Platelet Transcriptome Profiling in HIV and ATP-Binding Cassette Subfamily C Member 4 (ABCC4) as a Mediator of Platelet Activity
An unbiased platelet transcriptome profile identified ATP binding cassette subfamily C member 4 (ABCC4) as a novel mediator of platelet activity in virologically suppressed human immunodeficiency virus (HIV)-infected subjects on antiretroviral therapy. Using ex vivo and in vitro cellular and molecul...
Ausführliche Beschreibung
Autor*in: |
Emanuela Marcantoni, PhD [verfasserIn] Nicole Allen, BS [verfasserIn] Matthew R. Cambria, BA [verfasserIn] Rebecca Dann, BS [verfasserIn] Michael Cammer, BS [verfasserIn] Tenzin Lhakhang, BS [verfasserIn] Meagan P. O’Brien, MD [verfasserIn] Benjamin Kim, BS [verfasserIn] Tilla Worgall, MD, PhD [verfasserIn] Adriana Heguy, PhD [verfasserIn] Aristotelis Tsirigos, PhD [verfasserIn] Jeffrey S. Berger, MD, MS [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2018 |
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Übergeordnetes Werk: |
In: JACC: Basic to Translational Science - Elsevier, 2017, 3(2018), 1, Seite 9-22 |
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Übergeordnetes Werk: |
volume:3 ; year:2018 ; number:1 ; pages:9-22 |
Links: |
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DOI / URN: |
10.1016/j.jacbts.2017.10.005 |
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Katalog-ID: |
DOAJ020913753 |
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10.1016/j.jacbts.2017.10.005 doi (DE-627)DOAJ020913753 (DE-599)DOAJ9806d582f68f4ac59f37e12d3ef724e9 DE-627 ger DE-627 rakwb eng RC666-701 Emanuela Marcantoni, PhD verfasserin aut Platelet Transcriptome Profiling in HIV and ATP-Binding Cassette Subfamily C Member 4 (ABCC4) as a Mediator of Platelet Activity 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier An unbiased platelet transcriptome profile identified ATP binding cassette subfamily C member 4 (ABCC4) as a novel mediator of platelet activity in virologically suppressed human immunodeficiency virus (HIV)-infected subjects on antiretroviral therapy. Using ex vivo and in vitro cellular and molecular assays we demonstrated that ABCC4 regulated platelet activation by altering granule release and cyclic nucleotide homeostasis through a cAMP-protein kinase A (PKA)–mediated mechanism. Platelet ABCC4 inhibition attenuated platelet activation and effector cell function by reducing the release of inflammatory mediators, such as sphingosine-1-phosphate. ABCC4 inhibition may represent a novel antithrombotic strategy in HIV-infected subjects on antiretroviral therapy. ABCC4 cardiovascular disease HIV platelet activity Diseases of the circulatory (Cardiovascular) system Nicole Allen, BS verfasserin aut Matthew R. Cambria, BA verfasserin aut Rebecca Dann, BS verfasserin aut Michael Cammer, BS verfasserin aut Tenzin Lhakhang, BS verfasserin aut Meagan P. O’Brien, MD verfasserin aut Benjamin Kim, BS verfasserin aut Tilla Worgall, MD, PhD verfasserin aut Adriana Heguy, PhD verfasserin aut Aristotelis Tsirigos, PhD verfasserin aut Jeffrey S. Berger, MD, MS verfasserin aut In JACC: Basic to Translational Science Elsevier, 2017 3(2018), 1, Seite 9-22 (DE-627)865612463 (DE-600)2865010-4 2452302X nnns volume:3 year:2018 number:1 pages:9-22 https://doi.org/10.1016/j.jacbts.2017.10.005 kostenfrei https://doaj.org/article/9806d582f68f4ac59f37e12d3ef724e9 kostenfrei http://www.sciencedirect.com/science/article/pii/S2452302X17302796 kostenfrei https://doaj.org/toc/2452-302X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2018 1 9-22 |
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10.1016/j.jacbts.2017.10.005 doi (DE-627)DOAJ020913753 (DE-599)DOAJ9806d582f68f4ac59f37e12d3ef724e9 DE-627 ger DE-627 rakwb eng RC666-701 Emanuela Marcantoni, PhD verfasserin aut Platelet Transcriptome Profiling in HIV and ATP-Binding Cassette Subfamily C Member 4 (ABCC4) as a Mediator of Platelet Activity 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier An unbiased platelet transcriptome profile identified ATP binding cassette subfamily C member 4 (ABCC4) as a novel mediator of platelet activity in virologically suppressed human immunodeficiency virus (HIV)-infected subjects on antiretroviral therapy. Using ex vivo and in vitro cellular and molecular assays we demonstrated that ABCC4 regulated platelet activation by altering granule release and cyclic nucleotide homeostasis through a cAMP-protein kinase A (PKA)–mediated mechanism. Platelet ABCC4 inhibition attenuated platelet activation and effector cell function by reducing the release of inflammatory mediators, such as sphingosine-1-phosphate. ABCC4 inhibition may represent a novel antithrombotic strategy in HIV-infected subjects on antiretroviral therapy. ABCC4 cardiovascular disease HIV platelet activity Diseases of the circulatory (Cardiovascular) system Nicole Allen, BS verfasserin aut Matthew R. Cambria, BA verfasserin aut Rebecca Dann, BS verfasserin aut Michael Cammer, BS verfasserin aut Tenzin Lhakhang, BS verfasserin aut Meagan P. O’Brien, MD verfasserin aut Benjamin Kim, BS verfasserin aut Tilla Worgall, MD, PhD verfasserin aut Adriana Heguy, PhD verfasserin aut Aristotelis Tsirigos, PhD verfasserin aut Jeffrey S. Berger, MD, MS verfasserin aut In JACC: Basic to Translational Science Elsevier, 2017 3(2018), 1, Seite 9-22 (DE-627)865612463 (DE-600)2865010-4 2452302X nnns volume:3 year:2018 number:1 pages:9-22 https://doi.org/10.1016/j.jacbts.2017.10.005 kostenfrei https://doaj.org/article/9806d582f68f4ac59f37e12d3ef724e9 kostenfrei http://www.sciencedirect.com/science/article/pii/S2452302X17302796 kostenfrei https://doaj.org/toc/2452-302X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2018 1 9-22 |
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10.1016/j.jacbts.2017.10.005 doi (DE-627)DOAJ020913753 (DE-599)DOAJ9806d582f68f4ac59f37e12d3ef724e9 DE-627 ger DE-627 rakwb eng RC666-701 Emanuela Marcantoni, PhD verfasserin aut Platelet Transcriptome Profiling in HIV and ATP-Binding Cassette Subfamily C Member 4 (ABCC4) as a Mediator of Platelet Activity 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier An unbiased platelet transcriptome profile identified ATP binding cassette subfamily C member 4 (ABCC4) as a novel mediator of platelet activity in virologically suppressed human immunodeficiency virus (HIV)-infected subjects on antiretroviral therapy. Using ex vivo and in vitro cellular and molecular assays we demonstrated that ABCC4 regulated platelet activation by altering granule release and cyclic nucleotide homeostasis through a cAMP-protein kinase A (PKA)–mediated mechanism. Platelet ABCC4 inhibition attenuated platelet activation and effector cell function by reducing the release of inflammatory mediators, such as sphingosine-1-phosphate. ABCC4 inhibition may represent a novel antithrombotic strategy in HIV-infected subjects on antiretroviral therapy. ABCC4 cardiovascular disease HIV platelet activity Diseases of the circulatory (Cardiovascular) system Nicole Allen, BS verfasserin aut Matthew R. Cambria, BA verfasserin aut Rebecca Dann, BS verfasserin aut Michael Cammer, BS verfasserin aut Tenzin Lhakhang, BS verfasserin aut Meagan P. O’Brien, MD verfasserin aut Benjamin Kim, BS verfasserin aut Tilla Worgall, MD, PhD verfasserin aut Adriana Heguy, PhD verfasserin aut Aristotelis Tsirigos, PhD verfasserin aut Jeffrey S. Berger, MD, MS verfasserin aut In JACC: Basic to Translational Science Elsevier, 2017 3(2018), 1, Seite 9-22 (DE-627)865612463 (DE-600)2865010-4 2452302X nnns volume:3 year:2018 number:1 pages:9-22 https://doi.org/10.1016/j.jacbts.2017.10.005 kostenfrei https://doaj.org/article/9806d582f68f4ac59f37e12d3ef724e9 kostenfrei http://www.sciencedirect.com/science/article/pii/S2452302X17302796 kostenfrei https://doaj.org/toc/2452-302X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2018 1 9-22 |
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Emanuela Marcantoni, PhD @@aut@@ Nicole Allen, BS @@aut@@ Matthew R. Cambria, BA @@aut@@ Rebecca Dann, BS @@aut@@ Michael Cammer, BS @@aut@@ Tenzin Lhakhang, BS @@aut@@ Meagan P. O’Brien, MD @@aut@@ Benjamin Kim, BS @@aut@@ Tilla Worgall, MD, PhD @@aut@@ Adriana Heguy, PhD @@aut@@ Aristotelis Tsirigos, PhD @@aut@@ Jeffrey S. Berger, MD, MS @@aut@@ |
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Platelet Transcriptome Profiling in HIV and ATP-Binding Cassette Subfamily C Member 4 (ABCC4) as a Mediator of Platelet Activity |
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An unbiased platelet transcriptome profile identified ATP binding cassette subfamily C member 4 (ABCC4) as a novel mediator of platelet activity in virologically suppressed human immunodeficiency virus (HIV)-infected subjects on antiretroviral therapy. Using ex vivo and in vitro cellular and molecular assays we demonstrated that ABCC4 regulated platelet activation by altering granule release and cyclic nucleotide homeostasis through a cAMP-protein kinase A (PKA)–mediated mechanism. Platelet ABCC4 inhibition attenuated platelet activation and effector cell function by reducing the release of inflammatory mediators, such as sphingosine-1-phosphate. ABCC4 inhibition may represent a novel antithrombotic strategy in HIV-infected subjects on antiretroviral therapy. |
abstractGer |
An unbiased platelet transcriptome profile identified ATP binding cassette subfamily C member 4 (ABCC4) as a novel mediator of platelet activity in virologically suppressed human immunodeficiency virus (HIV)-infected subjects on antiretroviral therapy. Using ex vivo and in vitro cellular and molecular assays we demonstrated that ABCC4 regulated platelet activation by altering granule release and cyclic nucleotide homeostasis through a cAMP-protein kinase A (PKA)–mediated mechanism. Platelet ABCC4 inhibition attenuated platelet activation and effector cell function by reducing the release of inflammatory mediators, such as sphingosine-1-phosphate. ABCC4 inhibition may represent a novel antithrombotic strategy in HIV-infected subjects on antiretroviral therapy. |
abstract_unstemmed |
An unbiased platelet transcriptome profile identified ATP binding cassette subfamily C member 4 (ABCC4) as a novel mediator of platelet activity in virologically suppressed human immunodeficiency virus (HIV)-infected subjects on antiretroviral therapy. Using ex vivo and in vitro cellular and molecular assays we demonstrated that ABCC4 regulated platelet activation by altering granule release and cyclic nucleotide homeostasis through a cAMP-protein kinase A (PKA)–mediated mechanism. Platelet ABCC4 inhibition attenuated platelet activation and effector cell function by reducing the release of inflammatory mediators, such as sphingosine-1-phosphate. ABCC4 inhibition may represent a novel antithrombotic strategy in HIV-infected subjects on antiretroviral therapy. |
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