mathematics A mathematical model of chromosome recombination-induced drug resistance in cancer therapy
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topic_title	TP248.13-248.65 QA1-939 A mathematical model of chromosome recombination-induced drug resistance in cancer therapy delay differential equation genomic disorder non-clonal chromosome aberrations chemotherapy drug resistance
topic	misc TP248.13-248.65 misc QA1-939 misc delay differential equation misc genomic disorder misc non-clonal chromosome aberrations misc chemotherapy misc drug resistance misc Biotechnology misc Mathematics
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title	A mathematical model of chromosome recombination-induced drug resistance in cancer therapy
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title_sort	mathematical model of chromosome recombination-induced drug resistance in cancer therapy
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title_auth	A mathematical model of chromosome recombination-induced drug resistance in cancer therapy
abstract	Cytotoxic chemotherapeutics are common treatment methods of many cancers, and patients are often dosed at maximum tolerated dose (MTD), which is trying to eliminate cancer cells as much as possible. However, highly doses chemotherapy may induce unexpected gene mutations or DNA recombinations, which in turn result in unpredictable outcomes and drug resistance. In this study, we focus on the occurrence of DNA recombinations, and present a mathematical model for the influence of genomic disorder due to chemotherapy, and investigate how it may lead to drug resistance. We show that there is an optimal dose so that the tumor cells number is minimum at the steady state, which suggests the existence of an optimal dose of chemotherapy below the MTD. Model simulations show that when the dose is either low or high, the tumor cancer cells number may maintain a higher level steady state, or even sustained oscillations when the dose is too high, which are clinically inappropriate. Our results provide a theoretical study on the dose control of chemotherapy in cancer therapy.
abstractGer	Cytotoxic chemotherapeutics are common treatment methods of many cancers, and patients are often dosed at maximum tolerated dose (MTD), which is trying to eliminate cancer cells as much as possible. However, highly doses chemotherapy may induce unexpected gene mutations or DNA recombinations, which in turn result in unpredictable outcomes and drug resistance. In this study, we focus on the occurrence of DNA recombinations, and present a mathematical model for the influence of genomic disorder due to chemotherapy, and investigate how it may lead to drug resistance. We show that there is an optimal dose so that the tumor cells number is minimum at the steady state, which suggests the existence of an optimal dose of chemotherapy below the MTD. Model simulations show that when the dose is either low or high, the tumor cancer cells number may maintain a higher level steady state, or even sustained oscillations when the dose is too high, which are clinically inappropriate. Our results provide a theoretical study on the dose control of chemotherapy in cancer therapy.
abstract_unstemmed	Cytotoxic chemotherapeutics are common treatment methods of many cancers, and patients are often dosed at maximum tolerated dose (MTD), which is trying to eliminate cancer cells as much as possible. However, highly doses chemotherapy may induce unexpected gene mutations or DNA recombinations, which in turn result in unpredictable outcomes and drug resistance. In this study, we focus on the occurrence of DNA recombinations, and present a mathematical model for the influence of genomic disorder due to chemotherapy, and investigate how it may lead to drug resistance. We show that there is an optimal dose so that the tumor cells number is minimum at the steady state, which suggests the existence of an optimal dose of chemotherapy below the MTD. Model simulations show that when the dose is either low or high, the tumor cancer cells number may maintain a higher level steady state, or even sustained oscillations when the dose is too high, which are clinically inappropriate. Our results provide a theoretical study on the dose control of chemotherapy in cancer therapy.
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title_short	A mathematical model of chromosome recombination-induced drug resistance in cancer therapy
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A mathematical model of chromosome recombination-induced drug resistance in cancer therapy

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