Evaluation and integration of disparate classification systems for clefts of the lip

Orofacial clefting is a common birth defect with wide phenotypic variability. Many systems have been developed to classify cleft patterns to facilitate diagnosis, management, surgical treatment, and research. In this review, we examine the rationale for different existing classification schemes and...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Kathie H Wang [verfasserIn] Carrie L Heike [verfasserIn] Melissa eClarkson [verfasserIn] Jose L. V Mejino [verfasserIn] James F Brinkley [verfasserIn] Raymond W Tse [verfasserIn] Craig B Birgfeld [verfasserIn] David A Fitzsimons [verfasserIn] Timothy C Cox [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2014

Schlagwörter:	Cleft Lip ontology classification system orofacial clefts forme fruste incomplete cleft

Übergeordnetes Werk:	In: Frontiers in Physiology - Frontiers Media S.A., 2011, 5(2014)
Übergeordnetes Werk:	volume:5 ; year:2014

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fphys.2014.00163

Katalog-ID:	DOAJ020952686

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spelling	10.3389/fphys.2014.00163 doi (DE-627)DOAJ020952686 (DE-599)DOAJ0a0c9a600b754220af639ee8fd4026bf DE-627 ger DE-627 rakwb eng QP1-981 Kathie H Wang verfasserin aut Evaluation and integration of disparate classification systems for clefts of the lip 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Orofacial clefting is a common birth defect with wide phenotypic variability. Many systems have been developed to classify cleft patterns to facilitate diagnosis, management, surgical treatment, and research. In this review, we examine the rationale for different existing classification schemes and determine their inter-relationships, as well as strengths and deficiencies for subclassification of clefts of the lip. The various systems differ in how they describe and define attributes of cleft lip phenotypes. Application and analysis of the cleft lip classifications reveal discrepancies that may result in errors when comparing studies that use different systems. These inconsistencies in terminology, variable levels of subclassification, and ambiguity in some descriptions may confound analyses and impede further research aimed at understanding the genetics and etiology of clefts, development of effective treatment options for patients, as well as cross-institutional comparisons of outcome measures. Identification and reconciliation of discrepancies among existing systems is the first step towards creating a common standard to allow for a more explicit interpretation that will ultimately lead to a better understanding of the causes and manifestations of phenotypic variations in clefting. Cleft Lip ontology classification system orofacial clefts forme fruste incomplete cleft Physiology Carrie L Heike verfasserin aut Carrie L Heike verfasserin aut Carrie L Heike verfasserin aut Melissa eClarkson verfasserin aut Melissa eClarkson verfasserin aut Jose L. V Mejino verfasserin aut James F Brinkley verfasserin aut James F Brinkley verfasserin aut Raymond W Tse verfasserin aut Craig B Birgfeld verfasserin aut David A Fitzsimons verfasserin aut David A Fitzsimons verfasserin aut Timothy C Cox verfasserin aut Timothy C Cox verfasserin aut Timothy C Cox verfasserin aut Timothy C Cox verfasserin aut In Frontiers in Physiology Frontiers Media S.A., 2011 5(2014) (DE-627)631498788 (DE-600)2564217-0 1664042X nnns volume:5 year:2014 https://doi.org/10.3389/fphys.2014.00163 kostenfrei https://doaj.org/article/0a0c9a600b754220af639ee8fd4026bf kostenfrei http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00163/full kostenfrei https://doaj.org/toc/1664-042X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2014
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allfieldsGer	10.3389/fphys.2014.00163 doi (DE-627)DOAJ020952686 (DE-599)DOAJ0a0c9a600b754220af639ee8fd4026bf DE-627 ger DE-627 rakwb eng QP1-981 Kathie H Wang verfasserin aut Evaluation and integration of disparate classification systems for clefts of the lip 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Orofacial clefting is a common birth defect with wide phenotypic variability. Many systems have been developed to classify cleft patterns to facilitate diagnosis, management, surgical treatment, and research. In this review, we examine the rationale for different existing classification schemes and determine their inter-relationships, as well as strengths and deficiencies for subclassification of clefts of the lip. The various systems differ in how they describe and define attributes of cleft lip phenotypes. Application and analysis of the cleft lip classifications reveal discrepancies that may result in errors when comparing studies that use different systems. These inconsistencies in terminology, variable levels of subclassification, and ambiguity in some descriptions may confound analyses and impede further research aimed at understanding the genetics and etiology of clefts, development of effective treatment options for patients, as well as cross-institutional comparisons of outcome measures. Identification and reconciliation of discrepancies among existing systems is the first step towards creating a common standard to allow for a more explicit interpretation that will ultimately lead to a better understanding of the causes and manifestations of phenotypic variations in clefting. Cleft Lip ontology classification system orofacial clefts forme fruste incomplete cleft Physiology Carrie L Heike verfasserin aut Carrie L Heike verfasserin aut Carrie L Heike verfasserin aut Melissa eClarkson verfasserin aut Melissa eClarkson verfasserin aut Jose L. V Mejino verfasserin aut James F Brinkley verfasserin aut James F Brinkley verfasserin aut Raymond W Tse verfasserin aut Craig B Birgfeld verfasserin aut David A Fitzsimons verfasserin aut David A Fitzsimons verfasserin aut Timothy C Cox verfasserin aut Timothy C Cox verfasserin aut Timothy C Cox verfasserin aut Timothy C Cox verfasserin aut In Frontiers in Physiology Frontiers Media S.A., 2011 5(2014) (DE-627)631498788 (DE-600)2564217-0 1664042X nnns volume:5 year:2014 https://doi.org/10.3389/fphys.2014.00163 kostenfrei https://doaj.org/article/0a0c9a600b754220af639ee8fd4026bf kostenfrei http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00163/full kostenfrei https://doaj.org/toc/1664-042X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2014
allfieldsSound	10.3389/fphys.2014.00163 doi (DE-627)DOAJ020952686 (DE-599)DOAJ0a0c9a600b754220af639ee8fd4026bf DE-627 ger DE-627 rakwb eng QP1-981 Kathie H Wang verfasserin aut Evaluation and integration of disparate classification systems for clefts of the lip 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Orofacial clefting is a common birth defect with wide phenotypic variability. Many systems have been developed to classify cleft patterns to facilitate diagnosis, management, surgical treatment, and research. In this review, we examine the rationale for different existing classification schemes and determine their inter-relationships, as well as strengths and deficiencies for subclassification of clefts of the lip. The various systems differ in how they describe and define attributes of cleft lip phenotypes. Application and analysis of the cleft lip classifications reveal discrepancies that may result in errors when comparing studies that use different systems. These inconsistencies in terminology, variable levels of subclassification, and ambiguity in some descriptions may confound analyses and impede further research aimed at understanding the genetics and etiology of clefts, development of effective treatment options for patients, as well as cross-institutional comparisons of outcome measures. Identification and reconciliation of discrepancies among existing systems is the first step towards creating a common standard to allow for a more explicit interpretation that will ultimately lead to a better understanding of the causes and manifestations of phenotypic variations in clefting. Cleft Lip ontology classification system orofacial clefts forme fruste incomplete cleft Physiology Carrie L Heike verfasserin aut Carrie L Heike verfasserin aut Carrie L Heike verfasserin aut Melissa eClarkson verfasserin aut Melissa eClarkson verfasserin aut Jose L. V Mejino verfasserin aut James F Brinkley verfasserin aut James F Brinkley verfasserin aut Raymond W Tse verfasserin aut Craig B Birgfeld verfasserin aut David A Fitzsimons verfasserin aut David A Fitzsimons verfasserin aut Timothy C Cox verfasserin aut Timothy C Cox verfasserin aut Timothy C Cox verfasserin aut Timothy C Cox verfasserin aut In Frontiers in Physiology Frontiers Media S.A., 2011 5(2014) (DE-627)631498788 (DE-600)2564217-0 1664042X nnns volume:5 year:2014 https://doi.org/10.3389/fphys.2014.00163 kostenfrei https://doaj.org/article/0a0c9a600b754220af639ee8fd4026bf kostenfrei http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00163/full kostenfrei https://doaj.org/toc/1664-042X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2014
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author	Kathie H Wang
spellingShingle	Kathie H Wang misc QP1-981 misc Cleft Lip misc ontology misc classification system misc orofacial clefts misc forme fruste misc incomplete cleft misc Physiology Evaluation and integration of disparate classification systems for clefts of the lip
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topic_title	QP1-981 Evaluation and integration of disparate classification systems for clefts of the lip Cleft Lip ontology classification system orofacial clefts forme fruste incomplete cleft
topic	misc QP1-981 misc Cleft Lip misc ontology misc classification system misc orofacial clefts misc forme fruste misc incomplete cleft misc Physiology
topic_unstemmed	misc QP1-981 misc Cleft Lip misc ontology misc classification system misc orofacial clefts misc forme fruste misc incomplete cleft misc Physiology
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title	Evaluation and integration of disparate classification systems for clefts of the lip
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title_full	Evaluation and integration of disparate classification systems for clefts of the lip
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title_sort	evaluation and integration of disparate classification systems for clefts of the lip
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title_auth	Evaluation and integration of disparate classification systems for clefts of the lip
abstract	Orofacial clefting is a common birth defect with wide phenotypic variability. Many systems have been developed to classify cleft patterns to facilitate diagnosis, management, surgical treatment, and research. In this review, we examine the rationale for different existing classification schemes and determine their inter-relationships, as well as strengths and deficiencies for subclassification of clefts of the lip. The various systems differ in how they describe and define attributes of cleft lip phenotypes. Application and analysis of the cleft lip classifications reveal discrepancies that may result in errors when comparing studies that use different systems. These inconsistencies in terminology, variable levels of subclassification, and ambiguity in some descriptions may confound analyses and impede further research aimed at understanding the genetics and etiology of clefts, development of effective treatment options for patients, as well as cross-institutional comparisons of outcome measures. Identification and reconciliation of discrepancies among existing systems is the first step towards creating a common standard to allow for a more explicit interpretation that will ultimately lead to a better understanding of the causes and manifestations of phenotypic variations in clefting.
abstractGer	Orofacial clefting is a common birth defect with wide phenotypic variability. Many systems have been developed to classify cleft patterns to facilitate diagnosis, management, surgical treatment, and research. In this review, we examine the rationale for different existing classification schemes and determine their inter-relationships, as well as strengths and deficiencies for subclassification of clefts of the lip. The various systems differ in how they describe and define attributes of cleft lip phenotypes. Application and analysis of the cleft lip classifications reveal discrepancies that may result in errors when comparing studies that use different systems. These inconsistencies in terminology, variable levels of subclassification, and ambiguity in some descriptions may confound analyses and impede further research aimed at understanding the genetics and etiology of clefts, development of effective treatment options for patients, as well as cross-institutional comparisons of outcome measures. Identification and reconciliation of discrepancies among existing systems is the first step towards creating a common standard to allow for a more explicit interpretation that will ultimately lead to a better understanding of the causes and manifestations of phenotypic variations in clefting.
abstract_unstemmed	Orofacial clefting is a common birth defect with wide phenotypic variability. Many systems have been developed to classify cleft patterns to facilitate diagnosis, management, surgical treatment, and research. In this review, we examine the rationale for different existing classification schemes and determine their inter-relationships, as well as strengths and deficiencies for subclassification of clefts of the lip. The various systems differ in how they describe and define attributes of cleft lip phenotypes. Application and analysis of the cleft lip classifications reveal discrepancies that may result in errors when comparing studies that use different systems. These inconsistencies in terminology, variable levels of subclassification, and ambiguity in some descriptions may confound analyses and impede further research aimed at understanding the genetics and etiology of clefts, development of effective treatment options for patients, as well as cross-institutional comparisons of outcome measures. Identification and reconciliation of discrepancies among existing systems is the first step towards creating a common standard to allow for a more explicit interpretation that will ultimately lead to a better understanding of the causes and manifestations of phenotypic variations in clefting.
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title_short	Evaluation and integration of disparate classification systems for clefts of the lip
url	https://doi.org/10.3389/fphys.2014.00163 https://doaj.org/article/0a0c9a600b754220af639ee8fd4026bf http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00163/full https://doaj.org/toc/1664-042X
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author2	Carrie L Heike Melissa eClarkson Jose L. V Mejino James F Brinkley Raymond W Tse Craig B Birgfeld David A Fitzsimons Timothy C Cox
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Many systems have been developed to classify cleft patterns to facilitate diagnosis, management, surgical treatment, and research. In this review, we examine the rationale for different existing classification schemes and determine their inter-relationships, as well as strengths and deficiencies for subclassification of clefts of the lip. The various systems differ in how they describe and define attributes of cleft lip phenotypes. Application and analysis of the cleft lip classifications reveal discrepancies that may result in errors when comparing studies that use different systems. These inconsistencies in terminology, variable levels of subclassification, and ambiguity in some descriptions may confound analyses and impede further research aimed at understanding the genetics and etiology of clefts, development of effective treatment options for patients, as well as cross-institutional comparisons of outcome measures. 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Evaluation and integration of disparate classification systems for clefts of the lip

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