THE HIGH PLASMA RETINOL BINDING PROTEIN 4 LEVEL AS A RISK FACTOR CONSEQUENTLY OF TYPE 2 DIABETES MELLITUS OF ABDOMINAL OBESITY

Abdominal obesity (Ab-Ob) related to cardiometabolic risk, that is riskfactor constellation for succeeded cardiovasculer disease and type 2 DiabetesMellitus (DM). That factors such as atherogenic dislipidemia, hypertension,hyperglycemia, protrombotic state, and proinflammation state. Type 2 DMcharacterised by insulin resistance (IR). Plasma levels of retinol binding protein 4(RBP4) that is secreted by adipocytes are increased in insulin resistance (IR) state.Experiment in mice suggest that elevated RBP4 level cause IR. Although theunderlying mechanism is not clearly understood, RBP4 considered playimportance role consequently of type 2 DM in Ab-Ob.This research was carried out to determine the role of high plasma RBP4level as a risk factor consequently of type 2 DM in Ab-Ob. The research wasconducted by cross sectional analytic in 81 patients with Ab-Ob and case controlstudy with matching on 33 patients with Ab-Ob type 2 DM as cases and 33patients with Ab-Ob non type 2 DM as control. The plasma of TNF-<span class="fontstyle0"<α</span< , sTNFR1,and RBP4 levels was measured by ELISA. IR status of the patients wasdetermined by HOMA-IR, whereas the <span class="fontstyle0"<β</span<-cell function was determined byHOMA-B. Ab-Ob was defined by using criteria for Asian peoples (male WC <span class="fontstyle0"<≥</span< 90cm; female WC <span class="fontstyle0"<≥</span< 80 cm). The result of 81 patients with Ab-Ob showed that bothplasma of TNF-<span class="fontstyle0"<α</span< and sTNFR1 levels were significant positive correlated withplasma RBP4 level (coeficient correlation r = 0,294; p = 0,008 dan r = 0,458; p =<0,001 respectively). In addition, the plasma of RBP4 level significantly positivecorrelation with HOMA-IR (r = 0,450; p = 0,000) and significantly negativecorrelation with HOMA-B (r = -0,564; p = <0,001). In the matched case-controlstudy, it was shown that mean plasma of RBP4 level of type 2 DM group (76,08 ±16,84 <span class="fontstyle0"<µ</span<g/ml) statistically higher than that without type 2 DM group (41,13 ±14,75 <span class="fontstyle0"<µ</span<g/ml) (p = <0,001). The odds ratio higher plasma of RBP4 level was 5,426(CI 95%; 1,343 – 21, 928) statistically significant for increases risk type 2 DM (p= < 0,05). It has been proven that RBP4 was a dominant and consisten risk factor(66.9%, p = < 0.001) which influenced the incidence of type 2 DM in Ab-Ob. It can be concluded that high plasma of RBP4 level have a greater risk tosuffered from type 2 DM compared to low plasma of RBP4 in Ab-Ob. The highplasma of RBP4 level is most dominant and consistent risk factor consequently of type 2 DM. These mechanism could behind the association between high plasmaof RBP4 level and type 2 DM. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	AAG Budhitresna [verfasserIn] Ketut Suastika [verfasserIn] Nyoman Mantik Astawa [verfasserIn] Anwar Santoso [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch ; Indonesisch

Erschienen:	2012

Schlagwörter:	abdominal obesity, rbp4, homa-ir, homa-b and type 2 dm.

Übergeordnetes Werk:	In: Indonesia Journal of Biomedical Science - Universitas Udayana, 2017, 5(2012), 1
Übergeordnetes Werk:	volume:5 ; year:2012 ; number:1

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.15562/ijbs.v5i1.85

Katalog-ID:	DOAJ020353057

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245	1	4	\|a THE HIGH PLASMA RETINOL BINDING PROTEIN 4 LEVEL AS A RISK FACTOR CONSEQUENTLY OF TYPE 2 DIABETES MELLITUS OF ABDOMINAL OBESITY
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520			\|a Abdominal obesity (Ab-Ob) related to cardiometabolic risk, that is riskfactor constellation for succeeded cardiovasculer disease and type 2 DiabetesMellitus (DM). That factors such as atherogenic dislipidemia, hypertension,hyperglycemia, protrombotic state, and proinflammation state. Type 2 DMcharacterised by insulin resistance (IR). Plasma levels of retinol binding protein 4(RBP4) that is secreted by adipocytes are increased in insulin resistance (IR) state.Experiment in mice suggest that elevated RBP4 level cause IR. Although theunderlying mechanism is not clearly understood, RBP4 considered playimportance role consequently of type 2 DM in Ab-Ob.This research was carried out to determine the role of high plasma RBP4level as a risk factor consequently of type 2 DM in Ab-Ob. The research wasconducted by cross sectional analytic in 81 patients with Ab-Ob and case controlstudy with matching on 33 patients with Ab-Ob type 2 DM as cases and 33patients with Ab-Ob non type 2 DM as control. The plasma of TNF-<span class="fontstyle0"<α</span< , sTNFR1,and RBP4 levels was measured by ELISA. IR status of the patients wasdetermined by HOMA-IR, whereas the <span class="fontstyle0"<β</span<-cell function was determined byHOMA-B. Ab-Ob was defined by using criteria for Asian peoples (male WC <span class="fontstyle0"<≥</span< 90cm; female WC <span class="fontstyle0"<≥</span< 80 cm). The result of 81 patients with Ab-Ob showed that bothplasma of TNF-<span class="fontstyle0"<α</span< and sTNFR1 levels were significant positive correlated withplasma RBP4 level (coeficient correlation r = 0,294; p = 0,008 dan r = 0,458; p =<0,001 respectively). In addition, the plasma of RBP4 level significantly positivecorrelation with HOMA-IR (r = 0,450; p = 0,000) and significantly negativecorrelation with HOMA-B (r = -0,564; p = <0,001). In the matched case-controlstudy, it was shown that mean plasma of RBP4 level of type 2 DM group (76,08 ±16,84 <span class="fontstyle0"<µ</span<g/ml) statistically higher than that without type 2 DM group (41,13 ±14,75 <span class="fontstyle0"<µ</span<g/ml) (p = <0,001). The odds ratio higher plasma of RBP4 level was 5,426(CI 95%; 1,343 – 21, 928) statistically significant for increases risk type 2 DM (p= < 0,05). It has been proven that RBP4 was a dominant and consisten risk factor(66.9%, p = < 0.001) which influenced the incidence of type 2 DM in Ab-Ob. It can be concluded that high plasma of RBP4 level have a greater risk tosuffered from type 2 DM compared to low plasma of RBP4 in Ab-Ob. The highplasma of RBP4 level is most dominant and consistent risk factor consequently of type 2 DM. These mechanism could behind the association between high plasmaof RBP4 level and type 2 DM.
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allfields	10.15562/ijbs.v5i1.85 doi (DE-627)DOAJ020353057 (DE-599)DOAJ589379bb4d5e4534858ffe6063fd1582 DE-627 ger DE-627 rakwb eng ind R5-920 AAG Budhitresna verfasserin aut THE HIGH PLASMA RETINOL BINDING PROTEIN 4 LEVEL AS A RISK FACTOR CONSEQUENTLY OF TYPE 2 DIABETES MELLITUS OF ABDOMINAL OBESITY 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abdominal obesity (Ab-Ob) related to cardiometabolic risk, that is riskfactor constellation for succeeded cardiovasculer disease and type 2 DiabetesMellitus (DM). That factors such as atherogenic dislipidemia, hypertension,hyperglycemia, protrombotic state, and proinflammation state. Type 2 DMcharacterised by insulin resistance (IR). Plasma levels of retinol binding protein 4(RBP4) that is secreted by adipocytes are increased in insulin resistance (IR) state.Experiment in mice suggest that elevated RBP4 level cause IR. Although theunderlying mechanism is not clearly understood, RBP4 considered playimportance role consequently of type 2 DM in Ab-Ob.This research was carried out to determine the role of high plasma RBP4level as a risk factor consequently of type 2 DM in Ab-Ob. The research wasconducted by cross sectional analytic in 81 patients with Ab-Ob and case controlstudy with matching on 33 patients with Ab-Ob type 2 DM as cases and 33patients with Ab-Ob non type 2 DM as control. The plasma of TNF-<span class="fontstyle0"<α</span< , sTNFR1,and RBP4 levels was measured by ELISA. IR status of the patients wasdetermined by HOMA-IR, whereas the <span class="fontstyle0"<β</span<-cell function was determined byHOMA-B. Ab-Ob was defined by using criteria for Asian peoples (male WC <span class="fontstyle0"<≥</span< 90cm; female WC <span class="fontstyle0"<≥</span< 80 cm). The result of 81 patients with Ab-Ob showed that bothplasma of TNF-<span class="fontstyle0"<α</span< and sTNFR1 levels were significant positive correlated withplasma RBP4 level (coeficient correlation r = 0,294; p = 0,008 dan r = 0,458; p =<0,001 respectively). In addition, the plasma of RBP4 level significantly positivecorrelation with HOMA-IR (r = 0,450; p = 0,000) and significantly negativecorrelation with HOMA-B (r = -0,564; p = <0,001). In the matched case-controlstudy, it was shown that mean plasma of RBP4 level of type 2 DM group (76,08 ±16,84 <span class="fontstyle0"<µ</span<g/ml) statistically higher than that without type 2 DM group (41,13 ±14,75 <span class="fontstyle0"<µ</span<g/ml) (p = <0,001). The odds ratio higher plasma of RBP4 level was 5,426(CI 95%; 1,343 – 21, 928) statistically significant for increases risk type 2 DM (p= < 0,05). It has been proven that RBP4 was a dominant and consisten risk factor(66.9%, p = < 0.001) which influenced the incidence of type 2 DM in Ab-Ob. It can be concluded that high plasma of RBP4 level have a greater risk tosuffered from type 2 DM compared to low plasma of RBP4 in Ab-Ob. The highplasma of RBP4 level is most dominant and consistent risk factor consequently of type 2 DM. These mechanism could behind the association between high plasmaof RBP4 level and type 2 DM. abdominal obesity, rbp4, homa-ir, homa-b and type 2 dm. Medicine (General) Ketut Suastika verfasserin aut Nyoman Mantik Astawa verfasserin aut Anwar Santoso verfasserin aut In Indonesia Journal of Biomedical Science Universitas Udayana, 2017 5(2012), 1 (DE-627)1760634468 23022906 nnns volume:5 year:2012 number:1 https://doi.org/10.15562/ijbs.v5i1.85 kostenfrei https://doaj.org/article/589379bb4d5e4534858ffe6063fd1582 kostenfrei https://ijbs-udayana.org/index.php/ijbs/article/view/85 kostenfrei https://doaj.org/toc/2302-2906 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 5 2012 1
spelling	10.15562/ijbs.v5i1.85 doi (DE-627)DOAJ020353057 (DE-599)DOAJ589379bb4d5e4534858ffe6063fd1582 DE-627 ger DE-627 rakwb eng ind R5-920 AAG Budhitresna verfasserin aut THE HIGH PLASMA RETINOL BINDING PROTEIN 4 LEVEL AS A RISK FACTOR CONSEQUENTLY OF TYPE 2 DIABETES MELLITUS OF ABDOMINAL OBESITY 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abdominal obesity (Ab-Ob) related to cardiometabolic risk, that is riskfactor constellation for succeeded cardiovasculer disease and type 2 DiabetesMellitus (DM). That factors such as atherogenic dislipidemia, hypertension,hyperglycemia, protrombotic state, and proinflammation state. Type 2 DMcharacterised by insulin resistance (IR). Plasma levels of retinol binding protein 4(RBP4) that is secreted by adipocytes are increased in insulin resistance (IR) state.Experiment in mice suggest that elevated RBP4 level cause IR. Although theunderlying mechanism is not clearly understood, RBP4 considered playimportance role consequently of type 2 DM in Ab-Ob.This research was carried out to determine the role of high plasma RBP4level as a risk factor consequently of type 2 DM in Ab-Ob. The research wasconducted by cross sectional analytic in 81 patients with Ab-Ob and case controlstudy with matching on 33 patients with Ab-Ob type 2 DM as cases and 33patients with Ab-Ob non type 2 DM as control. The plasma of TNF-<span class="fontstyle0"<α</span< , sTNFR1,and RBP4 levels was measured by ELISA. IR status of the patients wasdetermined by HOMA-IR, whereas the <span class="fontstyle0"<β</span<-cell function was determined byHOMA-B. Ab-Ob was defined by using criteria for Asian peoples (male WC <span class="fontstyle0"<≥</span< 90cm; female WC <span class="fontstyle0"<≥</span< 80 cm). The result of 81 patients with Ab-Ob showed that bothplasma of TNF-<span class="fontstyle0"<α</span< and sTNFR1 levels were significant positive correlated withplasma RBP4 level (coeficient correlation r = 0,294; p = 0,008 dan r = 0,458; p =<0,001 respectively). In addition, the plasma of RBP4 level significantly positivecorrelation with HOMA-IR (r = 0,450; p = 0,000) and significantly negativecorrelation with HOMA-B (r = -0,564; p = <0,001). In the matched case-controlstudy, it was shown that mean plasma of RBP4 level of type 2 DM group (76,08 ±16,84 <span class="fontstyle0"<µ</span<g/ml) statistically higher than that without type 2 DM group (41,13 ±14,75 <span class="fontstyle0"<µ</span<g/ml) (p = <0,001). The odds ratio higher plasma of RBP4 level was 5,426(CI 95%; 1,343 – 21, 928) statistically significant for increases risk type 2 DM (p= < 0,05). It has been proven that RBP4 was a dominant and consisten risk factor(66.9%, p = < 0.001) which influenced the incidence of type 2 DM in Ab-Ob. It can be concluded that high plasma of RBP4 level have a greater risk tosuffered from type 2 DM compared to low plasma of RBP4 in Ab-Ob. The highplasma of RBP4 level is most dominant and consistent risk factor consequently of type 2 DM. These mechanism could behind the association between high plasmaof RBP4 level and type 2 DM. abdominal obesity, rbp4, homa-ir, homa-b and type 2 dm. Medicine (General) Ketut Suastika verfasserin aut Nyoman Mantik Astawa verfasserin aut Anwar Santoso verfasserin aut In Indonesia Journal of Biomedical Science Universitas Udayana, 2017 5(2012), 1 (DE-627)1760634468 23022906 nnns volume:5 year:2012 number:1 https://doi.org/10.15562/ijbs.v5i1.85 kostenfrei https://doaj.org/article/589379bb4d5e4534858ffe6063fd1582 kostenfrei https://ijbs-udayana.org/index.php/ijbs/article/view/85 kostenfrei https://doaj.org/toc/2302-2906 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 5 2012 1
allfields_unstemmed	10.15562/ijbs.v5i1.85 doi (DE-627)DOAJ020353057 (DE-599)DOAJ589379bb4d5e4534858ffe6063fd1582 DE-627 ger DE-627 rakwb eng ind R5-920 AAG Budhitresna verfasserin aut THE HIGH PLASMA RETINOL BINDING PROTEIN 4 LEVEL AS A RISK FACTOR CONSEQUENTLY OF TYPE 2 DIABETES MELLITUS OF ABDOMINAL OBESITY 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abdominal obesity (Ab-Ob) related to cardiometabolic risk, that is riskfactor constellation for succeeded cardiovasculer disease and type 2 DiabetesMellitus (DM). That factors such as atherogenic dislipidemia, hypertension,hyperglycemia, protrombotic state, and proinflammation state. Type 2 DMcharacterised by insulin resistance (IR). Plasma levels of retinol binding protein 4(RBP4) that is secreted by adipocytes are increased in insulin resistance (IR) state.Experiment in mice suggest that elevated RBP4 level cause IR. Although theunderlying mechanism is not clearly understood, RBP4 considered playimportance role consequently of type 2 DM in Ab-Ob.This research was carried out to determine the role of high plasma RBP4level as a risk factor consequently of type 2 DM in Ab-Ob. The research wasconducted by cross sectional analytic in 81 patients with Ab-Ob and case controlstudy with matching on 33 patients with Ab-Ob type 2 DM as cases and 33patients with Ab-Ob non type 2 DM as control. The plasma of TNF-<span class="fontstyle0"<α</span< , sTNFR1,and RBP4 levels was measured by ELISA. IR status of the patients wasdetermined by HOMA-IR, whereas the <span class="fontstyle0"<β</span<-cell function was determined byHOMA-B. Ab-Ob was defined by using criteria for Asian peoples (male WC <span class="fontstyle0"<≥</span< 90cm; female WC <span class="fontstyle0"<≥</span< 80 cm). The result of 81 patients with Ab-Ob showed that bothplasma of TNF-<span class="fontstyle0"<α</span< and sTNFR1 levels were significant positive correlated withplasma RBP4 level (coeficient correlation r = 0,294; p = 0,008 dan r = 0,458; p =<0,001 respectively). In addition, the plasma of RBP4 level significantly positivecorrelation with HOMA-IR (r = 0,450; p = 0,000) and significantly negativecorrelation with HOMA-B (r = -0,564; p = <0,001). In the matched case-controlstudy, it was shown that mean plasma of RBP4 level of type 2 DM group (76,08 ±16,84 <span class="fontstyle0"<µ</span<g/ml) statistically higher than that without type 2 DM group (41,13 ±14,75 <span class="fontstyle0"<µ</span<g/ml) (p = <0,001). The odds ratio higher plasma of RBP4 level was 5,426(CI 95%; 1,343 – 21, 928) statistically significant for increases risk type 2 DM (p= < 0,05). It has been proven that RBP4 was a dominant and consisten risk factor(66.9%, p = < 0.001) which influenced the incidence of type 2 DM in Ab-Ob. It can be concluded that high plasma of RBP4 level have a greater risk tosuffered from type 2 DM compared to low plasma of RBP4 in Ab-Ob. The highplasma of RBP4 level is most dominant and consistent risk factor consequently of type 2 DM. These mechanism could behind the association between high plasmaof RBP4 level and type 2 DM. abdominal obesity, rbp4, homa-ir, homa-b and type 2 dm. Medicine (General) Ketut Suastika verfasserin aut Nyoman Mantik Astawa verfasserin aut Anwar Santoso verfasserin aut In Indonesia Journal of Biomedical Science Universitas Udayana, 2017 5(2012), 1 (DE-627)1760634468 23022906 nnns volume:5 year:2012 number:1 https://doi.org/10.15562/ijbs.v5i1.85 kostenfrei https://doaj.org/article/589379bb4d5e4534858ffe6063fd1582 kostenfrei https://ijbs-udayana.org/index.php/ijbs/article/view/85 kostenfrei https://doaj.org/toc/2302-2906 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 5 2012 1
allfieldsGer	10.15562/ijbs.v5i1.85 doi (DE-627)DOAJ020353057 (DE-599)DOAJ589379bb4d5e4534858ffe6063fd1582 DE-627 ger DE-627 rakwb eng ind R5-920 AAG Budhitresna verfasserin aut THE HIGH PLASMA RETINOL BINDING PROTEIN 4 LEVEL AS A RISK FACTOR CONSEQUENTLY OF TYPE 2 DIABETES MELLITUS OF ABDOMINAL OBESITY 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abdominal obesity (Ab-Ob) related to cardiometabolic risk, that is riskfactor constellation for succeeded cardiovasculer disease and type 2 DiabetesMellitus (DM). That factors such as atherogenic dislipidemia, hypertension,hyperglycemia, protrombotic state, and proinflammation state. Type 2 DMcharacterised by insulin resistance (IR). Plasma levels of retinol binding protein 4(RBP4) that is secreted by adipocytes are increased in insulin resistance (IR) state.Experiment in mice suggest that elevated RBP4 level cause IR. Although theunderlying mechanism is not clearly understood, RBP4 considered playimportance role consequently of type 2 DM in Ab-Ob.This research was carried out to determine the role of high plasma RBP4level as a risk factor consequently of type 2 DM in Ab-Ob. The research wasconducted by cross sectional analytic in 81 patients with Ab-Ob and case controlstudy with matching on 33 patients with Ab-Ob type 2 DM as cases and 33patients with Ab-Ob non type 2 DM as control. The plasma of TNF-<span class="fontstyle0"<α</span< , sTNFR1,and RBP4 levels was measured by ELISA. IR status of the patients wasdetermined by HOMA-IR, whereas the <span class="fontstyle0"<β</span<-cell function was determined byHOMA-B. Ab-Ob was defined by using criteria for Asian peoples (male WC <span class="fontstyle0"<≥</span< 90cm; female WC <span class="fontstyle0"<≥</span< 80 cm). The result of 81 patients with Ab-Ob showed that bothplasma of TNF-<span class="fontstyle0"<α</span< and sTNFR1 levels were significant positive correlated withplasma RBP4 level (coeficient correlation r = 0,294; p = 0,008 dan r = 0,458; p =<0,001 respectively). In addition, the plasma of RBP4 level significantly positivecorrelation with HOMA-IR (r = 0,450; p = 0,000) and significantly negativecorrelation with HOMA-B (r = -0,564; p = <0,001). In the matched case-controlstudy, it was shown that mean plasma of RBP4 level of type 2 DM group (76,08 ±16,84 <span class="fontstyle0"<µ</span<g/ml) statistically higher than that without type 2 DM group (41,13 ±14,75 <span class="fontstyle0"<µ</span<g/ml) (p = <0,001). The odds ratio higher plasma of RBP4 level was 5,426(CI 95%; 1,343 – 21, 928) statistically significant for increases risk type 2 DM (p= < 0,05). It has been proven that RBP4 was a dominant and consisten risk factor(66.9%, p = < 0.001) which influenced the incidence of type 2 DM in Ab-Ob. It can be concluded that high plasma of RBP4 level have a greater risk tosuffered from type 2 DM compared to low plasma of RBP4 in Ab-Ob. The highplasma of RBP4 level is most dominant and consistent risk factor consequently of type 2 DM. These mechanism could behind the association between high plasmaof RBP4 level and type 2 DM. abdominal obesity, rbp4, homa-ir, homa-b and type 2 dm. Medicine (General) Ketut Suastika verfasserin aut Nyoman Mantik Astawa verfasserin aut Anwar Santoso verfasserin aut In Indonesia Journal of Biomedical Science Universitas Udayana, 2017 5(2012), 1 (DE-627)1760634468 23022906 nnns volume:5 year:2012 number:1 https://doi.org/10.15562/ijbs.v5i1.85 kostenfrei https://doaj.org/article/589379bb4d5e4534858ffe6063fd1582 kostenfrei https://ijbs-udayana.org/index.php/ijbs/article/view/85 kostenfrei https://doaj.org/toc/2302-2906 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 5 2012 1
allfieldsSound	10.15562/ijbs.v5i1.85 doi (DE-627)DOAJ020353057 (DE-599)DOAJ589379bb4d5e4534858ffe6063fd1582 DE-627 ger DE-627 rakwb eng ind R5-920 AAG Budhitresna verfasserin aut THE HIGH PLASMA RETINOL BINDING PROTEIN 4 LEVEL AS A RISK FACTOR CONSEQUENTLY OF TYPE 2 DIABETES MELLITUS OF ABDOMINAL OBESITY 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abdominal obesity (Ab-Ob) related to cardiometabolic risk, that is riskfactor constellation for succeeded cardiovasculer disease and type 2 DiabetesMellitus (DM). That factors such as atherogenic dislipidemia, hypertension,hyperglycemia, protrombotic state, and proinflammation state. Type 2 DMcharacterised by insulin resistance (IR). Plasma levels of retinol binding protein 4(RBP4) that is secreted by adipocytes are increased in insulin resistance (IR) state.Experiment in mice suggest that elevated RBP4 level cause IR. Although theunderlying mechanism is not clearly understood, RBP4 considered playimportance role consequently of type 2 DM in Ab-Ob.This research was carried out to determine the role of high plasma RBP4level as a risk factor consequently of type 2 DM in Ab-Ob. The research wasconducted by cross sectional analytic in 81 patients with Ab-Ob and case controlstudy with matching on 33 patients with Ab-Ob type 2 DM as cases and 33patients with Ab-Ob non type 2 DM as control. The plasma of TNF-<span class="fontstyle0"<α</span< , sTNFR1,and RBP4 levels was measured by ELISA. IR status of the patients wasdetermined by HOMA-IR, whereas the <span class="fontstyle0"<β</span<-cell function was determined byHOMA-B. Ab-Ob was defined by using criteria for Asian peoples (male WC <span class="fontstyle0"<≥</span< 90cm; female WC <span class="fontstyle0"<≥</span< 80 cm). The result of 81 patients with Ab-Ob showed that bothplasma of TNF-<span class="fontstyle0"<α</span< and sTNFR1 levels were significant positive correlated withplasma RBP4 level (coeficient correlation r = 0,294; p = 0,008 dan r = 0,458; p =<0,001 respectively). In addition, the plasma of RBP4 level significantly positivecorrelation with HOMA-IR (r = 0,450; p = 0,000) and significantly negativecorrelation with HOMA-B (r = -0,564; p = <0,001). In the matched case-controlstudy, it was shown that mean plasma of RBP4 level of type 2 DM group (76,08 ±16,84 <span class="fontstyle0"<µ</span<g/ml) statistically higher than that without type 2 DM group (41,13 ±14,75 <span class="fontstyle0"<µ</span<g/ml) (p = <0,001). The odds ratio higher plasma of RBP4 level was 5,426(CI 95%; 1,343 – 21, 928) statistically significant for increases risk type 2 DM (p= < 0,05). It has been proven that RBP4 was a dominant and consisten risk factor(66.9%, p = < 0.001) which influenced the incidence of type 2 DM in Ab-Ob. It can be concluded that high plasma of RBP4 level have a greater risk tosuffered from type 2 DM compared to low plasma of RBP4 in Ab-Ob. The highplasma of RBP4 level is most dominant and consistent risk factor consequently of type 2 DM. These mechanism could behind the association between high plasmaof RBP4 level and type 2 DM. abdominal obesity, rbp4, homa-ir, homa-b and type 2 dm. Medicine (General) Ketut Suastika verfasserin aut Nyoman Mantik Astawa verfasserin aut Anwar Santoso verfasserin aut In Indonesia Journal of Biomedical Science Universitas Udayana, 2017 5(2012), 1 (DE-627)1760634468 23022906 nnns volume:5 year:2012 number:1 https://doi.org/10.15562/ijbs.v5i1.85 kostenfrei https://doaj.org/article/589379bb4d5e4534858ffe6063fd1582 kostenfrei https://ijbs-udayana.org/index.php/ijbs/article/view/85 kostenfrei https://doaj.org/toc/2302-2906 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 5 2012 1
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IR status of the patients wasdetermined by HOMA-IR, whereas the <span class="fontstyle0"<β</span<-cell function was determined byHOMA-B. Ab-Ob was defined by using criteria for Asian peoples (male WC <span class="fontstyle0"<≥</span< 90cm; female WC <span class="fontstyle0"<≥</span< 80 cm). The result of 81 patients with Ab-Ob showed that bothplasma of TNF-<span class="fontstyle0"<α</span< and sTNFR1 levels were significant positive correlated withplasma RBP4 level (coeficient correlation r = 0,294; p = 0,008 dan r = 0,458; p =&lt;0,001 respectively). In addition, the plasma of RBP4 level significantly positivecorrelation with HOMA-IR (r = 0,450; p = 0,000) and significantly negativecorrelation with HOMA-B (r = -0,564; p = &lt;0,001). In the matched case-controlstudy, it was shown that mean plasma of RBP4 level of type 2 DM group (76,08 ±16,84 <span class="fontstyle0"<µ</span<g/ml) statistically higher than that without type 2 DM group (41,13 ±14,75 <span class="fontstyle0"<µ</span<g/ml) (p = &lt;0,001). The odds ratio higher plasma of RBP4 level was 5,426(CI 95%; 1,343 – 21, 928) statistically significant for increases risk type 2 DM (p= &lt; 0,05). It has been proven that RBP4 was a dominant and consisten risk factor(66.9%, p = &lt; 0.001) which influenced the incidence of type 2 DM in Ab-Ob. It can be concluded that high plasma of RBP4 level have a greater risk tosuffered from type 2 DM compared to low plasma of RBP4 in Ab-Ob. The highplasma of RBP4 level is most dominant and consistent risk factor consequently of type 2 DM. 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spellingShingle	AAG Budhitresna misc R5-920 misc abdominal obesity, rbp4, homa-ir, homa-b and type 2 dm. misc Medicine (General) THE HIGH PLASMA RETINOL BINDING PROTEIN 4 LEVEL AS A RISK FACTOR CONSEQUENTLY OF TYPE 2 DIABETES MELLITUS OF ABDOMINAL OBESITY
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topic_title	R5-920 THE HIGH PLASMA RETINOL BINDING PROTEIN 4 LEVEL AS A RISK FACTOR CONSEQUENTLY OF TYPE 2 DIABETES MELLITUS OF ABDOMINAL OBESITY abdominal obesity, rbp4, homa-ir, homa-b and type 2 dm
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title	THE HIGH PLASMA RETINOL BINDING PROTEIN 4 LEVEL AS A RISK FACTOR CONSEQUENTLY OF TYPE 2 DIABETES MELLITUS OF ABDOMINAL OBESITY
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title_full	THE HIGH PLASMA RETINOL BINDING PROTEIN 4 LEVEL AS A RISK FACTOR CONSEQUENTLY OF TYPE 2 DIABETES MELLITUS OF ABDOMINAL OBESITY
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title_sort	high plasma retinol binding protein 4 level as a risk factor consequently of type 2 diabetes mellitus of abdominal obesity
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title_auth	THE HIGH PLASMA RETINOL BINDING PROTEIN 4 LEVEL AS A RISK FACTOR CONSEQUENTLY OF TYPE 2 DIABETES MELLITUS OF ABDOMINAL OBESITY
abstract	Abdominal obesity (Ab-Ob) related to cardiometabolic risk, that is riskfactor constellation for succeeded cardiovasculer disease and type 2 DiabetesMellitus (DM). That factors such as atherogenic dislipidemia, hypertension,hyperglycemia, protrombotic state, and proinflammation state. Type 2 DMcharacterised by insulin resistance (IR). Plasma levels of retinol binding protein 4(RBP4) that is secreted by adipocytes are increased in insulin resistance (IR) state.Experiment in mice suggest that elevated RBP4 level cause IR. Although theunderlying mechanism is not clearly understood, RBP4 considered playimportance role consequently of type 2 DM in Ab-Ob.This research was carried out to determine the role of high plasma RBP4level as a risk factor consequently of type 2 DM in Ab-Ob. The research wasconducted by cross sectional analytic in 81 patients with Ab-Ob and case controlstudy with matching on 33 patients with Ab-Ob type 2 DM as cases and 33patients with Ab-Ob non type 2 DM as control. The plasma of TNF-<span class="fontstyle0"<α</span< , sTNFR1,and RBP4 levels was measured by ELISA. IR status of the patients wasdetermined by HOMA-IR, whereas the <span class="fontstyle0"<β</span<-cell function was determined byHOMA-B. Ab-Ob was defined by using criteria for Asian peoples (male WC <span class="fontstyle0"<≥</span< 90cm; female WC <span class="fontstyle0"<≥</span< 80 cm). The result of 81 patients with Ab-Ob showed that bothplasma of TNF-<span class="fontstyle0"<α</span< and sTNFR1 levels were significant positive correlated withplasma RBP4 level (coeficient correlation r = 0,294; p = 0,008 dan r = 0,458; p =<0,001 respectively). In addition, the plasma of RBP4 level significantly positivecorrelation with HOMA-IR (r = 0,450; p = 0,000) and significantly negativecorrelation with HOMA-B (r = -0,564; p = <0,001). In the matched case-controlstudy, it was shown that mean plasma of RBP4 level of type 2 DM group (76,08 ±16,84 <span class="fontstyle0"<µ</span<g/ml) statistically higher than that without type 2 DM group (41,13 ±14,75 <span class="fontstyle0"<µ</span<g/ml) (p = <0,001). The odds ratio higher plasma of RBP4 level was 5,426(CI 95%; 1,343 – 21, 928) statistically significant for increases risk type 2 DM (p= < 0,05). It has been proven that RBP4 was a dominant and consisten risk factor(66.9%, p = < 0.001) which influenced the incidence of type 2 DM in Ab-Ob. It can be concluded that high plasma of RBP4 level have a greater risk tosuffered from type 2 DM compared to low plasma of RBP4 in Ab-Ob. The highplasma of RBP4 level is most dominant and consistent risk factor consequently of type 2 DM. These mechanism could behind the association between high plasmaof RBP4 level and type 2 DM.
abstractGer	Abdominal obesity (Ab-Ob) related to cardiometabolic risk, that is riskfactor constellation for succeeded cardiovasculer disease and type 2 DiabetesMellitus (DM). That factors such as atherogenic dislipidemia, hypertension,hyperglycemia, protrombotic state, and proinflammation state. Type 2 DMcharacterised by insulin resistance (IR). Plasma levels of retinol binding protein 4(RBP4) that is secreted by adipocytes are increased in insulin resistance (IR) state.Experiment in mice suggest that elevated RBP4 level cause IR. Although theunderlying mechanism is not clearly understood, RBP4 considered playimportance role consequently of type 2 DM in Ab-Ob.This research was carried out to determine the role of high plasma RBP4level as a risk factor consequently of type 2 DM in Ab-Ob. The research wasconducted by cross sectional analytic in 81 patients with Ab-Ob and case controlstudy with matching on 33 patients with Ab-Ob type 2 DM as cases and 33patients with Ab-Ob non type 2 DM as control. The plasma of TNF-<span class="fontstyle0"<α</span< , sTNFR1,and RBP4 levels was measured by ELISA. IR status of the patients wasdetermined by HOMA-IR, whereas the <span class="fontstyle0"<β</span<-cell function was determined byHOMA-B. Ab-Ob was defined by using criteria for Asian peoples (male WC <span class="fontstyle0"<≥</span< 90cm; female WC <span class="fontstyle0"<≥</span< 80 cm). The result of 81 patients with Ab-Ob showed that bothplasma of TNF-<span class="fontstyle0"<α</span< and sTNFR1 levels were significant positive correlated withplasma RBP4 level (coeficient correlation r = 0,294; p = 0,008 dan r = 0,458; p =<0,001 respectively). In addition, the plasma of RBP4 level significantly positivecorrelation with HOMA-IR (r = 0,450; p = 0,000) and significantly negativecorrelation with HOMA-B (r = -0,564; p = <0,001). In the matched case-controlstudy, it was shown that mean plasma of RBP4 level of type 2 DM group (76,08 ±16,84 <span class="fontstyle0"<µ</span<g/ml) statistically higher than that without type 2 DM group (41,13 ±14,75 <span class="fontstyle0"<µ</span<g/ml) (p = <0,001). The odds ratio higher plasma of RBP4 level was 5,426(CI 95%; 1,343 – 21, 928) statistically significant for increases risk type 2 DM (p= < 0,05). It has been proven that RBP4 was a dominant and consisten risk factor(66.9%, p = < 0.001) which influenced the incidence of type 2 DM in Ab-Ob. It can be concluded that high plasma of RBP4 level have a greater risk tosuffered from type 2 DM compared to low plasma of RBP4 in Ab-Ob. The highplasma of RBP4 level is most dominant and consistent risk factor consequently of type 2 DM. These mechanism could behind the association between high plasmaof RBP4 level and type 2 DM.
abstract_unstemmed	Abdominal obesity (Ab-Ob) related to cardiometabolic risk, that is riskfactor constellation for succeeded cardiovasculer disease and type 2 DiabetesMellitus (DM). That factors such as atherogenic dislipidemia, hypertension,hyperglycemia, protrombotic state, and proinflammation state. Type 2 DMcharacterised by insulin resistance (IR). Plasma levels of retinol binding protein 4(RBP4) that is secreted by adipocytes are increased in insulin resistance (IR) state.Experiment in mice suggest that elevated RBP4 level cause IR. Although theunderlying mechanism is not clearly understood, RBP4 considered playimportance role consequently of type 2 DM in Ab-Ob.This research was carried out to determine the role of high plasma RBP4level as a risk factor consequently of type 2 DM in Ab-Ob. The research wasconducted by cross sectional analytic in 81 patients with Ab-Ob and case controlstudy with matching on 33 patients with Ab-Ob type 2 DM as cases and 33patients with Ab-Ob non type 2 DM as control. The plasma of TNF-<span class="fontstyle0"<α</span< , sTNFR1,and RBP4 levels was measured by ELISA. IR status of the patients wasdetermined by HOMA-IR, whereas the <span class="fontstyle0"<β</span<-cell function was determined byHOMA-B. Ab-Ob was defined by using criteria for Asian peoples (male WC <span class="fontstyle0"<≥</span< 90cm; female WC <span class="fontstyle0"<≥</span< 80 cm). The result of 81 patients with Ab-Ob showed that bothplasma of TNF-<span class="fontstyle0"<α</span< and sTNFR1 levels were significant positive correlated withplasma RBP4 level (coeficient correlation r = 0,294; p = 0,008 dan r = 0,458; p =<0,001 respectively). In addition, the plasma of RBP4 level significantly positivecorrelation with HOMA-IR (r = 0,450; p = 0,000) and significantly negativecorrelation with HOMA-B (r = -0,564; p = <0,001). In the matched case-controlstudy, it was shown that mean plasma of RBP4 level of type 2 DM group (76,08 ±16,84 <span class="fontstyle0"<µ</span<g/ml) statistically higher than that without type 2 DM group (41,13 ±14,75 <span class="fontstyle0"<µ</span<g/ml) (p = <0,001). The odds ratio higher plasma of RBP4 level was 5,426(CI 95%; 1,343 – 21, 928) statistically significant for increases risk type 2 DM (p= < 0,05). It has been proven that RBP4 was a dominant and consisten risk factor(66.9%, p = < 0.001) which influenced the incidence of type 2 DM in Ab-Ob. It can be concluded that high plasma of RBP4 level have a greater risk tosuffered from type 2 DM compared to low plasma of RBP4 in Ab-Ob. The highplasma of RBP4 level is most dominant and consistent risk factor consequently of type 2 DM. These mechanism could behind the association between high plasmaof RBP4 level and type 2 DM.
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title_short	THE HIGH PLASMA RETINOL BINDING PROTEIN 4 LEVEL AS A RISK FACTOR CONSEQUENTLY OF TYPE 2 DIABETES MELLITUS OF ABDOMINAL OBESITY
url	https://doi.org/10.15562/ijbs.v5i1.85 https://doaj.org/article/589379bb4d5e4534858ffe6063fd1582 https://ijbs-udayana.org/index.php/ijbs/article/view/85 https://doaj.org/toc/2302-2906
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author2	Ketut Suastika Nyoman Mantik Astawa Anwar Santoso
author2Str	Ketut Suastika Nyoman Mantik Astawa Anwar Santoso
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doi_str	10.15562/ijbs.v5i1.85
callnumber-a	R5-920
up_date	2024-07-03T14:27:36.027Z
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