Male pheromones modulate synaptic transmission at the C. elegans neuromuscular junction in a sexually dimorphic manner

The development of functional synapses in the nervous system is important for animal physiology and behaviors, and its disturbance has been linked with many neurodevelopmental disorders. The synaptic transmission efficacy can be modulated by the environment to accommodate external changes, which is...
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Autor*in:	Kang-Ying Qian [verfasserIn] Wan-Xin Zeng [verfasserIn] Yue Hao [verfasserIn] Xian-Ting Zeng [verfasserIn] Haowen Liu [verfasserIn] Lei Li [verfasserIn] Lili Chen [verfasserIn] Fu-min Tian [verfasserIn] Cindy Chang [verfasserIn] Qi Hall [verfasserIn] Chun-Xue Song [verfasserIn] Shangbang Gao [verfasserIn] Zhitao Hu [verfasserIn] Joshua M Kaplan [verfasserIn] Qian Li [verfasserIn] Xia-Jing Tong [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	synaptic transmission neuromuscular junction pheromone sexual dimorphism chemosensory neuron CaV2 calcium channel

Übergeordnetes Werk:	In: eLife - eLife Sciences Publications Ltd, 2013, 10(2021)
Übergeordnetes Werk:	volume:10 ; year:2021

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.7554/eLife.67170

Katalog-ID:	DOAJ021051585

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allfields	10.7554/eLife.67170 doi (DE-627)DOAJ021051585 (DE-599)DOAJ04234774dad0450aa5198a7b61230362 DE-627 ger DE-627 rakwb eng QH301-705.5 Kang-Ying Qian verfasserin aut Male pheromones modulate synaptic transmission at the C. elegans neuromuscular junction in a sexually dimorphic manner 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The development of functional synapses in the nervous system is important for animal physiology and behaviors, and its disturbance has been linked with many neurodevelopmental disorders. The synaptic transmission efficacy can be modulated by the environment to accommodate external changes, which is crucial for animal reproduction and survival. However, the underlying plasticity of synaptic transmission remains poorly understood. Here we show that in Caenorhabditis elegans, the male environment increases the hermaphrodite cholinergic transmission at the neuromuscular junction (NMJ), which alters hermaphrodites’ locomotion velocity and mating efficiency. We identify that the male-specific pheromones mediate this synaptic transmission modulation effect in a developmental stage-dependent manner. Dissection of the sensory circuits reveals that the AWB chemosensory neurons sense those male pheromones and further transduce the information to NMJ using cGMP signaling. Exposure of hermaphrodites to the male pheromones specifically increases the accumulation of presynaptic CaV2 calcium channels and clustering of postsynaptic acetylcholine receptors at cholinergic synapses of NMJ, which potentiates cholinergic synaptic transmission. Thus, our study demonstrates a circuit mechanism for synaptic modulation and behavioral flexibility by sexual dimorphic pheromones. synaptic transmission neuromuscular junction pheromone sexual dimorphism chemosensory neuron CaV2 calcium channel Medicine R Science Q Biology (General) Wan-Xin Zeng verfasserin aut Yue Hao verfasserin aut Xian-Ting Zeng verfasserin aut Haowen Liu verfasserin aut Lei Li verfasserin aut Lili Chen verfasserin aut Fu-min Tian verfasserin aut Cindy Chang verfasserin aut Qi Hall verfasserin aut Chun-Xue Song verfasserin aut Shangbang Gao verfasserin aut Zhitao Hu verfasserin aut Joshua M Kaplan verfasserin aut Qian Li verfasserin aut Xia-Jing Tong verfasserin aut In eLife eLife Sciences Publications Ltd, 2013 10(2021) (DE-627)728518384 (DE-600)2687154-3 2050084X nnns volume:10 year:2021 https://doi.org/10.7554/eLife.67170 kostenfrei https://doaj.org/article/04234774dad0450aa5198a7b61230362 kostenfrei https://elifesciences.org/articles/67170 kostenfrei https://doaj.org/toc/2050-084X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021
spelling	10.7554/eLife.67170 doi (DE-627)DOAJ021051585 (DE-599)DOAJ04234774dad0450aa5198a7b61230362 DE-627 ger DE-627 rakwb eng QH301-705.5 Kang-Ying Qian verfasserin aut Male pheromones modulate synaptic transmission at the C. elegans neuromuscular junction in a sexually dimorphic manner 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The development of functional synapses in the nervous system is important for animal physiology and behaviors, and its disturbance has been linked with many neurodevelopmental disorders. The synaptic transmission efficacy can be modulated by the environment to accommodate external changes, which is crucial for animal reproduction and survival. However, the underlying plasticity of synaptic transmission remains poorly understood. Here we show that in Caenorhabditis elegans, the male environment increases the hermaphrodite cholinergic transmission at the neuromuscular junction (NMJ), which alters hermaphrodites’ locomotion velocity and mating efficiency. We identify that the male-specific pheromones mediate this synaptic transmission modulation effect in a developmental stage-dependent manner. Dissection of the sensory circuits reveals that the AWB chemosensory neurons sense those male pheromones and further transduce the information to NMJ using cGMP signaling. Exposure of hermaphrodites to the male pheromones specifically increases the accumulation of presynaptic CaV2 calcium channels and clustering of postsynaptic acetylcholine receptors at cholinergic synapses of NMJ, which potentiates cholinergic synaptic transmission. Thus, our study demonstrates a circuit mechanism for synaptic modulation and behavioral flexibility by sexual dimorphic pheromones. synaptic transmission neuromuscular junction pheromone sexual dimorphism chemosensory neuron CaV2 calcium channel Medicine R Science Q Biology (General) Wan-Xin Zeng verfasserin aut Yue Hao verfasserin aut Xian-Ting Zeng verfasserin aut Haowen Liu verfasserin aut Lei Li verfasserin aut Lili Chen verfasserin aut Fu-min Tian verfasserin aut Cindy Chang verfasserin aut Qi Hall verfasserin aut Chun-Xue Song verfasserin aut Shangbang Gao verfasserin aut Zhitao Hu verfasserin aut Joshua M Kaplan verfasserin aut Qian Li verfasserin aut Xia-Jing Tong verfasserin aut In eLife eLife Sciences Publications Ltd, 2013 10(2021) (DE-627)728518384 (DE-600)2687154-3 2050084X nnns volume:10 year:2021 https://doi.org/10.7554/eLife.67170 kostenfrei https://doaj.org/article/04234774dad0450aa5198a7b61230362 kostenfrei https://elifesciences.org/articles/67170 kostenfrei https://doaj.org/toc/2050-084X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021
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allfieldsGer	10.7554/eLife.67170 doi (DE-627)DOAJ021051585 (DE-599)DOAJ04234774dad0450aa5198a7b61230362 DE-627 ger DE-627 rakwb eng QH301-705.5 Kang-Ying Qian verfasserin aut Male pheromones modulate synaptic transmission at the C. elegans neuromuscular junction in a sexually dimorphic manner 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The development of functional synapses in the nervous system is important for animal physiology and behaviors, and its disturbance has been linked with many neurodevelopmental disorders. The synaptic transmission efficacy can be modulated by the environment to accommodate external changes, which is crucial for animal reproduction and survival. However, the underlying plasticity of synaptic transmission remains poorly understood. Here we show that in Caenorhabditis elegans, the male environment increases the hermaphrodite cholinergic transmission at the neuromuscular junction (NMJ), which alters hermaphrodites’ locomotion velocity and mating efficiency. We identify that the male-specific pheromones mediate this synaptic transmission modulation effect in a developmental stage-dependent manner. Dissection of the sensory circuits reveals that the AWB chemosensory neurons sense those male pheromones and further transduce the information to NMJ using cGMP signaling. Exposure of hermaphrodites to the male pheromones specifically increases the accumulation of presynaptic CaV2 calcium channels and clustering of postsynaptic acetylcholine receptors at cholinergic synapses of NMJ, which potentiates cholinergic synaptic transmission. Thus, our study demonstrates a circuit mechanism for synaptic modulation and behavioral flexibility by sexual dimorphic pheromones. synaptic transmission neuromuscular junction pheromone sexual dimorphism chemosensory neuron CaV2 calcium channel Medicine R Science Q Biology (General) Wan-Xin Zeng verfasserin aut Yue Hao verfasserin aut Xian-Ting Zeng verfasserin aut Haowen Liu verfasserin aut Lei Li verfasserin aut Lili Chen verfasserin aut Fu-min Tian verfasserin aut Cindy Chang verfasserin aut Qi Hall verfasserin aut Chun-Xue Song verfasserin aut Shangbang Gao verfasserin aut Zhitao Hu verfasserin aut Joshua M Kaplan verfasserin aut Qian Li verfasserin aut Xia-Jing Tong verfasserin aut In eLife eLife Sciences Publications Ltd, 2013 10(2021) (DE-627)728518384 (DE-600)2687154-3 2050084X nnns volume:10 year:2021 https://doi.org/10.7554/eLife.67170 kostenfrei https://doaj.org/article/04234774dad0450aa5198a7b61230362 kostenfrei https://elifesciences.org/articles/67170 kostenfrei https://doaj.org/toc/2050-084X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021
allfieldsSound	10.7554/eLife.67170 doi (DE-627)DOAJ021051585 (DE-599)DOAJ04234774dad0450aa5198a7b61230362 DE-627 ger DE-627 rakwb eng QH301-705.5 Kang-Ying Qian verfasserin aut Male pheromones modulate synaptic transmission at the C. elegans neuromuscular junction in a sexually dimorphic manner 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The development of functional synapses in the nervous system is important for animal physiology and behaviors, and its disturbance has been linked with many neurodevelopmental disorders. The synaptic transmission efficacy can be modulated by the environment to accommodate external changes, which is crucial for animal reproduction and survival. However, the underlying plasticity of synaptic transmission remains poorly understood. Here we show that in Caenorhabditis elegans, the male environment increases the hermaphrodite cholinergic transmission at the neuromuscular junction (NMJ), which alters hermaphrodites’ locomotion velocity and mating efficiency. We identify that the male-specific pheromones mediate this synaptic transmission modulation effect in a developmental stage-dependent manner. Dissection of the sensory circuits reveals that the AWB chemosensory neurons sense those male pheromones and further transduce the information to NMJ using cGMP signaling. Exposure of hermaphrodites to the male pheromones specifically increases the accumulation of presynaptic CaV2 calcium channels and clustering of postsynaptic acetylcholine receptors at cholinergic synapses of NMJ, which potentiates cholinergic synaptic transmission. Thus, our study demonstrates a circuit mechanism for synaptic modulation and behavioral flexibility by sexual dimorphic pheromones. synaptic transmission neuromuscular junction pheromone sexual dimorphism chemosensory neuron CaV2 calcium channel Medicine R Science Q Biology (General) Wan-Xin Zeng verfasserin aut Yue Hao verfasserin aut Xian-Ting Zeng verfasserin aut Haowen Liu verfasserin aut Lei Li verfasserin aut Lili Chen verfasserin aut Fu-min Tian verfasserin aut Cindy Chang verfasserin aut Qi Hall verfasserin aut Chun-Xue Song verfasserin aut Shangbang Gao verfasserin aut Zhitao Hu verfasserin aut Joshua M Kaplan verfasserin aut Qian Li verfasserin aut Xia-Jing Tong verfasserin aut In eLife eLife Sciences Publications Ltd, 2013 10(2021) (DE-627)728518384 (DE-600)2687154-3 2050084X nnns volume:10 year:2021 https://doi.org/10.7554/eLife.67170 kostenfrei https://doaj.org/article/04234774dad0450aa5198a7b61230362 kostenfrei https://elifesciences.org/articles/67170 kostenfrei https://doaj.org/toc/2050-084X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021
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callnumber-first	Q - Science
author	Kang-Ying Qian
spellingShingle	Kang-Ying Qian misc QH301-705.5 misc synaptic transmission misc neuromuscular junction misc pheromone misc sexual dimorphism misc chemosensory neuron misc CaV2 calcium channel misc Medicine misc R misc Science misc Q misc Biology (General) Male pheromones modulate synaptic transmission at the C. elegans neuromuscular junction in a sexually dimorphic manner
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topic_title	QH301-705.5 Male pheromones modulate synaptic transmission at the C. elegans neuromuscular junction in a sexually dimorphic manner synaptic transmission neuromuscular junction pheromone sexual dimorphism chemosensory neuron CaV2 calcium channel
topic	misc QH301-705.5 misc synaptic transmission misc neuromuscular junction misc pheromone misc sexual dimorphism misc chemosensory neuron misc CaV2 calcium channel misc Medicine misc R misc Science misc Q misc Biology (General)
topic_unstemmed	misc QH301-705.5 misc synaptic transmission misc neuromuscular junction misc pheromone misc sexual dimorphism misc chemosensory neuron misc CaV2 calcium channel misc Medicine misc R misc Science misc Q misc Biology (General)
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title	Male pheromones modulate synaptic transmission at the C. elegans neuromuscular junction in a sexually dimorphic manner
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title_full	Male pheromones modulate synaptic transmission at the C. elegans neuromuscular junction in a sexually dimorphic manner
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author_browse	Kang-Ying Qian Wan-Xin Zeng Yue Hao Xian-Ting Zeng Haowen Liu Lei Li Lili Chen Fu-min Tian Cindy Chang Qi Hall Chun-Xue Song Shangbang Gao Zhitao Hu Joshua M Kaplan Qian Li Xia-Jing Tong
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title_sort	male pheromones modulate synaptic transmission at the c. elegans neuromuscular junction in a sexually dimorphic manner
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title_auth	Male pheromones modulate synaptic transmission at the C. elegans neuromuscular junction in a sexually dimorphic manner
abstract	The development of functional synapses in the nervous system is important for animal physiology and behaviors, and its disturbance has been linked with many neurodevelopmental disorders. The synaptic transmission efficacy can be modulated by the environment to accommodate external changes, which is crucial for animal reproduction and survival. However, the underlying plasticity of synaptic transmission remains poorly understood. Here we show that in Caenorhabditis elegans, the male environment increases the hermaphrodite cholinergic transmission at the neuromuscular junction (NMJ), which alters hermaphrodites’ locomotion velocity and mating efficiency. We identify that the male-specific pheromones mediate this synaptic transmission modulation effect in a developmental stage-dependent manner. Dissection of the sensory circuits reveals that the AWB chemosensory neurons sense those male pheromones and further transduce the information to NMJ using cGMP signaling. Exposure of hermaphrodites to the male pheromones specifically increases the accumulation of presynaptic CaV2 calcium channels and clustering of postsynaptic acetylcholine receptors at cholinergic synapses of NMJ, which potentiates cholinergic synaptic transmission. Thus, our study demonstrates a circuit mechanism for synaptic modulation and behavioral flexibility by sexual dimorphic pheromones.
abstractGer	The development of functional synapses in the nervous system is important for animal physiology and behaviors, and its disturbance has been linked with many neurodevelopmental disorders. The synaptic transmission efficacy can be modulated by the environment to accommodate external changes, which is crucial for animal reproduction and survival. However, the underlying plasticity of synaptic transmission remains poorly understood. Here we show that in Caenorhabditis elegans, the male environment increases the hermaphrodite cholinergic transmission at the neuromuscular junction (NMJ), which alters hermaphrodites’ locomotion velocity and mating efficiency. We identify that the male-specific pheromones mediate this synaptic transmission modulation effect in a developmental stage-dependent manner. Dissection of the sensory circuits reveals that the AWB chemosensory neurons sense those male pheromones and further transduce the information to NMJ using cGMP signaling. Exposure of hermaphrodites to the male pheromones specifically increases the accumulation of presynaptic CaV2 calcium channels and clustering of postsynaptic acetylcholine receptors at cholinergic synapses of NMJ, which potentiates cholinergic synaptic transmission. Thus, our study demonstrates a circuit mechanism for synaptic modulation and behavioral flexibility by sexual dimorphic pheromones.
abstract_unstemmed	The development of functional synapses in the nervous system is important for animal physiology and behaviors, and its disturbance has been linked with many neurodevelopmental disorders. The synaptic transmission efficacy can be modulated by the environment to accommodate external changes, which is crucial for animal reproduction and survival. However, the underlying plasticity of synaptic transmission remains poorly understood. Here we show that in Caenorhabditis elegans, the male environment increases the hermaphrodite cholinergic transmission at the neuromuscular junction (NMJ), which alters hermaphrodites’ locomotion velocity and mating efficiency. We identify that the male-specific pheromones mediate this synaptic transmission modulation effect in a developmental stage-dependent manner. Dissection of the sensory circuits reveals that the AWB chemosensory neurons sense those male pheromones and further transduce the information to NMJ using cGMP signaling. Exposure of hermaphrodites to the male pheromones specifically increases the accumulation of presynaptic CaV2 calcium channels and clustering of postsynaptic acetylcholine receptors at cholinergic synapses of NMJ, which potentiates cholinergic synaptic transmission. Thus, our study demonstrates a circuit mechanism for synaptic modulation and behavioral flexibility by sexual dimorphic pheromones.
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title_short	Male pheromones modulate synaptic transmission at the C. elegans neuromuscular junction in a sexually dimorphic manner
url	https://doi.org/10.7554/eLife.67170 https://doaj.org/article/04234774dad0450aa5198a7b61230362 https://elifesciences.org/articles/67170 https://doaj.org/toc/2050-084X
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author2	Wan-Xin Zeng Yue Hao Xian-Ting Zeng Haowen Liu Lei Li Lili Chen Fu-min Tian Cindy Chang Qi Hall Chun-Xue Song Shangbang Gao Zhitao Hu Joshua M Kaplan Qian Li Xia-Jing Tong
author2Str	Wan-Xin Zeng Yue Hao Xian-Ting Zeng Haowen Liu Lei Li Lili Chen Fu-min Tian Cindy Chang Qi Hall Chun-Xue Song Shangbang Gao Zhitao Hu Joshua M Kaplan Qian Li Xia-Jing Tong
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doi_str	10.7554/eLife.67170
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up_date	2024-07-03T18:35:52.251Z
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The synaptic transmission efficacy can be modulated by the environment to accommodate external changes, which is crucial for animal reproduction and survival. However, the underlying plasticity of synaptic transmission remains poorly understood. Here we show that in Caenorhabditis elegans, the male environment increases the hermaphrodite cholinergic transmission at the neuromuscular junction (NMJ), which alters hermaphrodites’ locomotion velocity and mating efficiency. We identify that the male-specific pheromones mediate this synaptic transmission modulation effect in a developmental stage-dependent manner. Dissection of the sensory circuits reveals that the AWB chemosensory neurons sense those male pheromones and further transduce the information to NMJ using cGMP signaling. Exposure of hermaphrodites to the male pheromones specifically increases the accumulation of presynaptic CaV2 calcium channels and clustering of postsynaptic acetylcholine receptors at cholinergic synapses of NMJ, which potentiates cholinergic synaptic transmission. 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Male pheromones modulate synaptic transmission at the C. elegans neuromuscular junction in a sexually dimorphic manner

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