THE HIGH PLASMA RETINOL BINDING PROTEIN 4 LEVEL AS A RISK FACTOR CONSEQUENTLY OF TYPE 2 DIABETES MELLITUS OF ABDOMINAL OBESITY
Abdominal obesity (Ab-Ob) related to cardiometabolic risk, that is riskfactor constellation for succeeded cardiovasculer disease and type 2 DiabetesMellitus (DM). That factors such as atherogenic dislipidemia, hypertension,hyperglycemia, protrombotic state, and proinflammation state. Type 2 DMcharac...
Ausführliche Beschreibung
Autor*in: |
AAG Budhitresna [verfasserIn] Ketut Suastika [verfasserIn] Nyoman Mantik Astawa [verfasserIn] Anwar Santoso [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch ; Indonesisch |
Erschienen: |
2012 |
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Schlagwörter: |
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Übergeordnetes Werk: |
In: Indonesia Journal of Biomedical Science - Universitas Udayana, 2017, 5(2012), 1 |
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Übergeordnetes Werk: |
volume:5 ; year:2012 ; number:1 |
Links: |
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DOI / URN: |
10.15562/ijbs.v5i1.85 |
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Katalog-ID: |
DOAJ020353057 |
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520 | |a Abdominal obesity (Ab-Ob) related to cardiometabolic risk, that is riskfactor constellation for succeeded cardiovasculer disease and type 2 DiabetesMellitus (DM). That factors such as atherogenic dislipidemia, hypertension,hyperglycemia, protrombotic state, and proinflammation state. Type 2 DMcharacterised by insulin resistance (IR). Plasma levels of retinol binding protein 4(RBP4) that is secreted by adipocytes are increased in insulin resistance (IR) state.Experiment in mice suggest that elevated RBP4 level cause IR. Although theunderlying mechanism is not clearly understood, RBP4 considered playimportance role consequently of type 2 DM in Ab-Ob.This research was carried out to determine the role of high plasma RBP4level as a risk factor consequently of type 2 DM in Ab-Ob. The research wasconducted by cross sectional analytic in 81 patients with Ab-Ob and case controlstudy with matching on 33 patients with Ab-Ob type 2 DM as cases and 33patients with Ab-Ob non type 2 DM as control. The plasma of TNF-<span class="fontstyle0"<α</span< , sTNFR1,and RBP4 levels was measured by ELISA. IR status of the patients wasdetermined by HOMA-IR, whereas the <span class="fontstyle0"<β</span<-cell function was determined byHOMA-B. Ab-Ob was defined by using criteria for Asian peoples (male WC <span class="fontstyle0"<≥</span< 90cm; female WC <span class="fontstyle0"<≥</span< 80 cm). The result of 81 patients with Ab-Ob showed that bothplasma of TNF-<span class="fontstyle0"<α</span< and sTNFR1 levels were significant positive correlated withplasma RBP4 level (coeficient correlation r = 0,294; p = 0,008 dan r = 0,458; p =<0,001 respectively). In addition, the plasma of RBP4 level significantly positivecorrelation with HOMA-IR (r = 0,450; p = 0,000) and significantly negativecorrelation with HOMA-B (r = -0,564; p = <0,001). In the matched case-controlstudy, it was shown that mean plasma of RBP4 level of type 2 DM group (76,08 ±16,84 <span class="fontstyle0"<µ</span<g/ml) statistically higher than that without type 2 DM group (41,13 ±14,75 <span class="fontstyle0"<µ</span<g/ml) (p = <0,001). The odds ratio higher plasma of RBP4 level was 5,426(CI 95%; 1,343 – 21, 928) statistically significant for increases risk type 2 DM (p= < 0,05). It has been proven that RBP4 was a dominant and consisten risk factor(66.9%, p = < 0.001) which influenced the incidence of type 2 DM in Ab-Ob. It can be concluded that high plasma of RBP4 level have a greater risk tosuffered from type 2 DM compared to low plasma of RBP4 in Ab-Ob. The highplasma of RBP4 level is most dominant and consistent risk factor consequently of type 2 DM. These mechanism could behind the association between high plasmaof RBP4 level and type 2 DM. | ||
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10.15562/ijbs.v5i1.85 doi (DE-627)DOAJ020353057 (DE-599)DOAJ589379bb4d5e4534858ffe6063fd1582 DE-627 ger DE-627 rakwb eng ind R5-920 AAG Budhitresna verfasserin aut THE HIGH PLASMA RETINOL BINDING PROTEIN 4 LEVEL AS A RISK FACTOR CONSEQUENTLY OF TYPE 2 DIABETES MELLITUS OF ABDOMINAL OBESITY 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abdominal obesity (Ab-Ob) related to cardiometabolic risk, that is riskfactor constellation for succeeded cardiovasculer disease and type 2 DiabetesMellitus (DM). That factors such as atherogenic dislipidemia, hypertension,hyperglycemia, protrombotic state, and proinflammation state. Type 2 DMcharacterised by insulin resistance (IR). Plasma levels of retinol binding protein 4(RBP4) that is secreted by adipocytes are increased in insulin resistance (IR) state.Experiment in mice suggest that elevated RBP4 level cause IR. Although theunderlying mechanism is not clearly understood, RBP4 considered playimportance role consequently of type 2 DM in Ab-Ob.This research was carried out to determine the role of high plasma RBP4level as a risk factor consequently of type 2 DM in Ab-Ob. The research wasconducted by cross sectional analytic in 81 patients with Ab-Ob and case controlstudy with matching on 33 patients with Ab-Ob type 2 DM as cases and 33patients with Ab-Ob non type 2 DM as control. The plasma of TNF-<span class="fontstyle0"<α</span< , sTNFR1,and RBP4 levels was measured by ELISA. IR status of the patients wasdetermined by HOMA-IR, whereas the <span class="fontstyle0"<β</span<-cell function was determined byHOMA-B. Ab-Ob was defined by using criteria for Asian peoples (male WC <span class="fontstyle0"<≥</span< 90cm; female WC <span class="fontstyle0"<≥</span< 80 cm). The result of 81 patients with Ab-Ob showed that bothplasma of TNF-<span class="fontstyle0"<α</span< and sTNFR1 levels were significant positive correlated withplasma RBP4 level (coeficient correlation r = 0,294; p = 0,008 dan r = 0,458; p =<0,001 respectively). In addition, the plasma of RBP4 level significantly positivecorrelation with HOMA-IR (r = 0,450; p = 0,000) and significantly negativecorrelation with HOMA-B (r = -0,564; p = <0,001). In the matched case-controlstudy, it was shown that mean plasma of RBP4 level of type 2 DM group (76,08 ±16,84 <span class="fontstyle0"<µ</span<g/ml) statistically higher than that without type 2 DM group (41,13 ±14,75 <span class="fontstyle0"<µ</span<g/ml) (p = <0,001). The odds ratio higher plasma of RBP4 level was 5,426(CI 95%; 1,343 – 21, 928) statistically significant for increases risk type 2 DM (p= < 0,05). It has been proven that RBP4 was a dominant and consisten risk factor(66.9%, p = < 0.001) which influenced the incidence of type 2 DM in Ab-Ob. It can be concluded that high plasma of RBP4 level have a greater risk tosuffered from type 2 DM compared to low plasma of RBP4 in Ab-Ob. The highplasma of RBP4 level is most dominant and consistent risk factor consequently of type 2 DM. These mechanism could behind the association between high plasmaof RBP4 level and type 2 DM. abdominal obesity, rbp4, homa-ir, homa-b and type 2 dm. Medicine (General) Ketut Suastika verfasserin aut Nyoman Mantik Astawa verfasserin aut Anwar Santoso verfasserin aut In Indonesia Journal of Biomedical Science Universitas Udayana, 2017 5(2012), 1 (DE-627)1760634468 23022906 nnns volume:5 year:2012 number:1 https://doi.org/10.15562/ijbs.v5i1.85 kostenfrei https://doaj.org/article/589379bb4d5e4534858ffe6063fd1582 kostenfrei https://ijbs-udayana.org/index.php/ijbs/article/view/85 kostenfrei https://doaj.org/toc/2302-2906 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 5 2012 1 |
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10.15562/ijbs.v5i1.85 doi (DE-627)DOAJ020353057 (DE-599)DOAJ589379bb4d5e4534858ffe6063fd1582 DE-627 ger DE-627 rakwb eng ind R5-920 AAG Budhitresna verfasserin aut THE HIGH PLASMA RETINOL BINDING PROTEIN 4 LEVEL AS A RISK FACTOR CONSEQUENTLY OF TYPE 2 DIABETES MELLITUS OF ABDOMINAL OBESITY 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abdominal obesity (Ab-Ob) related to cardiometabolic risk, that is riskfactor constellation for succeeded cardiovasculer disease and type 2 DiabetesMellitus (DM). That factors such as atherogenic dislipidemia, hypertension,hyperglycemia, protrombotic state, and proinflammation state. Type 2 DMcharacterised by insulin resistance (IR). Plasma levels of retinol binding protein 4(RBP4) that is secreted by adipocytes are increased in insulin resistance (IR) state.Experiment in mice suggest that elevated RBP4 level cause IR. Although theunderlying mechanism is not clearly understood, RBP4 considered playimportance role consequently of type 2 DM in Ab-Ob.This research was carried out to determine the role of high plasma RBP4level as a risk factor consequently of type 2 DM in Ab-Ob. The research wasconducted by cross sectional analytic in 81 patients with Ab-Ob and case controlstudy with matching on 33 patients with Ab-Ob type 2 DM as cases and 33patients with Ab-Ob non type 2 DM as control. The plasma of TNF-<span class="fontstyle0"<α</span< , sTNFR1,and RBP4 levels was measured by ELISA. IR status of the patients wasdetermined by HOMA-IR, whereas the <span class="fontstyle0"<β</span<-cell function was determined byHOMA-B. Ab-Ob was defined by using criteria for Asian peoples (male WC <span class="fontstyle0"<≥</span< 90cm; female WC <span class="fontstyle0"<≥</span< 80 cm). The result of 81 patients with Ab-Ob showed that bothplasma of TNF-<span class="fontstyle0"<α</span< and sTNFR1 levels were significant positive correlated withplasma RBP4 level (coeficient correlation r = 0,294; p = 0,008 dan r = 0,458; p =<0,001 respectively). In addition, the plasma of RBP4 level significantly positivecorrelation with HOMA-IR (r = 0,450; p = 0,000) and significantly negativecorrelation with HOMA-B (r = -0,564; p = <0,001). In the matched case-controlstudy, it was shown that mean plasma of RBP4 level of type 2 DM group (76,08 ±16,84 <span class="fontstyle0"<µ</span<g/ml) statistically higher than that without type 2 DM group (41,13 ±14,75 <span class="fontstyle0"<µ</span<g/ml) (p = <0,001). The odds ratio higher plasma of RBP4 level was 5,426(CI 95%; 1,343 – 21, 928) statistically significant for increases risk type 2 DM (p= < 0,05). It has been proven that RBP4 was a dominant and consisten risk factor(66.9%, p = < 0.001) which influenced the incidence of type 2 DM in Ab-Ob. It can be concluded that high plasma of RBP4 level have a greater risk tosuffered from type 2 DM compared to low plasma of RBP4 in Ab-Ob. The highplasma of RBP4 level is most dominant and consistent risk factor consequently of type 2 DM. These mechanism could behind the association between high plasmaof RBP4 level and type 2 DM. abdominal obesity, rbp4, homa-ir, homa-b and type 2 dm. Medicine (General) Ketut Suastika verfasserin aut Nyoman Mantik Astawa verfasserin aut Anwar Santoso verfasserin aut In Indonesia Journal of Biomedical Science Universitas Udayana, 2017 5(2012), 1 (DE-627)1760634468 23022906 nnns volume:5 year:2012 number:1 https://doi.org/10.15562/ijbs.v5i1.85 kostenfrei https://doaj.org/article/589379bb4d5e4534858ffe6063fd1582 kostenfrei https://ijbs-udayana.org/index.php/ijbs/article/view/85 kostenfrei https://doaj.org/toc/2302-2906 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 5 2012 1 |
allfields_unstemmed |
10.15562/ijbs.v5i1.85 doi (DE-627)DOAJ020353057 (DE-599)DOAJ589379bb4d5e4534858ffe6063fd1582 DE-627 ger DE-627 rakwb eng ind R5-920 AAG Budhitresna verfasserin aut THE HIGH PLASMA RETINOL BINDING PROTEIN 4 LEVEL AS A RISK FACTOR CONSEQUENTLY OF TYPE 2 DIABETES MELLITUS OF ABDOMINAL OBESITY 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abdominal obesity (Ab-Ob) related to cardiometabolic risk, that is riskfactor constellation for succeeded cardiovasculer disease and type 2 DiabetesMellitus (DM). That factors such as atherogenic dislipidemia, hypertension,hyperglycemia, protrombotic state, and proinflammation state. Type 2 DMcharacterised by insulin resistance (IR). Plasma levels of retinol binding protein 4(RBP4) that is secreted by adipocytes are increased in insulin resistance (IR) state.Experiment in mice suggest that elevated RBP4 level cause IR. Although theunderlying mechanism is not clearly understood, RBP4 considered playimportance role consequently of type 2 DM in Ab-Ob.This research was carried out to determine the role of high plasma RBP4level as a risk factor consequently of type 2 DM in Ab-Ob. The research wasconducted by cross sectional analytic in 81 patients with Ab-Ob and case controlstudy with matching on 33 patients with Ab-Ob type 2 DM as cases and 33patients with Ab-Ob non type 2 DM as control. The plasma of TNF-<span class="fontstyle0"<α</span< , sTNFR1,and RBP4 levels was measured by ELISA. IR status of the patients wasdetermined by HOMA-IR, whereas the <span class="fontstyle0"<β</span<-cell function was determined byHOMA-B. Ab-Ob was defined by using criteria for Asian peoples (male WC <span class="fontstyle0"<≥</span< 90cm; female WC <span class="fontstyle0"<≥</span< 80 cm). The result of 81 patients with Ab-Ob showed that bothplasma of TNF-<span class="fontstyle0"<α</span< and sTNFR1 levels were significant positive correlated withplasma RBP4 level (coeficient correlation r = 0,294; p = 0,008 dan r = 0,458; p =<0,001 respectively). In addition, the plasma of RBP4 level significantly positivecorrelation with HOMA-IR (r = 0,450; p = 0,000) and significantly negativecorrelation with HOMA-B (r = -0,564; p = <0,001). In the matched case-controlstudy, it was shown that mean plasma of RBP4 level of type 2 DM group (76,08 ±16,84 <span class="fontstyle0"<µ</span<g/ml) statistically higher than that without type 2 DM group (41,13 ±14,75 <span class="fontstyle0"<µ</span<g/ml) (p = <0,001). The odds ratio higher plasma of RBP4 level was 5,426(CI 95%; 1,343 – 21, 928) statistically significant for increases risk type 2 DM (p= < 0,05). It has been proven that RBP4 was a dominant and consisten risk factor(66.9%, p = < 0.001) which influenced the incidence of type 2 DM in Ab-Ob. It can be concluded that high plasma of RBP4 level have a greater risk tosuffered from type 2 DM compared to low plasma of RBP4 in Ab-Ob. The highplasma of RBP4 level is most dominant and consistent risk factor consequently of type 2 DM. These mechanism could behind the association between high plasmaof RBP4 level and type 2 DM. abdominal obesity, rbp4, homa-ir, homa-b and type 2 dm. Medicine (General) Ketut Suastika verfasserin aut Nyoman Mantik Astawa verfasserin aut Anwar Santoso verfasserin aut In Indonesia Journal of Biomedical Science Universitas Udayana, 2017 5(2012), 1 (DE-627)1760634468 23022906 nnns volume:5 year:2012 number:1 https://doi.org/10.15562/ijbs.v5i1.85 kostenfrei https://doaj.org/article/589379bb4d5e4534858ffe6063fd1582 kostenfrei https://ijbs-udayana.org/index.php/ijbs/article/view/85 kostenfrei https://doaj.org/toc/2302-2906 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 5 2012 1 |
allfieldsGer |
10.15562/ijbs.v5i1.85 doi (DE-627)DOAJ020353057 (DE-599)DOAJ589379bb4d5e4534858ffe6063fd1582 DE-627 ger DE-627 rakwb eng ind R5-920 AAG Budhitresna verfasserin aut THE HIGH PLASMA RETINOL BINDING PROTEIN 4 LEVEL AS A RISK FACTOR CONSEQUENTLY OF TYPE 2 DIABETES MELLITUS OF ABDOMINAL OBESITY 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abdominal obesity (Ab-Ob) related to cardiometabolic risk, that is riskfactor constellation for succeeded cardiovasculer disease and type 2 DiabetesMellitus (DM). That factors such as atherogenic dislipidemia, hypertension,hyperglycemia, protrombotic state, and proinflammation state. Type 2 DMcharacterised by insulin resistance (IR). Plasma levels of retinol binding protein 4(RBP4) that is secreted by adipocytes are increased in insulin resistance (IR) state.Experiment in mice suggest that elevated RBP4 level cause IR. Although theunderlying mechanism is not clearly understood, RBP4 considered playimportance role consequently of type 2 DM in Ab-Ob.This research was carried out to determine the role of high plasma RBP4level as a risk factor consequently of type 2 DM in Ab-Ob. The research wasconducted by cross sectional analytic in 81 patients with Ab-Ob and case controlstudy with matching on 33 patients with Ab-Ob type 2 DM as cases and 33patients with Ab-Ob non type 2 DM as control. The plasma of TNF-<span class="fontstyle0"<α</span< , sTNFR1,and RBP4 levels was measured by ELISA. IR status of the patients wasdetermined by HOMA-IR, whereas the <span class="fontstyle0"<β</span<-cell function was determined byHOMA-B. Ab-Ob was defined by using criteria for Asian peoples (male WC <span class="fontstyle0"<≥</span< 90cm; female WC <span class="fontstyle0"<≥</span< 80 cm). The result of 81 patients with Ab-Ob showed that bothplasma of TNF-<span class="fontstyle0"<α</span< and sTNFR1 levels were significant positive correlated withplasma RBP4 level (coeficient correlation r = 0,294; p = 0,008 dan r = 0,458; p =<0,001 respectively). In addition, the plasma of RBP4 level significantly positivecorrelation with HOMA-IR (r = 0,450; p = 0,000) and significantly negativecorrelation with HOMA-B (r = -0,564; p = <0,001). In the matched case-controlstudy, it was shown that mean plasma of RBP4 level of type 2 DM group (76,08 ±16,84 <span class="fontstyle0"<µ</span<g/ml) statistically higher than that without type 2 DM group (41,13 ±14,75 <span class="fontstyle0"<µ</span<g/ml) (p = <0,001). The odds ratio higher plasma of RBP4 level was 5,426(CI 95%; 1,343 – 21, 928) statistically significant for increases risk type 2 DM (p= < 0,05). It has been proven that RBP4 was a dominant and consisten risk factor(66.9%, p = < 0.001) which influenced the incidence of type 2 DM in Ab-Ob. It can be concluded that high plasma of RBP4 level have a greater risk tosuffered from type 2 DM compared to low plasma of RBP4 in Ab-Ob. The highplasma of RBP4 level is most dominant and consistent risk factor consequently of type 2 DM. These mechanism could behind the association between high plasmaof RBP4 level and type 2 DM. abdominal obesity, rbp4, homa-ir, homa-b and type 2 dm. Medicine (General) Ketut Suastika verfasserin aut Nyoman Mantik Astawa verfasserin aut Anwar Santoso verfasserin aut In Indonesia Journal of Biomedical Science Universitas Udayana, 2017 5(2012), 1 (DE-627)1760634468 23022906 nnns volume:5 year:2012 number:1 https://doi.org/10.15562/ijbs.v5i1.85 kostenfrei https://doaj.org/article/589379bb4d5e4534858ffe6063fd1582 kostenfrei https://ijbs-udayana.org/index.php/ijbs/article/view/85 kostenfrei https://doaj.org/toc/2302-2906 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 5 2012 1 |
allfieldsSound |
10.15562/ijbs.v5i1.85 doi (DE-627)DOAJ020353057 (DE-599)DOAJ589379bb4d5e4534858ffe6063fd1582 DE-627 ger DE-627 rakwb eng ind R5-920 AAG Budhitresna verfasserin aut THE HIGH PLASMA RETINOL BINDING PROTEIN 4 LEVEL AS A RISK FACTOR CONSEQUENTLY OF TYPE 2 DIABETES MELLITUS OF ABDOMINAL OBESITY 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abdominal obesity (Ab-Ob) related to cardiometabolic risk, that is riskfactor constellation for succeeded cardiovasculer disease and type 2 DiabetesMellitus (DM). That factors such as atherogenic dislipidemia, hypertension,hyperglycemia, protrombotic state, and proinflammation state. Type 2 DMcharacterised by insulin resistance (IR). Plasma levels of retinol binding protein 4(RBP4) that is secreted by adipocytes are increased in insulin resistance (IR) state.Experiment in mice suggest that elevated RBP4 level cause IR. Although theunderlying mechanism is not clearly understood, RBP4 considered playimportance role consequently of type 2 DM in Ab-Ob.This research was carried out to determine the role of high plasma RBP4level as a risk factor consequently of type 2 DM in Ab-Ob. The research wasconducted by cross sectional analytic in 81 patients with Ab-Ob and case controlstudy with matching on 33 patients with Ab-Ob type 2 DM as cases and 33patients with Ab-Ob non type 2 DM as control. The plasma of TNF-<span class="fontstyle0"<α</span< , sTNFR1,and RBP4 levels was measured by ELISA. IR status of the patients wasdetermined by HOMA-IR, whereas the <span class="fontstyle0"<β</span<-cell function was determined byHOMA-B. Ab-Ob was defined by using criteria for Asian peoples (male WC <span class="fontstyle0"<≥</span< 90cm; female WC <span class="fontstyle0"<≥</span< 80 cm). The result of 81 patients with Ab-Ob showed that bothplasma of TNF-<span class="fontstyle0"<α</span< and sTNFR1 levels were significant positive correlated withplasma RBP4 level (coeficient correlation r = 0,294; p = 0,008 dan r = 0,458; p =<0,001 respectively). In addition, the plasma of RBP4 level significantly positivecorrelation with HOMA-IR (r = 0,450; p = 0,000) and significantly negativecorrelation with HOMA-B (r = -0,564; p = <0,001). In the matched case-controlstudy, it was shown that mean plasma of RBP4 level of type 2 DM group (76,08 ±16,84 <span class="fontstyle0"<µ</span<g/ml) statistically higher than that without type 2 DM group (41,13 ±14,75 <span class="fontstyle0"<µ</span<g/ml) (p = <0,001). The odds ratio higher plasma of RBP4 level was 5,426(CI 95%; 1,343 – 21, 928) statistically significant for increases risk type 2 DM (p= < 0,05). It has been proven that RBP4 was a dominant and consisten risk factor(66.9%, p = < 0.001) which influenced the incidence of type 2 DM in Ab-Ob. It can be concluded that high plasma of RBP4 level have a greater risk tosuffered from type 2 DM compared to low plasma of RBP4 in Ab-Ob. The highplasma of RBP4 level is most dominant and consistent risk factor consequently of type 2 DM. These mechanism could behind the association between high plasmaof RBP4 level and type 2 DM. abdominal obesity, rbp4, homa-ir, homa-b and type 2 dm. Medicine (General) Ketut Suastika verfasserin aut Nyoman Mantik Astawa verfasserin aut Anwar Santoso verfasserin aut In Indonesia Journal of Biomedical Science Universitas Udayana, 2017 5(2012), 1 (DE-627)1760634468 23022906 nnns volume:5 year:2012 number:1 https://doi.org/10.15562/ijbs.v5i1.85 kostenfrei https://doaj.org/article/589379bb4d5e4534858ffe6063fd1582 kostenfrei https://ijbs-udayana.org/index.php/ijbs/article/view/85 kostenfrei https://doaj.org/toc/2302-2906 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 5 2012 1 |
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IR status of the patients wasdetermined by HOMA-IR, whereas the <span class="fontstyle0"<β</span<-cell function was determined byHOMA-B. Ab-Ob was defined by using criteria for Asian peoples (male WC <span class="fontstyle0"<≥</span< 90cm; female WC <span class="fontstyle0"<≥</span< 80 cm). The result of 81 patients with Ab-Ob showed that bothplasma of TNF-<span class="fontstyle0"<α</span< and sTNFR1 levels were significant positive correlated withplasma RBP4 level (coeficient correlation r = 0,294; p = 0,008 dan r = 0,458; p =&lt;0,001 respectively). In addition, the plasma of RBP4 level significantly positivecorrelation with HOMA-IR (r = 0,450; p = 0,000) and significantly negativecorrelation with HOMA-B (r = -0,564; p = &lt;0,001). 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R5-920 THE HIGH PLASMA RETINOL BINDING PROTEIN 4 LEVEL AS A RISK FACTOR CONSEQUENTLY OF TYPE 2 DIABETES MELLITUS OF ABDOMINAL OBESITY abdominal obesity, rbp4, homa-ir, homa-b and type 2 dm |
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THE HIGH PLASMA RETINOL BINDING PROTEIN 4 LEVEL AS A RISK FACTOR CONSEQUENTLY OF TYPE 2 DIABETES MELLITUS OF ABDOMINAL OBESITY |
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THE HIGH PLASMA RETINOL BINDING PROTEIN 4 LEVEL AS A RISK FACTOR CONSEQUENTLY OF TYPE 2 DIABETES MELLITUS OF ABDOMINAL OBESITY |
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high plasma retinol binding protein 4 level as a risk factor consequently of type 2 diabetes mellitus of abdominal obesity |
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THE HIGH PLASMA RETINOL BINDING PROTEIN 4 LEVEL AS A RISK FACTOR CONSEQUENTLY OF TYPE 2 DIABETES MELLITUS OF ABDOMINAL OBESITY |
abstract |
Abdominal obesity (Ab-Ob) related to cardiometabolic risk, that is riskfactor constellation for succeeded cardiovasculer disease and type 2 DiabetesMellitus (DM). That factors such as atherogenic dislipidemia, hypertension,hyperglycemia, protrombotic state, and proinflammation state. Type 2 DMcharacterised by insulin resistance (IR). Plasma levels of retinol binding protein 4(RBP4) that is secreted by adipocytes are increased in insulin resistance (IR) state.Experiment in mice suggest that elevated RBP4 level cause IR. Although theunderlying mechanism is not clearly understood, RBP4 considered playimportance role consequently of type 2 DM in Ab-Ob.This research was carried out to determine the role of high plasma RBP4level as a risk factor consequently of type 2 DM in Ab-Ob. The research wasconducted by cross sectional analytic in 81 patients with Ab-Ob and case controlstudy with matching on 33 patients with Ab-Ob type 2 DM as cases and 33patients with Ab-Ob non type 2 DM as control. The plasma of TNF-<span class="fontstyle0"<α</span< , sTNFR1,and RBP4 levels was measured by ELISA. IR status of the patients wasdetermined by HOMA-IR, whereas the <span class="fontstyle0"<β</span<-cell function was determined byHOMA-B. Ab-Ob was defined by using criteria for Asian peoples (male WC <span class="fontstyle0"<≥</span< 90cm; female WC <span class="fontstyle0"<≥</span< 80 cm). The result of 81 patients with Ab-Ob showed that bothplasma of TNF-<span class="fontstyle0"<α</span< and sTNFR1 levels were significant positive correlated withplasma RBP4 level (coeficient correlation r = 0,294; p = 0,008 dan r = 0,458; p =<0,001 respectively). In addition, the plasma of RBP4 level significantly positivecorrelation with HOMA-IR (r = 0,450; p = 0,000) and significantly negativecorrelation with HOMA-B (r = -0,564; p = <0,001). In the matched case-controlstudy, it was shown that mean plasma of RBP4 level of type 2 DM group (76,08 ±16,84 <span class="fontstyle0"<µ</span<g/ml) statistically higher than that without type 2 DM group (41,13 ±14,75 <span class="fontstyle0"<µ</span<g/ml) (p = <0,001). The odds ratio higher plasma of RBP4 level was 5,426(CI 95%; 1,343 – 21, 928) statistically significant for increases risk type 2 DM (p= < 0,05). It has been proven that RBP4 was a dominant and consisten risk factor(66.9%, p = < 0.001) which influenced the incidence of type 2 DM in Ab-Ob. It can be concluded that high plasma of RBP4 level have a greater risk tosuffered from type 2 DM compared to low plasma of RBP4 in Ab-Ob. The highplasma of RBP4 level is most dominant and consistent risk factor consequently of type 2 DM. These mechanism could behind the association between high plasmaof RBP4 level and type 2 DM. |
abstractGer |
Abdominal obesity (Ab-Ob) related to cardiometabolic risk, that is riskfactor constellation for succeeded cardiovasculer disease and type 2 DiabetesMellitus (DM). That factors such as atherogenic dislipidemia, hypertension,hyperglycemia, protrombotic state, and proinflammation state. Type 2 DMcharacterised by insulin resistance (IR). Plasma levels of retinol binding protein 4(RBP4) that is secreted by adipocytes are increased in insulin resistance (IR) state.Experiment in mice suggest that elevated RBP4 level cause IR. Although theunderlying mechanism is not clearly understood, RBP4 considered playimportance role consequently of type 2 DM in Ab-Ob.This research was carried out to determine the role of high plasma RBP4level as a risk factor consequently of type 2 DM in Ab-Ob. The research wasconducted by cross sectional analytic in 81 patients with Ab-Ob and case controlstudy with matching on 33 patients with Ab-Ob type 2 DM as cases and 33patients with Ab-Ob non type 2 DM as control. The plasma of TNF-<span class="fontstyle0"<α</span< , sTNFR1,and RBP4 levels was measured by ELISA. IR status of the patients wasdetermined by HOMA-IR, whereas the <span class="fontstyle0"<β</span<-cell function was determined byHOMA-B. Ab-Ob was defined by using criteria for Asian peoples (male WC <span class="fontstyle0"<≥</span< 90cm; female WC <span class="fontstyle0"<≥</span< 80 cm). The result of 81 patients with Ab-Ob showed that bothplasma of TNF-<span class="fontstyle0"<α</span< and sTNFR1 levels were significant positive correlated withplasma RBP4 level (coeficient correlation r = 0,294; p = 0,008 dan r = 0,458; p =<0,001 respectively). In addition, the plasma of RBP4 level significantly positivecorrelation with HOMA-IR (r = 0,450; p = 0,000) and significantly negativecorrelation with HOMA-B (r = -0,564; p = <0,001). In the matched case-controlstudy, it was shown that mean plasma of RBP4 level of type 2 DM group (76,08 ±16,84 <span class="fontstyle0"<µ</span<g/ml) statistically higher than that without type 2 DM group (41,13 ±14,75 <span class="fontstyle0"<µ</span<g/ml) (p = <0,001). The odds ratio higher plasma of RBP4 level was 5,426(CI 95%; 1,343 – 21, 928) statistically significant for increases risk type 2 DM (p= < 0,05). It has been proven that RBP4 was a dominant and consisten risk factor(66.9%, p = < 0.001) which influenced the incidence of type 2 DM in Ab-Ob. It can be concluded that high plasma of RBP4 level have a greater risk tosuffered from type 2 DM compared to low plasma of RBP4 in Ab-Ob. The highplasma of RBP4 level is most dominant and consistent risk factor consequently of type 2 DM. These mechanism could behind the association between high plasmaof RBP4 level and type 2 DM. |
abstract_unstemmed |
Abdominal obesity (Ab-Ob) related to cardiometabolic risk, that is riskfactor constellation for succeeded cardiovasculer disease and type 2 DiabetesMellitus (DM). That factors such as atherogenic dislipidemia, hypertension,hyperglycemia, protrombotic state, and proinflammation state. Type 2 DMcharacterised by insulin resistance (IR). Plasma levels of retinol binding protein 4(RBP4) that is secreted by adipocytes are increased in insulin resistance (IR) state.Experiment in mice suggest that elevated RBP4 level cause IR. Although theunderlying mechanism is not clearly understood, RBP4 considered playimportance role consequently of type 2 DM in Ab-Ob.This research was carried out to determine the role of high plasma RBP4level as a risk factor consequently of type 2 DM in Ab-Ob. The research wasconducted by cross sectional analytic in 81 patients with Ab-Ob and case controlstudy with matching on 33 patients with Ab-Ob type 2 DM as cases and 33patients with Ab-Ob non type 2 DM as control. The plasma of TNF-<span class="fontstyle0"<α</span< , sTNFR1,and RBP4 levels was measured by ELISA. IR status of the patients wasdetermined by HOMA-IR, whereas the <span class="fontstyle0"<β</span<-cell function was determined byHOMA-B. Ab-Ob was defined by using criteria for Asian peoples (male WC <span class="fontstyle0"<≥</span< 90cm; female WC <span class="fontstyle0"<≥</span< 80 cm). The result of 81 patients with Ab-Ob showed that bothplasma of TNF-<span class="fontstyle0"<α</span< and sTNFR1 levels were significant positive correlated withplasma RBP4 level (coeficient correlation r = 0,294; p = 0,008 dan r = 0,458; p =<0,001 respectively). In addition, the plasma of RBP4 level significantly positivecorrelation with HOMA-IR (r = 0,450; p = 0,000) and significantly negativecorrelation with HOMA-B (r = -0,564; p = <0,001). In the matched case-controlstudy, it was shown that mean plasma of RBP4 level of type 2 DM group (76,08 ±16,84 <span class="fontstyle0"<µ</span<g/ml) statistically higher than that without type 2 DM group (41,13 ±14,75 <span class="fontstyle0"<µ</span<g/ml) (p = <0,001). The odds ratio higher plasma of RBP4 level was 5,426(CI 95%; 1,343 – 21, 928) statistically significant for increases risk type 2 DM (p= < 0,05). It has been proven that RBP4 was a dominant and consisten risk factor(66.9%, p = < 0.001) which influenced the incidence of type 2 DM in Ab-Ob. It can be concluded that high plasma of RBP4 level have a greater risk tosuffered from type 2 DM compared to low plasma of RBP4 in Ab-Ob. The highplasma of RBP4 level is most dominant and consistent risk factor consequently of type 2 DM. These mechanism could behind the association between high plasmaof RBP4 level and type 2 DM. |
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THE HIGH PLASMA RETINOL BINDING PROTEIN 4 LEVEL AS A RISK FACTOR CONSEQUENTLY OF TYPE 2 DIABETES MELLITUS OF ABDOMINAL OBESITY |
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https://doi.org/10.15562/ijbs.v5i1.85 https://doaj.org/article/589379bb4d5e4534858ffe6063fd1582 https://ijbs-udayana.org/index.php/ijbs/article/view/85 https://doaj.org/toc/2302-2906 |
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That factors such as atherogenic dislipidemia, hypertension,hyperglycemia, protrombotic state, and proinflammation state. Type 2 DMcharacterised by insulin resistance (IR). Plasma levels of retinol binding protein 4(RBP4) that is secreted by adipocytes are increased in insulin resistance (IR) state.Experiment in mice suggest that elevated RBP4 level cause IR. Although theunderlying mechanism is not clearly understood, RBP4 considered playimportance role consequently of type 2 DM in Ab-Ob.This research was carried out to determine the role of high plasma RBP4level as a risk factor consequently of type 2 DM in Ab-Ob. The research wasconducted by cross sectional analytic in 81 patients with Ab-Ob and case controlstudy with matching on 33 patients with Ab-Ob type 2 DM as cases and 33patients with Ab-Ob non type 2 DM as control. The plasma of TNF-<span class="fontstyle0"<α</span< , sTNFR1,and RBP4 levels was measured by ELISA. IR status of the patients wasdetermined by HOMA-IR, whereas the <span class="fontstyle0"<β</span<-cell function was determined byHOMA-B. Ab-Ob was defined by using criteria for Asian peoples (male WC <span class="fontstyle0"<≥</span< 90cm; female WC <span class="fontstyle0"<≥</span< 80 cm). The result of 81 patients with Ab-Ob showed that bothplasma of TNF-<span class="fontstyle0"<α</span< and sTNFR1 levels were significant positive correlated withplasma RBP4 level (coeficient correlation r = 0,294; p = 0,008 dan r = 0,458; p =&lt;0,001 respectively). In addition, the plasma of RBP4 level significantly positivecorrelation with HOMA-IR (r = 0,450; p = 0,000) and significantly negativecorrelation with HOMA-B (r = -0,564; p = &lt;0,001). In the matched case-controlstudy, it was shown that mean plasma of RBP4 level of type 2 DM group (76,08 ±16,84 <span class="fontstyle0"<µ</span<g/ml) statistically higher than that without type 2 DM group (41,13 ±14,75 <span class="fontstyle0"<µ</span<g/ml) (p = &lt;0,001). The odds ratio higher plasma of RBP4 level was 5,426(CI 95%; 1,343 – 21, 928) statistically significant for increases risk type 2 DM (p= &lt; 0,05). It has been proven that RBP4 was a dominant and consisten risk factor(66.9%, p = &lt; 0.001) which influenced the incidence of type 2 DM in Ab-Ob. It can be concluded that high plasma of RBP4 level have a greater risk tosuffered from type 2 DM compared to low plasma of RBP4 in Ab-Ob. The highplasma of RBP4 level is most dominant and consistent risk factor consequently of type 2 DM. These mechanism could behind the association between high plasmaof RBP4 level and type 2 DM.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">abdominal obesity, rbp4, homa-ir, homa-b and type 2 dm.</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Medicine (General)</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ketut Suastika</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Nyoman Mantik Astawa</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Anwar Santoso</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Indonesia Journal of Biomedical Science</subfield><subfield code="d">Universitas Udayana, 2017</subfield><subfield code="g">5(2012), 1</subfield><subfield code="w">(DE-627)1760634468</subfield><subfield code="x">23022906</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:5</subfield><subfield code="g">year:2012</subfield><subfield code="g">number:1</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.15562/ijbs.v5i1.85</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/589379bb4d5e4534858ffe6063fd1582</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://ijbs-udayana.org/index.php/ijbs/article/view/85</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/2302-2906</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_DOAJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">5</subfield><subfield code="j">2012</subfield><subfield code="e">1</subfield></datafield></record></collection>
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