Platelet Transcriptome Profiling in HIV and ATP-Binding Cassette Subfamily C Member 4 (ABCC4) as a Mediator of Platelet Activity

An unbiased platelet transcriptome profile identified ATP binding cassette subfamily C member 4 (ABCC4) as a novel mediator of platelet activity in virologically suppressed human immunodeficiency virus (HIV)-infected subjects on antiretroviral therapy. Using ex vivo and in vitro cellular and molecul...
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Autor*in:	Emanuela Marcantoni, PhD [verfasserIn] Nicole Allen, BS [verfasserIn] Matthew R. Cambria, BA [verfasserIn] Rebecca Dann, BS [verfasserIn] Michael Cammer, BS [verfasserIn] Tenzin Lhakhang, BS [verfasserIn] Meagan P. O’Brien, MD [verfasserIn] Benjamin Kim, BS [verfasserIn] Tilla Worgall, MD, PhD [verfasserIn] Adriana Heguy, PhD [verfasserIn] Aristotelis Tsirigos, PhD [verfasserIn] Jeffrey S. Berger, MD, MS [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	ABCC4 cardiovascular disease HIV platelet activity

Übergeordnetes Werk:	In: JACC: Basic to Translational Science - Elsevier, 2017, 3(2018), 1, Seite 9-22
Übergeordnetes Werk:	volume:3 ; year:2018 ; number:1 ; pages:9-22

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.jacbts.2017.10.005

Katalog-ID:	DOAJ020913753

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700	0		\|a Jeffrey S. Berger, MD, MS \|e verfasserin \|4 aut
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Indexfelder

author_variant	m p e mp mpe a b n ab abn r c b m rcb rcbm d b r db dbr c b m cb cbm l b t lb lbt p o m m pom pomm k b b kb kbb w m p t wmp wmpt h p a hp hpa t p a tp tpa s b m m j sbmm sbmmj
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allfields	10.1016/j.jacbts.2017.10.005 doi (DE-627)DOAJ020913753 (DE-599)DOAJ9806d582f68f4ac59f37e12d3ef724e9 DE-627 ger DE-627 rakwb eng RC666-701 Emanuela Marcantoni, PhD verfasserin aut Platelet Transcriptome Profiling in HIV and ATP-Binding Cassette Subfamily C Member 4 (ABCC4) as a Mediator of Platelet Activity 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier An unbiased platelet transcriptome profile identified ATP binding cassette subfamily C member 4 (ABCC4) as a novel mediator of platelet activity in virologically suppressed human immunodeficiency virus (HIV)-infected subjects on antiretroviral therapy. Using ex vivo and in vitro cellular and molecular assays we demonstrated that ABCC4 regulated platelet activation by altering granule release and cyclic nucleotide homeostasis through a cAMP-protein kinase A (PKA)–mediated mechanism. Platelet ABCC4 inhibition attenuated platelet activation and effector cell function by reducing the release of inflammatory mediators, such as sphingosine-1-phosphate. ABCC4 inhibition may represent a novel antithrombotic strategy in HIV-infected subjects on antiretroviral therapy. ABCC4 cardiovascular disease HIV platelet activity Diseases of the circulatory (Cardiovascular) system Nicole Allen, BS verfasserin aut Matthew R. Cambria, BA verfasserin aut Rebecca Dann, BS verfasserin aut Michael Cammer, BS verfasserin aut Tenzin Lhakhang, BS verfasserin aut Meagan P. O’Brien, MD verfasserin aut Benjamin Kim, BS verfasserin aut Tilla Worgall, MD, PhD verfasserin aut Adriana Heguy, PhD verfasserin aut Aristotelis Tsirigos, PhD verfasserin aut Jeffrey S. Berger, MD, MS verfasserin aut In JACC: Basic to Translational Science Elsevier, 2017 3(2018), 1, Seite 9-22 (DE-627)865612463 (DE-600)2865010-4 2452302X nnns volume:3 year:2018 number:1 pages:9-22 https://doi.org/10.1016/j.jacbts.2017.10.005 kostenfrei https://doaj.org/article/9806d582f68f4ac59f37e12d3ef724e9 kostenfrei http://www.sciencedirect.com/science/article/pii/S2452302X17302796 kostenfrei https://doaj.org/toc/2452-302X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2018 1 9-22
spelling	10.1016/j.jacbts.2017.10.005 doi (DE-627)DOAJ020913753 (DE-599)DOAJ9806d582f68f4ac59f37e12d3ef724e9 DE-627 ger DE-627 rakwb eng RC666-701 Emanuela Marcantoni, PhD verfasserin aut Platelet Transcriptome Profiling in HIV and ATP-Binding Cassette Subfamily C Member 4 (ABCC4) as a Mediator of Platelet Activity 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier An unbiased platelet transcriptome profile identified ATP binding cassette subfamily C member 4 (ABCC4) as a novel mediator of platelet activity in virologically suppressed human immunodeficiency virus (HIV)-infected subjects on antiretroviral therapy. Using ex vivo and in vitro cellular and molecular assays we demonstrated that ABCC4 regulated platelet activation by altering granule release and cyclic nucleotide homeostasis through a cAMP-protein kinase A (PKA)–mediated mechanism. Platelet ABCC4 inhibition attenuated platelet activation and effector cell function by reducing the release of inflammatory mediators, such as sphingosine-1-phosphate. ABCC4 inhibition may represent a novel antithrombotic strategy in HIV-infected subjects on antiretroviral therapy. ABCC4 cardiovascular disease HIV platelet activity Diseases of the circulatory (Cardiovascular) system Nicole Allen, BS verfasserin aut Matthew R. Cambria, BA verfasserin aut Rebecca Dann, BS verfasserin aut Michael Cammer, BS verfasserin aut Tenzin Lhakhang, BS verfasserin aut Meagan P. O’Brien, MD verfasserin aut Benjamin Kim, BS verfasserin aut Tilla Worgall, MD, PhD verfasserin aut Adriana Heguy, PhD verfasserin aut Aristotelis Tsirigos, PhD verfasserin aut Jeffrey S. Berger, MD, MS verfasserin aut In JACC: Basic to Translational Science Elsevier, 2017 3(2018), 1, Seite 9-22 (DE-627)865612463 (DE-600)2865010-4 2452302X nnns volume:3 year:2018 number:1 pages:9-22 https://doi.org/10.1016/j.jacbts.2017.10.005 kostenfrei https://doaj.org/article/9806d582f68f4ac59f37e12d3ef724e9 kostenfrei http://www.sciencedirect.com/science/article/pii/S2452302X17302796 kostenfrei https://doaj.org/toc/2452-302X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2018 1 9-22
allfields_unstemmed	10.1016/j.jacbts.2017.10.005 doi (DE-627)DOAJ020913753 (DE-599)DOAJ9806d582f68f4ac59f37e12d3ef724e9 DE-627 ger DE-627 rakwb eng RC666-701 Emanuela Marcantoni, PhD verfasserin aut Platelet Transcriptome Profiling in HIV and ATP-Binding Cassette Subfamily C Member 4 (ABCC4) as a Mediator of Platelet Activity 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier An unbiased platelet transcriptome profile identified ATP binding cassette subfamily C member 4 (ABCC4) as a novel mediator of platelet activity in virologically suppressed human immunodeficiency virus (HIV)-infected subjects on antiretroviral therapy. Using ex vivo and in vitro cellular and molecular assays we demonstrated that ABCC4 regulated platelet activation by altering granule release and cyclic nucleotide homeostasis through a cAMP-protein kinase A (PKA)–mediated mechanism. Platelet ABCC4 inhibition attenuated platelet activation and effector cell function by reducing the release of inflammatory mediators, such as sphingosine-1-phosphate. ABCC4 inhibition may represent a novel antithrombotic strategy in HIV-infected subjects on antiretroviral therapy. ABCC4 cardiovascular disease HIV platelet activity Diseases of the circulatory (Cardiovascular) system Nicole Allen, BS verfasserin aut Matthew R. Cambria, BA verfasserin aut Rebecca Dann, BS verfasserin aut Michael Cammer, BS verfasserin aut Tenzin Lhakhang, BS verfasserin aut Meagan P. O’Brien, MD verfasserin aut Benjamin Kim, BS verfasserin aut Tilla Worgall, MD, PhD verfasserin aut Adriana Heguy, PhD verfasserin aut Aristotelis Tsirigos, PhD verfasserin aut Jeffrey S. Berger, MD, MS verfasserin aut In JACC: Basic to Translational Science Elsevier, 2017 3(2018), 1, Seite 9-22 (DE-627)865612463 (DE-600)2865010-4 2452302X nnns volume:3 year:2018 number:1 pages:9-22 https://doi.org/10.1016/j.jacbts.2017.10.005 kostenfrei https://doaj.org/article/9806d582f68f4ac59f37e12d3ef724e9 kostenfrei http://www.sciencedirect.com/science/article/pii/S2452302X17302796 kostenfrei https://doaj.org/toc/2452-302X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2018 1 9-22
allfieldsGer	10.1016/j.jacbts.2017.10.005 doi (DE-627)DOAJ020913753 (DE-599)DOAJ9806d582f68f4ac59f37e12d3ef724e9 DE-627 ger DE-627 rakwb eng RC666-701 Emanuela Marcantoni, PhD verfasserin aut Platelet Transcriptome Profiling in HIV and ATP-Binding Cassette Subfamily C Member 4 (ABCC4) as a Mediator of Platelet Activity 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier An unbiased platelet transcriptome profile identified ATP binding cassette subfamily C member 4 (ABCC4) as a novel mediator of platelet activity in virologically suppressed human immunodeficiency virus (HIV)-infected subjects on antiretroviral therapy. Using ex vivo and in vitro cellular and molecular assays we demonstrated that ABCC4 regulated platelet activation by altering granule release and cyclic nucleotide homeostasis through a cAMP-protein kinase A (PKA)–mediated mechanism. Platelet ABCC4 inhibition attenuated platelet activation and effector cell function by reducing the release of inflammatory mediators, such as sphingosine-1-phosphate. ABCC4 inhibition may represent a novel antithrombotic strategy in HIV-infected subjects on antiretroviral therapy. ABCC4 cardiovascular disease HIV platelet activity Diseases of the circulatory (Cardiovascular) system Nicole Allen, BS verfasserin aut Matthew R. Cambria, BA verfasserin aut Rebecca Dann, BS verfasserin aut Michael Cammer, BS verfasserin aut Tenzin Lhakhang, BS verfasserin aut Meagan P. O’Brien, MD verfasserin aut Benjamin Kim, BS verfasserin aut Tilla Worgall, MD, PhD verfasserin aut Adriana Heguy, PhD verfasserin aut Aristotelis Tsirigos, PhD verfasserin aut Jeffrey S. Berger, MD, MS verfasserin aut In JACC: Basic to Translational Science Elsevier, 2017 3(2018), 1, Seite 9-22 (DE-627)865612463 (DE-600)2865010-4 2452302X nnns volume:3 year:2018 number:1 pages:9-22 https://doi.org/10.1016/j.jacbts.2017.10.005 kostenfrei https://doaj.org/article/9806d582f68f4ac59f37e12d3ef724e9 kostenfrei http://www.sciencedirect.com/science/article/pii/S2452302X17302796 kostenfrei https://doaj.org/toc/2452-302X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2018 1 9-22
allfieldsSound	10.1016/j.jacbts.2017.10.005 doi (DE-627)DOAJ020913753 (DE-599)DOAJ9806d582f68f4ac59f37e12d3ef724e9 DE-627 ger DE-627 rakwb eng RC666-701 Emanuela Marcantoni, PhD verfasserin aut Platelet Transcriptome Profiling in HIV and ATP-Binding Cassette Subfamily C Member 4 (ABCC4) as a Mediator of Platelet Activity 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier An unbiased platelet transcriptome profile identified ATP binding cassette subfamily C member 4 (ABCC4) as a novel mediator of platelet activity in virologically suppressed human immunodeficiency virus (HIV)-infected subjects on antiretroviral therapy. Using ex vivo and in vitro cellular and molecular assays we demonstrated that ABCC4 regulated platelet activation by altering granule release and cyclic nucleotide homeostasis through a cAMP-protein kinase A (PKA)–mediated mechanism. Platelet ABCC4 inhibition attenuated platelet activation and effector cell function by reducing the release of inflammatory mediators, such as sphingosine-1-phosphate. ABCC4 inhibition may represent a novel antithrombotic strategy in HIV-infected subjects on antiretroviral therapy. ABCC4 cardiovascular disease HIV platelet activity Diseases of the circulatory (Cardiovascular) system Nicole Allen, BS verfasserin aut Matthew R. Cambria, BA verfasserin aut Rebecca Dann, BS verfasserin aut Michael Cammer, BS verfasserin aut Tenzin Lhakhang, BS verfasserin aut Meagan P. O’Brien, MD verfasserin aut Benjamin Kim, BS verfasserin aut Tilla Worgall, MD, PhD verfasserin aut Adriana Heguy, PhD verfasserin aut Aristotelis Tsirigos, PhD verfasserin aut Jeffrey S. Berger, MD, MS verfasserin aut In JACC: Basic to Translational Science Elsevier, 2017 3(2018), 1, Seite 9-22 (DE-627)865612463 (DE-600)2865010-4 2452302X nnns volume:3 year:2018 number:1 pages:9-22 https://doi.org/10.1016/j.jacbts.2017.10.005 kostenfrei https://doaj.org/article/9806d582f68f4ac59f37e12d3ef724e9 kostenfrei http://www.sciencedirect.com/science/article/pii/S2452302X17302796 kostenfrei https://doaj.org/toc/2452-302X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2018 1 9-22
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topic_facet	ABCC4 cardiovascular disease HIV platelet activity Diseases of the circulatory (Cardiovascular) system
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container_title	JACC: Basic to Translational Science
authorswithroles_txt_mv	Emanuela Marcantoni, PhD @@aut@@ Nicole Allen, BS @@aut@@ Matthew R. Cambria, BA @@aut@@ Rebecca Dann, BS @@aut@@ Michael Cammer, BS @@aut@@ Tenzin Lhakhang, BS @@aut@@ Meagan P. O’Brien, MD @@aut@@ Benjamin Kim, BS @@aut@@ Tilla Worgall, MD, PhD @@aut@@ Adriana Heguy, PhD @@aut@@ Aristotelis Tsirigos, PhD @@aut@@ Jeffrey S. Berger, MD, MS @@aut@@
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callnumber-first	R - Medicine
author	Emanuela Marcantoni, PhD
spellingShingle	Emanuela Marcantoni, PhD misc RC666-701 misc ABCC4 misc cardiovascular disease misc HIV misc platelet activity misc Diseases of the circulatory (Cardiovascular) system Platelet Transcriptome Profiling in HIV and ATP-Binding Cassette Subfamily C Member 4 (ABCC4) as a Mediator of Platelet Activity
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topic_title	RC666-701 Platelet Transcriptome Profiling in HIV and ATP-Binding Cassette Subfamily C Member 4 (ABCC4) as a Mediator of Platelet Activity ABCC4 cardiovascular disease HIV platelet activity
topic	misc RC666-701 misc ABCC4 misc cardiovascular disease misc HIV misc platelet activity misc Diseases of the circulatory (Cardiovascular) system
topic_unstemmed	misc RC666-701 misc ABCC4 misc cardiovascular disease misc HIV misc platelet activity misc Diseases of the circulatory (Cardiovascular) system
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title	Platelet Transcriptome Profiling in HIV and ATP-Binding Cassette Subfamily C Member 4 (ABCC4) as a Mediator of Platelet Activity
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title_full	Platelet Transcriptome Profiling in HIV and ATP-Binding Cassette Subfamily C Member 4 (ABCC4) as a Mediator of Platelet Activity
author_sort	Emanuela Marcantoni, PhD
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author_browse	Emanuela Marcantoni, PhD Nicole Allen, BS Matthew R. Cambria, BA Rebecca Dann, BS Michael Cammer, BS Tenzin Lhakhang, BS Meagan P. O’Brien, MD Benjamin Kim, BS Tilla Worgall, MD, PhD Adriana Heguy, PhD Aristotelis Tsirigos, PhD Jeffrey S. Berger, MD, MS
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title_sort	platelet transcriptome profiling in hiv and atp-binding cassette subfamily c member 4 (abcc4) as a mediator of platelet activity
callnumber	RC666-701
title_auth	Platelet Transcriptome Profiling in HIV and ATP-Binding Cassette Subfamily C Member 4 (ABCC4) as a Mediator of Platelet Activity
abstract	An unbiased platelet transcriptome profile identified ATP binding cassette subfamily C member 4 (ABCC4) as a novel mediator of platelet activity in virologically suppressed human immunodeficiency virus (HIV)-infected subjects on antiretroviral therapy. Using ex vivo and in vitro cellular and molecular assays we demonstrated that ABCC4 regulated platelet activation by altering granule release and cyclic nucleotide homeostasis through a cAMP-protein kinase A (PKA)–mediated mechanism. Platelet ABCC4 inhibition attenuated platelet activation and effector cell function by reducing the release of inflammatory mediators, such as sphingosine-1-phosphate. ABCC4 inhibition may represent a novel antithrombotic strategy in HIV-infected subjects on antiretroviral therapy.
abstractGer	An unbiased platelet transcriptome profile identified ATP binding cassette subfamily C member 4 (ABCC4) as a novel mediator of platelet activity in virologically suppressed human immunodeficiency virus (HIV)-infected subjects on antiretroviral therapy. Using ex vivo and in vitro cellular and molecular assays we demonstrated that ABCC4 regulated platelet activation by altering granule release and cyclic nucleotide homeostasis through a cAMP-protein kinase A (PKA)–mediated mechanism. Platelet ABCC4 inhibition attenuated platelet activation and effector cell function by reducing the release of inflammatory mediators, such as sphingosine-1-phosphate. ABCC4 inhibition may represent a novel antithrombotic strategy in HIV-infected subjects on antiretroviral therapy.
abstract_unstemmed	An unbiased platelet transcriptome profile identified ATP binding cassette subfamily C member 4 (ABCC4) as a novel mediator of platelet activity in virologically suppressed human immunodeficiency virus (HIV)-infected subjects on antiretroviral therapy. Using ex vivo and in vitro cellular and molecular assays we demonstrated that ABCC4 regulated platelet activation by altering granule release and cyclic nucleotide homeostasis through a cAMP-protein kinase A (PKA)–mediated mechanism. Platelet ABCC4 inhibition attenuated platelet activation and effector cell function by reducing the release of inflammatory mediators, such as sphingosine-1-phosphate. ABCC4 inhibition may represent a novel antithrombotic strategy in HIV-infected subjects on antiretroviral therapy.
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title_short	Platelet Transcriptome Profiling in HIV and ATP-Binding Cassette Subfamily C Member 4 (ABCC4) as a Mediator of Platelet Activity
url	https://doi.org/10.1016/j.jacbts.2017.10.005 https://doaj.org/article/9806d582f68f4ac59f37e12d3ef724e9 http://www.sciencedirect.com/science/article/pii/S2452302X17302796 https://doaj.org/toc/2452-302X
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author2	Nicole Allen, BS Matthew R. Cambria, BA Rebecca Dann, BS Michael Cammer, BS Tenzin Lhakhang, BS Meagan P. O’Brien, MD Benjamin Kim, BS Tilla Worgall, MD, PhD Adriana Heguy, PhD Aristotelis Tsirigos, PhD Jeffrey S. Berger, MD, MS
author2Str	Nicole Allen, BS Matthew R. Cambria, BA Rebecca Dann, BS Michael Cammer, BS Tenzin Lhakhang, BS Meagan P. O’Brien, MD Benjamin Kim, BS Tilla Worgall, MD, PhD Adriana Heguy, PhD Aristotelis Tsirigos, PhD Jeffrey S. Berger, MD, MS
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up_date	2024-07-03T17:45:32.832Z
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