Synergistic antitumor response with recombinant modified virus Ankara armed with CD40L and CD137L against peritoneal carcinomatosis

Recombinant-modified vaccinia virus Ankara (rMVA) is known to elicit potent antitumor immune responses in preclinical models due to its inherent ability to activate the innate immune system and the activation of adaptive responses mediated by the expression of tumor antigens and costimulus-providing...
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Autor*in:	Ángela Bella [verfasserIn] Leire Arrizabalaga [verfasserIn] Claudia Augusta Di Trani [verfasserIn] Assunta Cirella [verfasserIn] Myriam Fernandez-Sendin [verfasserIn] Celia Gomar [verfasserIn] Joan Salvador Russo-Cabrera [verfasserIn] Inmaculada Rodríguez [verfasserIn] José González-Gomariz [verfasserIn] Maite Alvarez [verfasserIn] Álvaro Teijeira [verfasserIn] José Medina-Echeverz [verfasserIn] Maria Hinterberger [verfasserIn] Hubertus Hochrein [verfasserIn] Ignacio Melero [verfasserIn] Pedro Berraondo [verfasserIn] Fernando Aranda [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Peritoneal carcinomatosis CD40L CD137L CD8 immune response cancer immunotherapy

Übergeordnetes Werk:	In: OncoImmunology - Taylor & Francis Group, 2020, 11(2022), 1
Übergeordnetes Werk:	volume:11 ; year:2022 ; number:1

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1080/2162402X.2022.2098657

Katalog-ID:	DOAJ020289634

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520			\|a Recombinant-modified vaccinia virus Ankara (rMVA) is known to elicit potent antitumor immune responses in preclinical models due to its inherent ability to activate the innate immune system and the activation of adaptive responses mediated by the expression of tumor antigens and costimulus-providing molecules, such as CD40L and CD137L. Here, we evaluated different rMVA vectors in preclinical peritoneal carcinomatosis models (ID8.OVA-Vegf/GFP and MC38). We compared rMVA vectors expressing a tumor antigen (OVA or gp70) either alone or co-expressed with CD40L or/and CD137L. In tumor-free mice, the vector coding for the triple combination was only slightly superior, whereas, in tumor-bearing animals, we observed a synergistic induction of T lymphocytes specific against vector-encoded and non-encoded tumor-associated antigens. The enhanced activation of the immune response was associated with improved survival in mice with peritoneal carcinomatosis treated with a rMVA vector encoding both CD40L and CD137L. Thus, the triple transgene combination in vaccinia viral vectors represents a promising strategy for the treatment of peritoneal carcinomatosis.
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allfields	10.1080/2162402X.2022.2098657 doi (DE-627)DOAJ020289634 (DE-599)DOAJf9d020b0324c489cb77988b46440b9e8 DE-627 ger DE-627 rakwb eng RC581-607 RC254-282 Ángela Bella verfasserin aut Synergistic antitumor response with recombinant modified virus Ankara armed with CD40L and CD137L against peritoneal carcinomatosis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Recombinant-modified vaccinia virus Ankara (rMVA) is known to elicit potent antitumor immune responses in preclinical models due to its inherent ability to activate the innate immune system and the activation of adaptive responses mediated by the expression of tumor antigens and costimulus-providing molecules, such as CD40L and CD137L. Here, we evaluated different rMVA vectors in preclinical peritoneal carcinomatosis models (ID8.OVA-Vegf/GFP and MC38). We compared rMVA vectors expressing a tumor antigen (OVA or gp70) either alone or co-expressed with CD40L or/and CD137L. In tumor-free mice, the vector coding for the triple combination was only slightly superior, whereas, in tumor-bearing animals, we observed a synergistic induction of T lymphocytes specific against vector-encoded and non-encoded tumor-associated antigens. The enhanced activation of the immune response was associated with improved survival in mice with peritoneal carcinomatosis treated with a rMVA vector encoding both CD40L and CD137L. Thus, the triple transgene combination in vaccinia viral vectors represents a promising strategy for the treatment of peritoneal carcinomatosis. Peritoneal carcinomatosis CD40L CD137L CD8 immune response cancer immunotherapy Immunologic diseases. Allergy Neoplasms. Tumors. Oncology. Including cancer and carcinogens Leire Arrizabalaga verfasserin aut Claudia Augusta Di Trani verfasserin aut Assunta Cirella verfasserin aut Myriam Fernandez-Sendin verfasserin aut Celia Gomar verfasserin aut Joan Salvador Russo-Cabrera verfasserin aut Inmaculada Rodríguez verfasserin aut José González-Gomariz verfasserin aut Maite Alvarez verfasserin aut Álvaro Teijeira verfasserin aut José Medina-Echeverz verfasserin aut Maria Hinterberger verfasserin aut Hubertus Hochrein verfasserin aut Ignacio Melero verfasserin aut Pedro Berraondo verfasserin aut Fernando Aranda verfasserin aut In OncoImmunology Taylor & Francis Group, 2020 11(2022), 1 (DE-627)683365428 (DE-600)2645309-5 2162402X nnns volume:11 year:2022 number:1 https://doi.org/10.1080/2162402X.2022.2098657 kostenfrei https://doaj.org/article/f9d020b0324c489cb77988b46440b9e8 kostenfrei https://www.tandfonline.com/doi/10.1080/2162402X.2022.2098657 kostenfrei https://doaj.org/toc/2162-402X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 1
spelling	10.1080/2162402X.2022.2098657 doi (DE-627)DOAJ020289634 (DE-599)DOAJf9d020b0324c489cb77988b46440b9e8 DE-627 ger DE-627 rakwb eng RC581-607 RC254-282 Ángela Bella verfasserin aut Synergistic antitumor response with recombinant modified virus Ankara armed with CD40L and CD137L against peritoneal carcinomatosis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Recombinant-modified vaccinia virus Ankara (rMVA) is known to elicit potent antitumor immune responses in preclinical models due to its inherent ability to activate the innate immune system and the activation of adaptive responses mediated by the expression of tumor antigens and costimulus-providing molecules, such as CD40L and CD137L. Here, we evaluated different rMVA vectors in preclinical peritoneal carcinomatosis models (ID8.OVA-Vegf/GFP and MC38). We compared rMVA vectors expressing a tumor antigen (OVA or gp70) either alone or co-expressed with CD40L or/and CD137L. In tumor-free mice, the vector coding for the triple combination was only slightly superior, whereas, in tumor-bearing animals, we observed a synergistic induction of T lymphocytes specific against vector-encoded and non-encoded tumor-associated antigens. The enhanced activation of the immune response was associated with improved survival in mice with peritoneal carcinomatosis treated with a rMVA vector encoding both CD40L and CD137L. Thus, the triple transgene combination in vaccinia viral vectors represents a promising strategy for the treatment of peritoneal carcinomatosis. Peritoneal carcinomatosis CD40L CD137L CD8 immune response cancer immunotherapy Immunologic diseases. Allergy Neoplasms. Tumors. Oncology. Including cancer and carcinogens Leire Arrizabalaga verfasserin aut Claudia Augusta Di Trani verfasserin aut Assunta Cirella verfasserin aut Myriam Fernandez-Sendin verfasserin aut Celia Gomar verfasserin aut Joan Salvador Russo-Cabrera verfasserin aut Inmaculada Rodríguez verfasserin aut José González-Gomariz verfasserin aut Maite Alvarez verfasserin aut Álvaro Teijeira verfasserin aut José Medina-Echeverz verfasserin aut Maria Hinterberger verfasserin aut Hubertus Hochrein verfasserin aut Ignacio Melero verfasserin aut Pedro Berraondo verfasserin aut Fernando Aranda verfasserin aut In OncoImmunology Taylor & Francis Group, 2020 11(2022), 1 (DE-627)683365428 (DE-600)2645309-5 2162402X nnns volume:11 year:2022 number:1 https://doi.org/10.1080/2162402X.2022.2098657 kostenfrei https://doaj.org/article/f9d020b0324c489cb77988b46440b9e8 kostenfrei https://www.tandfonline.com/doi/10.1080/2162402X.2022.2098657 kostenfrei https://doaj.org/toc/2162-402X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 1
allfields_unstemmed	10.1080/2162402X.2022.2098657 doi (DE-627)DOAJ020289634 (DE-599)DOAJf9d020b0324c489cb77988b46440b9e8 DE-627 ger DE-627 rakwb eng RC581-607 RC254-282 Ángela Bella verfasserin aut Synergistic antitumor response with recombinant modified virus Ankara armed with CD40L and CD137L against peritoneal carcinomatosis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Recombinant-modified vaccinia virus Ankara (rMVA) is known to elicit potent antitumor immune responses in preclinical models due to its inherent ability to activate the innate immune system and the activation of adaptive responses mediated by the expression of tumor antigens and costimulus-providing molecules, such as CD40L and CD137L. Here, we evaluated different rMVA vectors in preclinical peritoneal carcinomatosis models (ID8.OVA-Vegf/GFP and MC38). We compared rMVA vectors expressing a tumor antigen (OVA or gp70) either alone or co-expressed with CD40L or/and CD137L. In tumor-free mice, the vector coding for the triple combination was only slightly superior, whereas, in tumor-bearing animals, we observed a synergistic induction of T lymphocytes specific against vector-encoded and non-encoded tumor-associated antigens. The enhanced activation of the immune response was associated with improved survival in mice with peritoneal carcinomatosis treated with a rMVA vector encoding both CD40L and CD137L. Thus, the triple transgene combination in vaccinia viral vectors represents a promising strategy for the treatment of peritoneal carcinomatosis. Peritoneal carcinomatosis CD40L CD137L CD8 immune response cancer immunotherapy Immunologic diseases. Allergy Neoplasms. Tumors. Oncology. Including cancer and carcinogens Leire Arrizabalaga verfasserin aut Claudia Augusta Di Trani verfasserin aut Assunta Cirella verfasserin aut Myriam Fernandez-Sendin verfasserin aut Celia Gomar verfasserin aut Joan Salvador Russo-Cabrera verfasserin aut Inmaculada Rodríguez verfasserin aut José González-Gomariz verfasserin aut Maite Alvarez verfasserin aut Álvaro Teijeira verfasserin aut José Medina-Echeverz verfasserin aut Maria Hinterberger verfasserin aut Hubertus Hochrein verfasserin aut Ignacio Melero verfasserin aut Pedro Berraondo verfasserin aut Fernando Aranda verfasserin aut In OncoImmunology Taylor & Francis Group, 2020 11(2022), 1 (DE-627)683365428 (DE-600)2645309-5 2162402X nnns volume:11 year:2022 number:1 https://doi.org/10.1080/2162402X.2022.2098657 kostenfrei https://doaj.org/article/f9d020b0324c489cb77988b46440b9e8 kostenfrei https://www.tandfonline.com/doi/10.1080/2162402X.2022.2098657 kostenfrei https://doaj.org/toc/2162-402X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 1
allfieldsGer	10.1080/2162402X.2022.2098657 doi (DE-627)DOAJ020289634 (DE-599)DOAJf9d020b0324c489cb77988b46440b9e8 DE-627 ger DE-627 rakwb eng RC581-607 RC254-282 Ángela Bella verfasserin aut Synergistic antitumor response with recombinant modified virus Ankara armed with CD40L and CD137L against peritoneal carcinomatosis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Recombinant-modified vaccinia virus Ankara (rMVA) is known to elicit potent antitumor immune responses in preclinical models due to its inherent ability to activate the innate immune system and the activation of adaptive responses mediated by the expression of tumor antigens and costimulus-providing molecules, such as CD40L and CD137L. Here, we evaluated different rMVA vectors in preclinical peritoneal carcinomatosis models (ID8.OVA-Vegf/GFP and MC38). We compared rMVA vectors expressing a tumor antigen (OVA or gp70) either alone or co-expressed with CD40L or/and CD137L. In tumor-free mice, the vector coding for the triple combination was only slightly superior, whereas, in tumor-bearing animals, we observed a synergistic induction of T lymphocytes specific against vector-encoded and non-encoded tumor-associated antigens. The enhanced activation of the immune response was associated with improved survival in mice with peritoneal carcinomatosis treated with a rMVA vector encoding both CD40L and CD137L. Thus, the triple transgene combination in vaccinia viral vectors represents a promising strategy for the treatment of peritoneal carcinomatosis. Peritoneal carcinomatosis CD40L CD137L CD8 immune response cancer immunotherapy Immunologic diseases. Allergy Neoplasms. Tumors. Oncology. Including cancer and carcinogens Leire Arrizabalaga verfasserin aut Claudia Augusta Di Trani verfasserin aut Assunta Cirella verfasserin aut Myriam Fernandez-Sendin verfasserin aut Celia Gomar verfasserin aut Joan Salvador Russo-Cabrera verfasserin aut Inmaculada Rodríguez verfasserin aut José González-Gomariz verfasserin aut Maite Alvarez verfasserin aut Álvaro Teijeira verfasserin aut José Medina-Echeverz verfasserin aut Maria Hinterberger verfasserin aut Hubertus Hochrein verfasserin aut Ignacio Melero verfasserin aut Pedro Berraondo verfasserin aut Fernando Aranda verfasserin aut In OncoImmunology Taylor & Francis Group, 2020 11(2022), 1 (DE-627)683365428 (DE-600)2645309-5 2162402X nnns volume:11 year:2022 number:1 https://doi.org/10.1080/2162402X.2022.2098657 kostenfrei https://doaj.org/article/f9d020b0324c489cb77988b46440b9e8 kostenfrei https://www.tandfonline.com/doi/10.1080/2162402X.2022.2098657 kostenfrei https://doaj.org/toc/2162-402X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 1
allfieldsSound	10.1080/2162402X.2022.2098657 doi (DE-627)DOAJ020289634 (DE-599)DOAJf9d020b0324c489cb77988b46440b9e8 DE-627 ger DE-627 rakwb eng RC581-607 RC254-282 Ángela Bella verfasserin aut Synergistic antitumor response with recombinant modified virus Ankara armed with CD40L and CD137L against peritoneal carcinomatosis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Recombinant-modified vaccinia virus Ankara (rMVA) is known to elicit potent antitumor immune responses in preclinical models due to its inherent ability to activate the innate immune system and the activation of adaptive responses mediated by the expression of tumor antigens and costimulus-providing molecules, such as CD40L and CD137L. Here, we evaluated different rMVA vectors in preclinical peritoneal carcinomatosis models (ID8.OVA-Vegf/GFP and MC38). We compared rMVA vectors expressing a tumor antigen (OVA or gp70) either alone or co-expressed with CD40L or/and CD137L. In tumor-free mice, the vector coding for the triple combination was only slightly superior, whereas, in tumor-bearing animals, we observed a synergistic induction of T lymphocytes specific against vector-encoded and non-encoded tumor-associated antigens. The enhanced activation of the immune response was associated with improved survival in mice with peritoneal carcinomatosis treated with a rMVA vector encoding both CD40L and CD137L. Thus, the triple transgene combination in vaccinia viral vectors represents a promising strategy for the treatment of peritoneal carcinomatosis. Peritoneal carcinomatosis CD40L CD137L CD8 immune response cancer immunotherapy Immunologic diseases. Allergy Neoplasms. Tumors. Oncology. Including cancer and carcinogens Leire Arrizabalaga verfasserin aut Claudia Augusta Di Trani verfasserin aut Assunta Cirella verfasserin aut Myriam Fernandez-Sendin verfasserin aut Celia Gomar verfasserin aut Joan Salvador Russo-Cabrera verfasserin aut Inmaculada Rodríguez verfasserin aut José González-Gomariz verfasserin aut Maite Alvarez verfasserin aut Álvaro Teijeira verfasserin aut José Medina-Echeverz verfasserin aut Maria Hinterberger verfasserin aut Hubertus Hochrein verfasserin aut Ignacio Melero verfasserin aut Pedro Berraondo verfasserin aut Fernando Aranda verfasserin aut In OncoImmunology Taylor & Francis Group, 2020 11(2022), 1 (DE-627)683365428 (DE-600)2645309-5 2162402X nnns volume:11 year:2022 number:1 https://doi.org/10.1080/2162402X.2022.2098657 kostenfrei https://doaj.org/article/f9d020b0324c489cb77988b46440b9e8 kostenfrei https://www.tandfonline.com/doi/10.1080/2162402X.2022.2098657 kostenfrei https://doaj.org/toc/2162-402X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 1
language	English
source	In OncoImmunology 11(2022), 1 volume:11 year:2022 number:1
sourceStr	In OncoImmunology 11(2022), 1 volume:11 year:2022 number:1
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Peritoneal carcinomatosis CD40L CD137L CD8 immune response cancer immunotherapy Immunologic diseases. Allergy Neoplasms. Tumors. Oncology. Including cancer and carcinogens
isfreeaccess_bool	true
container_title	OncoImmunology
authorswithroles_txt_mv	Ángela Bella @@aut@@ Leire Arrizabalaga @@aut@@ Claudia Augusta Di Trani @@aut@@ Assunta Cirella @@aut@@ Myriam Fernandez-Sendin @@aut@@ Celia Gomar @@aut@@ Joan Salvador Russo-Cabrera @@aut@@ Inmaculada Rodríguez @@aut@@ José González-Gomariz @@aut@@ Maite Alvarez @@aut@@ Álvaro Teijeira @@aut@@ José Medina-Echeverz @@aut@@ Maria Hinterberger @@aut@@ Hubertus Hochrein @@aut@@ Ignacio Melero @@aut@@ Pedro Berraondo @@aut@@ Fernando Aranda @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	683365428
id	DOAJ020289634
language_de	englisch
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callnumber-first	R - Medicine
author	Ángela Bella
spellingShingle	Ángela Bella misc RC581-607 misc RC254-282 misc Peritoneal carcinomatosis misc CD40L misc CD137L misc CD8 immune response misc cancer immunotherapy misc Immunologic diseases. Allergy misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Synergistic antitumor response with recombinant modified virus Ankara armed with CD40L and CD137L against peritoneal carcinomatosis
authorStr	Ángela Bella
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topic_title	RC581-607 RC254-282 Synergistic antitumor response with recombinant modified virus Ankara armed with CD40L and CD137L against peritoneal carcinomatosis Peritoneal carcinomatosis CD40L CD137L CD8 immune response cancer immunotherapy
topic	misc RC581-607 misc RC254-282 misc Peritoneal carcinomatosis misc CD40L misc CD137L misc CD8 immune response misc cancer immunotherapy misc Immunologic diseases. Allergy misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC581-607 misc RC254-282 misc Peritoneal carcinomatosis misc CD40L misc CD137L misc CD8 immune response misc cancer immunotherapy misc Immunologic diseases. Allergy misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_browse	misc RC581-607 misc RC254-282 misc Peritoneal carcinomatosis misc CD40L misc CD137L misc CD8 immune response misc cancer immunotherapy misc Immunologic diseases. Allergy misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Synergistic antitumor response with recombinant modified virus Ankara armed with CD40L and CD137L against peritoneal carcinomatosis
ctrlnum	(DE-627)DOAJ020289634 (DE-599)DOAJf9d020b0324c489cb77988b46440b9e8
title_full	Synergistic antitumor response with recombinant modified virus Ankara armed with CD40L and CD137L against peritoneal carcinomatosis
author_sort	Ángela Bella
journal	OncoImmunology
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author_browse	Ángela Bella Leire Arrizabalaga Claudia Augusta Di Trani Assunta Cirella Myriam Fernandez-Sendin Celia Gomar Joan Salvador Russo-Cabrera Inmaculada Rodríguez José González-Gomariz Maite Alvarez Álvaro Teijeira José Medina-Echeverz Maria Hinterberger Hubertus Hochrein Ignacio Melero Pedro Berraondo Fernando Aranda
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class	RC581-607 RC254-282
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author-letter	Ángela Bella
doi_str_mv	10.1080/2162402X.2022.2098657
author2-role	verfasserin
title_sort	synergistic antitumor response with recombinant modified virus ankara armed with cd40l and cd137l against peritoneal carcinomatosis
callnumber	RC581-607
title_auth	Synergistic antitumor response with recombinant modified virus Ankara armed with CD40L and CD137L against peritoneal carcinomatosis
abstract	Recombinant-modified vaccinia virus Ankara (rMVA) is known to elicit potent antitumor immune responses in preclinical models due to its inherent ability to activate the innate immune system and the activation of adaptive responses mediated by the expression of tumor antigens and costimulus-providing molecules, such as CD40L and CD137L. Here, we evaluated different rMVA vectors in preclinical peritoneal carcinomatosis models (ID8.OVA-Vegf/GFP and MC38). We compared rMVA vectors expressing a tumor antigen (OVA or gp70) either alone or co-expressed with CD40L or/and CD137L. In tumor-free mice, the vector coding for the triple combination was only slightly superior, whereas, in tumor-bearing animals, we observed a synergistic induction of T lymphocytes specific against vector-encoded and non-encoded tumor-associated antigens. The enhanced activation of the immune response was associated with improved survival in mice with peritoneal carcinomatosis treated with a rMVA vector encoding both CD40L and CD137L. Thus, the triple transgene combination in vaccinia viral vectors represents a promising strategy for the treatment of peritoneal carcinomatosis.
abstractGer	Recombinant-modified vaccinia virus Ankara (rMVA) is known to elicit potent antitumor immune responses in preclinical models due to its inherent ability to activate the innate immune system and the activation of adaptive responses mediated by the expression of tumor antigens and costimulus-providing molecules, such as CD40L and CD137L. Here, we evaluated different rMVA vectors in preclinical peritoneal carcinomatosis models (ID8.OVA-Vegf/GFP and MC38). We compared rMVA vectors expressing a tumor antigen (OVA or gp70) either alone or co-expressed with CD40L or/and CD137L. In tumor-free mice, the vector coding for the triple combination was only slightly superior, whereas, in tumor-bearing animals, we observed a synergistic induction of T lymphocytes specific against vector-encoded and non-encoded tumor-associated antigens. The enhanced activation of the immune response was associated with improved survival in mice with peritoneal carcinomatosis treated with a rMVA vector encoding both CD40L and CD137L. Thus, the triple transgene combination in vaccinia viral vectors represents a promising strategy for the treatment of peritoneal carcinomatosis.
abstract_unstemmed	Recombinant-modified vaccinia virus Ankara (rMVA) is known to elicit potent antitumor immune responses in preclinical models due to its inherent ability to activate the innate immune system and the activation of adaptive responses mediated by the expression of tumor antigens and costimulus-providing molecules, such as CD40L and CD137L. Here, we evaluated different rMVA vectors in preclinical peritoneal carcinomatosis models (ID8.OVA-Vegf/GFP and MC38). We compared rMVA vectors expressing a tumor antigen (OVA or gp70) either alone or co-expressed with CD40L or/and CD137L. In tumor-free mice, the vector coding for the triple combination was only slightly superior, whereas, in tumor-bearing animals, we observed a synergistic induction of T lymphocytes specific against vector-encoded and non-encoded tumor-associated antigens. The enhanced activation of the immune response was associated with improved survival in mice with peritoneal carcinomatosis treated with a rMVA vector encoding both CD40L and CD137L. Thus, the triple transgene combination in vaccinia viral vectors represents a promising strategy for the treatment of peritoneal carcinomatosis.
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title_short	Synergistic antitumor response with recombinant modified virus Ankara armed with CD40L and CD137L against peritoneal carcinomatosis
url	https://doi.org/10.1080/2162402X.2022.2098657 https://doaj.org/article/f9d020b0324c489cb77988b46440b9e8 https://www.tandfonline.com/doi/10.1080/2162402X.2022.2098657 https://doaj.org/toc/2162-402X
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author2	Leire Arrizabalaga Claudia Augusta Di Trani Assunta Cirella Myriam Fernandez-Sendin Celia Gomar Joan Salvador Russo-Cabrera Inmaculada Rodríguez José González-Gomariz Maite Alvarez Álvaro Teijeira José Medina-Echeverz Maria Hinterberger Hubertus Hochrein Ignacio Melero Pedro Berraondo Fernando Aranda
author2Str	Leire Arrizabalaga Claudia Augusta Di Trani Assunta Cirella Myriam Fernandez-Sendin Celia Gomar Joan Salvador Russo-Cabrera Inmaculada Rodríguez José González-Gomariz Maite Alvarez Álvaro Teijeira José Medina-Echeverz Maria Hinterberger Hubertus Hochrein Ignacio Melero Pedro Berraondo Fernando Aranda
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doi_str	10.1080/2162402X.2022.2098657
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up_date	2024-07-03T14:05:18.291Z
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