Management of metastatic castration-resistant prostate cancer in Middle East African countries: Challenges and strategic recommendations

Despite the reliance on Western guidelines for managing prostate cancer (PC), there are wide variations and gaps in treatment among developing countries such as the Middle East African (MEA) region. A multidisciplinary team of experts from the MEA region engaged in a comprehensive discussion to iden...
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Autor*in:	Shouki Bazarbashi [verfasserIn] Abdullah Alsharm [verfasserIn] Alaa Meshref [verfasserIn] Hind Mrabti [verfasserIn] Jawaher Ansari [verfasserIn] Marwan Ghosn [verfasserIn] Mohamed Abdulla [verfasserIn] Yuksel Urun [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	genetic testing metastatic castration-resistant prostate cancer middle east african region multidisciplinary care

Übergeordnetes Werk:	In: Urology Annals - Wolters Kluwer Medknow Publications, 2009, 14(2022), 4, Seite 303-313
Übergeordnetes Werk:	volume:14 ; year:2022 ; number:4 ; pages:303-313

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.4103/ua.ua_148_21

Katalog-ID:	DOAJ020332807

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allfields	10.4103/ua.ua_148_21 doi (DE-627)DOAJ020332807 (DE-599)DOAJ400a15a07b5e43b8bdfc3e7b29b13ce6 DE-627 ger DE-627 rakwb eng RC870-923 Shouki Bazarbashi verfasserin aut Management of metastatic castration-resistant prostate cancer in Middle East African countries: Challenges and strategic recommendations 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Despite the reliance on Western guidelines for managing prostate cancer (PC), there are wide variations and gaps in treatment among developing countries such as the Middle East African (MEA) region. A multidisciplinary team of experts from the MEA region engaged in a comprehensive discussion to identify the real-world challenges in diagnostics and treatment of Metastatic Castration-Resistant Prostate Cancer (mCRPC) and provided insights on the urgent unmet needs. We present a consensus document on the region-specific barriers, key priority areas and strategic recommendations by experts for optimizing management of mCRPC in the MEA. Limited access to genetic testing and economic constraints were highlighted as major concerns in the MEA. As the therapeutic landscape continues to expand, treatment selection for mCRPC needs to be increasingly personalized. Enhanced genetic testing and judicious utilization of newer therapies like olaparib, articulated by reimbursement support, should be made accessible for the underserved populations in the MEA. Increasing awareness on testing through educational activities catalyzed by digital technologies can play a central role in overcoming barriers to patient care in the MEA region. The involvement of multidisciplinary teams can bridge the treatment gaps, facilitating holistic and optimal management of mCRPC. Region-specific guidelines can help health-care workers navigate challenges and deliver personalized management through collaborative efforts – thus curb health-care variations and drive consistency. Development of region-specific scalable guidelines for genetic testing and treatment of mCRPC, factoring in the trade-off for access, availability, and affordability, is crucial. genetic testing metastatic castration-resistant prostate cancer middle east african region multidisciplinary care Diseases of the genitourinary system. Urology Abdullah Alsharm verfasserin aut Alaa Meshref verfasserin aut Hind Mrabti verfasserin aut Jawaher Ansari verfasserin aut Marwan Ghosn verfasserin aut Mohamed Abdulla verfasserin aut Yuksel Urun verfasserin aut In Urology Annals Wolters Kluwer Medknow Publications, 2009 14(2022), 4, Seite 303-313 (DE-627)629375739 (DE-600)2557851-0 09747834 nnns volume:14 year:2022 number:4 pages:303-313 https://doi.org/10.4103/ua.ua_148_21 kostenfrei https://doaj.org/article/400a15a07b5e43b8bdfc3e7b29b13ce6 kostenfrei http://www.urologyannals.com/article.asp?issn=0974-7796;year=2022;volume=14;issue=4;spage=303;epage=313;aulast=Bazarbashi kostenfrei https://doaj.org/toc/0974-7796 Journal toc kostenfrei https://doaj.org/toc/0974-7834 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 4 303-313
spelling	10.4103/ua.ua_148_21 doi (DE-627)DOAJ020332807 (DE-599)DOAJ400a15a07b5e43b8bdfc3e7b29b13ce6 DE-627 ger DE-627 rakwb eng RC870-923 Shouki Bazarbashi verfasserin aut Management of metastatic castration-resistant prostate cancer in Middle East African countries: Challenges and strategic recommendations 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Despite the reliance on Western guidelines for managing prostate cancer (PC), there are wide variations and gaps in treatment among developing countries such as the Middle East African (MEA) region. A multidisciplinary team of experts from the MEA region engaged in a comprehensive discussion to identify the real-world challenges in diagnostics and treatment of Metastatic Castration-Resistant Prostate Cancer (mCRPC) and provided insights on the urgent unmet needs. We present a consensus document on the region-specific barriers, key priority areas and strategic recommendations by experts for optimizing management of mCRPC in the MEA. Limited access to genetic testing and economic constraints were highlighted as major concerns in the MEA. As the therapeutic landscape continues to expand, treatment selection for mCRPC needs to be increasingly personalized. Enhanced genetic testing and judicious utilization of newer therapies like olaparib, articulated by reimbursement support, should be made accessible for the underserved populations in the MEA. Increasing awareness on testing through educational activities catalyzed by digital technologies can play a central role in overcoming barriers to patient care in the MEA region. The involvement of multidisciplinary teams can bridge the treatment gaps, facilitating holistic and optimal management of mCRPC. Region-specific guidelines can help health-care workers navigate challenges and deliver personalized management through collaborative efforts – thus curb health-care variations and drive consistency. Development of region-specific scalable guidelines for genetic testing and treatment of mCRPC, factoring in the trade-off for access, availability, and affordability, is crucial. genetic testing metastatic castration-resistant prostate cancer middle east african region multidisciplinary care Diseases of the genitourinary system. Urology Abdullah Alsharm verfasserin aut Alaa Meshref verfasserin aut Hind Mrabti verfasserin aut Jawaher Ansari verfasserin aut Marwan Ghosn verfasserin aut Mohamed Abdulla verfasserin aut Yuksel Urun verfasserin aut In Urology Annals Wolters Kluwer Medknow Publications, 2009 14(2022), 4, Seite 303-313 (DE-627)629375739 (DE-600)2557851-0 09747834 nnns volume:14 year:2022 number:4 pages:303-313 https://doi.org/10.4103/ua.ua_148_21 kostenfrei https://doaj.org/article/400a15a07b5e43b8bdfc3e7b29b13ce6 kostenfrei http://www.urologyannals.com/article.asp?issn=0974-7796;year=2022;volume=14;issue=4;spage=303;epage=313;aulast=Bazarbashi kostenfrei https://doaj.org/toc/0974-7796 Journal toc kostenfrei https://doaj.org/toc/0974-7834 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 4 303-313
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allfieldsGer	10.4103/ua.ua_148_21 doi (DE-627)DOAJ020332807 (DE-599)DOAJ400a15a07b5e43b8bdfc3e7b29b13ce6 DE-627 ger DE-627 rakwb eng RC870-923 Shouki Bazarbashi verfasserin aut Management of metastatic castration-resistant prostate cancer in Middle East African countries: Challenges and strategic recommendations 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Despite the reliance on Western guidelines for managing prostate cancer (PC), there are wide variations and gaps in treatment among developing countries such as the Middle East African (MEA) region. A multidisciplinary team of experts from the MEA region engaged in a comprehensive discussion to identify the real-world challenges in diagnostics and treatment of Metastatic Castration-Resistant Prostate Cancer (mCRPC) and provided insights on the urgent unmet needs. We present a consensus document on the region-specific barriers, key priority areas and strategic recommendations by experts for optimizing management of mCRPC in the MEA. Limited access to genetic testing and economic constraints were highlighted as major concerns in the MEA. As the therapeutic landscape continues to expand, treatment selection for mCRPC needs to be increasingly personalized. Enhanced genetic testing and judicious utilization of newer therapies like olaparib, articulated by reimbursement support, should be made accessible for the underserved populations in the MEA. Increasing awareness on testing through educational activities catalyzed by digital technologies can play a central role in overcoming barriers to patient care in the MEA region. The involvement of multidisciplinary teams can bridge the treatment gaps, facilitating holistic and optimal management of mCRPC. Region-specific guidelines can help health-care workers navigate challenges and deliver personalized management through collaborative efforts – thus curb health-care variations and drive consistency. Development of region-specific scalable guidelines for genetic testing and treatment of mCRPC, factoring in the trade-off for access, availability, and affordability, is crucial. genetic testing metastatic castration-resistant prostate cancer middle east african region multidisciplinary care Diseases of the genitourinary system. Urology Abdullah Alsharm verfasserin aut Alaa Meshref verfasserin aut Hind Mrabti verfasserin aut Jawaher Ansari verfasserin aut Marwan Ghosn verfasserin aut Mohamed Abdulla verfasserin aut Yuksel Urun verfasserin aut In Urology Annals Wolters Kluwer Medknow Publications, 2009 14(2022), 4, Seite 303-313 (DE-627)629375739 (DE-600)2557851-0 09747834 nnns volume:14 year:2022 number:4 pages:303-313 https://doi.org/10.4103/ua.ua_148_21 kostenfrei https://doaj.org/article/400a15a07b5e43b8bdfc3e7b29b13ce6 kostenfrei http://www.urologyannals.com/article.asp?issn=0974-7796;year=2022;volume=14;issue=4;spage=303;epage=313;aulast=Bazarbashi kostenfrei https://doaj.org/toc/0974-7796 Journal toc kostenfrei https://doaj.org/toc/0974-7834 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 4 303-313
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source	In Urology Annals 14(2022), 4, Seite 303-313 volume:14 year:2022 number:4 pages:303-313
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topic_title	RC870-923 Management of metastatic castration-resistant prostate cancer in Middle East African countries: Challenges and strategic recommendations genetic testing metastatic castration-resistant prostate cancer middle east african region multidisciplinary care
topic	misc RC870-923 misc genetic testing misc metastatic castration-resistant prostate cancer misc middle east african region misc multidisciplinary care misc Diseases of the genitourinary system. Urology
topic_unstemmed	misc RC870-923 misc genetic testing misc metastatic castration-resistant prostate cancer misc middle east african region misc multidisciplinary care misc Diseases of the genitourinary system. Urology
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title	Management of metastatic castration-resistant prostate cancer in Middle East African countries: Challenges and strategic recommendations
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title_full	Management of metastatic castration-resistant prostate cancer in Middle East African countries: Challenges and strategic recommendations
author_sort	Shouki Bazarbashi
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author_browse	Shouki Bazarbashi Abdullah Alsharm Alaa Meshref Hind Mrabti Jawaher Ansari Marwan Ghosn Mohamed Abdulla Yuksel Urun
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title_sort	management of metastatic castration-resistant prostate cancer in middle east african countries: challenges and strategic recommendations
callnumber	RC870-923
title_auth	Management of metastatic castration-resistant prostate cancer in Middle East African countries: Challenges and strategic recommendations
abstract	Despite the reliance on Western guidelines for managing prostate cancer (PC), there are wide variations and gaps in treatment among developing countries such as the Middle East African (MEA) region. A multidisciplinary team of experts from the MEA region engaged in a comprehensive discussion to identify the real-world challenges in diagnostics and treatment of Metastatic Castration-Resistant Prostate Cancer (mCRPC) and provided insights on the urgent unmet needs. We present a consensus document on the region-specific barriers, key priority areas and strategic recommendations by experts for optimizing management of mCRPC in the MEA. Limited access to genetic testing and economic constraints were highlighted as major concerns in the MEA. As the therapeutic landscape continues to expand, treatment selection for mCRPC needs to be increasingly personalized. Enhanced genetic testing and judicious utilization of newer therapies like olaparib, articulated by reimbursement support, should be made accessible for the underserved populations in the MEA. Increasing awareness on testing through educational activities catalyzed by digital technologies can play a central role in overcoming barriers to patient care in the MEA region. The involvement of multidisciplinary teams can bridge the treatment gaps, facilitating holistic and optimal management of mCRPC. Region-specific guidelines can help health-care workers navigate challenges and deliver personalized management through collaborative efforts – thus curb health-care variations and drive consistency. Development of region-specific scalable guidelines for genetic testing and treatment of mCRPC, factoring in the trade-off for access, availability, and affordability, is crucial.
abstractGer	Despite the reliance on Western guidelines for managing prostate cancer (PC), there are wide variations and gaps in treatment among developing countries such as the Middle East African (MEA) region. A multidisciplinary team of experts from the MEA region engaged in a comprehensive discussion to identify the real-world challenges in diagnostics and treatment of Metastatic Castration-Resistant Prostate Cancer (mCRPC) and provided insights on the urgent unmet needs. We present a consensus document on the region-specific barriers, key priority areas and strategic recommendations by experts for optimizing management of mCRPC in the MEA. Limited access to genetic testing and economic constraints were highlighted as major concerns in the MEA. As the therapeutic landscape continues to expand, treatment selection for mCRPC needs to be increasingly personalized. Enhanced genetic testing and judicious utilization of newer therapies like olaparib, articulated by reimbursement support, should be made accessible for the underserved populations in the MEA. Increasing awareness on testing through educational activities catalyzed by digital technologies can play a central role in overcoming barriers to patient care in the MEA region. The involvement of multidisciplinary teams can bridge the treatment gaps, facilitating holistic and optimal management of mCRPC. Region-specific guidelines can help health-care workers navigate challenges and deliver personalized management through collaborative efforts – thus curb health-care variations and drive consistency. Development of region-specific scalable guidelines for genetic testing and treatment of mCRPC, factoring in the trade-off for access, availability, and affordability, is crucial.
abstract_unstemmed	Despite the reliance on Western guidelines for managing prostate cancer (PC), there are wide variations and gaps in treatment among developing countries such as the Middle East African (MEA) region. A multidisciplinary team of experts from the MEA region engaged in a comprehensive discussion to identify the real-world challenges in diagnostics and treatment of Metastatic Castration-Resistant Prostate Cancer (mCRPC) and provided insights on the urgent unmet needs. We present a consensus document on the region-specific barriers, key priority areas and strategic recommendations by experts for optimizing management of mCRPC in the MEA. Limited access to genetic testing and economic constraints were highlighted as major concerns in the MEA. As the therapeutic landscape continues to expand, treatment selection for mCRPC needs to be increasingly personalized. Enhanced genetic testing and judicious utilization of newer therapies like olaparib, articulated by reimbursement support, should be made accessible for the underserved populations in the MEA. Increasing awareness on testing through educational activities catalyzed by digital technologies can play a central role in overcoming barriers to patient care in the MEA region. The involvement of multidisciplinary teams can bridge the treatment gaps, facilitating holistic and optimal management of mCRPC. Region-specific guidelines can help health-care workers navigate challenges and deliver personalized management through collaborative efforts – thus curb health-care variations and drive consistency. Development of region-specific scalable guidelines for genetic testing and treatment of mCRPC, factoring in the trade-off for access, availability, and affordability, is crucial.
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title_short	Management of metastatic castration-resistant prostate cancer in Middle East African countries: Challenges and strategic recommendations
url	https://doi.org/10.4103/ua.ua_148_21 https://doaj.org/article/400a15a07b5e43b8bdfc3e7b29b13ce6 http://www.urologyannals.com/article.asp?issn=0974-7796;year=2022;volume=14;issue=4;spage=303;epage=313;aulast=Bazarbashi https://doaj.org/toc/0974-7796 https://doaj.org/toc/0974-7834
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