The prognostic value of neutrophil-to-lymphocyte ratio in patients with traumatic brain injury: A systematic review

Traumatic brain injury (TBI) places a heavy load on healthcare systems worldwide. Despite significant advancements in care, the TBI-related mortality is 30–50% and in most cases involves adolescents or young adults. Previous literature has suggested that neutrophil-to-lymphocyte ratio (NLR) may serv...
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Autor*in:	Sherief Ghozy [verfasserIn] Amr Ehab El-Qushayri [verfasserIn] Joseph Varney [verfasserIn] Salah Eddine Oussama Kacimi [verfasserIn] Eshak I. Bahbah [verfasserIn] Mostafa Ebraheem Morra [verfasserIn] Jaffer Shah [verfasserIn] Kevin M. Kallmes [verfasserIn] Alzhraa Salah Abbas [verfasserIn] Mohamed Elfil [verfasserIn] Badrah S. Alghamdi [verfasserIn] Ghulam Ashraf [verfasserIn] Rowa Alhabbab [verfasserIn] Adam A. Dmytriw [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	mortality neutrophil-to-lymphocyte ratio prediction traumatic brain injury systematic (literature) review

Übergeordnetes Werk:	In: Frontiers in Neurology - Frontiers Media S.A., 2010, 13(2022)
Übergeordnetes Werk:	volume:13 ; year:2022

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fneur.2022.1021877

Katalog-ID:	DOAJ021006725

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allfields	10.3389/fneur.2022.1021877 doi (DE-627)DOAJ021006725 (DE-599)DOAJ582da87f49c043b39ad69b92ce464313 DE-627 ger DE-627 rakwb eng RC346-429 Sherief Ghozy verfasserin aut The prognostic value of neutrophil-to-lymphocyte ratio in patients with traumatic brain injury: A systematic review 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Traumatic brain injury (TBI) places a heavy load on healthcare systems worldwide. Despite significant advancements in care, the TBI-related mortality is 30–50% and in most cases involves adolescents or young adults. Previous literature has suggested that neutrophil-to-lymphocyte ratio (NLR) may serve as a sensitive biomarker in predicting clinical outcomes following TBI. With conclusive evidence in this regard lacking, this study aimed to systematically review all original studies reporting the effectiveness of NLR as a predictor of TBI outcomes. A systematic search of eight databases was conducted according to the Preferred Reporting Items for Systematic Review and Meta-Analyses statement (PRISMA) recommendations. The risk of bias was assessed using the Quality in Prognostic Studies (QUIPS) tool. Eight studies were ultimately included in the study. In most of the studies interrogated, severity outcomes were successfully predicted by NLR in both univariate and multivariate prediction models, in different follow-up durations up to 6 months. A high NLR at 24 and 48 h after TBI in pediatric patients was associated with worse clinical outcomes. On pooling the NLR values within studies assessing its association with the outcome severity (favorable or not), patients with favorable outcomes had 37% lower NLR values than those with unfavorable ones (RoM= 0.63; 95% CI = 0.44–0.88; p = 0.007). However, there were considerable heterogeneity in effect estimates (I2 = 99%; p < 0.001). Moreover, NLR was a useful indicator of mortality at both 6-month and 1-year intervals. In conjunction with clinical and radiographic parameters, NLR might be a useful, inexpensive marker in predicting clinical outcomes in patients with TBI. However, the considerable heterogeneity in current literature keeps it under investigation with further studies are warranted to confirm the reliability of NLR in predicting TBI outcomes. mortality neutrophil-to-lymphocyte ratio prediction traumatic brain injury systematic (literature) review Neurology. Diseases of the nervous system Sherief Ghozy verfasserin aut Amr Ehab El-Qushayri verfasserin aut Joseph Varney verfasserin aut Salah Eddine Oussama Kacimi verfasserin aut Eshak I. Bahbah verfasserin aut Mostafa Ebraheem Morra verfasserin aut Jaffer Shah verfasserin aut Kevin M. Kallmes verfasserin aut Kevin M. Kallmes verfasserin aut Alzhraa Salah Abbas verfasserin aut Mohamed Elfil verfasserin aut Badrah S. Alghamdi verfasserin aut Badrah S. Alghamdi verfasserin aut Ghulam Ashraf verfasserin aut Rowa Alhabbab verfasserin aut Rowa Alhabbab verfasserin aut Adam A. Dmytriw verfasserin aut Adam A. Dmytriw verfasserin aut In Frontiers in Neurology Frontiers Media S.A., 2010 13(2022) (DE-627)631498753 (DE-600)2564214-5 16642295 nnns volume:13 year:2022 https://doi.org/10.3389/fneur.2022.1021877 kostenfrei https://doaj.org/article/582da87f49c043b39ad69b92ce464313 kostenfrei https://www.frontiersin.org/articles/10.3389/fneur.2022.1021877/full kostenfrei https://doaj.org/toc/1664-2295 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022
spelling	10.3389/fneur.2022.1021877 doi (DE-627)DOAJ021006725 (DE-599)DOAJ582da87f49c043b39ad69b92ce464313 DE-627 ger DE-627 rakwb eng RC346-429 Sherief Ghozy verfasserin aut The prognostic value of neutrophil-to-lymphocyte ratio in patients with traumatic brain injury: A systematic review 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Traumatic brain injury (TBI) places a heavy load on healthcare systems worldwide. Despite significant advancements in care, the TBI-related mortality is 30–50% and in most cases involves adolescents or young adults. Previous literature has suggested that neutrophil-to-lymphocyte ratio (NLR) may serve as a sensitive biomarker in predicting clinical outcomes following TBI. With conclusive evidence in this regard lacking, this study aimed to systematically review all original studies reporting the effectiveness of NLR as a predictor of TBI outcomes. A systematic search of eight databases was conducted according to the Preferred Reporting Items for Systematic Review and Meta-Analyses statement (PRISMA) recommendations. The risk of bias was assessed using the Quality in Prognostic Studies (QUIPS) tool. Eight studies were ultimately included in the study. In most of the studies interrogated, severity outcomes were successfully predicted by NLR in both univariate and multivariate prediction models, in different follow-up durations up to 6 months. A high NLR at 24 and 48 h after TBI in pediatric patients was associated with worse clinical outcomes. On pooling the NLR values within studies assessing its association with the outcome severity (favorable or not), patients with favorable outcomes had 37% lower NLR values than those with unfavorable ones (RoM= 0.63; 95% CI = 0.44–0.88; p = 0.007). However, there were considerable heterogeneity in effect estimates (I2 = 99%; p < 0.001). Moreover, NLR was a useful indicator of mortality at both 6-month and 1-year intervals. In conjunction with clinical and radiographic parameters, NLR might be a useful, inexpensive marker in predicting clinical outcomes in patients with TBI. However, the considerable heterogeneity in current literature keeps it under investigation with further studies are warranted to confirm the reliability of NLR in predicting TBI outcomes. mortality neutrophil-to-lymphocyte ratio prediction traumatic brain injury systematic (literature) review Neurology. Diseases of the nervous system Sherief Ghozy verfasserin aut Amr Ehab El-Qushayri verfasserin aut Joseph Varney verfasserin aut Salah Eddine Oussama Kacimi verfasserin aut Eshak I. Bahbah verfasserin aut Mostafa Ebraheem Morra verfasserin aut Jaffer Shah verfasserin aut Kevin M. Kallmes verfasserin aut Kevin M. Kallmes verfasserin aut Alzhraa Salah Abbas verfasserin aut Mohamed Elfil verfasserin aut Badrah S. Alghamdi verfasserin aut Badrah S. Alghamdi verfasserin aut Ghulam Ashraf verfasserin aut Rowa Alhabbab verfasserin aut Rowa Alhabbab verfasserin aut Adam A. Dmytriw verfasserin aut Adam A. Dmytriw verfasserin aut In Frontiers in Neurology Frontiers Media S.A., 2010 13(2022) (DE-627)631498753 (DE-600)2564214-5 16642295 nnns volume:13 year:2022 https://doi.org/10.3389/fneur.2022.1021877 kostenfrei https://doaj.org/article/582da87f49c043b39ad69b92ce464313 kostenfrei https://www.frontiersin.org/articles/10.3389/fneur.2022.1021877/full kostenfrei https://doaj.org/toc/1664-2295 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022
allfields_unstemmed	10.3389/fneur.2022.1021877 doi (DE-627)DOAJ021006725 (DE-599)DOAJ582da87f49c043b39ad69b92ce464313 DE-627 ger DE-627 rakwb eng RC346-429 Sherief Ghozy verfasserin aut The prognostic value of neutrophil-to-lymphocyte ratio in patients with traumatic brain injury: A systematic review 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Traumatic brain injury (TBI) places a heavy load on healthcare systems worldwide. Despite significant advancements in care, the TBI-related mortality is 30–50% and in most cases involves adolescents or young adults. Previous literature has suggested that neutrophil-to-lymphocyte ratio (NLR) may serve as a sensitive biomarker in predicting clinical outcomes following TBI. With conclusive evidence in this regard lacking, this study aimed to systematically review all original studies reporting the effectiveness of NLR as a predictor of TBI outcomes. A systematic search of eight databases was conducted according to the Preferred Reporting Items for Systematic Review and Meta-Analyses statement (PRISMA) recommendations. The risk of bias was assessed using the Quality in Prognostic Studies (QUIPS) tool. Eight studies were ultimately included in the study. In most of the studies interrogated, severity outcomes were successfully predicted by NLR in both univariate and multivariate prediction models, in different follow-up durations up to 6 months. A high NLR at 24 and 48 h after TBI in pediatric patients was associated with worse clinical outcomes. On pooling the NLR values within studies assessing its association with the outcome severity (favorable or not), patients with favorable outcomes had 37% lower NLR values than those with unfavorable ones (RoM= 0.63; 95% CI = 0.44–0.88; p = 0.007). However, there were considerable heterogeneity in effect estimates (I2 = 99%; p < 0.001). Moreover, NLR was a useful indicator of mortality at both 6-month and 1-year intervals. In conjunction with clinical and radiographic parameters, NLR might be a useful, inexpensive marker in predicting clinical outcomes in patients with TBI. However, the considerable heterogeneity in current literature keeps it under investigation with further studies are warranted to confirm the reliability of NLR in predicting TBI outcomes. mortality neutrophil-to-lymphocyte ratio prediction traumatic brain injury systematic (literature) review Neurology. Diseases of the nervous system Sherief Ghozy verfasserin aut Amr Ehab El-Qushayri verfasserin aut Joseph Varney verfasserin aut Salah Eddine Oussama Kacimi verfasserin aut Eshak I. Bahbah verfasserin aut Mostafa Ebraheem Morra verfasserin aut Jaffer Shah verfasserin aut Kevin M. Kallmes verfasserin aut Kevin M. Kallmes verfasserin aut Alzhraa Salah Abbas verfasserin aut Mohamed Elfil verfasserin aut Badrah S. Alghamdi verfasserin aut Badrah S. Alghamdi verfasserin aut Ghulam Ashraf verfasserin aut Rowa Alhabbab verfasserin aut Rowa Alhabbab verfasserin aut Adam A. Dmytriw verfasserin aut Adam A. Dmytriw verfasserin aut In Frontiers in Neurology Frontiers Media S.A., 2010 13(2022) (DE-627)631498753 (DE-600)2564214-5 16642295 nnns volume:13 year:2022 https://doi.org/10.3389/fneur.2022.1021877 kostenfrei https://doaj.org/article/582da87f49c043b39ad69b92ce464313 kostenfrei https://www.frontiersin.org/articles/10.3389/fneur.2022.1021877/full kostenfrei https://doaj.org/toc/1664-2295 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022
allfieldsGer	10.3389/fneur.2022.1021877 doi (DE-627)DOAJ021006725 (DE-599)DOAJ582da87f49c043b39ad69b92ce464313 DE-627 ger DE-627 rakwb eng RC346-429 Sherief Ghozy verfasserin aut The prognostic value of neutrophil-to-lymphocyte ratio in patients with traumatic brain injury: A systematic review 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Traumatic brain injury (TBI) places a heavy load on healthcare systems worldwide. Despite significant advancements in care, the TBI-related mortality is 30–50% and in most cases involves adolescents or young adults. Previous literature has suggested that neutrophil-to-lymphocyte ratio (NLR) may serve as a sensitive biomarker in predicting clinical outcomes following TBI. With conclusive evidence in this regard lacking, this study aimed to systematically review all original studies reporting the effectiveness of NLR as a predictor of TBI outcomes. A systematic search of eight databases was conducted according to the Preferred Reporting Items for Systematic Review and Meta-Analyses statement (PRISMA) recommendations. The risk of bias was assessed using the Quality in Prognostic Studies (QUIPS) tool. Eight studies were ultimately included in the study. In most of the studies interrogated, severity outcomes were successfully predicted by NLR in both univariate and multivariate prediction models, in different follow-up durations up to 6 months. A high NLR at 24 and 48 h after TBI in pediatric patients was associated with worse clinical outcomes. On pooling the NLR values within studies assessing its association with the outcome severity (favorable or not), patients with favorable outcomes had 37% lower NLR values than those with unfavorable ones (RoM= 0.63; 95% CI = 0.44–0.88; p = 0.007). However, there were considerable heterogeneity in effect estimates (I2 = 99%; p < 0.001). Moreover, NLR was a useful indicator of mortality at both 6-month and 1-year intervals. In conjunction with clinical and radiographic parameters, NLR might be a useful, inexpensive marker in predicting clinical outcomes in patients with TBI. However, the considerable heterogeneity in current literature keeps it under investigation with further studies are warranted to confirm the reliability of NLR in predicting TBI outcomes. mortality neutrophil-to-lymphocyte ratio prediction traumatic brain injury systematic (literature) review Neurology. Diseases of the nervous system Sherief Ghozy verfasserin aut Amr Ehab El-Qushayri verfasserin aut Joseph Varney verfasserin aut Salah Eddine Oussama Kacimi verfasserin aut Eshak I. Bahbah verfasserin aut Mostafa Ebraheem Morra verfasserin aut Jaffer Shah verfasserin aut Kevin M. Kallmes verfasserin aut Kevin M. Kallmes verfasserin aut Alzhraa Salah Abbas verfasserin aut Mohamed Elfil verfasserin aut Badrah S. Alghamdi verfasserin aut Badrah S. Alghamdi verfasserin aut Ghulam Ashraf verfasserin aut Rowa Alhabbab verfasserin aut Rowa Alhabbab verfasserin aut Adam A. Dmytriw verfasserin aut Adam A. Dmytriw verfasserin aut In Frontiers in Neurology Frontiers Media S.A., 2010 13(2022) (DE-627)631498753 (DE-600)2564214-5 16642295 nnns volume:13 year:2022 https://doi.org/10.3389/fneur.2022.1021877 kostenfrei https://doaj.org/article/582da87f49c043b39ad69b92ce464313 kostenfrei https://www.frontiersin.org/articles/10.3389/fneur.2022.1021877/full kostenfrei https://doaj.org/toc/1664-2295 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022
allfieldsSound	10.3389/fneur.2022.1021877 doi (DE-627)DOAJ021006725 (DE-599)DOAJ582da87f49c043b39ad69b92ce464313 DE-627 ger DE-627 rakwb eng RC346-429 Sherief Ghozy verfasserin aut The prognostic value of neutrophil-to-lymphocyte ratio in patients with traumatic brain injury: A systematic review 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Traumatic brain injury (TBI) places a heavy load on healthcare systems worldwide. Despite significant advancements in care, the TBI-related mortality is 30–50% and in most cases involves adolescents or young adults. Previous literature has suggested that neutrophil-to-lymphocyte ratio (NLR) may serve as a sensitive biomarker in predicting clinical outcomes following TBI. With conclusive evidence in this regard lacking, this study aimed to systematically review all original studies reporting the effectiveness of NLR as a predictor of TBI outcomes. A systematic search of eight databases was conducted according to the Preferred Reporting Items for Systematic Review and Meta-Analyses statement (PRISMA) recommendations. The risk of bias was assessed using the Quality in Prognostic Studies (QUIPS) tool. Eight studies were ultimately included in the study. In most of the studies interrogated, severity outcomes were successfully predicted by NLR in both univariate and multivariate prediction models, in different follow-up durations up to 6 months. A high NLR at 24 and 48 h after TBI in pediatric patients was associated with worse clinical outcomes. On pooling the NLR values within studies assessing its association with the outcome severity (favorable or not), patients with favorable outcomes had 37% lower NLR values than those with unfavorable ones (RoM= 0.63; 95% CI = 0.44–0.88; p = 0.007). However, there were considerable heterogeneity in effect estimates (I2 = 99%; p < 0.001). Moreover, NLR was a useful indicator of mortality at both 6-month and 1-year intervals. In conjunction with clinical and radiographic parameters, NLR might be a useful, inexpensive marker in predicting clinical outcomes in patients with TBI. However, the considerable heterogeneity in current literature keeps it under investigation with further studies are warranted to confirm the reliability of NLR in predicting TBI outcomes. mortality neutrophil-to-lymphocyte ratio prediction traumatic brain injury systematic (literature) review Neurology. Diseases of the nervous system Sherief Ghozy verfasserin aut Amr Ehab El-Qushayri verfasserin aut Joseph Varney verfasserin aut Salah Eddine Oussama Kacimi verfasserin aut Eshak I. Bahbah verfasserin aut Mostafa Ebraheem Morra verfasserin aut Jaffer Shah verfasserin aut Kevin M. Kallmes verfasserin aut Kevin M. Kallmes verfasserin aut Alzhraa Salah Abbas verfasserin aut Mohamed Elfil verfasserin aut Badrah S. Alghamdi verfasserin aut Badrah S. Alghamdi verfasserin aut Ghulam Ashraf verfasserin aut Rowa Alhabbab verfasserin aut Rowa Alhabbab verfasserin aut Adam A. Dmytriw verfasserin aut Adam A. Dmytriw verfasserin aut In Frontiers in Neurology Frontiers Media S.A., 2010 13(2022) (DE-627)631498753 (DE-600)2564214-5 16642295 nnns volume:13 year:2022 https://doi.org/10.3389/fneur.2022.1021877 kostenfrei https://doaj.org/article/582da87f49c043b39ad69b92ce464313 kostenfrei https://www.frontiersin.org/articles/10.3389/fneur.2022.1021877/full kostenfrei https://doaj.org/toc/1664-2295 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022
language	English
source	In Frontiers in Neurology 13(2022) volume:13 year:2022
sourceStr	In Frontiers in Neurology 13(2022) volume:13 year:2022
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	mortality neutrophil-to-lymphocyte ratio prediction traumatic brain injury systematic (literature) review Neurology. Diseases of the nervous system
isfreeaccess_bool	true
container_title	Frontiers in Neurology
authorswithroles_txt_mv	Sherief Ghozy @@aut@@ Amr Ehab El-Qushayri @@aut@@ Joseph Varney @@aut@@ Salah Eddine Oussama Kacimi @@aut@@ Eshak I. Bahbah @@aut@@ Mostafa Ebraheem Morra @@aut@@ Jaffer Shah @@aut@@ Kevin M. Kallmes @@aut@@ Alzhraa Salah Abbas @@aut@@ Mohamed Elfil @@aut@@ Badrah S. Alghamdi @@aut@@ Ghulam Ashraf @@aut@@ Rowa Alhabbab @@aut@@ Adam A. Dmytriw @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	631498753
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language_de	englisch
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callnumber-first	R - Medicine
author	Sherief Ghozy
spellingShingle	Sherief Ghozy misc RC346-429 misc mortality misc neutrophil-to-lymphocyte ratio misc prediction misc traumatic brain injury misc systematic (literature) review misc Neurology. Diseases of the nervous system The prognostic value of neutrophil-to-lymphocyte ratio in patients with traumatic brain injury: A systematic review
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topic_title	RC346-429 The prognostic value of neutrophil-to-lymphocyte ratio in patients with traumatic brain injury: A systematic review mortality neutrophil-to-lymphocyte ratio prediction traumatic brain injury systematic (literature) review
topic	misc RC346-429 misc mortality misc neutrophil-to-lymphocyte ratio misc prediction misc traumatic brain injury misc systematic (literature) review misc Neurology. Diseases of the nervous system
topic_unstemmed	misc RC346-429 misc mortality misc neutrophil-to-lymphocyte ratio misc prediction misc traumatic brain injury misc systematic (literature) review misc Neurology. Diseases of the nervous system
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title	The prognostic value of neutrophil-to-lymphocyte ratio in patients with traumatic brain injury: A systematic review
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title_full	The prognostic value of neutrophil-to-lymphocyte ratio in patients with traumatic brain injury: A systematic review
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author_browse	Sherief Ghozy Amr Ehab El-Qushayri Joseph Varney Salah Eddine Oussama Kacimi Eshak I. Bahbah Mostafa Ebraheem Morra Jaffer Shah Kevin M. Kallmes Alzhraa Salah Abbas Mohamed Elfil Badrah S. Alghamdi Ghulam Ashraf Rowa Alhabbab Adam A. Dmytriw
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title_sort	prognostic value of neutrophil-to-lymphocyte ratio in patients with traumatic brain injury: a systematic review
callnumber	RC346-429
title_auth	The prognostic value of neutrophil-to-lymphocyte ratio in patients with traumatic brain injury: A systematic review
abstract	Traumatic brain injury (TBI) places a heavy load on healthcare systems worldwide. Despite significant advancements in care, the TBI-related mortality is 30–50% and in most cases involves adolescents or young adults. Previous literature has suggested that neutrophil-to-lymphocyte ratio (NLR) may serve as a sensitive biomarker in predicting clinical outcomes following TBI. With conclusive evidence in this regard lacking, this study aimed to systematically review all original studies reporting the effectiveness of NLR as a predictor of TBI outcomes. A systematic search of eight databases was conducted according to the Preferred Reporting Items for Systematic Review and Meta-Analyses statement (PRISMA) recommendations. The risk of bias was assessed using the Quality in Prognostic Studies (QUIPS) tool. Eight studies were ultimately included in the study. In most of the studies interrogated, severity outcomes were successfully predicted by NLR in both univariate and multivariate prediction models, in different follow-up durations up to 6 months. A high NLR at 24 and 48 h after TBI in pediatric patients was associated with worse clinical outcomes. On pooling the NLR values within studies assessing its association with the outcome severity (favorable or not), patients with favorable outcomes had 37% lower NLR values than those with unfavorable ones (RoM= 0.63; 95% CI = 0.44–0.88; p = 0.007). However, there were considerable heterogeneity in effect estimates (I2 = 99%; p < 0.001). Moreover, NLR was a useful indicator of mortality at both 6-month and 1-year intervals. In conjunction with clinical and radiographic parameters, NLR might be a useful, inexpensive marker in predicting clinical outcomes in patients with TBI. However, the considerable heterogeneity in current literature keeps it under investigation with further studies are warranted to confirm the reliability of NLR in predicting TBI outcomes.
abstractGer	Traumatic brain injury (TBI) places a heavy load on healthcare systems worldwide. Despite significant advancements in care, the TBI-related mortality is 30–50% and in most cases involves adolescents or young adults. Previous literature has suggested that neutrophil-to-lymphocyte ratio (NLR) may serve as a sensitive biomarker in predicting clinical outcomes following TBI. With conclusive evidence in this regard lacking, this study aimed to systematically review all original studies reporting the effectiveness of NLR as a predictor of TBI outcomes. A systematic search of eight databases was conducted according to the Preferred Reporting Items for Systematic Review and Meta-Analyses statement (PRISMA) recommendations. The risk of bias was assessed using the Quality in Prognostic Studies (QUIPS) tool. Eight studies were ultimately included in the study. In most of the studies interrogated, severity outcomes were successfully predicted by NLR in both univariate and multivariate prediction models, in different follow-up durations up to 6 months. A high NLR at 24 and 48 h after TBI in pediatric patients was associated with worse clinical outcomes. On pooling the NLR values within studies assessing its association with the outcome severity (favorable or not), patients with favorable outcomes had 37% lower NLR values than those with unfavorable ones (RoM= 0.63; 95% CI = 0.44–0.88; p = 0.007). However, there were considerable heterogeneity in effect estimates (I2 = 99%; p < 0.001). Moreover, NLR was a useful indicator of mortality at both 6-month and 1-year intervals. In conjunction with clinical and radiographic parameters, NLR might be a useful, inexpensive marker in predicting clinical outcomes in patients with TBI. However, the considerable heterogeneity in current literature keeps it under investigation with further studies are warranted to confirm the reliability of NLR in predicting TBI outcomes.
abstract_unstemmed	Traumatic brain injury (TBI) places a heavy load on healthcare systems worldwide. Despite significant advancements in care, the TBI-related mortality is 30–50% and in most cases involves adolescents or young adults. Previous literature has suggested that neutrophil-to-lymphocyte ratio (NLR) may serve as a sensitive biomarker in predicting clinical outcomes following TBI. With conclusive evidence in this regard lacking, this study aimed to systematically review all original studies reporting the effectiveness of NLR as a predictor of TBI outcomes. A systematic search of eight databases was conducted according to the Preferred Reporting Items for Systematic Review and Meta-Analyses statement (PRISMA) recommendations. The risk of bias was assessed using the Quality in Prognostic Studies (QUIPS) tool. Eight studies were ultimately included in the study. In most of the studies interrogated, severity outcomes were successfully predicted by NLR in both univariate and multivariate prediction models, in different follow-up durations up to 6 months. A high NLR at 24 and 48 h after TBI in pediatric patients was associated with worse clinical outcomes. On pooling the NLR values within studies assessing its association with the outcome severity (favorable or not), patients with favorable outcomes had 37% lower NLR values than those with unfavorable ones (RoM= 0.63; 95% CI = 0.44–0.88; p = 0.007). However, there were considerable heterogeneity in effect estimates (I2 = 99%; p < 0.001). Moreover, NLR was a useful indicator of mortality at both 6-month and 1-year intervals. In conjunction with clinical and radiographic parameters, NLR might be a useful, inexpensive marker in predicting clinical outcomes in patients with TBI. However, the considerable heterogeneity in current literature keeps it under investigation with further studies are warranted to confirm the reliability of NLR in predicting TBI outcomes.
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title_short	The prognostic value of neutrophil-to-lymphocyte ratio in patients with traumatic brain injury: A systematic review
url	https://doi.org/10.3389/fneur.2022.1021877 https://doaj.org/article/582da87f49c043b39ad69b92ce464313 https://www.frontiersin.org/articles/10.3389/fneur.2022.1021877/full https://doaj.org/toc/1664-2295
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The prognostic value of neutrophil-to-lymphocyte ratio in patients with traumatic brain injury: A systematic review

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