Targeted deletion of AKAP7 in dentate granule cells impairs spatial discrimination

Protein Kinase A (PKA) mediates synaptic plasticity and is widely implicated in learning and memory. The hippocampal dentate gyrus (DG) is thought to be responsible for processing and encoding distinct contextual associations in response to highly similar inputs. The mossy fiber (MF) axons of the de...
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Autor*in:	Brian W Jones [verfasserIn] Jennifer Deem [verfasserIn] Thomas J Younts [verfasserIn] Michael Weisenhaus [verfasserIn] Christina A Sanford [verfasserIn] Margaret C Slack [verfasserIn] Jenesa Chin [verfasserIn] Daniela Nachmanson [verfasserIn] Alex McKennon [verfasserIn] Pablo E Castillo [verfasserIn] G Stanley McKnight [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2016

Schlagwörter:	PKA anchoring synaptic plasticity spatial discrimination

Übergeordnetes Werk:	In: eLife - eLife Sciences Publications Ltd, 2013, 5(2016)
Übergeordnetes Werk:	volume:5 ; year:2016

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.7554/eLife.20695

Katalog-ID:	DOAJ02046522X

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allfieldsSound	10.7554/eLife.20695 doi (DE-627)DOAJ02046522X (DE-599)DOAJccb6d67e37424b3596d95ff7b4e0d75b DE-627 ger DE-627 rakwb eng QH301-705.5 Brian W Jones verfasserin aut Targeted deletion of AKAP7 in dentate granule cells impairs spatial discrimination 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Protein Kinase A (PKA) mediates synaptic plasticity and is widely implicated in learning and memory. The hippocampal dentate gyrus (DG) is thought to be responsible for processing and encoding distinct contextual associations in response to highly similar inputs. The mossy fiber (MF) axons of the dentate granule cells convey strong excitatory drive to CA3 pyramidal neurons and express presynaptic, PKA-dependent forms of plasticity. Here, we demonstrate an essential role for the PKA anchoring protein, AKAP7, in mouse MF axons and terminals. Genetic ablation of AKAP7 specifically from dentate granule cells results in disruption of MF-CA3 LTP directly initiated by cAMP, and the AKAP7 mutant mice are selectively deficient in pattern separation behaviors. Our results suggest that the AKAP7/PKA complex in the MF projections plays an essential role in synaptic plasticity and contextual memory formation. PKA anchoring synaptic plasticity spatial discrimination Medicine R Science Q Biology (General) Jennifer Deem verfasserin aut Thomas J Younts verfasserin aut Michael Weisenhaus verfasserin aut Christina A Sanford verfasserin aut Margaret C Slack verfasserin aut Jenesa Chin verfasserin aut Daniela Nachmanson verfasserin aut Alex McKennon verfasserin aut Pablo E Castillo verfasserin aut G Stanley McKnight verfasserin aut In eLife eLife Sciences Publications Ltd, 2013 5(2016) (DE-627)728518384 (DE-600)2687154-3 2050084X nnns volume:5 year:2016 https://doi.org/10.7554/eLife.20695 kostenfrei https://doaj.org/article/ccb6d67e37424b3596d95ff7b4e0d75b kostenfrei https://elifesciences.org/articles/20695 kostenfrei https://doaj.org/toc/2050-084X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2016
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container_title	eLife
authorswithroles_txt_mv	Brian W Jones @@aut@@ Jennifer Deem @@aut@@ Thomas J Younts @@aut@@ Michael Weisenhaus @@aut@@ Christina A Sanford @@aut@@ Margaret C Slack @@aut@@ Jenesa Chin @@aut@@ Daniela Nachmanson @@aut@@ Alex McKennon @@aut@@ Pablo E Castillo @@aut@@ G Stanley McKnight @@aut@@
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author	Brian W Jones
spellingShingle	Brian W Jones misc QH301-705.5 misc PKA anchoring misc synaptic plasticity misc spatial discrimination misc Medicine misc R misc Science misc Q misc Biology (General) Targeted deletion of AKAP7 in dentate granule cells impairs spatial discrimination
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topic_title	QH301-705.5 Targeted deletion of AKAP7 in dentate granule cells impairs spatial discrimination PKA anchoring synaptic plasticity spatial discrimination
topic	misc QH301-705.5 misc PKA anchoring misc synaptic plasticity misc spatial discrimination misc Medicine misc R misc Science misc Q misc Biology (General)
topic_unstemmed	misc QH301-705.5 misc PKA anchoring misc synaptic plasticity misc spatial discrimination misc Medicine misc R misc Science misc Q misc Biology (General)
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title	Targeted deletion of AKAP7 in dentate granule cells impairs spatial discrimination
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title_sort	targeted deletion of akap7 in dentate granule cells impairs spatial discrimination
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title_auth	Targeted deletion of AKAP7 in dentate granule cells impairs spatial discrimination
abstract	Protein Kinase A (PKA) mediates synaptic plasticity and is widely implicated in learning and memory. The hippocampal dentate gyrus (DG) is thought to be responsible for processing and encoding distinct contextual associations in response to highly similar inputs. The mossy fiber (MF) axons of the dentate granule cells convey strong excitatory drive to CA3 pyramidal neurons and express presynaptic, PKA-dependent forms of plasticity. Here, we demonstrate an essential role for the PKA anchoring protein, AKAP7, in mouse MF axons and terminals. Genetic ablation of AKAP7 specifically from dentate granule cells results in disruption of MF-CA3 LTP directly initiated by cAMP, and the AKAP7 mutant mice are selectively deficient in pattern separation behaviors. Our results suggest that the AKAP7/PKA complex in the MF projections plays an essential role in synaptic plasticity and contextual memory formation.
abstractGer	Protein Kinase A (PKA) mediates synaptic plasticity and is widely implicated in learning and memory. The hippocampal dentate gyrus (DG) is thought to be responsible for processing and encoding distinct contextual associations in response to highly similar inputs. The mossy fiber (MF) axons of the dentate granule cells convey strong excitatory drive to CA3 pyramidal neurons and express presynaptic, PKA-dependent forms of plasticity. Here, we demonstrate an essential role for the PKA anchoring protein, AKAP7, in mouse MF axons and terminals. Genetic ablation of AKAP7 specifically from dentate granule cells results in disruption of MF-CA3 LTP directly initiated by cAMP, and the AKAP7 mutant mice are selectively deficient in pattern separation behaviors. Our results suggest that the AKAP7/PKA complex in the MF projections plays an essential role in synaptic plasticity and contextual memory formation.
abstract_unstemmed	Protein Kinase A (PKA) mediates synaptic plasticity and is widely implicated in learning and memory. The hippocampal dentate gyrus (DG) is thought to be responsible for processing and encoding distinct contextual associations in response to highly similar inputs. The mossy fiber (MF) axons of the dentate granule cells convey strong excitatory drive to CA3 pyramidal neurons and express presynaptic, PKA-dependent forms of plasticity. Here, we demonstrate an essential role for the PKA anchoring protein, AKAP7, in mouse MF axons and terminals. Genetic ablation of AKAP7 specifically from dentate granule cells results in disruption of MF-CA3 LTP directly initiated by cAMP, and the AKAP7 mutant mice are selectively deficient in pattern separation behaviors. Our results suggest that the AKAP7/PKA complex in the MF projections plays an essential role in synaptic plasticity and contextual memory formation.
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title_short	Targeted deletion of AKAP7 in dentate granule cells impairs spatial discrimination
url	https://doi.org/10.7554/eLife.20695 https://doaj.org/article/ccb6d67e37424b3596d95ff7b4e0d75b https://elifesciences.org/articles/20695 https://doaj.org/toc/2050-084X
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Targeted deletion of AKAP7 in dentate granule cells impairs spatial discrimination

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