Functional Evolution of Subolesin/Akirin

The Subolesin/Akirin constitutes a good model for the study of functional evolution because these proteins have been conserved throughout the metazoan and play a role in the regulation of different biological processes. Here, we investigated the evolutionary history of Subolesin/Akirin with recent r...
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Autor*in:	Sara Artigas-Jerónimo [verfasserIn] Margarita Villar [verfasserIn] Alejandro Cabezas-Cruz [verfasserIn] James J. Valdés [verfasserIn] Agustín Estrada-Peña [verfasserIn] Pilar Alberdi [verfasserIn] José de la Fuente [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	immune response vaccine interactome regulome phylogeny tick

Übergeordnetes Werk:	In: Frontiers in Physiology - Frontiers Media S.A., 2011, 9(2018)
Übergeordnetes Werk:	volume:9 ; year:2018

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fphys.2018.01612

Katalog-ID:	DOAJ020599021

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allfieldsSound	10.3389/fphys.2018.01612 doi (DE-627)DOAJ020599021 (DE-599)DOAJ2c0ecf7c3c9240d4bf85b7757696587a DE-627 ger DE-627 rakwb eng QP1-981 Sara Artigas-Jerónimo verfasserin aut Functional Evolution of Subolesin/Akirin 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The Subolesin/Akirin constitutes a good model for the study of functional evolution because these proteins have been conserved throughout the metazoan and play a role in the regulation of different biological processes. Here, we investigated the evolutionary history of Subolesin/Akirin with recent results on their structure, protein-protein interactions and function in different species to provide insights into the functional evolution of these regulatory proteins, and their potential as vaccine antigens for the control of ectoparasite infestations and pathogen infection. The results suggest that Subolesin/Akirin evolved conserving not only its sequence and structure, but also its function and role in cell interactome and regulome in response to pathogen infection and other biological processes. This functional conservation provides a platform for further characterization of the function of these regulatory proteins, and how their evolution can meet species-specific demands. Furthermore, the conserved functional evolution of Subolesin/Akirin correlates with the protective capacity shown by these proteins in vaccine formulations for the control of different arthropod and pathogen species. These results encourage further research to characterize the structure and function of these proteins, and to develop new vaccine formulations by combining Subolesin/Akirin with interacting proteins for the control of multiple ectoparasite infestations and pathogen infection. immune response vaccine interactome regulome phylogeny tick Physiology Margarita Villar verfasserin aut Alejandro Cabezas-Cruz verfasserin aut James J. Valdés verfasserin aut James J. Valdés verfasserin aut James J. Valdés verfasserin aut Agustín Estrada-Peña verfasserin aut Pilar Alberdi verfasserin aut José de la Fuente verfasserin aut José de la Fuente verfasserin aut In Frontiers in Physiology Frontiers Media S.A., 2011 9(2018) (DE-627)631498788 (DE-600)2564217-0 1664042X nnns volume:9 year:2018 https://doi.org/10.3389/fphys.2018.01612 kostenfrei https://doaj.org/article/2c0ecf7c3c9240d4bf85b7757696587a kostenfrei https://www.frontiersin.org/article/10.3389/fphys.2018.01612/full kostenfrei https://doaj.org/toc/1664-042X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2018
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source	In Frontiers in Physiology 9(2018) volume:9 year:2018
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authorswithroles_txt_mv	Sara Artigas-Jerónimo @@aut@@ Margarita Villar @@aut@@ Alejandro Cabezas-Cruz @@aut@@ James J. Valdés @@aut@@ Agustín Estrada-Peña @@aut@@ Pilar Alberdi @@aut@@ José de la Fuente @@aut@@
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author	Sara Artigas-Jerónimo
spellingShingle	Sara Artigas-Jerónimo misc QP1-981 misc immune response misc vaccine misc interactome misc regulome misc phylogeny misc tick misc Physiology Functional Evolution of Subolesin/Akirin
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topic_title	QP1-981 Functional Evolution of Subolesin/Akirin immune response vaccine interactome regulome phylogeny tick
topic	misc QP1-981 misc immune response misc vaccine misc interactome misc regulome misc phylogeny misc tick misc Physiology
topic_unstemmed	misc QP1-981 misc immune response misc vaccine misc interactome misc regulome misc phylogeny misc tick misc Physiology
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title	Functional Evolution of Subolesin/Akirin
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title_full	Functional Evolution of Subolesin/Akirin
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title_sort	functional evolution of subolesin/akirin
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title_auth	Functional Evolution of Subolesin/Akirin
abstract	The Subolesin/Akirin constitutes a good model for the study of functional evolution because these proteins have been conserved throughout the metazoan and play a role in the regulation of different biological processes. Here, we investigated the evolutionary history of Subolesin/Akirin with recent results on their structure, protein-protein interactions and function in different species to provide insights into the functional evolution of these regulatory proteins, and their potential as vaccine antigens for the control of ectoparasite infestations and pathogen infection. The results suggest that Subolesin/Akirin evolved conserving not only its sequence and structure, but also its function and role in cell interactome and regulome in response to pathogen infection and other biological processes. This functional conservation provides a platform for further characterization of the function of these regulatory proteins, and how their evolution can meet species-specific demands. Furthermore, the conserved functional evolution of Subolesin/Akirin correlates with the protective capacity shown by these proteins in vaccine formulations for the control of different arthropod and pathogen species. These results encourage further research to characterize the structure and function of these proteins, and to develop new vaccine formulations by combining Subolesin/Akirin with interacting proteins for the control of multiple ectoparasite infestations and pathogen infection.
abstractGer	The Subolesin/Akirin constitutes a good model for the study of functional evolution because these proteins have been conserved throughout the metazoan and play a role in the regulation of different biological processes. Here, we investigated the evolutionary history of Subolesin/Akirin with recent results on their structure, protein-protein interactions and function in different species to provide insights into the functional evolution of these regulatory proteins, and their potential as vaccine antigens for the control of ectoparasite infestations and pathogen infection. The results suggest that Subolesin/Akirin evolved conserving not only its sequence and structure, but also its function and role in cell interactome and regulome in response to pathogen infection and other biological processes. This functional conservation provides a platform for further characterization of the function of these regulatory proteins, and how their evolution can meet species-specific demands. Furthermore, the conserved functional evolution of Subolesin/Akirin correlates with the protective capacity shown by these proteins in vaccine formulations for the control of different arthropod and pathogen species. These results encourage further research to characterize the structure and function of these proteins, and to develop new vaccine formulations by combining Subolesin/Akirin with interacting proteins for the control of multiple ectoparasite infestations and pathogen infection.
abstract_unstemmed	The Subolesin/Akirin constitutes a good model for the study of functional evolution because these proteins have been conserved throughout the metazoan and play a role in the regulation of different biological processes. Here, we investigated the evolutionary history of Subolesin/Akirin with recent results on their structure, protein-protein interactions and function in different species to provide insights into the functional evolution of these regulatory proteins, and their potential as vaccine antigens for the control of ectoparasite infestations and pathogen infection. The results suggest that Subolesin/Akirin evolved conserving not only its sequence and structure, but also its function and role in cell interactome and regulome in response to pathogen infection and other biological processes. This functional conservation provides a platform for further characterization of the function of these regulatory proteins, and how their evolution can meet species-specific demands. Furthermore, the conserved functional evolution of Subolesin/Akirin correlates with the protective capacity shown by these proteins in vaccine formulations for the control of different arthropod and pathogen species. These results encourage further research to characterize the structure and function of these proteins, and to develop new vaccine formulations by combining Subolesin/Akirin with interacting proteins for the control of multiple ectoparasite infestations and pathogen infection.
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title_short	Functional Evolution of Subolesin/Akirin
url	https://doi.org/10.3389/fphys.2018.01612 https://doaj.org/article/2c0ecf7c3c9240d4bf85b7757696587a https://www.frontiersin.org/article/10.3389/fphys.2018.01612/full https://doaj.org/toc/1664-042X
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author2	Margarita Villar Alejandro Cabezas-Cruz James J. Valdés Agustín Estrada-Peña Pilar Alberdi José de la Fuente
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up_date	2024-07-03T15:52:24.159Z
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Functional Evolution of Subolesin/Akirin

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