The Role of MicroRNAs in HER2-Positive Breast Cancer: Where We Are and Future Prospective

Breast cancer that highly expresses human epidermal growth factor receptor 2 (HER2+) represents one of the major breast cancer subtypes, and was associated with a poor prognosis until the introduction of HER2-targeted therapies such as trastuzumab. Unfortunately, up to 30% of patients with HER2+ loc...
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Gespeichert in:

Autor*in:	Valentina Fogazzi [verfasserIn] Marcel Kapahnke [verfasserIn] Alessandra Cataldo [verfasserIn] Ilaria Plantamura [verfasserIn] Elda Tagliabue [verfasserIn] Serena Di Cosimo [verfasserIn] Giulia Cosentino [verfasserIn] Marilena V. Iorio [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	breast cancer microRNA HER2

Übergeordnetes Werk:	In: Cancers - MDPI AG, 2010, 14(2022), 21, p 5326
Übergeordnetes Werk:	volume:14 ; year:2022 ; number:21, p 5326

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/cancers14215326

Katalog-ID:	DOAJ020724853

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authorswithroles_txt_mv	Valentina Fogazzi @@aut@@ Marcel Kapahnke @@aut@@ Alessandra Cataldo @@aut@@ Ilaria Plantamura @@aut@@ Elda Tagliabue @@aut@@ Serena Di Cosimo @@aut@@ Giulia Cosentino @@aut@@ Marilena V. Iorio @@aut@@
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callnumber-first	R - Medicine
author	Valentina Fogazzi
spellingShingle	Valentina Fogazzi misc RC254-282 misc breast cancer misc microRNA misc HER2 misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens The Role of MicroRNAs in HER2-Positive Breast Cancer: Where We Are and Future Prospective
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topic_title	RC254-282 The Role of MicroRNAs in HER2-Positive Breast Cancer: Where We Are and Future Prospective breast cancer microRNA HER2
topic	misc RC254-282 misc breast cancer misc microRNA misc HER2 misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc breast cancer misc microRNA misc HER2 misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	The Role of MicroRNAs in HER2-Positive Breast Cancer: Where We Are and Future Prospective
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title_full	The Role of MicroRNAs in HER2-Positive Breast Cancer: Where We Are and Future Prospective
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author_browse	Valentina Fogazzi Marcel Kapahnke Alessandra Cataldo Ilaria Plantamura Elda Tagliabue Serena Di Cosimo Giulia Cosentino Marilena V. Iorio
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title_sort	role of micrornas in her2-positive breast cancer: where we are and future prospective
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title_auth	The Role of MicroRNAs in HER2-Positive Breast Cancer: Where We Are and Future Prospective
abstract	Breast cancer that highly expresses human epidermal growth factor receptor 2 (HER2+) represents one of the major breast cancer subtypes, and was associated with a poor prognosis until the introduction of HER2-targeted therapies such as trastuzumab. Unfortunately, up to 30% of patients with HER2+ localized breast cancer continue to relapse, despite treatment. MicroRNAs (miRNAs) are small (approximately 20 nucleotides long) non-coding regulatory oligonucleotides. They function as post-transcriptional regulators of gene expression, binding complementarily to a target mRNA and leading to the arrest of translation or mRNA degradation. In the last two decades, translational research has focused on these small molecules because of their highly differentiated expression patterns in blood and tumor tissue, as well as their potential biological function. In cancer research, they have become pivotal for the thorough understanding of oncogenic biological processes. They might also provide an efficient approach to early monitoring of tumor progression or response to therapy. Indeed, changes in their expression patterns can represent a flag for deeper biological changes. In this review, we sum up the recent literature regarding miRNAs in HER2+ breast cancer, taking into account their potential as powerful prognostic and predictive biomarkers, as well as therapeutic tools.
abstractGer	Breast cancer that highly expresses human epidermal growth factor receptor 2 (HER2+) represents one of the major breast cancer subtypes, and was associated with a poor prognosis until the introduction of HER2-targeted therapies such as trastuzumab. Unfortunately, up to 30% of patients with HER2+ localized breast cancer continue to relapse, despite treatment. MicroRNAs (miRNAs) are small (approximately 20 nucleotides long) non-coding regulatory oligonucleotides. They function as post-transcriptional regulators of gene expression, binding complementarily to a target mRNA and leading to the arrest of translation or mRNA degradation. In the last two decades, translational research has focused on these small molecules because of their highly differentiated expression patterns in blood and tumor tissue, as well as their potential biological function. In cancer research, they have become pivotal for the thorough understanding of oncogenic biological processes. They might also provide an efficient approach to early monitoring of tumor progression or response to therapy. Indeed, changes in their expression patterns can represent a flag for deeper biological changes. In this review, we sum up the recent literature regarding miRNAs in HER2+ breast cancer, taking into account their potential as powerful prognostic and predictive biomarkers, as well as therapeutic tools.
abstract_unstemmed	Breast cancer that highly expresses human epidermal growth factor receptor 2 (HER2+) represents one of the major breast cancer subtypes, and was associated with a poor prognosis until the introduction of HER2-targeted therapies such as trastuzumab. Unfortunately, up to 30% of patients with HER2+ localized breast cancer continue to relapse, despite treatment. MicroRNAs (miRNAs) are small (approximately 20 nucleotides long) non-coding regulatory oligonucleotides. They function as post-transcriptional regulators of gene expression, binding complementarily to a target mRNA and leading to the arrest of translation or mRNA degradation. In the last two decades, translational research has focused on these small molecules because of their highly differentiated expression patterns in blood and tumor tissue, as well as their potential biological function. In cancer research, they have become pivotal for the thorough understanding of oncogenic biological processes. They might also provide an efficient approach to early monitoring of tumor progression or response to therapy. Indeed, changes in their expression patterns can represent a flag for deeper biological changes. In this review, we sum up the recent literature regarding miRNAs in HER2+ breast cancer, taking into account their potential as powerful prognostic and predictive biomarkers, as well as therapeutic tools.
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title_short	The Role of MicroRNAs in HER2-Positive Breast Cancer: Where We Are and Future Prospective
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