SARS-CoV2 Infection During Pregnancy Causes Persistent Immune Abnormalities in Women Without Affecting the Newborns
SARS-CoV2 infection in pregnancy and exposed newborns is poorly known. We performed a longitudinal analysis of immune system and determined soluble cytokine levels in pregnant women infected with SARS-CoV2 and in their newborns. Women with confirmed SARS-CoV2 infection and their exposed uninfected n...
Ausführliche Beschreibung
Autor*in: |
Elena Vazquez-Alejo [verfasserIn] Laura Tarancon-Diez [verfasserIn] Itzíar Carrasco [verfasserIn] Sara Vigil-Vázquez [verfasserIn] Mar Muñoz-Chapuli [verfasserIn] Elena Rincón-López [verfasserIn] Jesús Saavedra-Lozano [verfasserIn] Mar Santos-Sebastián [verfasserIn] David Aguilera-Alonso [verfasserIn] Alicia Hernanz-Lobo [verfasserIn] Begoña Santiago-García [verfasserIn] Juan Antonio de León-Luis [verfasserIn] Patricia Muñoz [verfasserIn] Manuel Sánchez-Luna [verfasserIn] María Luisa Navarro [verfasserIn] Mª Ángeles Muñoz-Fernández [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2022 |
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Schlagwörter: |
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Übergeordnetes Werk: |
In: Frontiers in Immunology - Frontiers Media S.A., 2011, 13(2022) |
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Übergeordnetes Werk: |
volume:13 ; year:2022 |
Links: |
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DOI / URN: |
10.3389/fimmu.2022.947549 |
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Katalog-ID: |
DOAJ020234759 |
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10.3389/fimmu.2022.947549 doi (DE-627)DOAJ020234759 (DE-599)DOAJ660b57f9f1c046e58310142aafd64e2f DE-627 ger DE-627 rakwb eng RC581-607 Elena Vazquez-Alejo verfasserin aut SARS-CoV2 Infection During Pregnancy Causes Persistent Immune Abnormalities in Women Without Affecting the Newborns 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier SARS-CoV2 infection in pregnancy and exposed newborns is poorly known. We performed a longitudinal analysis of immune system and determined soluble cytokine levels in pregnant women infected with SARS-CoV2 and in their newborns. Women with confirmed SARS-CoV2 infection and their exposed uninfected newborns were recruited from Hospital General Universitario Gregorio Marañón. Peripheral blood mononuclear cells (PBMCs), cord cells and plasma were collected at birth and 6 months later. Immunophenotyping of natural killer (NK), monocytes and CD4/CD8 T-cells were studied in cryopreserved PBMCs and cord cells by multiparametric flow cytometry. Up to 4 soluble pro/anti-inflammatory cytokines were assessed in plasma/cord plasma by ELISA assay. SARS-CoV2-infected mothers and their newborns were compared to matched healthy non-SARS-CoV2-infected mothers and their newborns. The TNFα and IL-10 levels of infected mothers were higher at baseline than those of healthy controls. Infected mothers showed increased NK cells activation and reduced expression of maturation markers that reverted after 6 months. They also had high levels of Central Memory and low Effector Memory CD4-T cell subsets. Additionally, the increased CD4- and CD8-T cell activation (CD154 and CD38) and exhaustion (TIM3/TIGIT) levels at baseline compared to controls remained elevated after 6 months. Regarding Treg cells, the levels were lower at infected mothers at baseline but reverted after 6 months. No newborn was infected at birth. The lower levels of monocytes, NK and CD4-T cells observed at SARS-CoV2-exposed newborns compared to unexposed controls significantly increased 6 months later. In conclusion, SARS-CoV2 infection during pregnancy shows differences in immunological components that could lead newborns to future clinical implications after birth. However, SARS-CoV2 exposed 6-months-old newborns showed no immune misbalance, whereas the infected mothers maintain increased activation and exhaustion levels in T-cells after 6 months. SARS-CoV2 pregnancy SARS-CoV2 exposed newborns immune system longitudinal analysis Immunologic diseases. Allergy Laura Tarancon-Diez verfasserin aut Itzíar Carrasco verfasserin aut Itzíar Carrasco verfasserin aut Sara Vigil-Vázquez verfasserin aut Mar Muñoz-Chapuli verfasserin aut Elena Rincón-López verfasserin aut Elena Rincón-López verfasserin aut Elena Rincón-López verfasserin aut Jesús Saavedra-Lozano verfasserin aut Jesús Saavedra-Lozano verfasserin aut Jesús Saavedra-Lozano verfasserin aut Jesús Saavedra-Lozano verfasserin aut Mar Santos-Sebastián verfasserin aut Mar Santos-Sebastián verfasserin aut Mar Santos-Sebastián verfasserin aut David Aguilera-Alonso verfasserin aut David Aguilera-Alonso verfasserin aut David Aguilera-Alonso verfasserin aut Alicia Hernanz-Lobo verfasserin aut Alicia Hernanz-Lobo verfasserin aut Alicia Hernanz-Lobo verfasserin aut Begoña Santiago-García verfasserin aut Begoña Santiago-García verfasserin aut Begoña Santiago-García verfasserin aut Juan Antonio de León-Luis verfasserin aut Juan Antonio de León-Luis verfasserin aut Patricia Muñoz verfasserin aut Manuel Sánchez-Luna verfasserin aut Manuel Sánchez-Luna verfasserin aut María Luisa Navarro verfasserin aut María Luisa Navarro verfasserin aut María Luisa Navarro verfasserin aut María Luisa Navarro verfasserin aut Mª Ángeles Muñoz-Fernández verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 13(2022) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:13 year:2022 https://doi.org/10.3389/fimmu.2022.947549 kostenfrei https://doaj.org/article/660b57f9f1c046e58310142aafd64e2f kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2022.947549/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022 |
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10.3389/fimmu.2022.947549 doi (DE-627)DOAJ020234759 (DE-599)DOAJ660b57f9f1c046e58310142aafd64e2f DE-627 ger DE-627 rakwb eng RC581-607 Elena Vazquez-Alejo verfasserin aut SARS-CoV2 Infection During Pregnancy Causes Persistent Immune Abnormalities in Women Without Affecting the Newborns 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier SARS-CoV2 infection in pregnancy and exposed newborns is poorly known. We performed a longitudinal analysis of immune system and determined soluble cytokine levels in pregnant women infected with SARS-CoV2 and in their newborns. Women with confirmed SARS-CoV2 infection and their exposed uninfected newborns were recruited from Hospital General Universitario Gregorio Marañón. Peripheral blood mononuclear cells (PBMCs), cord cells and plasma were collected at birth and 6 months later. Immunophenotyping of natural killer (NK), monocytes and CD4/CD8 T-cells were studied in cryopreserved PBMCs and cord cells by multiparametric flow cytometry. Up to 4 soluble pro/anti-inflammatory cytokines were assessed in plasma/cord plasma by ELISA assay. SARS-CoV2-infected mothers and their newborns were compared to matched healthy non-SARS-CoV2-infected mothers and their newborns. The TNFα and IL-10 levels of infected mothers were higher at baseline than those of healthy controls. Infected mothers showed increased NK cells activation and reduced expression of maturation markers that reverted after 6 months. They also had high levels of Central Memory and low Effector Memory CD4-T cell subsets. Additionally, the increased CD4- and CD8-T cell activation (CD154 and CD38) and exhaustion (TIM3/TIGIT) levels at baseline compared to controls remained elevated after 6 months. Regarding Treg cells, the levels were lower at infected mothers at baseline but reverted after 6 months. No newborn was infected at birth. The lower levels of monocytes, NK and CD4-T cells observed at SARS-CoV2-exposed newborns compared to unexposed controls significantly increased 6 months later. In conclusion, SARS-CoV2 infection during pregnancy shows differences in immunological components that could lead newborns to future clinical implications after birth. However, SARS-CoV2 exposed 6-months-old newborns showed no immune misbalance, whereas the infected mothers maintain increased activation and exhaustion levels in T-cells after 6 months. SARS-CoV2 pregnancy SARS-CoV2 exposed newborns immune system longitudinal analysis Immunologic diseases. Allergy Laura Tarancon-Diez verfasserin aut Itzíar Carrasco verfasserin aut Itzíar Carrasco verfasserin aut Sara Vigil-Vázquez verfasserin aut Mar Muñoz-Chapuli verfasserin aut Elena Rincón-López verfasserin aut Elena Rincón-López verfasserin aut Elena Rincón-López verfasserin aut Jesús Saavedra-Lozano verfasserin aut Jesús Saavedra-Lozano verfasserin aut Jesús Saavedra-Lozano verfasserin aut Jesús Saavedra-Lozano verfasserin aut Mar Santos-Sebastián verfasserin aut Mar Santos-Sebastián verfasserin aut Mar Santos-Sebastián verfasserin aut David Aguilera-Alonso verfasserin aut David Aguilera-Alonso verfasserin aut David Aguilera-Alonso verfasserin aut Alicia Hernanz-Lobo verfasserin aut Alicia Hernanz-Lobo verfasserin aut Alicia Hernanz-Lobo verfasserin aut Begoña Santiago-García verfasserin aut Begoña Santiago-García verfasserin aut Begoña Santiago-García verfasserin aut Juan Antonio de León-Luis verfasserin aut Juan Antonio de León-Luis verfasserin aut Patricia Muñoz verfasserin aut Manuel Sánchez-Luna verfasserin aut Manuel Sánchez-Luna verfasserin aut María Luisa Navarro verfasserin aut María Luisa Navarro verfasserin aut María Luisa Navarro verfasserin aut María Luisa Navarro verfasserin aut Mª Ángeles Muñoz-Fernández verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 13(2022) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:13 year:2022 https://doi.org/10.3389/fimmu.2022.947549 kostenfrei https://doaj.org/article/660b57f9f1c046e58310142aafd64e2f kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2022.947549/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022 |
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10.3389/fimmu.2022.947549 doi (DE-627)DOAJ020234759 (DE-599)DOAJ660b57f9f1c046e58310142aafd64e2f DE-627 ger DE-627 rakwb eng RC581-607 Elena Vazquez-Alejo verfasserin aut SARS-CoV2 Infection During Pregnancy Causes Persistent Immune Abnormalities in Women Without Affecting the Newborns 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier SARS-CoV2 infection in pregnancy and exposed newborns is poorly known. We performed a longitudinal analysis of immune system and determined soluble cytokine levels in pregnant women infected with SARS-CoV2 and in their newborns. Women with confirmed SARS-CoV2 infection and their exposed uninfected newborns were recruited from Hospital General Universitario Gregorio Marañón. Peripheral blood mononuclear cells (PBMCs), cord cells and plasma were collected at birth and 6 months later. Immunophenotyping of natural killer (NK), monocytes and CD4/CD8 T-cells were studied in cryopreserved PBMCs and cord cells by multiparametric flow cytometry. Up to 4 soluble pro/anti-inflammatory cytokines were assessed in plasma/cord plasma by ELISA assay. SARS-CoV2-infected mothers and their newborns were compared to matched healthy non-SARS-CoV2-infected mothers and their newborns. The TNFα and IL-10 levels of infected mothers were higher at baseline than those of healthy controls. Infected mothers showed increased NK cells activation and reduced expression of maturation markers that reverted after 6 months. They also had high levels of Central Memory and low Effector Memory CD4-T cell subsets. Additionally, the increased CD4- and CD8-T cell activation (CD154 and CD38) and exhaustion (TIM3/TIGIT) levels at baseline compared to controls remained elevated after 6 months. Regarding Treg cells, the levels were lower at infected mothers at baseline but reverted after 6 months. No newborn was infected at birth. The lower levels of monocytes, NK and CD4-T cells observed at SARS-CoV2-exposed newborns compared to unexposed controls significantly increased 6 months later. In conclusion, SARS-CoV2 infection during pregnancy shows differences in immunological components that could lead newborns to future clinical implications after birth. However, SARS-CoV2 exposed 6-months-old newborns showed no immune misbalance, whereas the infected mothers maintain increased activation and exhaustion levels in T-cells after 6 months. SARS-CoV2 pregnancy SARS-CoV2 exposed newborns immune system longitudinal analysis Immunologic diseases. Allergy Laura Tarancon-Diez verfasserin aut Itzíar Carrasco verfasserin aut Itzíar Carrasco verfasserin aut Sara Vigil-Vázquez verfasserin aut Mar Muñoz-Chapuli verfasserin aut Elena Rincón-López verfasserin aut Elena Rincón-López verfasserin aut Elena Rincón-López verfasserin aut Jesús Saavedra-Lozano verfasserin aut Jesús Saavedra-Lozano verfasserin aut Jesús Saavedra-Lozano verfasserin aut Jesús Saavedra-Lozano verfasserin aut Mar Santos-Sebastián verfasserin aut Mar Santos-Sebastián verfasserin aut Mar Santos-Sebastián verfasserin aut David Aguilera-Alonso verfasserin aut David Aguilera-Alonso verfasserin aut David Aguilera-Alonso verfasserin aut Alicia Hernanz-Lobo verfasserin aut Alicia Hernanz-Lobo verfasserin aut Alicia Hernanz-Lobo verfasserin aut Begoña Santiago-García verfasserin aut Begoña Santiago-García verfasserin aut Begoña Santiago-García verfasserin aut Juan Antonio de León-Luis verfasserin aut Juan Antonio de León-Luis verfasserin aut Patricia Muñoz verfasserin aut Manuel Sánchez-Luna verfasserin aut Manuel Sánchez-Luna verfasserin aut María Luisa Navarro verfasserin aut María Luisa Navarro verfasserin aut María Luisa Navarro verfasserin aut María Luisa Navarro verfasserin aut Mª Ángeles Muñoz-Fernández verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 13(2022) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:13 year:2022 https://doi.org/10.3389/fimmu.2022.947549 kostenfrei https://doaj.org/article/660b57f9f1c046e58310142aafd64e2f kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2022.947549/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022 |
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10.3389/fimmu.2022.947549 doi (DE-627)DOAJ020234759 (DE-599)DOAJ660b57f9f1c046e58310142aafd64e2f DE-627 ger DE-627 rakwb eng RC581-607 Elena Vazquez-Alejo verfasserin aut SARS-CoV2 Infection During Pregnancy Causes Persistent Immune Abnormalities in Women Without Affecting the Newborns 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier SARS-CoV2 infection in pregnancy and exposed newborns is poorly known. We performed a longitudinal analysis of immune system and determined soluble cytokine levels in pregnant women infected with SARS-CoV2 and in their newborns. Women with confirmed SARS-CoV2 infection and their exposed uninfected newborns were recruited from Hospital General Universitario Gregorio Marañón. Peripheral blood mononuclear cells (PBMCs), cord cells and plasma were collected at birth and 6 months later. Immunophenotyping of natural killer (NK), monocytes and CD4/CD8 T-cells were studied in cryopreserved PBMCs and cord cells by multiparametric flow cytometry. Up to 4 soluble pro/anti-inflammatory cytokines were assessed in plasma/cord plasma by ELISA assay. SARS-CoV2-infected mothers and their newborns were compared to matched healthy non-SARS-CoV2-infected mothers and their newborns. The TNFα and IL-10 levels of infected mothers were higher at baseline than those of healthy controls. Infected mothers showed increased NK cells activation and reduced expression of maturation markers that reverted after 6 months. They also had high levels of Central Memory and low Effector Memory CD4-T cell subsets. Additionally, the increased CD4- and CD8-T cell activation (CD154 and CD38) and exhaustion (TIM3/TIGIT) levels at baseline compared to controls remained elevated after 6 months. Regarding Treg cells, the levels were lower at infected mothers at baseline but reverted after 6 months. No newborn was infected at birth. The lower levels of monocytes, NK and CD4-T cells observed at SARS-CoV2-exposed newborns compared to unexposed controls significantly increased 6 months later. In conclusion, SARS-CoV2 infection during pregnancy shows differences in immunological components that could lead newborns to future clinical implications after birth. However, SARS-CoV2 exposed 6-months-old newborns showed no immune misbalance, whereas the infected mothers maintain increased activation and exhaustion levels in T-cells after 6 months. SARS-CoV2 pregnancy SARS-CoV2 exposed newborns immune system longitudinal analysis Immunologic diseases. Allergy Laura Tarancon-Diez verfasserin aut Itzíar Carrasco verfasserin aut Itzíar Carrasco verfasserin aut Sara Vigil-Vázquez verfasserin aut Mar Muñoz-Chapuli verfasserin aut Elena Rincón-López verfasserin aut Elena Rincón-López verfasserin aut Elena Rincón-López verfasserin aut Jesús Saavedra-Lozano verfasserin aut Jesús Saavedra-Lozano verfasserin aut Jesús Saavedra-Lozano verfasserin aut Jesús Saavedra-Lozano verfasserin aut Mar Santos-Sebastián verfasserin aut Mar Santos-Sebastián verfasserin aut Mar Santos-Sebastián verfasserin aut David Aguilera-Alonso verfasserin aut David Aguilera-Alonso verfasserin aut David Aguilera-Alonso verfasserin aut Alicia Hernanz-Lobo verfasserin aut Alicia Hernanz-Lobo verfasserin aut Alicia Hernanz-Lobo verfasserin aut Begoña Santiago-García verfasserin aut Begoña Santiago-García verfasserin aut Begoña Santiago-García verfasserin aut Juan Antonio de León-Luis verfasserin aut Juan Antonio de León-Luis verfasserin aut Patricia Muñoz verfasserin aut Manuel Sánchez-Luna verfasserin aut Manuel Sánchez-Luna verfasserin aut María Luisa Navarro verfasserin aut María Luisa Navarro verfasserin aut María Luisa Navarro verfasserin aut María Luisa Navarro verfasserin aut Mª Ángeles Muñoz-Fernández verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 13(2022) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:13 year:2022 https://doi.org/10.3389/fimmu.2022.947549 kostenfrei https://doaj.org/article/660b57f9f1c046e58310142aafd64e2f kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2022.947549/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022 |
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Elena Vazquez-Alejo @@aut@@ Laura Tarancon-Diez @@aut@@ Itzíar Carrasco @@aut@@ Sara Vigil-Vázquez @@aut@@ Mar Muñoz-Chapuli @@aut@@ Elena Rincón-López @@aut@@ Jesús Saavedra-Lozano @@aut@@ Mar Santos-Sebastián @@aut@@ David Aguilera-Alonso @@aut@@ Alicia Hernanz-Lobo @@aut@@ Begoña Santiago-García @@aut@@ Juan Antonio de León-Luis @@aut@@ Patricia Muñoz @@aut@@ Manuel Sánchez-Luna @@aut@@ María Luisa Navarro @@aut@@ Mª Ángeles Muñoz-Fernández @@aut@@ |
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Infected mothers showed increased NK cells activation and reduced expression of maturation markers that reverted after 6 months. They also had high levels of Central Memory and low Effector Memory CD4-T cell subsets. Additionally, the increased CD4- and CD8-T cell activation (CD154 and CD38) and exhaustion (TIM3/TIGIT) levels at baseline compared to controls remained elevated after 6 months. Regarding Treg cells, the levels were lower at infected mothers at baseline but reverted after 6 months. No newborn was infected at birth. The lower levels of monocytes, NK and CD4-T cells observed at SARS-CoV2-exposed newborns compared to unexposed controls significantly increased 6 months later. In conclusion, SARS-CoV2 infection during pregnancy shows differences in immunological components that could lead newborns to future clinical implications after birth. 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Elena Vazquez-Alejo misc RC581-607 misc SARS-CoV2 misc pregnancy misc SARS-CoV2 exposed newborns misc immune system misc longitudinal analysis misc Immunologic diseases. Allergy SARS-CoV2 Infection During Pregnancy Causes Persistent Immune Abnormalities in Women Without Affecting the Newborns |
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RC581-607 SARS-CoV2 Infection During Pregnancy Causes Persistent Immune Abnormalities in Women Without Affecting the Newborns SARS-CoV2 pregnancy SARS-CoV2 exposed newborns immune system longitudinal analysis |
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Elena Vazquez-Alejo Laura Tarancon-Diez Itzíar Carrasco Sara Vigil-Vázquez Mar Muñoz-Chapuli Elena Rincón-López Jesús Saavedra-Lozano Mar Santos-Sebastián David Aguilera-Alonso Alicia Hernanz-Lobo Begoña Santiago-García Juan Antonio de León-Luis Patricia Muñoz Manuel Sánchez-Luna María Luisa Navarro Mª Ángeles Muñoz-Fernández |
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sars-cov2 infection during pregnancy causes persistent immune abnormalities in women without affecting the newborns |
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SARS-CoV2 Infection During Pregnancy Causes Persistent Immune Abnormalities in Women Without Affecting the Newborns |
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SARS-CoV2 infection in pregnancy and exposed newborns is poorly known. We performed a longitudinal analysis of immune system and determined soluble cytokine levels in pregnant women infected with SARS-CoV2 and in their newborns. Women with confirmed SARS-CoV2 infection and their exposed uninfected newborns were recruited from Hospital General Universitario Gregorio Marañón. Peripheral blood mononuclear cells (PBMCs), cord cells and plasma were collected at birth and 6 months later. Immunophenotyping of natural killer (NK), monocytes and CD4/CD8 T-cells were studied in cryopreserved PBMCs and cord cells by multiparametric flow cytometry. Up to 4 soluble pro/anti-inflammatory cytokines were assessed in plasma/cord plasma by ELISA assay. SARS-CoV2-infected mothers and their newborns were compared to matched healthy non-SARS-CoV2-infected mothers and their newborns. The TNFα and IL-10 levels of infected mothers were higher at baseline than those of healthy controls. Infected mothers showed increased NK cells activation and reduced expression of maturation markers that reverted after 6 months. They also had high levels of Central Memory and low Effector Memory CD4-T cell subsets. Additionally, the increased CD4- and CD8-T cell activation (CD154 and CD38) and exhaustion (TIM3/TIGIT) levels at baseline compared to controls remained elevated after 6 months. Regarding Treg cells, the levels were lower at infected mothers at baseline but reverted after 6 months. No newborn was infected at birth. The lower levels of monocytes, NK and CD4-T cells observed at SARS-CoV2-exposed newborns compared to unexposed controls significantly increased 6 months later. In conclusion, SARS-CoV2 infection during pregnancy shows differences in immunological components that could lead newborns to future clinical implications after birth. However, SARS-CoV2 exposed 6-months-old newborns showed no immune misbalance, whereas the infected mothers maintain increased activation and exhaustion levels in T-cells after 6 months. |
abstractGer |
SARS-CoV2 infection in pregnancy and exposed newborns is poorly known. We performed a longitudinal analysis of immune system and determined soluble cytokine levels in pregnant women infected with SARS-CoV2 and in their newborns. Women with confirmed SARS-CoV2 infection and their exposed uninfected newborns were recruited from Hospital General Universitario Gregorio Marañón. Peripheral blood mononuclear cells (PBMCs), cord cells and plasma were collected at birth and 6 months later. Immunophenotyping of natural killer (NK), monocytes and CD4/CD8 T-cells were studied in cryopreserved PBMCs and cord cells by multiparametric flow cytometry. Up to 4 soluble pro/anti-inflammatory cytokines were assessed in plasma/cord plasma by ELISA assay. SARS-CoV2-infected mothers and their newborns were compared to matched healthy non-SARS-CoV2-infected mothers and their newborns. The TNFα and IL-10 levels of infected mothers were higher at baseline than those of healthy controls. Infected mothers showed increased NK cells activation and reduced expression of maturation markers that reverted after 6 months. They also had high levels of Central Memory and low Effector Memory CD4-T cell subsets. Additionally, the increased CD4- and CD8-T cell activation (CD154 and CD38) and exhaustion (TIM3/TIGIT) levels at baseline compared to controls remained elevated after 6 months. Regarding Treg cells, the levels were lower at infected mothers at baseline but reverted after 6 months. No newborn was infected at birth. The lower levels of monocytes, NK and CD4-T cells observed at SARS-CoV2-exposed newborns compared to unexposed controls significantly increased 6 months later. In conclusion, SARS-CoV2 infection during pregnancy shows differences in immunological components that could lead newborns to future clinical implications after birth. However, SARS-CoV2 exposed 6-months-old newborns showed no immune misbalance, whereas the infected mothers maintain increased activation and exhaustion levels in T-cells after 6 months. |
abstract_unstemmed |
SARS-CoV2 infection in pregnancy and exposed newborns is poorly known. We performed a longitudinal analysis of immune system and determined soluble cytokine levels in pregnant women infected with SARS-CoV2 and in their newborns. Women with confirmed SARS-CoV2 infection and their exposed uninfected newborns were recruited from Hospital General Universitario Gregorio Marañón. Peripheral blood mononuclear cells (PBMCs), cord cells and plasma were collected at birth and 6 months later. Immunophenotyping of natural killer (NK), monocytes and CD4/CD8 T-cells were studied in cryopreserved PBMCs and cord cells by multiparametric flow cytometry. Up to 4 soluble pro/anti-inflammatory cytokines were assessed in plasma/cord plasma by ELISA assay. SARS-CoV2-infected mothers and their newborns were compared to matched healthy non-SARS-CoV2-infected mothers and their newborns. The TNFα and IL-10 levels of infected mothers were higher at baseline than those of healthy controls. Infected mothers showed increased NK cells activation and reduced expression of maturation markers that reverted after 6 months. They also had high levels of Central Memory and low Effector Memory CD4-T cell subsets. Additionally, the increased CD4- and CD8-T cell activation (CD154 and CD38) and exhaustion (TIM3/TIGIT) levels at baseline compared to controls remained elevated after 6 months. Regarding Treg cells, the levels were lower at infected mothers at baseline but reverted after 6 months. No newborn was infected at birth. The lower levels of monocytes, NK and CD4-T cells observed at SARS-CoV2-exposed newborns compared to unexposed controls significantly increased 6 months later. In conclusion, SARS-CoV2 infection during pregnancy shows differences in immunological components that could lead newborns to future clinical implications after birth. However, SARS-CoV2 exposed 6-months-old newborns showed no immune misbalance, whereas the infected mothers maintain increased activation and exhaustion levels in T-cells after 6 months. |
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SARS-CoV2 Infection During Pregnancy Causes Persistent Immune Abnormalities in Women Without Affecting the Newborns |
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Infected mothers showed increased NK cells activation and reduced expression of maturation markers that reverted after 6 months. They also had high levels of Central Memory and low Effector Memory CD4-T cell subsets. Additionally, the increased CD4- and CD8-T cell activation (CD154 and CD38) and exhaustion (TIM3/TIGIT) levels at baseline compared to controls remained elevated after 6 months. Regarding Treg cells, the levels were lower at infected mothers at baseline but reverted after 6 months. No newborn was infected at birth. The lower levels of monocytes, NK and CD4-T cells observed at SARS-CoV2-exposed newborns compared to unexposed controls significantly increased 6 months later. In conclusion, SARS-CoV2 infection during pregnancy shows differences in immunological components that could lead newborns to future clinical implications after birth. 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