Changes and significance of serum levels of VEGF, ES, TKLK, TSP and sICAM-1 in patients with diabetic retinopathy

AIM: To investigate the changes of serum levels of vascular endothelial growth factor(VEGF), Endostatin(ES), thrombospondin(TSP), tissue kallikrein(TKLK)and soluble intercellular adhesion molecule-1(sICAM-1)in patients with diabetic retinopathy(DR)and its clinical significance. <p<METHODS: Sel...
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Autor*in:	Li-Mei Hu [verfasserIn] Wu-Chao Yan [verfasserIn] Wei-Dong Ren [verfasserIn] Hui-Ying Liu [verfasserIn] Wen-Juan Deng [verfasserIn] Zheng-Rong Xu [verfasserIn] Li-Juan Zuo [verfasserIn] Jun Gu [verfasserIn] Li Shi [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	vascular endothelial growth factor endostatin platelet reactive protein tissue kallikrein soluble intercellular adhesion molecule -1 diabetic retinopathy

Übergeordnetes Werk:	In: Guoji Yanke Zazhi - Press of International Journal of Ophthalmology (IJO PRESS), 2017, 17(2017), 12, Seite 2304-2307
Übergeordnetes Werk:	volume:17 ; year:2017 ; number:12 ; pages:2304-2307

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.3980/j.issn.1672-5123.2017.12.28

Katalog-ID:	DOAJ020496869

Internformat


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520			\|a AIM: To investigate the changes of serum levels of vascular endothelial growth factor(VEGF), Endostatin(ES), thrombospondin(TSP), tissue kallikrein(TKLK)and soluble intercellular adhesion molecule-1(sICAM-1)in patients with diabetic retinopathy(DR)and its clinical significance. <p<METHODS: Selected 60 patients with non-proliferative diabetic retinopathy(NPDR group), 60 patients with proliferative diabetic retinopathy(PDR group)were enrolled in this study. Sixty diabetic patients without diabetic retinopathy(DM group)and 60 healthy people(control group)were also enrolled. Collection time was from January 2014 to December 2016. Serum levels of VEGF, ES, TSP, TKLK and sICAM-1 were measured and compared. <p<RESULTS: The levels of serum VEGF, TKLK and sICAM-1 in PDR group were significantly higher than those in NPDR group, DM group and control group(<i<P</i<<0.05). The ES of PDR group was significantly lower than that of NPDR group, DM group and control group(<i<P</i<<0.05). The levels of VEGF, TKLK and ES in the NPDR group were significantly higher than those in the DM group and the control group(<i<P</i<<0.05). The serum VEGF in the NPDR group was positively correlated with the levels of ES, TKLK and sICAM-1(<i<P</i<<0.05). The serum VEGF of PDR group was positively related to the levels of TKLK and sICAM-1(<i<P</i<<0.05). There was no significant relationship between serum VEGF with ES and TSP in PDR group(<i<P</i<<0.05). <p<CONCLUSION: The levels of serum ES, TSP, TKLK and sICAM-1 in patients with DR have changed significantly, and the process of retinopathy has been affected by regulating the level of VEGF.
650		4	\|a vascular endothelial growth factor
650		4	\|a endostatin
650		4	\|a platelet reactive protein
650		4	\|a tissue kallikrein
650		4	\|a soluble intercellular adhesion molecule -1
650		4	\|a diabetic retinopathy
653		0	\|a Ophthalmology
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700	0		\|a Wei-Dong Ren \|e verfasserin \|4 aut
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700	0		\|a Wen-Juan Deng \|e verfasserin \|4 aut
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700	0		\|a Li-Juan Zuo \|e verfasserin \|4 aut
700	0		\|a Jun Gu \|e verfasserin \|4 aut
700	0		\|a Li Shi \|e verfasserin \|4 aut
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allfields	10.3980/j.issn.1672-5123.2017.12.28 doi (DE-627)DOAJ020496869 (DE-599)DOAJccfe68de8afd42b194390502b30d5a0a DE-627 ger DE-627 rakwb eng RE1-994 Li-Mei Hu verfasserin aut Changes and significance of serum levels of VEGF, ES, TKLK, TSP and sICAM-1 in patients with diabetic retinopathy 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier AIM: To investigate the changes of serum levels of vascular endothelial growth factor(VEGF), Endostatin(ES), thrombospondin(TSP), tissue kallikrein(TKLK)and soluble intercellular adhesion molecule-1(sICAM-1)in patients with diabetic retinopathy(DR)and its clinical significance. <p<METHODS: Selected 60 patients with non-proliferative diabetic retinopathy(NPDR group), 60 patients with proliferative diabetic retinopathy(PDR group)were enrolled in this study. Sixty diabetic patients without diabetic retinopathy(DM group)and 60 healthy people(control group)were also enrolled. Collection time was from January 2014 to December 2016. Serum levels of VEGF, ES, TSP, TKLK and sICAM-1 were measured and compared. <p<RESULTS: The levels of serum VEGF, TKLK and sICAM-1 in PDR group were significantly higher than those in NPDR group, DM group and control group(<i<P</i<<0.05). The ES of PDR group was significantly lower than that of NPDR group, DM group and control group(<i<P</i<<0.05). The levels of VEGF, TKLK and ES in the NPDR group were significantly higher than those in the DM group and the control group(<i<P</i<<0.05). The serum VEGF in the NPDR group was positively correlated with the levels of ES, TKLK and sICAM-1(<i<P</i<<0.05). The serum VEGF of PDR group was positively related to the levels of TKLK and sICAM-1(<i<P</i<<0.05). There was no significant relationship between serum VEGF with ES and TSP in PDR group(<i<P</i<<0.05). <p<CONCLUSION: The levels of serum ES, TSP, TKLK and sICAM-1 in patients with DR have changed significantly, and the process of retinopathy has been affected by regulating the level of VEGF. vascular endothelial growth factor endostatin platelet reactive protein tissue kallikrein soluble intercellular adhesion molecule -1 diabetic retinopathy Ophthalmology Wu-Chao Yan verfasserin aut Wei-Dong Ren verfasserin aut Hui-Ying Liu verfasserin aut Wen-Juan Deng verfasserin aut Zheng-Rong Xu verfasserin aut Li-Juan Zuo verfasserin aut Jun Gu verfasserin aut Li Shi verfasserin aut In Guoji Yanke Zazhi Press of International Journal of Ophthalmology (IJO PRESS), 2017 17(2017), 12, Seite 2304-2307 (DE-627)1680946854 16725123 nnns volume:17 year:2017 number:12 pages:2304-2307 https://doi.org/10.3980/j.issn.1672-5123.2017.12.28 kostenfrei https://doaj.org/article/ccfe68de8afd42b194390502b30d5a0a kostenfrei http://ies.ijo.cn/cn_publish/2017/12/201712028.pdf kostenfrei https://doaj.org/toc/1672-5123 Journal toc kostenfrei https://doaj.org/toc/1672-5123 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_2817 AR 17 2017 12 2304-2307
spelling	10.3980/j.issn.1672-5123.2017.12.28 doi (DE-627)DOAJ020496869 (DE-599)DOAJccfe68de8afd42b194390502b30d5a0a DE-627 ger DE-627 rakwb eng RE1-994 Li-Mei Hu verfasserin aut Changes and significance of serum levels of VEGF, ES, TKLK, TSP and sICAM-1 in patients with diabetic retinopathy 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier AIM: To investigate the changes of serum levels of vascular endothelial growth factor(VEGF), Endostatin(ES), thrombospondin(TSP), tissue kallikrein(TKLK)and soluble intercellular adhesion molecule-1(sICAM-1)in patients with diabetic retinopathy(DR)and its clinical significance. <p<METHODS: Selected 60 patients with non-proliferative diabetic retinopathy(NPDR group), 60 patients with proliferative diabetic retinopathy(PDR group)were enrolled in this study. Sixty diabetic patients without diabetic retinopathy(DM group)and 60 healthy people(control group)were also enrolled. Collection time was from January 2014 to December 2016. Serum levels of VEGF, ES, TSP, TKLK and sICAM-1 were measured and compared. <p<RESULTS: The levels of serum VEGF, TKLK and sICAM-1 in PDR group were significantly higher than those in NPDR group, DM group and control group(<i<P</i<<0.05). The ES of PDR group was significantly lower than that of NPDR group, DM group and control group(<i<P</i<<0.05). The levels of VEGF, TKLK and ES in the NPDR group were significantly higher than those in the DM group and the control group(<i<P</i<<0.05). The serum VEGF in the NPDR group was positively correlated with the levels of ES, TKLK and sICAM-1(<i<P</i<<0.05). The serum VEGF of PDR group was positively related to the levels of TKLK and sICAM-1(<i<P</i<<0.05). There was no significant relationship between serum VEGF with ES and TSP in PDR group(<i<P</i<<0.05). <p<CONCLUSION: The levels of serum ES, TSP, TKLK and sICAM-1 in patients with DR have changed significantly, and the process of retinopathy has been affected by regulating the level of VEGF. vascular endothelial growth factor endostatin platelet reactive protein tissue kallikrein soluble intercellular adhesion molecule -1 diabetic retinopathy Ophthalmology Wu-Chao Yan verfasserin aut Wei-Dong Ren verfasserin aut Hui-Ying Liu verfasserin aut Wen-Juan Deng verfasserin aut Zheng-Rong Xu verfasserin aut Li-Juan Zuo verfasserin aut Jun Gu verfasserin aut Li Shi verfasserin aut In Guoji Yanke Zazhi Press of International Journal of Ophthalmology (IJO PRESS), 2017 17(2017), 12, Seite 2304-2307 (DE-627)1680946854 16725123 nnns volume:17 year:2017 number:12 pages:2304-2307 https://doi.org/10.3980/j.issn.1672-5123.2017.12.28 kostenfrei https://doaj.org/article/ccfe68de8afd42b194390502b30d5a0a kostenfrei http://ies.ijo.cn/cn_publish/2017/12/201712028.pdf kostenfrei https://doaj.org/toc/1672-5123 Journal toc kostenfrei https://doaj.org/toc/1672-5123 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_2817 AR 17 2017 12 2304-2307
allfields_unstemmed	10.3980/j.issn.1672-5123.2017.12.28 doi (DE-627)DOAJ020496869 (DE-599)DOAJccfe68de8afd42b194390502b30d5a0a DE-627 ger DE-627 rakwb eng RE1-994 Li-Mei Hu verfasserin aut Changes and significance of serum levels of VEGF, ES, TKLK, TSP and sICAM-1 in patients with diabetic retinopathy 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier AIM: To investigate the changes of serum levels of vascular endothelial growth factor(VEGF), Endostatin(ES), thrombospondin(TSP), tissue kallikrein(TKLK)and soluble intercellular adhesion molecule-1(sICAM-1)in patients with diabetic retinopathy(DR)and its clinical significance. <p<METHODS: Selected 60 patients with non-proliferative diabetic retinopathy(NPDR group), 60 patients with proliferative diabetic retinopathy(PDR group)were enrolled in this study. Sixty diabetic patients without diabetic retinopathy(DM group)and 60 healthy people(control group)were also enrolled. Collection time was from January 2014 to December 2016. Serum levels of VEGF, ES, TSP, TKLK and sICAM-1 were measured and compared. <p<RESULTS: The levels of serum VEGF, TKLK and sICAM-1 in PDR group were significantly higher than those in NPDR group, DM group and control group(<i<P</i<<0.05). The ES of PDR group was significantly lower than that of NPDR group, DM group and control group(<i<P</i<<0.05). The levels of VEGF, TKLK and ES in the NPDR group were significantly higher than those in the DM group and the control group(<i<P</i<<0.05). The serum VEGF in the NPDR group was positively correlated with the levels of ES, TKLK and sICAM-1(<i<P</i<<0.05). The serum VEGF of PDR group was positively related to the levels of TKLK and sICAM-1(<i<P</i<<0.05). There was no significant relationship between serum VEGF with ES and TSP in PDR group(<i<P</i<<0.05). <p<CONCLUSION: The levels of serum ES, TSP, TKLK and sICAM-1 in patients with DR have changed significantly, and the process of retinopathy has been affected by regulating the level of VEGF. vascular endothelial growth factor endostatin platelet reactive protein tissue kallikrein soluble intercellular adhesion molecule -1 diabetic retinopathy Ophthalmology Wu-Chao Yan verfasserin aut Wei-Dong Ren verfasserin aut Hui-Ying Liu verfasserin aut Wen-Juan Deng verfasserin aut Zheng-Rong Xu verfasserin aut Li-Juan Zuo verfasserin aut Jun Gu verfasserin aut Li Shi verfasserin aut In Guoji Yanke Zazhi Press of International Journal of Ophthalmology (IJO PRESS), 2017 17(2017), 12, Seite 2304-2307 (DE-627)1680946854 16725123 nnns volume:17 year:2017 number:12 pages:2304-2307 https://doi.org/10.3980/j.issn.1672-5123.2017.12.28 kostenfrei https://doaj.org/article/ccfe68de8afd42b194390502b30d5a0a kostenfrei http://ies.ijo.cn/cn_publish/2017/12/201712028.pdf kostenfrei https://doaj.org/toc/1672-5123 Journal toc kostenfrei https://doaj.org/toc/1672-5123 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_2817 AR 17 2017 12 2304-2307
allfieldsGer	10.3980/j.issn.1672-5123.2017.12.28 doi (DE-627)DOAJ020496869 (DE-599)DOAJccfe68de8afd42b194390502b30d5a0a DE-627 ger DE-627 rakwb eng RE1-994 Li-Mei Hu verfasserin aut Changes and significance of serum levels of VEGF, ES, TKLK, TSP and sICAM-1 in patients with diabetic retinopathy 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier AIM: To investigate the changes of serum levels of vascular endothelial growth factor(VEGF), Endostatin(ES), thrombospondin(TSP), tissue kallikrein(TKLK)and soluble intercellular adhesion molecule-1(sICAM-1)in patients with diabetic retinopathy(DR)and its clinical significance. <p<METHODS: Selected 60 patients with non-proliferative diabetic retinopathy(NPDR group), 60 patients with proliferative diabetic retinopathy(PDR group)were enrolled in this study. Sixty diabetic patients without diabetic retinopathy(DM group)and 60 healthy people(control group)were also enrolled. Collection time was from January 2014 to December 2016. Serum levels of VEGF, ES, TSP, TKLK and sICAM-1 were measured and compared. <p<RESULTS: The levels of serum VEGF, TKLK and sICAM-1 in PDR group were significantly higher than those in NPDR group, DM group and control group(<i<P</i<<0.05). The ES of PDR group was significantly lower than that of NPDR group, DM group and control group(<i<P</i<<0.05). The levels of VEGF, TKLK and ES in the NPDR group were significantly higher than those in the DM group and the control group(<i<P</i<<0.05). The serum VEGF in the NPDR group was positively correlated with the levels of ES, TKLK and sICAM-1(<i<P</i<<0.05). The serum VEGF of PDR group was positively related to the levels of TKLK and sICAM-1(<i<P</i<<0.05). There was no significant relationship between serum VEGF with ES and TSP in PDR group(<i<P</i<<0.05). <p<CONCLUSION: The levels of serum ES, TSP, TKLK and sICAM-1 in patients with DR have changed significantly, and the process of retinopathy has been affected by regulating the level of VEGF. vascular endothelial growth factor endostatin platelet reactive protein tissue kallikrein soluble intercellular adhesion molecule -1 diabetic retinopathy Ophthalmology Wu-Chao Yan verfasserin aut Wei-Dong Ren verfasserin aut Hui-Ying Liu verfasserin aut Wen-Juan Deng verfasserin aut Zheng-Rong Xu verfasserin aut Li-Juan Zuo verfasserin aut Jun Gu verfasserin aut Li Shi verfasserin aut In Guoji Yanke Zazhi Press of International Journal of Ophthalmology (IJO PRESS), 2017 17(2017), 12, Seite 2304-2307 (DE-627)1680946854 16725123 nnns volume:17 year:2017 number:12 pages:2304-2307 https://doi.org/10.3980/j.issn.1672-5123.2017.12.28 kostenfrei https://doaj.org/article/ccfe68de8afd42b194390502b30d5a0a kostenfrei http://ies.ijo.cn/cn_publish/2017/12/201712028.pdf kostenfrei https://doaj.org/toc/1672-5123 Journal toc kostenfrei https://doaj.org/toc/1672-5123 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_2817 AR 17 2017 12 2304-2307
allfieldsSound	10.3980/j.issn.1672-5123.2017.12.28 doi (DE-627)DOAJ020496869 (DE-599)DOAJccfe68de8afd42b194390502b30d5a0a DE-627 ger DE-627 rakwb eng RE1-994 Li-Mei Hu verfasserin aut Changes and significance of serum levels of VEGF, ES, TKLK, TSP and sICAM-1 in patients with diabetic retinopathy 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier AIM: To investigate the changes of serum levels of vascular endothelial growth factor(VEGF), Endostatin(ES), thrombospondin(TSP), tissue kallikrein(TKLK)and soluble intercellular adhesion molecule-1(sICAM-1)in patients with diabetic retinopathy(DR)and its clinical significance. <p<METHODS: Selected 60 patients with non-proliferative diabetic retinopathy(NPDR group), 60 patients with proliferative diabetic retinopathy(PDR group)were enrolled in this study. Sixty diabetic patients without diabetic retinopathy(DM group)and 60 healthy people(control group)were also enrolled. Collection time was from January 2014 to December 2016. Serum levels of VEGF, ES, TSP, TKLK and sICAM-1 were measured and compared. <p<RESULTS: The levels of serum VEGF, TKLK and sICAM-1 in PDR group were significantly higher than those in NPDR group, DM group and control group(<i<P</i<<0.05). The ES of PDR group was significantly lower than that of NPDR group, DM group and control group(<i<P</i<<0.05). The levels of VEGF, TKLK and ES in the NPDR group were significantly higher than those in the DM group and the control group(<i<P</i<<0.05). The serum VEGF in the NPDR group was positively correlated with the levels of ES, TKLK and sICAM-1(<i<P</i<<0.05). The serum VEGF of PDR group was positively related to the levels of TKLK and sICAM-1(<i<P</i<<0.05). There was no significant relationship between serum VEGF with ES and TSP in PDR group(<i<P</i<<0.05). <p<CONCLUSION: The levels of serum ES, TSP, TKLK and sICAM-1 in patients with DR have changed significantly, and the process of retinopathy has been affected by regulating the level of VEGF. vascular endothelial growth factor endostatin platelet reactive protein tissue kallikrein soluble intercellular adhesion molecule -1 diabetic retinopathy Ophthalmology Wu-Chao Yan verfasserin aut Wei-Dong Ren verfasserin aut Hui-Ying Liu verfasserin aut Wen-Juan Deng verfasserin aut Zheng-Rong Xu verfasserin aut Li-Juan Zuo verfasserin aut Jun Gu verfasserin aut Li Shi verfasserin aut In Guoji Yanke Zazhi Press of International Journal of Ophthalmology (IJO PRESS), 2017 17(2017), 12, Seite 2304-2307 (DE-627)1680946854 16725123 nnns volume:17 year:2017 number:12 pages:2304-2307 https://doi.org/10.3980/j.issn.1672-5123.2017.12.28 kostenfrei https://doaj.org/article/ccfe68de8afd42b194390502b30d5a0a kostenfrei http://ies.ijo.cn/cn_publish/2017/12/201712028.pdf kostenfrei https://doaj.org/toc/1672-5123 Journal toc kostenfrei https://doaj.org/toc/1672-5123 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_2817 AR 17 2017 12 2304-2307
language	English
source	In Guoji Yanke Zazhi 17(2017), 12, Seite 2304-2307 volume:17 year:2017 number:12 pages:2304-2307
sourceStr	In Guoji Yanke Zazhi 17(2017), 12, Seite 2304-2307 volume:17 year:2017 number:12 pages:2304-2307
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	vascular endothelial growth factor endostatin platelet reactive protein tissue kallikrein soluble intercellular adhesion molecule -1 diabetic retinopathy Ophthalmology
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container_title	Guoji Yanke Zazhi
authorswithroles_txt_mv	Li-Mei Hu @@aut@@ Wu-Chao Yan @@aut@@ Wei-Dong Ren @@aut@@ Hui-Ying Liu @@aut@@ Wen-Juan Deng @@aut@@ Zheng-Rong Xu @@aut@@ Li-Juan Zuo @@aut@@ Jun Gu @@aut@@ Li Shi @@aut@@
publishDateDaySort_date	2017-01-01T00:00:00Z
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Sixty diabetic patients without diabetic retinopathy(DM group)and 60 healthy people(control group)were also enrolled. Collection time was from January 2014 to December 2016. Serum levels of VEGF, ES, TSP, TKLK and sICAM-1 were measured and compared. <p<RESULTS: The levels of serum VEGF, TKLK and sICAM-1 in PDR group were significantly higher than those in NPDR group, DM group and control group(<i<P</i<<0.05). The ES of PDR group was significantly lower than that of NPDR group, DM group and control group(<i<P</i<<0.05). The levels of VEGF, TKLK and ES in the NPDR group were significantly higher than those in the DM group and the control group(<i<P</i<<0.05). The serum VEGF in the NPDR group was positively correlated with the levels of ES, TKLK and sICAM-1(<i<P</i<<0.05). The serum VEGF of PDR group was positively related to the levels of TKLK and sICAM-1(<i<P</i<<0.05). 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callnumber-first	R - Medicine
author	Li-Mei Hu
spellingShingle	Li-Mei Hu misc RE1-994 misc vascular endothelial growth factor misc endostatin misc platelet reactive protein misc tissue kallikrein misc soluble intercellular adhesion molecule -1 misc diabetic retinopathy misc Ophthalmology Changes and significance of serum levels of VEGF, ES, TKLK, TSP and sICAM-1 in patients with diabetic retinopathy
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topic_title	RE1-994 Changes and significance of serum levels of VEGF, ES, TKLK, TSP and sICAM-1 in patients with diabetic retinopathy vascular endothelial growth factor endostatin platelet reactive protein tissue kallikrein soluble intercellular adhesion molecule -1 diabetic retinopathy
topic	misc RE1-994 misc vascular endothelial growth factor misc endostatin misc platelet reactive protein misc tissue kallikrein misc soluble intercellular adhesion molecule -1 misc diabetic retinopathy misc Ophthalmology
topic_unstemmed	misc RE1-994 misc vascular endothelial growth factor misc endostatin misc platelet reactive protein misc tissue kallikrein misc soluble intercellular adhesion molecule -1 misc diabetic retinopathy misc Ophthalmology
topic_browse	misc RE1-994 misc vascular endothelial growth factor misc endostatin misc platelet reactive protein misc tissue kallikrein misc soluble intercellular adhesion molecule -1 misc diabetic retinopathy misc Ophthalmology
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title	Changes and significance of serum levels of VEGF, ES, TKLK, TSP and sICAM-1 in patients with diabetic retinopathy
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title_full	Changes and significance of serum levels of VEGF, ES, TKLK, TSP and sICAM-1 in patients with diabetic retinopathy
author_sort	Li-Mei Hu
journal	Guoji Yanke Zazhi
journalStr	Guoji Yanke Zazhi
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author_browse	Li-Mei Hu Wu-Chao Yan Wei-Dong Ren Hui-Ying Liu Wen-Juan Deng Zheng-Rong Xu Li-Juan Zuo Jun Gu Li Shi
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class	RE1-994
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author-letter	Li-Mei Hu
doi_str_mv	10.3980/j.issn.1672-5123.2017.12.28
author2-role	verfasserin
title_sort	changes and significance of serum levels of vegf, es, tklk, tsp and sicam-1 in patients with diabetic retinopathy
callnumber	RE1-994
title_auth	Changes and significance of serum levels of VEGF, ES, TKLK, TSP and sICAM-1 in patients with diabetic retinopathy
abstract	AIM: To investigate the changes of serum levels of vascular endothelial growth factor(VEGF), Endostatin(ES), thrombospondin(TSP), tissue kallikrein(TKLK)and soluble intercellular adhesion molecule-1(sICAM-1)in patients with diabetic retinopathy(DR)and its clinical significance. <p<METHODS: Selected 60 patients with non-proliferative diabetic retinopathy(NPDR group), 60 patients with proliferative diabetic retinopathy(PDR group)were enrolled in this study. Sixty diabetic patients without diabetic retinopathy(DM group)and 60 healthy people(control group)were also enrolled. Collection time was from January 2014 to December 2016. Serum levels of VEGF, ES, TSP, TKLK and sICAM-1 were measured and compared. <p<RESULTS: The levels of serum VEGF, TKLK and sICAM-1 in PDR group were significantly higher than those in NPDR group, DM group and control group(<i<P</i<<0.05). The ES of PDR group was significantly lower than that of NPDR group, DM group and control group(<i<P</i<<0.05). The levels of VEGF, TKLK and ES in the NPDR group were significantly higher than those in the DM group and the control group(<i<P</i<<0.05). The serum VEGF in the NPDR group was positively correlated with the levels of ES, TKLK and sICAM-1(<i<P</i<<0.05). The serum VEGF of PDR group was positively related to the levels of TKLK and sICAM-1(<i<P</i<<0.05). There was no significant relationship between serum VEGF with ES and TSP in PDR group(<i<P</i<<0.05). <p<CONCLUSION: The levels of serum ES, TSP, TKLK and sICAM-1 in patients with DR have changed significantly, and the process of retinopathy has been affected by regulating the level of VEGF.
abstractGer	AIM: To investigate the changes of serum levels of vascular endothelial growth factor(VEGF), Endostatin(ES), thrombospondin(TSP), tissue kallikrein(TKLK)and soluble intercellular adhesion molecule-1(sICAM-1)in patients with diabetic retinopathy(DR)and its clinical significance. <p<METHODS: Selected 60 patients with non-proliferative diabetic retinopathy(NPDR group), 60 patients with proliferative diabetic retinopathy(PDR group)were enrolled in this study. Sixty diabetic patients without diabetic retinopathy(DM group)and 60 healthy people(control group)were also enrolled. Collection time was from January 2014 to December 2016. Serum levels of VEGF, ES, TSP, TKLK and sICAM-1 were measured and compared. <p<RESULTS: The levels of serum VEGF, TKLK and sICAM-1 in PDR group were significantly higher than those in NPDR group, DM group and control group(<i<P</i<<0.05). The ES of PDR group was significantly lower than that of NPDR group, DM group and control group(<i<P</i<<0.05). The levels of VEGF, TKLK and ES in the NPDR group were significantly higher than those in the DM group and the control group(<i<P</i<<0.05). The serum VEGF in the NPDR group was positively correlated with the levels of ES, TKLK and sICAM-1(<i<P</i<<0.05). The serum VEGF of PDR group was positively related to the levels of TKLK and sICAM-1(<i<P</i<<0.05). There was no significant relationship between serum VEGF with ES and TSP in PDR group(<i<P</i<<0.05). <p<CONCLUSION: The levels of serum ES, TSP, TKLK and sICAM-1 in patients with DR have changed significantly, and the process of retinopathy has been affected by regulating the level of VEGF.
abstract_unstemmed	AIM: To investigate the changes of serum levels of vascular endothelial growth factor(VEGF), Endostatin(ES), thrombospondin(TSP), tissue kallikrein(TKLK)and soluble intercellular adhesion molecule-1(sICAM-1)in patients with diabetic retinopathy(DR)and its clinical significance. <p<METHODS: Selected 60 patients with non-proliferative diabetic retinopathy(NPDR group), 60 patients with proliferative diabetic retinopathy(PDR group)were enrolled in this study. Sixty diabetic patients without diabetic retinopathy(DM group)and 60 healthy people(control group)were also enrolled. Collection time was from January 2014 to December 2016. Serum levels of VEGF, ES, TSP, TKLK and sICAM-1 were measured and compared. <p<RESULTS: The levels of serum VEGF, TKLK and sICAM-1 in PDR group were significantly higher than those in NPDR group, DM group and control group(<i<P</i<<0.05). The ES of PDR group was significantly lower than that of NPDR group, DM group and control group(<i<P</i<<0.05). The levels of VEGF, TKLK and ES in the NPDR group were significantly higher than those in the DM group and the control group(<i<P</i<<0.05). The serum VEGF in the NPDR group was positively correlated with the levels of ES, TKLK and sICAM-1(<i<P</i<<0.05). The serum VEGF of PDR group was positively related to the levels of TKLK and sICAM-1(<i<P</i<<0.05). There was no significant relationship between serum VEGF with ES and TSP in PDR group(<i<P</i<<0.05). <p<CONCLUSION: The levels of serum ES, TSP, TKLK and sICAM-1 in patients with DR have changed significantly, and the process of retinopathy has been affected by regulating the level of VEGF.
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title_short	Changes and significance of serum levels of VEGF, ES, TKLK, TSP and sICAM-1 in patients with diabetic retinopathy
url	https://doi.org/10.3980/j.issn.1672-5123.2017.12.28 https://doaj.org/article/ccfe68de8afd42b194390502b30d5a0a http://ies.ijo.cn/cn_publish/2017/12/201712028.pdf https://doaj.org/toc/1672-5123
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author2	Wu-Chao Yan Wei-Dong Ren Hui-Ying Liu Wen-Juan Deng Zheng-Rong Xu Li-Juan Zuo Jun Gu Li Shi
author2Str	Wu-Chao Yan Wei-Dong Ren Hui-Ying Liu Wen-Juan Deng Zheng-Rong Xu Li-Juan Zuo Jun Gu Li Shi
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up_date	2024-07-03T15:17:43.228Z
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Changes and significance of serum levels of VEGF, ES, TKLK, TSP and sICAM-1 in patients with diabetic retinopathy

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