Improvement of therapy efficacy in children with atopic dermatitis due to emollient complex

Active studies of atopic dermatitis (AtD) have revealed new disease pathways and confirmed the complex treatment approach need, including different forms of emollients (creams and bath treatments). Study aim: to show effectiveness of locally produced moisturizing cream and bathing oil combination (L...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	A. V. Kamaev [verfasserIn] O. V. Trusova [verfasserIn] U. A. Butyrina [verfasserIn] I. V. Makarova [verfasserIn]

Format:	E-Artikel
Sprache:	Russisch

Erschienen:	2019

Schlagwörter:	дети атопический дерматит эмолиенты эффективность лечения

Übergeordnetes Werk:	In: Rossijskij Vestnik Perinatologii i Pediatrii - Ltd. “The National Academy of Pediatric Science and Innovation”, 2018, 64(2019), 3, Seite 109-116
Übergeordnetes Werk:	volume:64 ; year:2019 ; number:3 ; pages:109-116

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.21508/1027-4065-2019-64-3-109-117

Katalog-ID:	DOAJ020844743

Internformat


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520			\|a Active studies of atopic dermatitis (AtD) have revealed new disease pathways and confirmed the complex treatment approach need, including different forms of emollients (creams and bath treatments). Study aim: to show effectiveness of locally produced moisturizing cream and bathing oil combination (Lipobase baby trademark) in the complex treatment of babies and toddlers with AtD.Patients and methods. Thirty children (60% boys) aged from 6 to 36 months with mild/moderate AtD were included in open prospective non-comparative study 30 days long. Initial and after each 2 weeks SCORAD and dairies for 10 points skin itch and sleep disturbance scores, moisturizers consumption and adverse events were evaluated. Global evaluation of treatment effectiveness score were performed by patient’s doctor.Results. Medium compliance for moisturizers consumption was 89.2% days. Medium SCORAD results decreased from visit 1 to 3: from 23.5±7.3 points to 18.7±4.9 points and to 14.6±3.1 points. After 2 weeks complex therapy including investigated moisturizers, medium day skin itch score was reduced from 6.4 to 3.6 points, also as sleep disturbance score from 2.6 to 1.2 points. Direct moderate correlation (r=0.64, p=0.012) was revealed between number of days without skin itch or sleep disturbance and compliance to moisturizers consumption. No any adverse event caused by investigated products was registered.Conclusion. Inclusion of locally produced moisturizing cream and bathing oil (Lipobase baby trademark) in the complex AtD therapy improve the treatment efficacy.Conflict of interest: Products of medical cosmetics for use in this Protocol are provided by the Pharmatek Company LLC. Representatives of the Company did not participate in the statistical processing, interpretation of the results and preparation of this publication.
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allfields	10.21508/1027-4065-2019-64-3-109-117 doi (DE-627)DOAJ020844743 (DE-599)DOAJ4d3207d328da43ee83a25c9fd721b390 DE-627 ger DE-627 rakwb rus RJ1-570 A. V. Kamaev verfasserin aut Improvement of therapy efficacy in children with atopic dermatitis due to emollient complex 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Active studies of atopic dermatitis (AtD) have revealed new disease pathways and confirmed the complex treatment approach need, including different forms of emollients (creams and bath treatments). Study aim: to show effectiveness of locally produced moisturizing cream and bathing oil combination (Lipobase baby trademark) in the complex treatment of babies and toddlers with AtD.Patients and methods. Thirty children (60% boys) aged from 6 to 36 months with mild/moderate AtD were included in open prospective non-comparative study 30 days long. Initial and after each 2 weeks SCORAD and dairies for 10 points skin itch and sleep disturbance scores, moisturizers consumption and adverse events were evaluated. Global evaluation of treatment effectiveness score were performed by patient’s doctor.Results. Medium compliance for moisturizers consumption was 89.2% days. Medium SCORAD results decreased from visit 1 to 3: from 23.5±7.3 points to 18.7±4.9 points and to 14.6±3.1 points. After 2 weeks complex therapy including investigated moisturizers, medium day skin itch score was reduced from 6.4 to 3.6 points, also as sleep disturbance score from 2.6 to 1.2 points. Direct moderate correlation (r=0.64, p=0.012) was revealed between number of days without skin itch or sleep disturbance and compliance to moisturizers consumption. No any adverse event caused by investigated products was registered.Conclusion. Inclusion of locally produced moisturizing cream and bathing oil (Lipobase baby trademark) in the complex AtD therapy improve the treatment efficacy.Conflict of interest: Products of medical cosmetics for use in this Protocol are provided by the Pharmatek Company LLC. Representatives of the Company did not participate in the statistical processing, interpretation of the results and preparation of this publication. дети атопический дерматит эмолиенты эффективность лечения Pediatrics O. V. Trusova verfasserin aut U. A. Butyrina verfasserin aut I. V. Makarova verfasserin aut In Rossijskij Vestnik Perinatologii i Pediatrii Ltd. “The National Academy of Pediatric Science and Innovation”, 2018 64(2019), 3, Seite 109-116 (DE-627)1043470638 25002228 nnns volume:64 year:2019 number:3 pages:109-116 https://doi.org/10.21508/1027-4065-2019-64-3-109-117 kostenfrei https://doaj.org/article/4d3207d328da43ee83a25c9fd721b390 kostenfrei https://www.ped-perinatology.ru/jour/article/view/902 kostenfrei https://doaj.org/toc/1027-4065 Journal toc kostenfrei https://doaj.org/toc/2500-2228 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 64 2019 3 109-116
spelling	10.21508/1027-4065-2019-64-3-109-117 doi (DE-627)DOAJ020844743 (DE-599)DOAJ4d3207d328da43ee83a25c9fd721b390 DE-627 ger DE-627 rakwb rus RJ1-570 A. V. Kamaev verfasserin aut Improvement of therapy efficacy in children with atopic dermatitis due to emollient complex 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Active studies of atopic dermatitis (AtD) have revealed new disease pathways and confirmed the complex treatment approach need, including different forms of emollients (creams and bath treatments). Study aim: to show effectiveness of locally produced moisturizing cream and bathing oil combination (Lipobase baby trademark) in the complex treatment of babies and toddlers with AtD.Patients and methods. Thirty children (60% boys) aged from 6 to 36 months with mild/moderate AtD were included in open prospective non-comparative study 30 days long. Initial and after each 2 weeks SCORAD and dairies for 10 points skin itch and sleep disturbance scores, moisturizers consumption and adverse events were evaluated. Global evaluation of treatment effectiveness score were performed by patient’s doctor.Results. Medium compliance for moisturizers consumption was 89.2% days. Medium SCORAD results decreased from visit 1 to 3: from 23.5±7.3 points to 18.7±4.9 points and to 14.6±3.1 points. After 2 weeks complex therapy including investigated moisturizers, medium day skin itch score was reduced from 6.4 to 3.6 points, also as sleep disturbance score from 2.6 to 1.2 points. Direct moderate correlation (r=0.64, p=0.012) was revealed between number of days without skin itch or sleep disturbance and compliance to moisturizers consumption. No any adverse event caused by investigated products was registered.Conclusion. Inclusion of locally produced moisturizing cream and bathing oil (Lipobase baby trademark) in the complex AtD therapy improve the treatment efficacy.Conflict of interest: Products of medical cosmetics for use in this Protocol are provided by the Pharmatek Company LLC. Representatives of the Company did not participate in the statistical processing, interpretation of the results and preparation of this publication. дети атопический дерматит эмолиенты эффективность лечения Pediatrics O. V. Trusova verfasserin aut U. A. Butyrina verfasserin aut I. V. Makarova verfasserin aut In Rossijskij Vestnik Perinatologii i Pediatrii Ltd. “The National Academy of Pediatric Science and Innovation”, 2018 64(2019), 3, Seite 109-116 (DE-627)1043470638 25002228 nnns volume:64 year:2019 number:3 pages:109-116 https://doi.org/10.21508/1027-4065-2019-64-3-109-117 kostenfrei https://doaj.org/article/4d3207d328da43ee83a25c9fd721b390 kostenfrei https://www.ped-perinatology.ru/jour/article/view/902 kostenfrei https://doaj.org/toc/1027-4065 Journal toc kostenfrei https://doaj.org/toc/2500-2228 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 64 2019 3 109-116
allfields_unstemmed	10.21508/1027-4065-2019-64-3-109-117 doi (DE-627)DOAJ020844743 (DE-599)DOAJ4d3207d328da43ee83a25c9fd721b390 DE-627 ger DE-627 rakwb rus RJ1-570 A. V. Kamaev verfasserin aut Improvement of therapy efficacy in children with atopic dermatitis due to emollient complex 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Active studies of atopic dermatitis (AtD) have revealed new disease pathways and confirmed the complex treatment approach need, including different forms of emollients (creams and bath treatments). Study aim: to show effectiveness of locally produced moisturizing cream and bathing oil combination (Lipobase baby trademark) in the complex treatment of babies and toddlers with AtD.Patients and methods. Thirty children (60% boys) aged from 6 to 36 months with mild/moderate AtD were included in open prospective non-comparative study 30 days long. Initial and after each 2 weeks SCORAD and dairies for 10 points skin itch and sleep disturbance scores, moisturizers consumption and adverse events were evaluated. Global evaluation of treatment effectiveness score were performed by patient’s doctor.Results. Medium compliance for moisturizers consumption was 89.2% days. Medium SCORAD results decreased from visit 1 to 3: from 23.5±7.3 points to 18.7±4.9 points and to 14.6±3.1 points. After 2 weeks complex therapy including investigated moisturizers, medium day skin itch score was reduced from 6.4 to 3.6 points, also as sleep disturbance score from 2.6 to 1.2 points. Direct moderate correlation (r=0.64, p=0.012) was revealed between number of days without skin itch or sleep disturbance and compliance to moisturizers consumption. No any adverse event caused by investigated products was registered.Conclusion. Inclusion of locally produced moisturizing cream and bathing oil (Lipobase baby trademark) in the complex AtD therapy improve the treatment efficacy.Conflict of interest: Products of medical cosmetics for use in this Protocol are provided by the Pharmatek Company LLC. Representatives of the Company did not participate in the statistical processing, interpretation of the results and preparation of this publication. дети атопический дерматит эмолиенты эффективность лечения Pediatrics O. V. Trusova verfasserin aut U. A. Butyrina verfasserin aut I. V. Makarova verfasserin aut In Rossijskij Vestnik Perinatologii i Pediatrii Ltd. “The National Academy of Pediatric Science and Innovation”, 2018 64(2019), 3, Seite 109-116 (DE-627)1043470638 25002228 nnns volume:64 year:2019 number:3 pages:109-116 https://doi.org/10.21508/1027-4065-2019-64-3-109-117 kostenfrei https://doaj.org/article/4d3207d328da43ee83a25c9fd721b390 kostenfrei https://www.ped-perinatology.ru/jour/article/view/902 kostenfrei https://doaj.org/toc/1027-4065 Journal toc kostenfrei https://doaj.org/toc/2500-2228 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 64 2019 3 109-116
allfieldsGer	10.21508/1027-4065-2019-64-3-109-117 doi (DE-627)DOAJ020844743 (DE-599)DOAJ4d3207d328da43ee83a25c9fd721b390 DE-627 ger DE-627 rakwb rus RJ1-570 A. V. Kamaev verfasserin aut Improvement of therapy efficacy in children with atopic dermatitis due to emollient complex 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Active studies of atopic dermatitis (AtD) have revealed new disease pathways and confirmed the complex treatment approach need, including different forms of emollients (creams and bath treatments). Study aim: to show effectiveness of locally produced moisturizing cream and bathing oil combination (Lipobase baby trademark) in the complex treatment of babies and toddlers with AtD.Patients and methods. Thirty children (60% boys) aged from 6 to 36 months with mild/moderate AtD were included in open prospective non-comparative study 30 days long. Initial and after each 2 weeks SCORAD and dairies for 10 points skin itch and sleep disturbance scores, moisturizers consumption and adverse events were evaluated. Global evaluation of treatment effectiveness score were performed by patient’s doctor.Results. Medium compliance for moisturizers consumption was 89.2% days. Medium SCORAD results decreased from visit 1 to 3: from 23.5±7.3 points to 18.7±4.9 points and to 14.6±3.1 points. After 2 weeks complex therapy including investigated moisturizers, medium day skin itch score was reduced from 6.4 to 3.6 points, also as sleep disturbance score from 2.6 to 1.2 points. Direct moderate correlation (r=0.64, p=0.012) was revealed between number of days without skin itch or sleep disturbance and compliance to moisturizers consumption. No any adverse event caused by investigated products was registered.Conclusion. Inclusion of locally produced moisturizing cream and bathing oil (Lipobase baby trademark) in the complex AtD therapy improve the treatment efficacy.Conflict of interest: Products of medical cosmetics for use in this Protocol are provided by the Pharmatek Company LLC. Representatives of the Company did not participate in the statistical processing, interpretation of the results and preparation of this publication. дети атопический дерматит эмолиенты эффективность лечения Pediatrics O. V. Trusova verfasserin aut U. A. Butyrina verfasserin aut I. V. Makarova verfasserin aut In Rossijskij Vestnik Perinatologii i Pediatrii Ltd. “The National Academy of Pediatric Science and Innovation”, 2018 64(2019), 3, Seite 109-116 (DE-627)1043470638 25002228 nnns volume:64 year:2019 number:3 pages:109-116 https://doi.org/10.21508/1027-4065-2019-64-3-109-117 kostenfrei https://doaj.org/article/4d3207d328da43ee83a25c9fd721b390 kostenfrei https://www.ped-perinatology.ru/jour/article/view/902 kostenfrei https://doaj.org/toc/1027-4065 Journal toc kostenfrei https://doaj.org/toc/2500-2228 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 64 2019 3 109-116
allfieldsSound	10.21508/1027-4065-2019-64-3-109-117 doi (DE-627)DOAJ020844743 (DE-599)DOAJ4d3207d328da43ee83a25c9fd721b390 DE-627 ger DE-627 rakwb rus RJ1-570 A. V. Kamaev verfasserin aut Improvement of therapy efficacy in children with atopic dermatitis due to emollient complex 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Active studies of atopic dermatitis (AtD) have revealed new disease pathways and confirmed the complex treatment approach need, including different forms of emollients (creams and bath treatments). Study aim: to show effectiveness of locally produced moisturizing cream and bathing oil combination (Lipobase baby trademark) in the complex treatment of babies and toddlers with AtD.Patients and methods. Thirty children (60% boys) aged from 6 to 36 months with mild/moderate AtD were included in open prospective non-comparative study 30 days long. Initial and after each 2 weeks SCORAD and dairies for 10 points skin itch and sleep disturbance scores, moisturizers consumption and adverse events were evaluated. Global evaluation of treatment effectiveness score were performed by patient’s doctor.Results. Medium compliance for moisturizers consumption was 89.2% days. Medium SCORAD results decreased from visit 1 to 3: from 23.5±7.3 points to 18.7±4.9 points and to 14.6±3.1 points. After 2 weeks complex therapy including investigated moisturizers, medium day skin itch score was reduced from 6.4 to 3.6 points, also as sleep disturbance score from 2.6 to 1.2 points. Direct moderate correlation (r=0.64, p=0.012) was revealed between number of days without skin itch or sleep disturbance and compliance to moisturizers consumption. No any adverse event caused by investigated products was registered.Conclusion. Inclusion of locally produced moisturizing cream and bathing oil (Lipobase baby trademark) in the complex AtD therapy improve the treatment efficacy.Conflict of interest: Products of medical cosmetics for use in this Protocol are provided by the Pharmatek Company LLC. Representatives of the Company did not participate in the statistical processing, interpretation of the results and preparation of this publication. дети атопический дерматит эмолиенты эффективность лечения Pediatrics O. V. Trusova verfasserin aut U. A. Butyrina verfasserin aut I. V. Makarova verfasserin aut In Rossijskij Vestnik Perinatologii i Pediatrii Ltd. “The National Academy of Pediatric Science and Innovation”, 2018 64(2019), 3, Seite 109-116 (DE-627)1043470638 25002228 nnns volume:64 year:2019 number:3 pages:109-116 https://doi.org/10.21508/1027-4065-2019-64-3-109-117 kostenfrei https://doaj.org/article/4d3207d328da43ee83a25c9fd721b390 kostenfrei https://www.ped-perinatology.ru/jour/article/view/902 kostenfrei https://doaj.org/toc/1027-4065 Journal toc kostenfrei https://doaj.org/toc/2500-2228 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 64 2019 3 109-116
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source	In Rossijskij Vestnik Perinatologii i Pediatrii 64(2019), 3, Seite 109-116 volume:64 year:2019 number:3 pages:109-116
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Kamaev</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Improvement of therapy efficacy in children with atopic dermatitis due to emollient complex</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2019</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Active studies of atopic dermatitis (AtD) have revealed new disease pathways and confirmed the complex treatment approach need, including different forms of emollients (creams and bath treatments). Study aim: to show effectiveness of locally produced moisturizing cream and bathing oil combination (Lipobase baby trademark) in the complex treatment of babies and toddlers with AtD.Patients and methods. Thirty children (60% boys) aged from 6 to 36 months with mild/moderate AtD were included in open prospective non-comparative study 30 days long. Initial and after each 2 weeks SCORAD and dairies for 10 points skin itch and sleep disturbance scores, moisturizers consumption and adverse events were evaluated. Global evaluation of treatment effectiveness score were performed by patient’s doctor.Results. Medium compliance for moisturizers consumption was 89.2% days. Medium SCORAD results decreased from visit 1 to 3: from 23.5±7.3 points to 18.7±4.9 points and to 14.6±3.1 points. After 2 weeks complex therapy including investigated moisturizers, medium day skin itch score was reduced from 6.4 to 3.6 points, also as sleep disturbance score from 2.6 to 1.2 points. Direct moderate correlation (r=0.64, p=0.012) was revealed between number of days without skin itch or sleep disturbance and compliance to moisturizers consumption. No any adverse event caused by investigated products was registered.Conclusion. Inclusion of locally produced moisturizing cream and bathing oil (Lipobase baby trademark) in the complex AtD therapy improve the treatment efficacy.Conflict of interest: Products of medical cosmetics for use in this Protocol are provided by the Pharmatek Company LLC. 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author	A. V. Kamaev
spellingShingle	A. V. Kamaev misc RJ1-570 misc дети misc атопический дерматит misc эмолиенты misc эффективность лечения misc Pediatrics Improvement of therapy efficacy in children with atopic dermatitis due to emollient complex
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topic	misc RJ1-570 misc дети misc атопический дерматит misc эмолиенты misc эффективность лечения misc Pediatrics
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title	Improvement of therapy efficacy in children with atopic dermatitis due to emollient complex
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title_full	Improvement of therapy efficacy in children with atopic dermatitis due to emollient complex
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title_sort	improvement of therapy efficacy in children with atopic dermatitis due to emollient complex
callnumber	RJ1-570
title_auth	Improvement of therapy efficacy in children with atopic dermatitis due to emollient complex
abstract	Active studies of atopic dermatitis (AtD) have revealed new disease pathways and confirmed the complex treatment approach need, including different forms of emollients (creams and bath treatments). Study aim: to show effectiveness of locally produced moisturizing cream and bathing oil combination (Lipobase baby trademark) in the complex treatment of babies and toddlers with AtD.Patients and methods. Thirty children (60% boys) aged from 6 to 36 months with mild/moderate AtD were included in open prospective non-comparative study 30 days long. Initial and after each 2 weeks SCORAD and dairies for 10 points skin itch and sleep disturbance scores, moisturizers consumption and adverse events were evaluated. Global evaluation of treatment effectiveness score were performed by patient’s doctor.Results. Medium compliance for moisturizers consumption was 89.2% days. Medium SCORAD results decreased from visit 1 to 3: from 23.5±7.3 points to 18.7±4.9 points and to 14.6±3.1 points. After 2 weeks complex therapy including investigated moisturizers, medium day skin itch score was reduced from 6.4 to 3.6 points, also as sleep disturbance score from 2.6 to 1.2 points. Direct moderate correlation (r=0.64, p=0.012) was revealed between number of days without skin itch or sleep disturbance and compliance to moisturizers consumption. No any adverse event caused by investigated products was registered.Conclusion. Inclusion of locally produced moisturizing cream and bathing oil (Lipobase baby trademark) in the complex AtD therapy improve the treatment efficacy.Conflict of interest: Products of medical cosmetics for use in this Protocol are provided by the Pharmatek Company LLC. Representatives of the Company did not participate in the statistical processing, interpretation of the results and preparation of this publication.
abstractGer	Active studies of atopic dermatitis (AtD) have revealed new disease pathways and confirmed the complex treatment approach need, including different forms of emollients (creams and bath treatments). Study aim: to show effectiveness of locally produced moisturizing cream and bathing oil combination (Lipobase baby trademark) in the complex treatment of babies and toddlers with AtD.Patients and methods. Thirty children (60% boys) aged from 6 to 36 months with mild/moderate AtD were included in open prospective non-comparative study 30 days long. Initial and after each 2 weeks SCORAD and dairies for 10 points skin itch and sleep disturbance scores, moisturizers consumption and adverse events were evaluated. Global evaluation of treatment effectiveness score were performed by patient’s doctor.Results. Medium compliance for moisturizers consumption was 89.2% days. Medium SCORAD results decreased from visit 1 to 3: from 23.5±7.3 points to 18.7±4.9 points and to 14.6±3.1 points. After 2 weeks complex therapy including investigated moisturizers, medium day skin itch score was reduced from 6.4 to 3.6 points, also as sleep disturbance score from 2.6 to 1.2 points. Direct moderate correlation (r=0.64, p=0.012) was revealed between number of days without skin itch or sleep disturbance and compliance to moisturizers consumption. No any adverse event caused by investigated products was registered.Conclusion. Inclusion of locally produced moisturizing cream and bathing oil (Lipobase baby trademark) in the complex AtD therapy improve the treatment efficacy.Conflict of interest: Products of medical cosmetics for use in this Protocol are provided by the Pharmatek Company LLC. Representatives of the Company did not participate in the statistical processing, interpretation of the results and preparation of this publication.
abstract_unstemmed	Active studies of atopic dermatitis (AtD) have revealed new disease pathways and confirmed the complex treatment approach need, including different forms of emollients (creams and bath treatments). Study aim: to show effectiveness of locally produced moisturizing cream and bathing oil combination (Lipobase baby trademark) in the complex treatment of babies and toddlers with AtD.Patients and methods. Thirty children (60% boys) aged from 6 to 36 months with mild/moderate AtD were included in open prospective non-comparative study 30 days long. Initial and after each 2 weeks SCORAD and dairies for 10 points skin itch and sleep disturbance scores, moisturizers consumption and adverse events were evaluated. Global evaluation of treatment effectiveness score were performed by patient’s doctor.Results. Medium compliance for moisturizers consumption was 89.2% days. Medium SCORAD results decreased from visit 1 to 3: from 23.5±7.3 points to 18.7±4.9 points and to 14.6±3.1 points. After 2 weeks complex therapy including investigated moisturizers, medium day skin itch score was reduced from 6.4 to 3.6 points, also as sleep disturbance score from 2.6 to 1.2 points. Direct moderate correlation (r=0.64, p=0.012) was revealed between number of days without skin itch or sleep disturbance and compliance to moisturizers consumption. No any adverse event caused by investigated products was registered.Conclusion. Inclusion of locally produced moisturizing cream and bathing oil (Lipobase baby trademark) in the complex AtD therapy improve the treatment efficacy.Conflict of interest: Products of medical cosmetics for use in this Protocol are provided by the Pharmatek Company LLC. Representatives of the Company did not participate in the statistical processing, interpretation of the results and preparation of this publication.
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title_short	Improvement of therapy efficacy in children with atopic dermatitis due to emollient complex
url	https://doi.org/10.21508/1027-4065-2019-64-3-109-117 https://doaj.org/article/4d3207d328da43ee83a25c9fd721b390 https://www.ped-perinatology.ru/jour/article/view/902 https://doaj.org/toc/1027-4065 https://doaj.org/toc/2500-2228
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V. Kamaev</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Improvement of therapy efficacy in children with atopic dermatitis due to emollient complex</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2019</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Active studies of atopic dermatitis (AtD) have revealed new disease pathways and confirmed the complex treatment approach need, including different forms of emollients (creams and bath treatments). Study aim: to show effectiveness of locally produced moisturizing cream and bathing oil combination (Lipobase baby trademark) in the complex treatment of babies and toddlers with AtD.Patients and methods. Thirty children (60% boys) aged from 6 to 36 months with mild/moderate AtD were included in open prospective non-comparative study 30 days long. Initial and after each 2 weeks SCORAD and dairies for 10 points skin itch and sleep disturbance scores, moisturizers consumption and adverse events were evaluated. Global evaluation of treatment effectiveness score were performed by patient’s doctor.Results. Medium compliance for moisturizers consumption was 89.2% days. Medium SCORAD results decreased from visit 1 to 3: from 23.5±7.3 points to 18.7±4.9 points and to 14.6±3.1 points. After 2 weeks complex therapy including investigated moisturizers, medium day skin itch score was reduced from 6.4 to 3.6 points, also as sleep disturbance score from 2.6 to 1.2 points. Direct moderate correlation (r=0.64, p=0.012) was revealed between number of days without skin itch or sleep disturbance and compliance to moisturizers consumption. No any adverse event caused by investigated products was registered.Conclusion. Inclusion of locally produced moisturizing cream and bathing oil (Lipobase baby trademark) in the complex AtD therapy improve the treatment efficacy.Conflict of interest: Products of medical cosmetics for use in this Protocol are provided by the Pharmatek Company LLC. Representatives of the Company did not participate in the statistical processing, interpretation of the results and preparation of this publication.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">дети</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">атопический дерматит</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">эмолиенты</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">эффективность лечения</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Pediatrics</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">O. V. Trusova</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">U. A. 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Improvement of therapy efficacy in children with atopic dermatitis due to emollient complex

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